{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:18:37Z","timestamp":1789006717605,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA138292"],"award-info":[{"award-number":["P30CA138292"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.ctarc.2021.100329","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:32:59Z","timestamp":1612571579000},"page":"100329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Impact of high-risk features for stage II adenocarcinoma of the appendix"],"prefix":"10.1016","volume":"27","author":[{"given":"Mehmet","family":"Akce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Zakka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKenna","family":"Penley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatunji B.","family":"Alese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid L.","family":"Shaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusmita","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel F.","family":"El-Rayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ctarc.2021.100329_bib0001","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1634\/theoncologist.2017-0081","article-title":"Appendiceal mucinous neoplasms: diagnosis and management","volume":"22","author":"Shaib","year":"2017","journal-title":"Oncologist"},{"issue":"2","key":"10.1016\/j.ctarc.2021.100329_bib0002","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"issue":"12","key":"10.1016\/j.ctarc.2021.100329_bib0003","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.10589","article-title":"Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998","volume":"94","author":"McCusker","year":"2002","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100329_bib0004","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00000658-199401000-00009","article-title":"The natural history of surgically treated primary adenocarcinoma of the appendix","volume":"219","author":"Nitecki","year":"1994","journal-title":"Ann. Surg."},{"key":"10.1016\/j.ctarc.2021.100329_bib0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijso.2016.06.003","article-title":"Primary adenocarcinoma of the appendix: experience at La Paz University Hospital of Madrid (1967\u20132014)","volume":"4","author":"Le\u00f3n Arellano","year":"2016","journal-title":"Int. J. Surg. Open"},{"issue":"11","key":"10.1016\/j.ctarc.2021.100329_bib0006","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00384-019-03387-y","article-title":"Epidemiology of and prognostic factors for appendiceal carcinomas: a retrospective, population-based study","volume":"34","author":"Mo","year":"2019","journal-title":"Int. J. Colorectal Dis."},{"issue":"4","key":"10.1016\/j.ctarc.2021.100329_bib0007","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0035-1564433","article-title":"Management of appendix cancer","volume":"28","author":"Kelly","year":"2015","journal-title":"Clin. Colon Rectal Surg."},{"issue":"6","key":"10.1016\/j.ctarc.2021.100329_bib0008","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1097\/SLA.0b013e318269d680","article-title":"Improving the AJCC\/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade","volume":"257","author":"Overman","year":"2013","journal-title":"Ann. Surg."},{"key":"10.1016\/j.ctarc.2021.100329_bib0009","article-title":"What is new in 2019 World Health Organization (WHO) classification of tumors of the digestive system: review of selected updates on neuroendocrine neoplasms, appendiceal tumors, and molecular testing","author":"Assarzadegan","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"6 Suppl 9","key":"10.1016\/j.ctarc.2021.100329_bib0010","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1053\/j.seminoncol.2005.04.016","article-title":"Adjuvant chemotherapy of stage III colon cancer","volume":"32","author":"Benson","year":"2005","journal-title":"Semin. Oncol."},{"issue":"13","key":"10.1016\/j.ctarc.2021.100329_bib0011","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMoa1713709","article-title":"Duration of adjuvant chemotherapy for stage III colon cancer","volume":"378","author":"Grothey","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.ctarc.2021.100329_bib0012","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1056\/NEJMoa032709","article-title":"Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer","volume":"350","author":"Andr\u00e9","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.ctarc.2021.100329_bib0013","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1200\/JCO.2008.19.5362","article-title":"Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials","volume":"27","author":"Sargent","year":"2009","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"issue":"35","key":"10.1016\/j.ctarc.2021.100329_bib0014","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1200\/JCO.2015.63.4238","article-title":"Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study","volume":"33","author":"Andr\u00e9","year":"2015","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.ctarc.2021.100329_bib0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1200\/JOP.2016.017210","article-title":"Adjuvant chemotherapy for stage II colon cancer: a clinical dilemma","volume":"13","author":"Kannarkatt","year":"2017","journal-title":"J. Oncol. Pract."},{"issue":"27","key":"10.1016\/j.ctarc.2021.100329_bib0016","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1200\/JCO.2012.42.5645","volume":"30","author":"Tournigand","year":"2012","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.ctarc.2021.100329_bib0017","first-page":"143","article-title":"Do high-risk features support the use of adjuvant chemotherapy in stage II colon cancer?","volume":"100","author":"Artac","year":"2014","journal-title":"Turk. Oncol. Group Study Tumori."},{"issue":"16","key":"10.1016\/j.ctarc.2021.100329_bib0018","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1200\/JCO.2004.05.063","article-title":"American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer","volume":"22","author":"Benson","year":"2004","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.ctarc.2021.100329_bib0019","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/cncr.29072","article-title":"Adjuvant chemotherapy use and outcomes of patients with high-risk versus low-risk stage II colon cancer","volume":"121","author":"Kumar","year":"2015","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.ctarc.2021.100329_bib0020","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s00432-016-2208-2","article-title":"High-risk clinicopathological features and their predictive significance in Korean patients with stage II colon cancer","volume":"142","author":"Park","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.ctarc.2021.100329_bib0021","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3747\/co.23.3330","article-title":"Adjuvant systemic chemotherapy for stages II and III colon cancer after complete resection: a clinical practice guideline","volume":"23","author":"Meyers","year":"2016","journal-title":"Curr. Oncol. Toronto Ont."},{"issue":"21","key":"10.1016\/j.ctarc.2021.100329_bib0022","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1002\/cncr.30181","article-title":"Adjuvant chemotherapy is associated with improved survival in patients with stage II colon cancer","volume":"122","author":"Casadaban","year":"2016","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100329_bib0023","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jso.21914","article-title":"High-risk stage II colon cancer after curative resection","volume":"104","author":"Sato","year":"2011","journal-title":"J. Surg. Oncol."},{"issue":"1","key":"10.1016\/j.ctarc.2021.100329_bib0024","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ijc.30053","article-title":"Adjuvant chemotherapy is not associated with improved survival for all high-risk factors in stage II colon cancer","volume":"139","author":"Verhoeff","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"Suppl 6","key":"10.1016\/j.ctarc.2021.100329_bib0025","article-title":"Early colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Labianca","year":"2013","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ctarc.2021.100329_bib0026","unstructured":"National Comprehensive Cancer Network. Colon Cancer (Version 2.2020) [Available from: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colon_blocks.pdf."},{"issue":"4","key":"10.1016\/j.ctarc.2021.100329_bib0027","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1053\/j.seminoncol.2011.05.005","article-title":"Challenges in the management of stage II colon cancer","volume":"38","author":"Dotan","year":"2011","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.ctarc.2021.100329_bib0028","doi-asserted-by":"crossref","first-page":"39027","DOI":"10.1038\/srep39027","article-title":"The management and prognostic prediction of adenocarcinoma of appendix","volume":"6","author":"Xie","year":"2016","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.ctarc.2021.100329_bib0029","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/DCR.0000000000001530","article-title":"The American Society of Colon and Rectal Surgeons, clinical practice guidelines for the management of appendiceal neoplasms","volume":"62","author":"Glasgow","year":"2019","journal-title":"Dis. Colon Rectum"},{"issue":"2","key":"10.1016\/j.ctarc.2021.100329_bib0030","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cncr.29744","article-title":"The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: analysis of the National Cancer Data Base","volume":"122","author":"Asare","year":"2016","journal-title":"Cancer"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294221000289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294221000289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T06:19:01Z","timestamp":1762841941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294221000289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":30,"alternative-id":["S2468294221000289"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2021.100329","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of high-risk features for stage II adenocarcinoma of the appendix","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2021.100329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100329"}}