{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:13:44Z","timestamp":1790111624741,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Department of Education of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"National Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["State Chinese Medicine Medical Policy Letter [2024] No. 90"],"award-info":[{"award-number":["State Chinese Medicine Medical Policy Letter [2024] No. 90"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stress and Chaperones"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cstres.2026.100212","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:54:03Z","timestamp":1788620043000},"page":"100212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acupuncture suppresses the endoplasmic reticulum stress-c-Jun N-terminal kinase pathway to inhibit chondrocyte apoptosis and attenuate knee osteoarthritis"],"prefix":"10.1016","volume":"31","author":[{"given":"Renzhong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minshun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanbing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cstres.2026.100212_bib1","doi-asserted-by":"crossref","first-page":"ITC129","DOI":"10.7326\/ANNALS-24-01249","article-title":"Knee osteoarthritis","volume":"177","author":"Gelber","year":"2024","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cstres.2026.100212_bib2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/0269215520971795","article-title":"Stationary cycling exercise for knee osteoarthritis: a systematic review and meta-analysis","volume":"35","author":"Luan","year":"2021","journal-title":"Clin Rehabil"},{"key":"10.1016\/j.cstres.2026.100212_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2021.105276","article-title":"The application of whole-body vibration training in knee osteoarthritis","volume":"89","author":"Wang","year":"2022","journal-title":"Jt Bone Spine"},{"key":"10.1016\/j.cstres.2026.100212_bib4","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00270-025-04188-3","article-title":"Genicular artery embolization for symptomatic knee osteoarthritis: a comprehensive review of techniques and clinical outcomes","volume":"48","author":"Ahmed","year":"2025","journal-title":"Cardiovasc Interv Radiol"},{"key":"10.1016\/j.cstres.2026.100212_bib5","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s00256-022-04233-z","article-title":"The influence of meniscal pathology in the incidence of knee osteoarthritis: a review","volume":"52","author":"Mass","year":"2023","journal-title":"Skelet Radiol"},{"key":"10.1016\/j.cstres.2026.100212_bib6","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.joca.2022.08.002","article-title":"The relationship between meniscal pathologies, cartilage loss, joint replacement and pain in knee osteoarthritis: a systematic review","volume":"30","author":"Ghouri","year":"2022","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.cstres.2026.100212_bib7","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.2147\/JPR.S517224","article-title":"Epigenetics and herbs: potential therapeutic strategies for osteoarthritis of the knee","volume":"18","author":"Zheng","year":"2025","journal-title":"J Pain Res"},{"key":"10.1016\/j.cstres.2026.100212_bib8","doi-asserted-by":"crossref","first-page":"10408","DOI":"10.3390\/ijms262110408","article-title":"Infrapatellar fat pad in knee osteoarthritis: a comprehensive review of pathophysiology and targeted therapeutic strategies","volume":"26","author":"Mallia","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cstres.2026.100212_bib9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4062\/biomolther.2025.203","article-title":"Recent advances in therapeutic approaches for knee osteoarthritis: a narrative review","volume":"34","author":"Hossain","year":"2026","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.cstres.2026.100212_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/annrheumdis-2017-212863","article-title":"Single-cell RNA-seq analysis reveals the progression of human osteoarthritis","volume":"78","author":"Ji","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cstres.2026.100212_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400615","article-title":"Nanomaterials: recent advances in knee osteoarthritis treatment","volume":"13","author":"Peng","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.cstres.2026.100212_bib12","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.3390\/ijms23147817","article-title":"Cranial base synchondrosis: chondrocytes at the Hub","volume":"23","author":"Hallett","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cstres.2026.100212_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113726","article-title":"Trimethylamine-N-oxide sensitizes chondrocytes to mechanical loading through the upregulation of Piezo1","volume":"175","author":"Zhuang","year":"2023","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.cstres.2026.100212_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/jcp.30537","article-title":"IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis","volume":"237","author":"Huang","year":"2022","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.cstres.2026.100212_bib15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s10565-025-10071-1","article-title":"Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway","volume":"41","author":"Qiao","year":"2025","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.cstres.2026.100212_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2023.105642","article-title":"The role of autophagy in mitigating osteoarthritis progression via regulation of chondrocyte apoptosis: a review","volume":"91","author":"Kong","year":"2024","journal-title":"Jt Bone Spine"},{"key":"10.1016\/j.cstres.2026.100212_bib17","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255192","article-title":"ER-phagy: selective autophagy of the endoplasmic reticulum","volume":"23","author":"Mochida","year":"2022","journal-title":"EMBO Rep"},{"key":"10.1016\/j.cstres.2026.100212_bib18","doi-asserted-by":"crossref","first-page":"15186","DOI":"10.3390\/ijms232315186","article-title":"Endoplasmic reticulum stress signaling and neuronal cell death","volume":"23","author":"Merighi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cstres.2026.100212_bib19","article-title":"Endoplasmic reticulum-mitochondria crosstalk: new mechanisms in the development of atherosclerosis","volume":"16","author":"Li","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cstres.2026.100212_bib20","first-page":"79","article-title":"Endoplasmic reticulum and its significance in periodontal disease","volume":"24","author":"Zhai","year":"2021","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.cstres.2026.100212_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jare.2021.06.007","article-title":"Characteristics of sensory innervation in synovium of rats within different knee osteoarthritis models and the correlation between synovial fibrosis and hyperalgesia","volume":"35","author":"Zhang","year":"2021","journal-title":"J Adv Res"},{"key":"10.1016\/j.cstres.2026.100212_bib22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13063-017-2061-x","article-title":"Effect of aquatic physical therapy on pain perception, functional capacity and quality of life in older people with knee osteoarthritis: study protocol for a randomized controlled trial","volume":"18","author":"Alcalde","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.cstres.2026.100212_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.cstres.2026.100212_bib24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2174\/0929867327666200210144114","article-title":"Recent advances in c-Jun N-terminal kinase (JNK) inhibitors","volume":"28","author":"Li","year":"2021","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.cstres.2026.100212_bib25","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.3390\/molecules26185688","article-title":"Novel c-Jun N-terminal kinase (JNK) inhibitors with an 11H-Indeno[1,2-b]quinoxalin-11-one Scaffold","volume":"26","author":"Liakhov","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.cstres.2026.100212_bib26","first-page":"755","article-title":"c\u2011Jun N\u2011terminal kinase\/transforming growth factor\u2011\u03b2\/Smad3 pathway: Is it associated with endoplasmic reticulum stress\u2011mediated renal interstitial fibrosis?","volume":"20","author":"Liu","year":"2019","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.cstres.2026.100212_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12192-020-01174-1","article-title":"Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK)","volume":"26","author":"Bressler","year":"2021","journal-title":"Cell Stress Chaperon"},{"key":"10.1016\/j.cstres.2026.100212_bib28","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s11916-024-01242-6","article-title":"Durable effects of acupuncture for knee osteoarthritis: a systematic review and meta-analysis","volume":"28","author":"Chen","year":"2024","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.cstres.2026.100212_bib29","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/bmjebm-2023-112626","article-title":"Clinical effect and contributing factors of acupuncture for knee osteoarthritis: a systematic review and pairwise and exploratory network meta-analysis","volume":"29","author":"Liu","year":"2024","journal-title":"BMJ Evid Based Med"},{"key":"10.1016\/j.cstres.2026.100212_bib30","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/art.41584","article-title":"Efficacy of intensive acupuncture versus sham acupuncture in knee osteoarthritis: a randomized controlled trial","volume":"73","author":"Tu","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.cstres.2026.100212_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/jebm.12526","article-title":"Acupuncture for treatment of knee osteoarthritis: a clinical practice guideline","volume":"16","author":"Luo","year":"2023","journal-title":"J Evid Based Med"},{"key":"10.1016\/j.cstres.2026.100212_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jebm.12532","article-title":"Acupuncture for knee osteoarthritis: a systematic review and meta-analysis","volume":"16","author":"Mei","year":"2023","journal-title":"J Evid Based Med"},{"key":"10.1016\/j.cstres.2026.100212_bib33","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.molcel.2023.02.021","article-title":"Mitochondrial pores at the crossroad between cell death and inflammatory signaling [J]","volume":"83","author":"Flores-Romero","year":"2023","journal-title":"Mol Cell"},{"key":"10.1016\/j.cstres.2026.100212_bib34","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.2147\/JPR.S416242","article-title":"Electroacupuncture exerts chondroprotective effect in knee osteoarthritis of rabbits through the mitophagy pathway [J]","volume":"16","author":"Xing","year":"2023","journal-title":"J Pain Res"},{"key":"10.1016\/j.cstres.2026.100212_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bcp.2017.12.022","article-title":"Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells [J]","volume":"148","author":"Dehart","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.cstres.2026.100212_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41392-025-02556-6","article-title":"Osteoarthritis: molecular pathogenesis and potential therapeutic options","volume":"11","author":"Zhang","year":"2026","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.cstres.2026.100212_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/19476035231181446","article-title":"PKC-\u03b4 promotes IL-1\u03b2-induced apoptosis of rat chondrocytes and via activating JNK and P38 MAPK pathways","volume":"15","author":"Lu","year":"2024","journal-title":"Cartilage"},{"key":"10.1016\/j.cstres.2026.100212_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109724","article-title":"Electroacupuncture alleviates cartilage degradation:Improvement in cartilage biomechanics via pain relief and potentiation of muscle function in a rabbit model of knee osteoarthritis[J]","volume":"123","author":"Shi","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.cstres.2026.100212_bib39","unstructured":"Z.R. Li. Experimental Acupuncture Science China Press of Traditional Chinese Medicine, Beijing, China (2007)."},{"key":"10.1016\/j.cstres.2026.100212_bib40","article-title":"Overall adjustment acupuncture improves osteoporosis and exerts an endocrine-modulating effect in ovariectomized rats","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cstres.2026.100212_bib41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cbi.2017.08.011","article-title":"Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells","volume":"277","author":"Lu","year":"2017","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.cstres.2026.100212_bib42","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520929858","article-title":"c-Jun NH2-terminal kinase suppression significantly inhibits the growth of transplanted breast tumors in mice","volume":"48","author":"Huang","year":"2020","journal-title":"J Int Med Res"},{"key":"10.1016\/j.cstres.2026.100212_bib43","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x2024e13238","article-title":"Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats","volume":"57","author":"He","year":"2024","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.cstres.2026.100212_bib44","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1177\/1535370220952342","article-title":"Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2\/CCR2 signaling pathway","volume":"245","author":"Li","year":"2020","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.cstres.2026.100212_bib45","doi-asserted-by":"crossref","DOI":"10.2460\/ajvr.24.11.0341","article-title":"Short-term manual acupuncture decreased markers of systemic inflammation and altered articular cartilage transcripts in the Dunkin-Hartley model of osteoarthritis","volume":"86","author":"Spittler","year":"2025","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.cstres.2026.100212_bib46","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12989-024-00595-5","article-title":"Microplastics caused embryonic growth retardation and placental dysfunction in pregnant mice by activating GRP78\/IRE1\u03b1\/JNK axis induced apoptosis and endoplasmic reticulum stress","volume":"21","author":"Bai","year":"2024","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.cstres.2026.100212_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.193","article-title":"Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78\/BiP","volume":"5","author":"Chen","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.cstres.2026.100212_bib48","doi-asserted-by":"crossref","first-page":"G829","DOI":"10.1152\/ajpgi.2000.278.6.G829","article-title":"Lessons from genetically engineered animal models. \u216b. IL-10-deficient (IL-10 (-\/-) mice and intestinal inflammation[J","volume":"278","author":"Rennick","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cstres.2026.100212_bib49","first-page":"313","article-title":"Advances in the dual immunoregulatory role of interleukin-10 and its application in anti-inflammation","volume":"59","author":"Zhenli","year":"2023","journal-title":"J Qingdao Univ (Med Sci)"},{"key":"10.1016\/j.cstres.2026.100212_bib50","doi-asserted-by":"crossref","first-page":"G829","DOI":"10.1152\/ajpgi.2000.278.6.G829","article-title":"Lessons from genetically engineered animal models. \u216b. IL-10-deficient (IL-10 (-\/-) mice and intestinal inflammation[J","volume":"278","author":"Rennick","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Cell Stress and Chaperones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814526000702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1355814526000702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:51:10Z","timestamp":1790110270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1355814526000702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S1355814526000702"],"URL":"https:\/\/doi.org\/10.1016\/j.cstres.2026.100212","relation":{},"ISSN":["1355-8145"],"issn-type":[{"value":"1355-8145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acupuncture suppresses the endoplasmic reticulum stress-c-Jun N-terminal kinase pathway to inhibit chondrocyte apoptosis and attenuate knee osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Cell Stress and Chaperones","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cstres.2026.100212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Cell Stress Society International.","name":"copyright","label":"Copyright"}],"article-number":"100212"}}