{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:01:36Z","timestamp":1790910096216,"version":"4.1.0"},"reference-count":81,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":148,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005440","name":"Central Finland Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2025,1,1]]},"DOI":"10.1016\/j.csbj.2025.05.052","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:39:41Z","timestamp":1748597981000},"page":"2298-2312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evolution is in the details: Regulatory differences in modern human and Neanderthal"],"prefix":"10.34133","volume":"27","author":[{"given":"Harlan R.","family":"Barker","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland"},{"name":"Fimlab Ltd., Tampere University Hospital, Tampere 33520, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Parkkila","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland"},{"name":"Fimlab Ltd., Tampere University Hospital, Tampere 33520, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martti E.E.","family":"Tolvanen","sequence":"additional","affiliation":[{"name":"Department of Computing, University of Turku, Turku 20014, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188021"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1405138111"},{"key":"e_1_3_6_4_2","doi-asserted-by":"crossref","unstructured":"Pr\u00fcfer K. Hajdinjak M. Vernot B. Skov L. Hsieh P. Peyr\u00e9gne S. et al: A high-coverage neandertal genome from vindija cave in Croatia. Science 2017; 358: 655. \u3008http:\/\/science.sciencemag.org\/\u3009. (Available).","DOI":"10.1126\/science.aao1887"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature26151"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09710"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224344"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12886"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814338116"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.60"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4493-4"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240647"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0307731"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0686-2"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1109\/MCSE.2007.55"},{"key":"e_1_3_6_16_2","unstructured":"Waskom M. Gelbart M. Botvinnik O. Ostblom J. Hobson P. Lukauskas S. et al. mwaskom\/seaborn: v0.11.1 2020 (December 2020). doi:10.5281\/zenodo.4379347."},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn615"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1038"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1506-7"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20188746"},{"key":"e_1_3_6_24_2","unstructured":"Chippada B. forceatlas2: Fastest Gephi\u2019s ForceAtlas2 graph layout algorithm implemented for Python and NetworkX. Github; Available: \u3008https:\/\/github.com\/bhargavchippada\/forceatlas2\u3009."},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098679"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw943"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav8130"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4077"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209923"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.022"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24080"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.071"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.01.022"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.005439"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1120"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04434-5"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.12.036"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-013-0356-y"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23724"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31071"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13595"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.254"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/35097076"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4380"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss271"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.048"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo7257"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6748"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05377-7"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.04.025"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2013.82"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00397"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(17)38689-1"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00079"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.06.002"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-019-9292-y"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2956"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-00757-x"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv199"},{"key":"e_1_3_6_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp239"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016199"},{"key":"e_1_3_6_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-015-9831-y"},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08301"},{"key":"e_1_3_6_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt295"},{"key":"e_1_3_6_68_2","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716648290"},{"key":"e_1_3_6_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.129"},{"key":"e_1_3_6_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.09.008"},{"key":"e_1_3_6_71_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58741"},{"key":"e_1_3_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2020.03.002"},{"key":"e_1_3_6_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.2338"},{"key":"e_1_3_6_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icz025"},{"key":"e_1_3_6_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-022-02732-9"},{"key":"e_1_3_6_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18015"},{"key":"e_1_3_6_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.02.023"},{"key":"e_1_3_6_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhevol.2010.04.005"},{"key":"e_1_3_6_79_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw1268"},{"key":"e_1_3_6_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2696"},{"key":"e_1_3_6_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby058"},{"key":"e_1_3_6_82_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001626"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037025002156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037025002156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2025.05.052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:33:11Z","timestamp":1775219591000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2025.05.052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":81,"alternative-id":["10.1016\/j.csbj.2025.05.052"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2025.05.052","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.04.282749","asserted-by":"object"}]},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolution is in the details: Regulatory differences in modern human and Neanderthal","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2025.05.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}