{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:44:43Z","timestamp":1791582283575,"version":"4.3.4"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":326,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008628","name":"Ministry of Electronics and Information Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["D\/HPC\/2(1)\/2014\/ CORP"],"award-info":[{"award-number":["D\/HPC\/2(1)\/2014\/ CORP"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["3191"],"award-info":[{"award-number":["3191"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR40160\/BTIS\/137\/64\/2023"],"award-info":[{"award-number":["BT\/PR40160\/BTIS\/137\/64\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR50983\/MED\/29\/1650\/2023"],"award-info":[{"award-number":["BT\/PR50983\/MED\/29\/1650\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR40325\/BTIS\/137\/1\/2020"],"award-info":[{"award-number":["BT\/PR40325\/BTIS\/137\/1\/2020"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/BI\/TCB\/007\/2021"],"award-info":[{"award-number":["BT\/BI\/TCB\/007\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR40267\/BTIS\/137\/67\/2023"],"award-info":[{"award-number":["BT\/PR40267\/BTIS\/137\/67\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100026280","name":"BRIC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100026280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011753","name":"National Institute of Immunology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2025,1,1]]},"DOI":"10.1016\/j.csbj.2025.11.054","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T17:07:54Z","timestamp":1764004074000},"page":"5425-5440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>In silico<\/i>\n                    analysis of the functional implications of drug resistance associated mutations in\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.34133","volume":"27","author":[{"given":"Ankita","family":"Pal","sequence":"first","affiliation":[{"name":"Bioinformatics Center, BRIC-National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Pal","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, BRIC-National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Mahapatra","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, BRIC-National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apratim","family":"Pandey","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, BRIC-National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasisa","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, BRIC-National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2024.107325","article-title":"Insights from the 2024 WHO Global Tuberculosis Report - More Comprehensive Action, Innovation, and Investments required for achieving WHO End TB goals","volume":"150","author":"Goletti D.","year":"2025","unstructured":"Goletti D. et al: Insights from the 2024 WHO Global Tuberculosis Report - More Comprehensive Action, Innovation, and Investments required for achieving WHO End TB goals. Int J Infect Dis 2025; 150: 107325.","journal-title":"Int J Infect Dis"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"e265","DOI":"10.1016\/S2666-5247(21)00301-3","article-title":"The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis","volume":"3","author":"Walker T.M.","year":"2022","unstructured":"Walker T.M. et al: The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis. Lancet Microbe 2022; 3: e265.","journal-title":"Lancet Microbe"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"1027394","DOI":"10.3389\/fcimb.2022.1027394","article-title":"The evolving biology of Mycobacterium tuberculosis drug resistance","volume":"12","author":"Jones R.M.","year":"2022","unstructured":"Jones R.M. et al: The evolving biology of Mycobacterium tuberculosis drug resistance. Front Cell Infect Microbiol 2022; 12: 1027394.","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_5_5_2","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.954074","article-title":"Evolution of Mycobacterium tuberculosis drug resistance in the genomic era","volume":"12","author":"Nimmo C.","year":"2022","unstructured":"Nimmo C. et al: Evolution of Mycobacterium tuberculosis drug resistance in the genomic era. Front Cell Infect Microbiol 2022; 12: 954074.","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12337"},{"key":"e_1_3_5_7_2","doi-asserted-by":"crossref","first-page":"15356","DOI":"10.1038\/s41598-018-33370-6","article-title":"Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis","volume":"8","author":"Portelli S.","year":"2018","unstructured":"Portelli S. et al: Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis. Sci Rep 2018; 8: 15356.","journal-title":"Sci Rep"},{"key":"e_1_3_5_8_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1128\/AAC.01024-12","article-title":"Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis","volume":"57","author":"Pang Y.","year":"2013","unstructured":"Pang Y. et al: Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis. Antimicrob Agents Chemother 2013; 57: 893.","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_5_9_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jiph.2018.04.005","article-title":"Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis","volume":"11","author":"Zaw M.T.","year":"2018","unstructured":"Zaw M.T., Emran N.A. and Lin Z.: Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis. J Infect Public Health 2018; 11: 605.","journal-title":"J Infect Public Health"},{"key":"e_1_3_5_10_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/jac\/dkq519","article-title":"Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis","volume":"66","author":"Siu G.K.","year":"2011","unstructured":"Siu G.K. et al: Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis. J Antimicrob Chemother 2011; 66: 730.","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27030885","article-title":"The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding","volume":"27","author":"Amusengeri A.","year":"2022","unstructured":"Amusengeri A., Khan A. and Tastan Bishop O.: The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding. Molecules 2022; 27.","journal-title":"Molecules"},{"key":"e_1_3_5_12_2","doi-asserted-by":"crossref","first-page":"12300","DOI":"10.1074\/jbc.M113.529164","article-title":"Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding","volume":"289","author":"Mustaev A.","year":"2014","unstructured":"Mustaev A. et al: Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. J Biol Chem 2014; 289: 12300.","journal-title":"J Biol Chem"},{"key":"e_1_3_5_13_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/187152607781001763","article-title":"Mycobacterium tuberculosis DNA gyrase as a target for drug discovery","volume":"7","author":"Mdluli K.","year":"2007","unstructured":"Mdluli K. and Ma Z.: Mycobacterium tuberculosis DNA gyrase as a target for drug discovery. Infect Disord Drug Targets 2007; 7: 159.","journal-title":"Infect Disord Drug Targets"},{"key":"e_1_3_5_14_2","doi-asserted-by":"crossref","first-page":"E839","DOI":"10.1073\/pnas.1525055113","article-title":"Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase","volume":"113","author":"Aldred K.J.","year":"2016","unstructured":"Aldred K.J. et al: Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase. Proc Natl Acad Sci USA 2016; 113: E839.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_5_15_2","doi-asserted-by":"crossref","first-page":"vbaf050","DOI":"10.1093\/bioadv\/vbaf050","article-title":"Machine learning-based approach for identification of new resistance associated mutations from whole genome sequences of Mycobacterium tuberculosis","volume":"5","author":"Pal A.","year":"2025","unstructured":"Pal A. and Mohanty D.: Machine learning-based approach for identification of new resistance associated mutations from whole genome sequences of Mycobacterium tuberculosis. Bioinform Adv 2025; 5: vbaf050.","journal-title":"Bioinform Adv"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/31159"},{"key":"e_1_3_5_17_2","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Gene Ontology C.","year":"2023","unstructured":"Gene Ontology C. et al: The Gene Ontology knowledgebase in 2023. Genetics 2023; 224.","journal-title":"Genetics"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"e_1_3_5_20_2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/bib\/bbx083","article-title":"PATRIC as a unique resource for studying antimicrobial resistance","volume":"20","author":"Antonopoulos D.A.","year":"2019","unstructured":"Antonopoulos D.A. et al: PATRIC as a unique resource for studying antimicrobial resistance. Brief Bioinform 2019; 20: 1094.","journal-title":"Brief Bioinform"},{"key":"e_1_3_5_21_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001721","article-title":"A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics","volume":"20","author":"The C.C.","year":"2022","unstructured":"The C.C.: A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics. PLoS Biol 2022; 20: e3001721.","journal-title":"PLoS Biol"},{"key":"e_1_3_5_22_2","unstructured":"Seemann T. SNIPPY; Rapid haploid variant calling and core genome alignment. Available from: \u3008https:\/\/github.com\/tseemann\/snippy\u3009."},{"key":"e_1_3_5_23_2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/nar\/26.1.320","article-title":"Pfam: multiple sequence alignments and HMM-profiles of protein domains","volume":"26","author":"Sonnhammer E.L.","year":"1998","unstructured":"Sonnhammer E.L. et al: Pfam: multiple sequence alignments and HMM-profiles of protein domains. Nucleic Acids Res 1998; 26: 320.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt691"},{"key":"e_1_3_5_25_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ja.2015.9","article-title":"Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates","volume":"68","author":"Li G.","year":"2015","unstructured":"Li G. et al: Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates. J Antibiot (Tokyo) 2015; 68: 431.","journal-title":"J Antibiot (Tokyo)"},{"key":"e_1_3_5_26_2","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1016\/j.ijmyco.2016.09.067","article-title":"Increased expression of efflux pump genes in extensively drug-resistant isolates of Mycobacterium tuberculosis","volume":"5","author":"Kanji A.","year":"2016","unstructured":"Kanji A. et al: Increased expression of efflux pump genes in extensively drug-resistant isolates of Mycobacterium tuberculosis. Int J Mycobacteriol 2016; 5: S150.","journal-title":"Int J Mycobacteriol"},{"key":"e_1_3_5_27_2","doi-asserted-by":"crossref","DOI":"10.1128\/jb.00165-23","article-title":"Three genes controlling streptomycin susceptibility in Agrobacterium fabrum","volume":"205","author":"Howarth R.E.","year":"2023","unstructured":"Howarth R.E. et al: Three genes controlling streptomycin susceptibility in Agrobacterium fabrum. J Bacteriol 2023; 205: e0016523.","journal-title":"J Bacteriol"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2017.04.002"},{"key":"e_1_3_5_29_2","doi-asserted-by":"crossref","DOI":"10.1002\/pro.5257","article-title":"SG-ML-PLAP: A structure-guided machine learning-based scoring function for protein-ligand binding affinity prediction","volume":"34","author":"Pal S.","year":"2025","unstructured":"Pal S., Pal A. and Mohanty D.: SG-ML-PLAP: A structure-guided machine learning-based scoring function for protein-ligand binding affinity prediction. Protein Sci 2025; 34: e5257.","journal-title":"Protein Sci"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26518-0"},{"key":"e_1_3_5_31_2","doi-asserted-by":"crossref","first-page":"16484","DOI":"10.1074\/jbc.M113.468892","article-title":"Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones","volume":"288","author":"Gokulan K.","year":"2013","unstructured":"Gokulan K. et al: Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. J Biol Chem 2013; 288: 16484.","journal-title":"J Biol Chem"},{"key":"e_1_3_5_32_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-3-642-14541-4_8","article-title":"Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy","volume":"201","author":"Keppler D.","year":"2011","unstructured":"Keppler D.: Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy. Handb Exp Pharm 2011; 201: 299.","journal-title":"Handb Exp Pharm"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.22.6068-6071.1998"},{"key":"e_1_3_5_34_2","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02510-23","article-title":"Overexpression of efflux pump genes is one of the mechanisms causing drug resistance in Mycobacterium tuberculosis","volume":"12","author":"Long Y.","year":"2024","unstructured":"Long Y. et al: Overexpression of efflux pump genes is one of the mechanisms causing drug resistance in Mycobacterium tuberculosis. Microbiol Spectr 2024; 12: e0251023.","journal-title":"Microbiol Spectr"},{"key":"e_1_3_5_35_2","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2165\/11317030-000000000-00000","article-title":"Efflux-mediated drug resistance in bacteria: an update","volume":"69","author":"Li X.Z.","year":"2009","unstructured":"Li X.Z. and Nikaido H.: Efflux-mediated drug resistance in bacteria: an update. Drugs 2009; 69: 1555.","journal-title":"Drugs"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku411"},{"key":"e_1_3_5_37_2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a027029","article-title":"Aminoglycosides: An Overview","volume":"6","author":"Krause K.M.","year":"2016","unstructured":"Krause K.M. et al: Aminoglycosides: An Overview. Cold Spring Harb Perspect Med 2016; 6.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_3_5_38_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1471-2180-14-165","article-title":"Molecular characterization of amikacin, kanamycin and capreomycin resistance in M\/XDR-TB strains isolated in Thailand","volume":"14","author":"Sowajassatakul A.","year":"2014","unstructured":"Sowajassatakul A. et al: Molecular characterization of amikacin, kanamycin and capreomycin resistance in M\/XDR-TB strains isolated in Thailand. BMC Microbiol 2014; 14: 165.","journal-title":"BMC Microbiol"},{"key":"e_1_3_5_39_2","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1128\/AAC.00851-09","article-title":"High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gene","volume":"53","author":"Jugheli L.","year":"2009","unstructured":"Jugheli L. et al: High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gene. Antimicrob Agents Chemother 2009; 53: 5064.","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_5_40_2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/AAC.04438-14","article-title":"Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium tuberculosis","volume":"59","author":"Reeves A.Z.","year":"2015","unstructured":"Reeves A.Z. et al: Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 2015; 59: 444.","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba9102"},{"key":"e_1_3_5_42_2","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1128\/AAC.41.8.1677","article-title":"Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations","volume":"41","author":"Sreevatsan S.","year":"1997","unstructured":"Sreevatsan S. et al: Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations. Antimicrob Agents Chemother 1997; 41: 1677.","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_5_43_2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.4103\/lungindia.lungindia_120_21","article-title":"Correlation of inhA mutations and ethionamide susceptibility: Experience from national reference center for tuberculosis","volume":"38","author":"Sarin R.","year":"2021","unstructured":"Sarin R. et al: Correlation of inhA mutations and ethionamide susceptibility: Experience from national reference center for tuberculosis. Lung India 2021; 38: 520.","journal-title":"Lung India"},{"key":"e_1_3_5_44_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2147\/IDR.S268799","article-title":"The Value of the inhA Mutation Detection in Predicting Ethionamide Resistance Using Melting Curve Technology","volume":"14","author":"Song Y.","year":"2021","unstructured":"Song Y. et al: The Value of the inhA Mutation Detection in Predicting Ethionamide Resistance Using Melting Curve Technology. Infect Drug Resist 2021; 14: 329.","journal-title":"Infect Drug Resist"},{"key":"e_1_3_5_45_2","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1093\/jac\/dkt090","article-title":"High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations","volume":"68","author":"Machado D.","year":"2013","unstructured":"Machado D. et al: High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations. J Antimicrob Chemother 2013; 68: 1728.","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_46_2","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3389\/fmicb.2017.00710","article-title":"EthA\/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide","volume":"8","author":"Ang M.L.T.","year":"2017","unstructured":"Ang M.L.T. et al: EthA\/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide. Front Microbiol 2017; 8: 710.","journal-title":"Front Microbiol"},{"key":"e_1_3_5_47_2","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.5588\/ijtld.15.0864","article-title":"Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis","volume":"20","author":"Bollela V.R.","year":"2016","unstructured":"Bollela V.R. et al: Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis. Int J Tube Lung Dis 2016; 20: 1099.","journal-title":"Int J Tube Lung Dis"},{"key":"e_1_3_5_48_2","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1038\/s41598-018-21378-x","article-title":"Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations","volume":"8","author":"Lempens P.","year":"2018","unstructured":"Lempens P. et al: Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations. Sci Rep 2018; 8: 3246.","journal-title":"Sci Rep"},{"key":"e_1_3_5_49_2","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1128\/AAC.01691-09","article-title":"Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis","volume":"54","author":"Ando H.","year":"2010","unstructured":"Ando H. et al: Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 2010; 54: 1793.","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_5_50_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijmyco.2015.09.001","article-title":"Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables","volume":"5","author":"Kambli P.","year":"2016","unstructured":"Kambli P. et al: Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables. Int J Mycobacteriol 2016; 5: 1.","journal-title":"Int J Mycobacteriol"},{"key":"e_1_3_5_51_2","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/jac\/dks178","article-title":"The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region","volume":"67","author":"Gikalo M.B.","year":"2012","unstructured":"Gikalo M.B. et al: The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region. J Antimicrob Chemother 2012; 67: 2107.","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01049-15"},{"key":"e_1_3_5_53_2","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1128\/AAC.02583-13","article-title":"Moxifloxacin retains antimycobacterial activity in the presence of gyrA mutations","volume":"58","author":"McGrath M.","year":"2014","unstructured":"McGrath M. et al: Moxifloxacin retains antimycobacterial activity in the presence of gyrA mutations. Antimicrob Agents Chemother 2014; 58: 2912.","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_5_54_2","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1073\/pnas.1525047113","article-title":"Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis","volume":"113","author":"Blower T.R.","year":"2016","unstructured":"Blower T.R. et al: Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2016; 113: 1706.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_5_55_2","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/s41598-020-58635-x","article-title":"Structure guided prediction of Pyrazinamide resistance mutations in pncA","volume":"10","author":"Karmakar M.","year":"2020","unstructured":"Karmakar M. et al: Structure guided prediction of Pyrazinamide resistance mutations in pncA. Sci Rep 2020; 10: 1875.","journal-title":"Sci Rep"},{"key":"e_1_3_5_56_2","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.2147\/IDR.S333433","article-title":"rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis","volume":"14","author":"Li M.C.","year":"2021","unstructured":"Li M.C. et al: rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis. Infect Drug Resist 2021; 14: 4119.","journal-title":"Infect Drug Resist"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.8.2663-2666.1999"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.03.001"},{"key":"e_1_3_5_59_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jmii.2012.08.020","article-title":"rrs and rpsL mutations in streptomycin-resistant isolates of Mycobacterium tuberculosis from Mexico","volume":"46","author":"Cuevas-Cordoba B.","year":"2013","unstructured":"Cuevas-Cordoba B. et al: rrs and rpsL mutations in streptomycin-resistant isolates of Mycobacterium tuberculosis from Mexico. J Microbiol Immunol Infect 2013; 46: 30.","journal-title":"J Microbiol Immunol Infect"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037025005239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037025005239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2025.11.054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:36:42Z","timestamp":1775219802000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2025.11.054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":58,"alternative-id":["10.1016\/j.csbj.2025.11.054"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2025.11.054","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico analysis of the functional implications of drug resistance associated mutations in Mycobacterium tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2025.11.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}