{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:57:01Z","timestamp":1774439821677,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"am","delay-in-days":443,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"French Ligue Nationale Contre le Cancer","award":["P30 CA23100"],"award-info":[{"award-number":["P30 CA23100"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007813","name":"Center for AIDS Research","doi-asserted-by":"crossref","award":["P30 AI036214"],"award-info":[{"award-number":["P30 AI036214"]}],"id":[{"id":"10.13039\/100007813","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.ctarc.2019.100129","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T07:14:31Z","timestamp":1552720471000},"page":"100129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Hepatocellular carcinoma: Clinical-pathological features and HIV infection in Mozambican patients,"],"prefix":"10.1016","volume":"19","author":[{"given":"Lina","family":"Cunha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Carrilho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michella","family":"Loforte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cremildo","family":"Maueia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fab\u00edola","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assucena","family":"Guisseve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mbofana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Maibaze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana","family":"Mondlane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzmira","family":"Dimande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Machatine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Tsueng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-7873","authenticated-orcid":false,"given":"Eduardo Samo","family":"Gudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-1592","authenticated-orcid":false,"given":"Pascal","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctarc.2019.100129_bib0001","series-title":"Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]","article-title":"GLOBOCAN 2012 v1.0","author":"Ferlay","year":"2013"},{"key":"10.1016\/j.ctarc.2019.100129_bib0002","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1665-2681(19)31354-7","article-title":"Epidemiology of hepatocellular carcinoma in sub-Saharan Africa","volume":"12","author":"Kew","year":"2013","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0003","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/ijc.2910510406","article-title":"Alcohol consumption as a risk factor for hepatocellular carcinoma in urban southern African blacks","volume":"51","author":"Mohamed","year":"1992","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0004","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/hep.510270614","article-title":"Dietary iron overload as a risk factor for hepatocellular carcinoma in Black Africans","volume":"27","author":"Mandishona","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.ctarc.2019.100129_bib0005","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S1473-3099(07)70135-4","article-title":"Clinical implications of HIV and hepatitis B co-infection in Asia and Africa","volume":"7","author":"Hoffmann","year":"2007","journal-title":"Lancet Inf. Dis."},{"key":"10.1016\/j.ctarc.2019.100129_bib0006","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/1097-0142(196011\/12)13:6<1085::AID-CNCR2820130603>3.0.CO;2-Y","article-title":"Cancer of the liver and cirrhosis in Trans-saharan Africa and the United States of America","volume":"13","author":"Steiner","year":"1960","journal-title":"Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0007","first-page":"119","article-title":"The incidence of cancer in South Afiica","volume":"6","author":"Casalis","year":"1911","journal-title":"Transvaal Med. J."},{"key":"10.1016\/j.ctarc.2019.100129_bib0008","first-page":"83","article-title":"Malignant disease in the Bantu of Johannesburg and the Witwatersrand gold mines","volume":"1","author":"Berman","year":"1935","journal-title":"Proc. Transvaal Mine Med. Off. Assoc."},{"key":"10.1016\/j.ctarc.2019.100129_bib0009","first-page":"1550","article-title":"Sur les tumeurs malignes primaires du foie chez les indig\u00e8nes de la colonie portugaise de Mo\u00e7ambique","volume":"47","author":"Prates","year":"1939","journal-title":"Presse. Med."},{"key":"10.1016\/j.ctarc.2019.100129_bib0010","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0013-9351(79)90072-0","article-title":"Hepatic cancers in man: quantitative perspectives","volume":"19","author":"Popper","year":"1979","journal-title":"Environ. Res."},{"key":"10.1016\/j.ctarc.2019.100129_bib0011","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/bjc.1971.50","article-title":"The cancer pattern in African gold miners","volume":"25","author":"Robertson","year":"1971","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0012","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/bjc.1982.266","article-title":"Analyses of cancer incidence in black gold miners from Southern Africa (1964-79)","volume":"46","author":"Bradshaw","year":"1982","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130469","article-title":"Trends in cancer incidence in Maputo, Mozambique, 1991\u20132008","volume":"10","author":"Lorenzoni","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ctarc.2019.100129_bib0014","unstructured":"C.H.o. Maputo, Registo Oncol\u00f3gico do Hospital Central de Maputo - Relat\u00f3rio de 2015, Maputo, 2017."},{"issue":"Jun 22","key":"10.1016\/j.ctarc.2019.100129_bib0015","article-title":"Cancer incidence in Mozambique in 2015\u20132016: data from the Maputo Central Hospital Cancer Registry","author":"Carrilho","year":"2018","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.ctarc.2019.100129_bib0016","article-title":"Cancer in sub-Saharan Africa","author":"Parkin","year":"2018","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.ctarc.2019.100129_bib0017","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S2468-1253(17)30295-9","article-title":"Hepatitis B in sub-Saharan Africa: strategies to achieve the 2030 elimination targets","author":"Spearman","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0018","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/jmv.21010","article-title":"Use of replacement blood donors to study the epidemiology of major blood-borne viruses in the general population of Maputo, Mozambique","volume":"79","author":"Cunha","year":"2007","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0019","series-title":"Riscos Comportamentais e Informa\u00e7\u00e3o Sobre o HIV e SIDA Em Mo\u00e7ambique 2009 (INSIDA 2009)","article-title":"Inqu\u00e9rito Nacional de Preval\u00eancia","year":"2010"},{"key":"10.1016\/j.ctarc.2019.100129_bib0020","series-title":"Inqu\u00e9rito De Indicadores de Imuniza\u00e7\u00e3o, Mal\u00e1ria e HIV\/SIDA Em Mo\u00e7ambique 2015 (IMASIDA 2015)","article-title":"Instituto Nacional de Estatistica (INE), I. International","year":"2017"},{"key":"10.1016\/j.ctarc.2019.100129_bib0021","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1634\/theoncologist.2010-0400","article-title":"Hepatocellular carcinoma in HIV-infected patients: check early, treat hard","volume":"16","author":"Berretta","year":"2011","journal-title":"Oncologist"},{"key":"10.1016\/j.ctarc.2019.100129_bib0022","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1053\/j.gastro.2004.09.011","article-title":"Primary liver cancer: worldwide incidence and trends","volume":"127","author":"Bosch","year":"2004","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"10.1016\/j.ctarc.2019.100129_bib0023","first-page":"S20","article-title":"Hepatitis B virus and HIV infection among patients with primary hepatocellular carcinoma in Kampala, Uganda","volume":"11","author":"Ocama","year":"2011","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.ctarc.2019.100129_bib0024","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S2468-1253(16)30161-3","article-title":"Characteristics, management, and outcomes of patients with hepatocellular carcinoma in Africa: a multicountry observational study from the Africa Liver Cancer Consortium","volume":"2","author":"Yang","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0025","first-page":"306","article-title":"Some characteristics of Mozambican Shangaans with primary hepatocellular cancer","volume":"51","author":"Kew","year":"1977","journal-title":"S. Afr. Med. J."},{"key":"10.1016\/j.ctarc.2019.100129_bib0026","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4269\/ajtmh.1993.48.237","article-title":"Absence of a relationship between antibodies to hepatitis C virus and hepatocellular carcinoma in Mozambique","volume":"48","author":"Dazza","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ctarc.2019.100129_bib0027","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2006.05.013","article-title":"The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide","volume":"45","author":"Perz","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0028","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/sj.bjc.6603649","article-title":"Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review","volume":"96","author":"Raza","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0029","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/hep.27969","article-title":"World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma","volume":"62","author":"de Martel","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ctarc.2019.100129_bib0030","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(02)11913-1","article-title":"HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)","volume":"360","author":"Thio","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ctarc.2019.100129_bib0031","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.bjc.6605756","article-title":"Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study","volume":"103","author":"Franceschi","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0032","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(02)11913-1","article-title":"HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)","volume":"360","author":"Thio","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ctarc.2019.100129_bib0033","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(10)62001-6","article-title":"Increasing burden of liver disease in patients with HIV infection","volume":"377","author":"Joshi","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ctarc.2019.100129_bib0034","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1097\/QAD.0b013e32831103ad","article-title":"Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma","volume":"22","author":"Clifford","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.ctarc.2019.100129_bib0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0002-9270(00)02167-5","article-title":"Hepatocellular carcinoma in HIV-infected patients with chronic hepatitis C","volume":"96","author":"Garc\u00eda-Samaniego","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0036","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jhep.2007.06.010","article-title":"Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a US\u2013Canadian multicenter study","volume":"47","author":"Br\u00e4u","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0037","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4254\/wjh.v6.i11.783","article-title":"Problem of hepatocellular carcinoma in West Africa","volume":"6","author":"Ladep","year":"2014","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196057","article-title":"Analysis of risk factors associated with hepatocellular carcinoma in black South Africans: 2000-2012","volume":"13","author":"Mak","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ctarc.2019.100129_bib0039","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3748\/wjg.v24.i5.613","article-title":"Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus: a retrospective cohort study","volume":"24","author":"Marcon","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0040","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/s13104-018-3646-5","article-title":"Association between alcohol use and HIV status: findings from Zambia and Zimbabwe","volume":"11","author":"Musuka","year":"2018","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.ctarc.2019.100129_bib0041","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ctarc.2019.100129_bib0042","article-title":"Primary liver cancer rate and aflatoxin intake in a high cancer area","volume":"48","author":"Van Rensburg","year":"1974","journal-title":"S. Afr. Med. J."},{"key":"10.1016\/j.ctarc.2019.100129_bib0043","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/bjc.1985.107","article-title":"Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei","volume":"51","author":"Van Rensburg","year":"1985","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/agriculture8070087","article-title":"Aflatoxins in Mozambique: etiology, epidemiology and control","volume":"8","author":"Cambaza","year":"2018","journal-title":"Agriculture"},{"key":"10.1016\/j.ctarc.2019.100129_bib0045","doi-asserted-by":"crossref","first-page":"E951","DOI":"10.3390\/ijerph14090951","article-title":"Aflatoxin b1 contamination in chicken livers and gizzards from industrial and small abattoirs, measured by ELISA technique in Maputo, Mozambique","volume":"14","author":"Sineque","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ctarc.2019.100129_bib0046","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ijc.20103","article-title":"Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa","volume":"110","author":"Szymanska","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ctarc.2019.100129_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/S1386-6532(05)80005-8","article-title":"Clinical impact of occult HBV infection","volume":"34","author":"Chemin","year":"2005","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ctarc.2019.100129_bib0048","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.3748\/wjg.v20.i20.5951","article-title":"Occult hepatitis B virus and hepatocellular carcinoma","volume":"20","author":"Pollicino","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ctarc.2019.100129_bib0049","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1440-1746.2008.05481.x","article-title":"Occult hepatitis B virus infection in Southern African blacks with hepatocellular carcinoma","volume":"23","author":"Kew","year":"2008","journal-title":"J. Gastroenterol. Hepatol."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294218301291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294218301291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T06:18:55Z","timestamp":1762841935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294218301291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":49,"alternative-id":["S2468294218301291"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2019.100129","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocellular carcinoma: Clinical-pathological features and HIV infection in Mozambican patients,","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2019.100129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100129"}}