{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:40:34Z","timestamp":1793745634294,"version":"4.6.1"},"reference-count":100,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.cstres.2025.03.001","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T08:07:03Z","timestamp":1742198823000},"page":"119-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Endoplasmic reticulum stress in acute pancreatitis: Exploring the molecular mechanisms and therapeutic targets"],"prefix":"10.1016","volume":"30","author":[{"given":"Xiaoliang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiJuan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-7778","authenticated-orcid":false,"given":"Haiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cstres.2025.03.001_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2468-1253(16)30004-8","article-title":"Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies","volume":"1","author":"Xiao","year":"2016","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.cstres.2025.03.001_bib2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1053\/j.gastro.2018.11.082","article-title":"Acute pancreatitis: a multifaceted set of organelle and cellular interactions","volume":"156","author":"Habtezion","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cstres.2025.03.001_bib3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrgastro.2010.114","article-title":"Etiology and diagnosis of acute biliary pancreatitis","volume":"7","author":"van Geenen","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cstres.2025.03.001_bib4","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1440-1746.2010.06445.x","article-title":"Mechanisms of alcoholic pancreatitis","volume":"25","author":"Apte","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.cstres.2025.03.001_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MPA.0000000000000273","article-title":"A multicenter study on etiology of acute pancreatitis in beijing during 5 years","volume":"44","author":"Zheng","year":"2015","journal-title":"Pancreas"},{"key":"10.1016\/j.cstres.2025.03.001_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.hpb.2018.08.003","article-title":"A systematic review and meta-analysis of the aetiology of acute pancreatitis","volume":"21","author":"Zilio","year":"2019","journal-title":"HPB"},{"key":"10.1016\/j.cstres.2025.03.001_bib7","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s40265-022-01766-4","article-title":"Acute pancreatitis: diagnosis and treatment","volume":"82","author":"Szatmary","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.cstres.2025.03.001_bib8","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1053\/j.gastro.2018.01.031","article-title":"Initial medical treatment of acute pancreatitis: American Gastroenterological Association Institute Technical Review","volume":"154","author":"Vege","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cstres.2025.03.001_bib9","first-page":"148","article-title":"The unfolded protein response: an emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinoma","volume":"22","author":"Borrello","year":"2022"},{"key":"10.1016\/j.cstres.2025.03.001_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4592346","article-title":"4-Phenylbutyric acid attenuates pancreatic beta-cell injury in rats with experimental severe acute pancreatitis","volume":"2016","author":"Hong","year":"2016","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.cstres.2025.03.001_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00535-016-1238-5","article-title":"A small molecule inhibitor of NF\u03baB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis","volume":"52","author":"Kanak","year":"2017","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.cstres.2025.03.001_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/MPA.0b013e318259f6ca","article-title":"4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini","volume":"42","author":"Malo","year":"2013","journal-title":"Pancreas"},{"key":"10.1016\/j.cstres.2025.03.001_bib13","doi-asserted-by":"crossref","first-page":"G877","DOI":"10.1152\/ajpgi.00423.2009","article-title":"Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini","volume":"299","author":"Malo","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cstres.2025.03.001_bib14","doi-asserted-by":"crossref","first-page":"G773","DOI":"10.1152\/ajpgi.00483.2010","article-title":"Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis","volume":"301","author":"Seyhun","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cstres.2025.03.001_bib15","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/MPA.0000000000001082","article-title":"Melatonin attenuates endoplasmic reticulum stress in acute pancreatitis","volume":"47","author":"Zhao","year":"2018","journal-title":"Pancreas"},{"key":"10.1016\/j.cstres.2025.03.001_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J"},{"key":"10.1016\/j.cstres.2025.03.001_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pathmechdis.3.121806.151434","article-title":"Endoplasmic reticulum stress in disease pathogenesis","volume":"3","author":"Lin","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.cstres.2025.03.001_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.cstres.2025.03.001_bib20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.cstres.2025.03.001_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"10.1016\/j.cstres.2025.03.001_bib22","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3390\/biomedicines9070791","article-title":"Roles of XBP1s in transcriptional regulation of target genes","volume":"9","author":"Park","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.cstres.2025.03.001_bib23","first-page":"3513","article-title":"Melatonin attenuates the in\ufb02ammatory response via inhibiting the C\/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis","volume":"42","author":"Zhao","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.cstres.2025.03.001_bib24","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1053\/j.gastro.2019.01.268","article-title":"Early intra-acinar events in pathogenesis of pancreatitis","volume":"156","author":"Saluja","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cstres.2025.03.001_bib25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/biomedicines10010108","article-title":"Targeting endoplasmic reticulum stress as an effective treatment for alcoholic pancreatitis","volume":"10","author":"Li","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.cstres.2025.03.001_bib26","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1159\/000327212","article-title":"Alcohol abuse, endoplasmic reticulum stress and pancreatitis","volume":"28","author":"Pandol","year":"2010","journal-title":"Dig Dis"},{"key":"10.1016\/j.cstres.2025.03.001_bib27","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1053\/j.gastro.2017.08.036","article-title":"The combination of alcohol and cigarette smoke induces endoplasmic reticulum stress and cell death in pancreatic acinar cells","volume":"153","author":"Lugea","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cstres.2025.03.001_bib28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.gastro.2010.11.038","article-title":"Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage","volume":"140","author":"Lugea","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cstres.2025.03.001_bib29","first-page":"2318","article-title":"Hypertriglyceridemia aggravates ER stress and pathogenesis of acute pancreatitis","volume":"59","author":"Zeng","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.cstres.2025.03.001_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.biocel.2016.08.035","article-title":"Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein \u03b2-CCAAT-enhancer-binding protein \u03b1 activation","volume":"79","author":"Wu","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.cstres.2025.03.001_bib31","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1242\/jcs.026062","article-title":"Initiation and execution of lipotoxic ER stress in pancreatic \u03b2-cells","volume":"121","author":"Cunha","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib32","doi-asserted-by":"crossref","first-page":"G1804","DOI":"10.1152\/ajpgi.00078.2007","article-title":"Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells","volume":"292","author":"Kubisch","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cstres.2025.03.001_bib33","first-page":"196","article-title":"The role of endoplasmic reticulum stress in cell injury induced by methimazole on pancreatic cells","volume":"13","author":"Yaz\u0131c\u0131","year":"2023","journal-title":"Adv Pharm Bull"},{"key":"10.1016\/j.cstres.2025.03.001_bib34","first-page":"G238","article-title":"Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis","volume":"291","author":"Kubisch","year":"2006","journal-title":"Am J Physiol Liver Physiol"},{"key":"10.1016\/j.cstres.2025.03.001_bib35","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1053\/j.gastro.2011.06.045","article-title":"Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice","volume":"141","author":"Hess","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cstres.2025.03.001_bib36","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","article-title":"ER stress: autophagy induction, inhibition and selection","volume":"11","author":"Rashid","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.cstres.2025.03.001_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.758311","article-title":"Crosstalk between ER stress, autophagy and inflammation","volume":"8","author":"Chipurupalli","year":"2021","journal-title":"Front Med"},{"key":"10.1016\/j.cstres.2025.03.001_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3858\/emm.2012.44.2.030","article-title":"Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic \u03b2-cells","volume":"44","author":"Quan","year":"2012","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.cstres.2025.03.001_bib39","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/sj.cdd.4402200","article-title":"Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium","volume":"14","author":"H\u00f8yer-Hansen","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.cstres.2025.03.001_bib40","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1159\/000453164","article-title":"Melatonin induces anti-inflammatory effects to play a protective role via endoplasmic reticulum stress in acute pancreatitis","volume":"40","author":"Chen","year":"2016","journal-title":"Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol"},{"key":"10.1016\/j.cstres.2025.03.001_bib41","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1007\/s10753-020-01228-7","article-title":"Rapamycin alleviates hypertriglyceridemia-related acute pancreatitis via restoring autophagy flux and inhibiting endoplasmic reticulum stress","volume":"43","author":"Mei","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.cstres.2025.03.001_bib42","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.4161\/auto.21994","article-title":"Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic \u03b2 cell death","volume":"8","author":"Bartolome","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.cstres.2025.03.001_bib43","doi-asserted-by":"crossref","first-page":"E6166","DOI":"10.1073\/pnas.1519384112","article-title":"Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress","volume":"112","author":"Antonucci","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cstres.2025.03.001_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.devcel.2017.11.024","article-title":"CCPG1 is a non-canonical autophagy cargo receptor essential for ER-phagy and pancreatic ER proteostasis","volume":"44","author":"Smith","year":"2018","journal-title":"Dev Cell"},{"key":"10.1016\/j.cstres.2025.03.001_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.968639","article-title":"Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsin\u00a0B-mediated AP-1 activation","volume":"13","author":"Han","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.cstres.2025.03.001_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110293","article-title":"Endoplasmic reticulum stress promotes caspase-1-dependent acinar cell pyroptosis through the PERK pathway to aggravate acute pancreatitis","volume":"120","author":"Yan","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.cstres.2025.03.001_bib47","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41418-023-01153-w","article-title":"Apoptotic cell death in disease\u2014current understanding of the NCCD 2023","volume":"30","author":"Vitale","year":"2023","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.cstres.2025.03.001_bib48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/mi.2016.101","article-title":"Immunopathogenesis of pancreatitis","volume":"10","author":"Watanabe","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.cstres.2025.03.001_bib49","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1111\/febs.13598","article-title":"Cell death induced by endoplasmic reticulum stress","volume":"283","author":"Iurlaro","year":"2016","journal-title":"FEBS J"},{"key":"10.1016\/j.cstres.2025.03.001_bib50","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10495-022-01729-w","article-title":"Pyroptosis in acute pancreatitis and its therapeutic regulation","volume":"27","author":"Al Mamun","year":"2022","journal-title":"Apoptosis"},{"key":"10.1016\/j.cstres.2025.03.001_bib51","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cstres.2023.12.003","article-title":"Endoplasmic reticulum stress-mediated cell death in cardiovascular disease","volume":"29","author":"An","year":"2024","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.cstres.2025.03.001_bib52","article-title":"Induction mechanism of ferroptosis, necroptosis, and pyroptosis: a novel therapeutic target in nervous system diseases","volume":"24","author":"Tang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21218387","article-title":"The regulation of ferroptosis by tumor suppressor p53 and its pathway","volume":"21","author":"Liu","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib54","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3390\/biom14111369","article-title":"The role and interactive mechanism of endoplasmic reticulum stress and ferroptosis in musculoskeletal disorders","volume":"14","author":"Guo","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.cstres.2025.03.001_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114123","article-title":"Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis","volume":"245","author":"He","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.cstres.2025.03.001_bib56","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2021.09.008","article-title":"Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells","volume":"175","author":"Zhao","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.cstres.2025.03.001_bib57","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41420-024-02007-1","article-title":"Ferroptosis exacerbates hyperlipidemic acute pancreatitis by enhancing lipid peroxidation and modulating the immune microenvironment","volume":"10","author":"Gu","year":"2024","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.cstres.2025.03.001_bib58","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1097\/CM9.0000000000002096","article-title":"Ferroptosis and its emerging roles in acute pancreatitis","volume":"135","author":"Li","year":"2022","journal-title":"Chin Med J"},{"key":"10.1016\/j.cstres.2025.03.001_bib59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12876-024-03345-1","article-title":"Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis","volume":"24","author":"Li","year":"2024","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.cstres.2025.03.001_bib60","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jcmgh.2021.09.008","article-title":"Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.cstres.2025.03.001_bib61","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15206","article-title":"Iron overload induces islet \u03b2 cell ferroptosis by activating ASK1\/P-P38\/CHOP signaling pathway","volume":"11","author":"Deng","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.cstres.2025.03.001_bib62","doi-asserted-by":"crossref","first-page":"9548","DOI":"10.1038\/s41598-024-60159-7","article-title":"Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats","volume":"14","author":"Xiang","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.cstres.2025.03.001_bib63","first-page":"G189","article-title":"Apoptosis versus necrosis in acute pancreatitis","volume":"286","author":"Bhatia","year":"2004","journal-title":"Am J Physiol Liver Physiol"},{"key":"10.1016\/j.cstres.2025.03.001_bib64","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0968-0004(96)10073-6","article-title":"The ER-overload response: activation of NF-kappa B","volume":"22","author":"Pahl","year":"1997","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045078","article-title":"ER stress activates NF-\u03baB by integrating functions of basal IKK activity, IRE1 and PERK","volume":"7","author":"Tam","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cstres.2025.03.001_bib66","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1177\/1753425913508593","article-title":"Endoplasmic reticulum stress is sufficient for the induction of IL-1\u03b2 production via activation of the NF-\u03baB and inflammasome pathways","volume":"20","author":"Kim","year":"2013","journal-title":"Innate Immun"},{"key":"10.1016\/j.cstres.2025.03.001_bib67","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41420-023-01550-7","article-title":"The trigger for pancreatic disease: NLRP3 inflammasome","volume":"9","author":"Liu","year":"2023","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.cstres.2025.03.001_bib68","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.3390\/ijms23073528","article-title":"The role of endoplasmic reticulum stress and NLRP3 inflammasome in liver disorders","volume":"23","author":"Lu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib69","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2165\/11591280-000000000-00000","article-title":"Clinical and experimental applications of sodium phenylbutyrate","volume":"11","author":"Iannitti","year":"2011","journal-title":"Drugs R D"},{"key":"10.1016\/j.cstres.2025.03.001_bib70","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.biocel.2015.01.015","article-title":"The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis","volume":"61","author":"Kolb","year":"2015","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.cstres.2025.03.001_bib71","first-page":"G838","article-title":"Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis","volume":"315","author":"Hong","year":"2018","journal-title":"Am J Physiol Liver Physiol"},{"key":"10.1016\/j.cstres.2025.03.001_bib72","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/bph.12306","article-title":"Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues","volume":"170","author":"Zhang","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.cstres.2025.03.001_bib73","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3390\/cells8121471","article-title":"Tauroursodeoxycholate-bile acid with chaperoning activity: molecular and cellular effects and therapeutic perspectives","volume":"8","author":"Kusaczuk","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.cstres.2025.03.001_bib74","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2021.01.034","article-title":"Anti-inflammatory effects of melatonin: a systematic review and meta-analysis of clinical trials","volume":"93","author":"Cho","year":"2021","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.cstres.2025.03.001_bib75","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1749-6632.2000.tb05402.x","article-title":"Melatonin and its relation to the immune system and inflammation","volume":"917","author":"Reiter","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib76","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/ph14030232","article-title":"Melatonin improves endoplasmic reticulum stress-mediated IRE1\u03b1 pathway in Z\u00fccker diabetic fatty rat","volume":"14","author":"Aouichat","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.cstres.2025.03.001_bib77","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s13287-020-01948-5","article-title":"Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage","volume":"11","author":"Fan","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.cstres.2025.03.001_bib78","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1080\/15384101.2020.1810401","article-title":"Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway","volume":"19","author":"Song","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cstres.2025.03.001_bib79","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3892\/mmr.2020.11219","article-title":"Melatonin inhibits the endoplasmic reticulum stress\u2011induced, C\/EBP homologous protein\u2011mediated pathway in acute pancreatitis","volume":"22","author":"Zhao","year":"2020","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.cstres.2025.03.001_bib80","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.3390\/ijms21155386","article-title":"NLRP3 inflammasome-mediated inflammation in acute pancreatitis","volume":"21","author":"Ferrero-Andr\u00e9s","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cstres.2025.03.001_bib81","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1111\/jcmm.14216","article-title":"Deletion of pancreatic \u03b2-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia","volume":"23","author":"Ahmed Abdalhamid Osman","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.cstres.2025.03.001_bib82","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1111\/dom.15621","article-title":"Adenosine kinase inhibits \u03b2-cell proliferation by upregulating DNA methyltransferase 3A expression","volume":"26","author":"Chen","year":"2024","journal-title":"Diabetes, Obes Metab"},{"key":"10.1016\/j.cstres.2025.03.001_bib83","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.2337\/db16-0816","article-title":"Genetic disruption of adenosine kinase in mouse pancreatic \u03b2-cells protects against high-fat diet\u2013induced glucose intolerance","volume":"66","author":"Navarro","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.cstres.2025.03.001_bib84","first-page":"1","article-title":"Adenosine kinase inhibition prevents severe acute pancreatitis via suppressing inflammation and acinar cell necroptosis","volume":"10","author":"Sun","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.cstres.2025.03.001_bib85","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.3390\/nu14132591","article-title":"Drug D, a diosgenin derive, inhibits L-arginine-induced acute pancreatitis through meditating GSDMD in the endoplasmic reticulum via the TXNIP\/HIF-1\u03b1 pathway","volume":"14","author":"Zhang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.cstres.2025.03.001_bib86","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbrc.2018.12.108","article-title":"Genistein protects against acute pancreatitis via activation of an apoptotic pathway mediated through endoplasmic reticulum stress in rats","volume":"509","author":"Xia","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cstres.2025.03.001_bib87","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s10753-013-9634-y","article-title":"Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis","volume":"36","author":"Wu","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.cstres.2025.03.001_bib88","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41419-021-03923-1","article-title":"Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS\/ER stress\/Cathepsin B axis","volume":"12","author":"He","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.cstres.2025.03.001_bib89","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00424-018-02247-y","article-title":"The exocrine pancreas is an extracardiac source of atrial natriuretic peptide","volume":"471","author":"Najenson","year":"2019","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.cstres.2025.03.001_bib90","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbadis.2018.12.004","article-title":"Atrial natriuretic peptide attenuates endoplasmic reticulum stress in experimental acute pancreatitis","volume":"1865","author":"Courreges","year":"2019","journal-title":"Biochim Biophys acta Mol basis Dis"},{"key":"10.1016\/j.cstres.2025.03.001_bib91","doi-asserted-by":"crossref","DOI":"10.1111\/apha.12992","article-title":"Atrial natriuretic peptide reduces inflammation and enhances apoptosis in rat acute pancreatitis","volume":"222","author":"Najenson","year":"2018","journal-title":"Acta Physiol"},{"key":"10.1016\/j.cstres.2025.03.001_bib92","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fendo.2019.00524","article-title":"Irisin: a Hope in Understanding and Managing Obesity and Metabolic Syndrome","volume":"10","author":"Arhire","year":"2019","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.cstres.2025.03.001_bib93","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1089\/ars.2019.7731","article-title":"Low serum irisin concentration is associated with poor outcomes in patients with acute pancreatitis, and irisin administration protects against experimental acute pancreatitis","volume":"31","author":"Ren","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.cstres.2025.03.001_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110101","article-title":"Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis","volume":"126","author":"Ren","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.cstres.2025.03.001_bib95","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.3748\/wjg.v25.i45.6653","article-title":"Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis","volume":"25","author":"Ren","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cstres.2025.03.001_bib96","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3390\/biom14060643","article-title":"Irisin ameliorate acute pancreatitis and acinar cell viability through modulation of the unfolded protein response (UPR) and PPAR\u03b3-PGC1\u03b1-FNDC5 pathways","volume":"14","author":"Horwitz","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.cstres.2025.03.001_bib97","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.matbio.2018.01.011","article-title":"TSG-6: a multifunctional protein with anti-inflammatory and tissue-protective properties","volume":"78\u201379","author":"Day","year":"2019","journal-title":"Matrix Biol"},{"key":"10.1016\/j.cstres.2025.03.001_bib98","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s13287-018-1009-8","article-title":"TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates severe acute pancreatitis via ER stress downregulation in mice","volume":"9","author":"Li","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.cstres.2025.03.001_bib99","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.bbrc.2015.01.027","article-title":"TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway","volume":"457","author":"Tang","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cstres.2025.03.001_bib100","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s11626-016-0011-7","article-title":"TRAM1 protects AR42J cells from caerulein-induced acute pancreatitis through ER stress-apoptosis pathway","volume":"52","author":"Cai","year":"2016","journal-title":"In Vitro Cell Dev Biol Anim"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814525000124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814525000124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T13:07:24Z","timestamp":1747832844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814525000124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1355814525000124"],"URL":"https:\/\/doi.org\/10.1016\/j.cstres.2025.03.001","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic reticulum stress in acute pancreatitis: Exploring the molecular mechanisms and therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cstres.2025.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Cell Stress Society International.","name":"copyright","label":"Copyright"}]}}