{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T22:15:26Z","timestamp":1778969726751,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":109,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011851","name":"Kom op tegen Kanker","doi-asserted-by":"publisher","award":["000019482"],"award-info":[{"award-number":["000019482"]}],"id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.ctarc.2021.100380","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T01:38:41Z","timestamp":1619314721000},"page":"100380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Ultra-low coverage whole genome sequencing of ccfDNA in multiple myeloma: A tool for laboratory routine?"],"prefix":"10.1016","volume":"28","author":[{"given":"Laura Yissel","family":"Rengifo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"Smits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieselot","family":"Buedts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Delforge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Dehaspe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Tousseyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Boeckx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Lehnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucienne","family":"Michaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris Robert","family":"Vermeesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Dewaele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/j.ctarc.2021.100380_bib0001","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1200\/JCO.2015.61.2267","article-title":"Revised international staging system for multiple myeloma: a report from international myeloma working group","volume":"33","author":"Palumbo","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctarc.2021.100380_bib0002","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1038\/nrdp.2017.46","article-title":"Multiple myeloma","volume":"3","author":"Kumar","year":"2017","journal-title":"Nat Rev Dis Prim"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100380_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04001-5","article-title":"Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma","volume":"9","author":"Manier","year":"2018","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.ctarc.2021.100380_bib0004","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41408-018-0068-5","article-title":"A systematic classification of death causes in multiple myeloma","volume":"8","author":"Mai","year":"2018","journal-title":"Blood Cancer J"},{"issue":"24","key":"10.1016\/j.ctarc.2021.100380_bib0005","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1182\/blood-2016-01-631200","article-title":"Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group","volume":"127","author":"Sonneveld","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ctarc.2021.100380_bib0006","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5808\/GI.2017.15.3.87","article-title":"Chromothripsis in treatment resistance in multiple myeloma","volume":"15","author":"Lee","year":"2017","journal-title":"Genomics Inform"},{"issue":"3","key":"10.1016\/j.ctarc.2021.100380_bib0007","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1182\/blood-2011-03-344069","article-title":"Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients","volume":"118","author":"Magrangeas","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100380_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13039-018-0357-5","article-title":"Chromothripsis 18 in multiple myeloma patient with rapid extramedullary relapse","volume":"11","author":"Smetana","year":"2018","journal-title":"Mol Cytogenet"},{"key":"10.1016\/j.ctarc.2021.100380_bib0009","doi-asserted-by":"crossref","unstructured":"Maura F., Bolli N., Angelopoulos N., et\u00a0al. Genomic landscape and chronological reconstruction of driver events in multiple myeloma. Nat Commun. 2019:1\u201312. doi:10.1038\/s41467-019-11680-1.","DOI":"10.1038\/s41467-019-11680-1"},{"issue":"8","key":"10.1016\/j.ctarc.2021.100380_bib0010","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/leu.2016.366","article-title":"Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma","volume":"31","author":"Mithraprabhu","year":"2017","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.ctarc.2021.100380_bib0011","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1038\/s41375-019-0469-x","article-title":"Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patients","volume":"33","author":"Mithraprabhu","year":"2019","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100380_bib0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cancergencyto.2010.11.002","article-title":"The prognostic significance of cytogenetics and molecular profiling in multiple myeloma","volume":"204","author":"Sawyer","year":"2011","journal-title":"Cancer Genet"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100380_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-00296-y","article-title":"Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing","volume":"8","author":"Rasche","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.ctarc.2021.100380_bib0014","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/S2352-3026(14)00039-8","article-title":"Non-invasive detection of genomic imbalances in Hodgkin\/Reed-Sternberg cells in early and advanced stage Hodgkin\u2019s lymphoma by sequencing of circulating cell-free DNA: a technical proof-of-principle study","volume":"2","author":"Vandenberghe","year":"2015","journal-title":"Lancet Haematol"},{"issue":"5","key":"10.1016\/j.ctarc.2021.100380_bib0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S1470-2045(15)70106-3","article-title":"Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a correlative biomarker study","volume":"16","author":"Roschewski","year":"2015","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100380_bib0016","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00965-y","article-title":"Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors","volume":"8","author":"Adalsteinsson","year":"2017","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.ctarc.2021.100380_bib0017","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/gcc.22848","article-title":"Ultra-low depth sequencing of plasma cell DNA for the detection of copy number aberrations in multiple myeloma","volume":"59","author":"Buedts","year":"2020","journal-title":"Genes Chromosom Cancer"},{"issue":"8","key":"10.1016\/j.ctarc.2021.100380_bib0018","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3324\/haematol.2011.056176","article-title":"Report from the European myeloma network on interphase FISH in multiple myeloma and related disorders","volume":"97","author":"Ross","year":"2012","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100380_bib0019","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"11","key":"10.1016\/j.ctarc.2021.100380_bib0020","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1182\/blood-2018-10-880831","article-title":"High subclonal fraction of 17p deletion is associated with poor prognosis in multiple myeloma","volume":"133","author":"Thakurta","year":"2019","journal-title":"Blood"},{"issue":"6_suppl","key":"10.1016\/j.ctarc.2021.100380_bib0021","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1200\/JCO.2018.36.6_suppl.195","article-title":"Tumor fraction in circulating free DNA as a biomarker of disease dynamics in metastatic prostate cancer","volume":"36","author":"Choudhury","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctarc.2021.100380_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms15086","article-title":"Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates","volume":"8","author":"Kis","year":"2017","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.ctarc.2021.100380_bib0023","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3324\/haematol.2016.160564","article-title":"Monitoring multiple myeloma by quantification of recurrent mutations in serum","volume":"102","author":"Rustad","year":"2017","journal-title":"Haematologica"},{"issue":"8","key":"10.1016\/j.ctarc.2021.100380_bib0024","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1038\/s41375-018-0115-z","article-title":"Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing","volume":"32","author":"Guo","year":"2018","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.ctarc.2021.100380_bib0025","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1182\/blood-2014-10-567370","article-title":"Genetics of multiple myeloma: another heterogeneity level?","volume":"125","author":"Corre","year":"2015","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ctarc.2021.100380_bib0026","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cge.13561","article-title":"Low-depth sequencing for copy number abnormalities in multiple myeloma supersedes fluorescent in situ hybridization in scope and resolution","volume":"96","author":"Elnenaei","year":"2019","journal-title":"Clin Genet"},{"key":"10.1016\/j.ctarc.2021.100380_bib0027","doi-asserted-by":"crossref","unstructured":"Joshua D.E. Tumor Burden BT - Biology and Management of Multiple Myeloma. In: Berenson JR, ed. Totowa, NJ: Humana Press; 2004:127\u2013136. doi:10.1007\/978-1-59259-817-5_7.","DOI":"10.1007\/978-1-59259-817-5_7"},{"key":"10.1016\/j.ctarc.2021.100380_bib0028","first-page":"190","article-title":"Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients","volume":"2019","author":"Vrabel","year":"2019","journal-title":"Eur J Haematol"},{"issue":"1","key":"10.1016\/j.ctarc.2021.100380_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-017-0037-4","article-title":"Pathogenesis of bone disease in multiple myeloma: from bench to bedside","volume":"8","author":"Terpos","year":"2018","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.ctarc.2021.100380_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cancergen.2020.01.001","article-title":"The combination of WGS and RNA-Seq is superior to conventional diagnostic tests in multiple myeloma: ready for prime time?","volume":"242","author":"H\u00f6llein","year":"2020","journal-title":"Cancer Genet"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294221000782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294221000782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T06:22:12Z","timestamp":1762842132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294221000782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":30,"alternative-id":["S2468294221000782"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2021.100380","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultra-low coverage whole genome sequencing of ccfDNA in multiple myeloma: A tool for laboratory routine?","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2021.100380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100380"}}