{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:10:26Z","timestamp":1788502226647,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["WJZJ-202318"],"award-info":[{"award-number":["WJZJ-202318"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474542"],"award-info":[{"award-number":["82474542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cstres.2025.100114","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T07:02:12Z","timestamp":1757660532000},"page":"100114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monocyte USP7-p65 axis mediates immune responses to the immunogenicity of nucleus pulposus"],"prefix":"10.1016","volume":"30","author":[{"given":"Peng","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2395-2042","authenticated-orcid":false,"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cstres.2025.100114_bib1","article-title":"Global, regional, and national burden of low back pain in working-age population from 1990 to 2021 and projections for 2050 [J]","volume":"13","author":"Zhang","year":"2025","journal-title":"Front Public Health"},{"key":"10.1016\/j.cstres.2025.100114_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101733","article-title":"The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration J]","volume":"81","author":"Sun","year":"2022","journal-title":"Age Res Rev"},{"key":"10.1016\/j.cstres.2025.100114_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1155746","article-title":"Immune exposure: how macrophages interact with the nucleus pulposus [J]","volume":"14","author":"Feng","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.cstres.2025.100114_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.spinee.2017.09.018","article-title":"Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration [J]","volume":"18","author":"Nakazawa","year":"2018","journal-title":"Spine J Off J N Am Spine Soc"},{"key":"10.1016\/j.cstres.2025.100114_bib5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.spinee.2017.12.004","article-title":"Modic type 1 change is an autoimmune response that requires a proinflammatory milieu provided by the \u201cModic disc\u201d [J]","volume":"18","author":"Dudli","year":"2018","journal-title":"Spine J Off J N Am Spine Soc"},{"key":"10.1016\/j.cstres.2025.100114_bib6","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1021\/acsnano.3c00093","article-title":"Targeting endogenous reactive oxygen species removal and regulating regenerative microenvironment at annulus fibrosus defects promote tissue repair [J]","volume":"17","author":"Han","year":"2023","journal-title":"ACS nano"},{"key":"10.1016\/j.cstres.2025.100114_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1382652","article-title":"Immunization against nucleus pulposus antigens to accelerate degenerative disc disease in a rabbit model [J]","volume":"11","author":"Bonilla","year":"2024","journal-title":"Front Veterinary Sci"},{"key":"10.1016\/j.cstres.2025.100114_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/01.brs.0000251651.61844.2d","article-title":"Autoimmune properties of nucleus pulposus: an experimental study in pigs [J]","volume":"32","author":"Geiss","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.cstres.2025.100114_bib9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00002517-200108000-00010","article-title":"In vivo macrophage recruitment by murine intervertebral disc cells [J]","volume":"14","author":"Rand","year":"2001","journal-title":"J Spinal Disord"},{"key":"10.1016\/j.cstres.2025.100114_bib10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.orthres.2004.08.020","article-title":"Experimental studies on the effects of recombinant human matrix metalloproteinases on herniated disc tissues\u2014how to facilitate the natural resorption process of herniated discs [J]","volume":"23","author":"Haro","year":"2005","journal-title":"J Orthop Res Off Publ Orthop Res Soc"},{"key":"10.1016\/j.cstres.2025.100114_bib11","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/jor.24560","article-title":"Long-term histological analysis of innervation and macrophage infiltration in a mouse model of intervertebral disc injury-induced low back pain [J]","volume":"38","author":"Lee","year":"2020","journal-title":"J Orthop Res Off Publ Orthop Res Soc"},{"key":"10.1016\/j.cstres.2025.100114_bib12","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s12276-024-01168-4","article-title":"Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2\/7-CCR2 signaling pathway [J]","volume":"56","author":"Tian","year":"2024","journal-title":"Exp Mole Med"},{"key":"10.1016\/j.cstres.2025.100114_bib13","article-title":"Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism [J]","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.cstres.2025.100114_bib14","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1186\/s12967-024-05962-6","article-title":"Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth [J]","volume":"22","author":"Gu","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.cstres.2025.100114_bib15","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.3390\/biomedicines12122734","article-title":"The role and mechanism of deubiquitinase USP7 in tumor-associated inflammation [J]","volume":"12","author":"Wang","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.cstres.2025.100114_bib16","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1073\/pnas.1208446110","article-title":"Deubiquitination of NF-kappaB by Ubiquitin-Specific Protease-7 promotes transcription [J]","volume":"110","author":"Colleran","year":"2013","journal-title":"Proc Nat Acad Sci U S A"},{"key":"10.1016\/j.cstres.2025.100114_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41420-025-02481-1","article-title":"USP7 promotes endothelial activation to aggravate sepsis-induced acute lung injury through PDK1\/AKT\/NF-kappaB signaling pathway [J]","volume":"11","author":"Liu","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.cstres.2025.100114_bib18","doi-asserted-by":"crossref","first-page":"e44766","DOI":"10.15252\/embr.201744766","article-title":"USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation [J]","volume":"19","author":"Palazon-Riquelme","year":"2018","journal-title":"EMBO Rep"},{"key":"10.1016\/j.cstres.2025.100114_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.22203\/eCM.v019a02","article-title":"Primary immune system responders to nucleus pulposus cells: evidence for immune response in disc herniation [J]","volume":"19","author":"Murai","year":"2010","journal-title":"Eur Cells Mater"},{"key":"10.1016\/j.cstres.2025.100114_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17472-1","article-title":"Toll-like receptor activation induces degeneration of human intervertebral discs [J]","volume":"7","author":"Krock","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.cstres.2025.100114_bib21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/jor.24154","article-title":"High mobility group box-1 induces pro-inflammatory signaling in human nucleus pulposus cells via toll-like receptor 4-dependent pathway [J]","volume":"37","author":"Shah","year":"2019","journal-title":"J Orthop Res Off Publ Orthop Res Soc"},{"key":"10.1016\/j.cstres.2025.100114_bib22","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1016\/j.jmb.2016.04.030","article-title":"For better or worse: cytosolic DNA sensing during intracellular bacterial infection induces potent innate immune responses [J]","volume":"428","author":"Patrick","year":"2016","journal-title":"J Mole Biol"},{"key":"10.1016\/j.cstres.2025.100114_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202309032","article-title":"Shared and compartment-specific processes in nucleus pulposus and annulus fibrosus during intervertebral disc degeneration [J]","volume":"11","author":"Swahn","year":"2024","journal-title":"Adv Sci"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814525000598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814525000598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:27:20Z","timestamp":1773116840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814525000598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1355814525000598"],"URL":"https:\/\/doi.org\/10.1016\/j.cstres.2025.100114","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monocyte USP7-p65 axis mediates immune responses to the immunogenicity of nucleus pulposus","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cstres.2025.100114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Cell Stress Society International.","name":"copyright","label":"Copyright"}],"article-number":"100114"}}