{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:53:49Z","timestamp":1785178429570,"version":"3.55.0"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010679","name":"Pasteur Institute of Iran","doi-asserted-by":"publisher","award":["970"],"award-info":[{"award-number":["970"]}],"id":[{"id":"10.13039\/501100010679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.ctarc.2022.100512","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T12:00:22Z","timestamp":1641556822000},"page":"100512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Autophagy Modulation and Cancer Combination Therapy: A Smart Approach in Cancer Therapy"],"prefix":"10.1016","volume":"30","author":[{"given":"Ali","family":"Salimi-Jeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad","family":"Ghabeshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Gol Mohammad pour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan Ollah","family":"Jazaeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Araiinejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Sheikholeslami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Abdoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Edalat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Abdoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0001","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/cdd.2017.41","article-title":"mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism","volume":"24","author":"Lampada","year":"2017","journal-title":"Cell Death & Differentiation"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0002","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.surg.2012.08.016","article-title":"Autophagic activation potentiates the antiproliferative effects of tyrosine kinase inhibitors in medullary thyroid cancer","volume":"152","author":"Lin","year":"2012","journal-title":"Surgery"},{"issue":"9","key":"10.1016\/j.ctarc.2022.100512_bib0003","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1535-7163.MCT-11-0047","article-title":"The role of autophagy in cancer: therapeutic implications","volume":"10","author":"Yang","year":"2011","journal-title":"Molecular cancer therapeutics"},{"key":"10.1016\/j.ctarc.2022.100512_bib0004","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fcell.2018.00128","article-title":"Crosstalk between mammalian autophagy and the ubiquitin-proteasome system","volume":"6","author":"Kocaturk","year":"2018","journal-title":"Frontiers in cell and developmental biology"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"White","year":"2012","journal-title":"Nature reviews. Cancer"},{"key":"10.1016\/j.ctarc.2022.100512_bib0006","first-page":"57","volume":"100","author":"Hanahan","year":"2000","journal-title":"The hallmarks of cancer Cell"},{"key":"10.1016\/j.ctarc.2022.100512_bib0007","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mad.2016.12.011","article-title":"Autophagy induction reduces telomerase activity in HeLa cells","volume":"163","author":"Taji","year":"2017","journal-title":"Mechanisms of ageing and development"},{"issue":"22","key":"10.1016\/j.ctarc.2022.100512_bib0008","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes & development"},{"issue":"1563","key":"10.1016\/j.ctarc.2022.100512_bib0009","article-title":"Autophagy in the Regulation of Tissue Differentiation and Homeostasis","volume":"8","author":"Perrotta","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"41","key":"10.1016\/j.ctarc.2022.100512_bib0010","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.3748\/wjg.v24.i41.4643","article-title":"Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma","volume":"24","author":"Huang","year":"2018","journal-title":"World journal of gastroenterology"},{"issue":"4","key":"10.1016\/j.ctarc.2022.100512_bib0011","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.prp.2014.11.005","article-title":"Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma","volume":"211","author":"Won","year":"2015","journal-title":"Pathology-Research and Practice"},{"key":"10.1016\/j.ctarc.2022.100512_bib0012","doi-asserted-by":"crossref","unstructured":"Wang, Y. and W.-D. Le, Autophagy and ubiquitin-proteasome system. Autophagy: Biology and Diseases, 2019: p. 527-550.","DOI":"10.1007\/978-981-15-0602-4_25"},{"key":"10.1016\/j.ctarc.2022.100512_bib0013","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fncel.2018.00126","article-title":"Interplay between the autophagy-lysosomal pathway and the ubiquitin-proteasome system: a target for therapeutic development in Alzheimer's disease","volume":"12","author":"Bustamante","year":"2018","journal-title":"Frontiers in cellular neuroscience"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0014","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.molcel.2021.01.009","article-title":"Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling","volume":"81","author":"Zellner","year":"2021","journal-title":"Molecular cell"},{"issue":"4","key":"10.1016\/j.ctarc.2022.100512_bib0015","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0016","first-page":"143","article-title":"Role of autophagy in resistance to oxaliplatin in hepatocellular carcinoma cells","volume":"27","author":"Du","year":"2012","journal-title":"Oncol Rep"},{"issue":"8","key":"10.1016\/j.ctarc.2022.100512_bib0017","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1089\/vim.2019.0042","article-title":"Harmonized Autophagy Versus Full-Fledged Hepatitis B Virus: Victorious or Defeated","volume":"32","author":"Abdoli","year":"2019","journal-title":"Viral immunology"},{"issue":"5","key":"10.1016\/j.ctarc.2022.100512_bib0018","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1182\/blood-2016-07-692707","article-title":"Autophagy, a key mechanism of oncogenesis and resistance in leukemia","volume":"129","author":"Auberger","year":"2017","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.ctarc.2022.100512_bib0019","doi-asserted-by":"crossref","first-page":"17163","DOI":"10.1074\/jbc.M114.558288","article-title":"Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells *","volume":"289","author":"Wang","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"10.1016\/j.ctarc.2022.100512_bib0020","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1083\/jcb.201711002","article-title":"Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy","volume":"217","author":"Mejlvang","year":"2018","journal-title":"Journal of Cell Biology"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-00369-y","article-title":"Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation","volume":"8","author":"Tan","year":"2017","journal-title":"Nature communications"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0022","doi-asserted-by":"crossref","first-page":"e12876","DOI":"10.1111\/acel.12876","article-title":"Autophagy and aging: Maintaining the proteome through exercise and caloric restriction","volume":"18","author":"Escobar","year":"2019","journal-title":"Aging cell"},{"key":"10.1016\/j.ctarc.2022.100512_bib0023","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2147\/CMAR.S156530","article-title":"Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer","volume":"10","author":"Lu","year":"2018","journal-title":"Cancer management and research"},{"key":"10.1016\/j.ctarc.2022.100512_bib0024","article-title":"Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy","volume":"265","author":"Ramirez","year":"2021","journal-title":"Life Sciences"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0025","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1172\/JCI28833","article-title":"Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma","volume":"117","author":"Amaravadi","year":"2007","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0026","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","article-title":"Autophagy and autophagy-related proteins in cancer","volume":"19","author":"Li","year":"2020","journal-title":"Molecular Cancer"},{"issue":"2064","key":"10.1016\/j.ctarc.2022.100512_bib0027","article-title":"The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity","volume":"10","author":"Chavez-Dominguez","year":"2020","journal-title":"Frontiers in Oncology"},{"issue":"9","key":"10.1016\/j.ctarc.2022.100512_bib0028","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.3390\/ijms21093289","article-title":"Roles of autophagy in oxidative stress","volume":"21","author":"Yun","year":"2020","journal-title":"International journal of molecular sciences"},{"issue":"12","key":"10.1016\/j.ctarc.2022.100512_bib0029","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1172\/JCI20039","article-title":"Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene","volume":"112","author":"Qu","year":"2003","journal-title":"The Journal of clinical investigation"},{"issue":"25","key":"10.1016\/j.ctarc.2022.100512_bib0030","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1073\/pnas.2436255100","article-title":"Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor","volume":"100","author":"Yue","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"13","key":"10.1016\/j.ctarc.2022.100512_bib0031","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1101\/gad.1565707","article-title":"Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis","volume":"21","author":"Karantza-Wadsworth","year":"2007","journal-title":"Genes & development"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0032","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.onc.1207178","article-title":"Manipulation of nonsense mediated decay identifies gene mutations in colon cancer C ells with microsatellite instability","volume":"23","author":"Ionov","year":"2004","journal-title":"Oncogene"},{"issue":"25","key":"10.1016\/j.ctarc.2022.100512_bib0033","doi-asserted-by":"crossref","first-page":"18573","DOI":"10.1074\/jbc.M701194200","article-title":"Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C\/autophagin-3","volume":"282","author":"Mari\u00f1o","year":"2007","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0034","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","article-title":"Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis","volume":"10","author":"Degenhardt","year":"2006","journal-title":"Cancer cell"},{"issue":"19","key":"10.1016\/j.ctarc.2022.100512_bib0035","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1158\/0008-5472.CAN-06-1597","article-title":"Autophagy in cancer: good, bad, or both?","volume":"66","author":"Hippert","year":"2006","journal-title":"Cancer research"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0036","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4161\/auto.3269","article-title":"Role of autophagy in cancer: management of metabolic stress","volume":"3","author":"Jin","year":"2007","journal-title":"Autophagy"},{"issue":"7137","key":"10.1016\/j.ctarc.2022.100512_bib0037","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/446745a","article-title":"Cell biology: autophagy and cancer","volume":"446","author":"Levine","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0038","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cell.2004.11.046","article-title":"Growth factor regulation of autophagy and cell survival in the absence of apoptosis","volume":"120","author":"Lum","year":"2005","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0039","doi-asserted-by":"crossref","DOI":"10.1101\/gad.1545107","article-title":"Autophagy suppresses tumor progression by limiting chromosomal instability","volume":"21","author":"Mathew","year":"2007","journal-title":"Genes & development"},{"issue":"7","key":"10.1016\/j.ctarc.2022.100512_bib0040","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3390\/ijms18071496","article-title":"Clinical applications of autophagy proteins in cancer: from potential targets to biomarkers","volume":"18","author":"Bortnik","year":"2017","journal-title":"International journal of molecular sciences"},{"issue":"24","key":"10.1016\/j.ctarc.2022.100512_bib0041","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1111\/febs.13540","article-title":"p62\/SQSTM 1 functions as a signaling hub and an autophagy adaptor","volume":"282","author":"Katsuragi","year":"2015","journal-title":"The FEBS journal"},{"issue":"4","key":"10.1016\/j.ctarc.2022.100512_bib0042","first-page":"397","article-title":"When autophagy meets cancer through p62\/SQSTM1","volume":"2","author":"Puissant","year":"2012","journal-title":"American journal of cancer research"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0043","first-page":"129","article-title":"Clinicopathological correlations of autophagy-related proteins LC3, Beclin 1 and p62 in gastric cancer","volume":"36","author":"Masuda","year":"2016","journal-title":"Anticancer research"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0044","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12957-016-0946-x","article-title":"Prognostic relevance of autophagy-related markers LC3, p62\/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status","volume":"14","author":"Schmitz","year":"2016","journal-title":"World journal of surgical oncology"},{"key":"10.1016\/j.ctarc.2022.100512_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/723176","article-title":"Correlation of altered expression of the autophagy marker LC3B with poor prognosis in astrocytoma","volume":"2014","author":"Winardi","year":"2014","journal-title":"BioMed research international"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0046","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1186\/s12885-015-1574-5","article-title":"LC3B globular structures correlate with survival in esophageal adenocarcinoma","volume":"15","author":"El-Mashed","year":"2015","journal-title":"BMC cancer"},{"issue":"5","key":"10.1016\/j.ctarc.2022.100512_bib0047","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/bjc.2014.355","article-title":"Prognostic significance of p62\/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma","volume":"111","author":"Liu","year":"2014","journal-title":"British journal of cancer"},{"issue":"12","key":"10.1016\/j.ctarc.2022.100512_bib0048","doi-asserted-by":"crossref","first-page":"12225","DOI":"10.1007\/s13277-014-2531-7","article-title":"Autophagic LC3B overexpression correlates with malignant progression and predicts a poor prognosis in hepatocellular carcinoma","volume":"35","author":"Wu","year":"2014","journal-title":"Tumor Biology"},{"issue":"4","key":"10.1016\/j.ctarc.2022.100512_bib0049","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.200801099","article-title":"Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents","volume":"183","author":"Degtyarev","year":"2008","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ctarc.2022.100512_bib0051","doi-asserted-by":"crossref","unstructured":"Yang, S., et\u00a0al., Pancreatic cancers require autophagy for tumor growth. Genes & development, 2011.","DOI":"10.1101\/gad.2016111"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0052","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1124\/jpet.105.084145","article-title":"Role of tyrosine kinase inhibitors in cancer therapy","volume":"315","author":"Arora","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0053","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1056\/NEJMra044389","article-title":"Tyrosine kinases as targets for cancer therapy","volume":"353","author":"Krause","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ctarc.2022.100512_bib0054","series-title":"Protein tyrosine kinases: from inhibitors to useful drugs","author":"Fabbro","year":"2006"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.biochem.69.1.373","article-title":"Protein tyrosine kinase structure and function","volume":"69","author":"Hubbard","year":"2000","journal-title":"Annual review of biochemistry"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0056","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.3390\/ijms19113466","article-title":"The roles of autophagy in cancer","volume":"19","author":"Yun","year":"2018","journal-title":"International journal of molecular sciences"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0057","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/cancers13020184","article-title":"Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia","volume":"13","author":"K Bhanumathy","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0058","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s12672-010-0053-3","article-title":"Targeting tyrosine kinases and autophagy in prostate cancer","volume":"2","author":"Kung","year":"2011","journal-title":"Hormones and Cancer"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0059","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4161\/auto.2.2.2463","article-title":"Autophagy and cancer therapy","volume":"2","author":"Kondo","year":"2006","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43042-019-0035-0","article-title":"Exploring receptor tyrosine kinases-inhibitors in Cancer treatments","volume":"20","author":"Metibemu","year":"2019","journal-title":"Egyptian Journal of Medical Human Genetics"},{"issue":"36","key":"10.1016\/j.ctarc.2022.100512_bib0061","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1038\/onc.2010.236","article-title":"The role of signaling pathways in the development and treatment of hepatocellular carcinoma","volume":"29","author":"Whittaker","year":"2010","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-018-0794-0","article-title":"The role of RICTOR downstream of receptor tyrosine kinase in cancers","volume":"17","author":"Jebali","year":"2018","journal-title":"Molecular cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0063","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: Mechanisms of ERK-induced cell death\u2013apoptosis, autophagy and senescence","volume":"277","author":"Cagnol","year":"2010","journal-title":"The FEBS journal"},{"issue":"965","key":"10.1016\/j.ctarc.2022.100512_bib0064","article-title":"RAS: Striking at the Core of the Oncogenic Circuitry","volume":"9","author":"Gimple","year":"2019","journal-title":"Frontiers in Oncology"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0065","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrc3106","article-title":"RAS oncogenes: weaving a tumorigenic web","volume":"11","author":"Pylayeva-Gupta","year":"2011","journal-title":"Nature reviews. Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0066","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/biology9010004","article-title":"The role of Beclin 1-dependent autophagy in cancer","volume":"9","author":"Vega-Rub\u00edn-de-Celis","year":"2020","journal-title":"Biology"},{"issue":"9","key":"10.1016\/j.ctarc.2022.100512_bib0067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-020-02998-6","article-title":"PI3K\/AKT pathway as a key link modulates the multidrug resistance of cancers","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death & Disease"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0068","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1111\/j.1349-7006.2008.00932.x","article-title":"Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors","volume":"99","author":"Mishima","year":"2008","journal-title":"Cancer science"},{"issue":"sup1","key":"10.1016\/j.ctarc.2022.100512_bib0069","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/10428194.2010.546913","article-title":"Inhibition of autophagy: a new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors","volume":"52","author":"Calabretta","year":"2011","journal-title":"Leukemia & lymphoma"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0070","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3390\/cancers12030731","article-title":"Tyrosine kinase inhibitors in cancer: breakthrough and challenges of targeted therapy","volume":"12","author":"Pottier","year":"2020","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.ctarc.2022.100512_bib0071","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.apsb.2011.10.007","article-title":"Mechanisms of acquired resistance to tyrosine kinase inhibitors","volume":"1","author":"Chen","year":"2011","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0072","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/cdd.2008.107","article-title":"The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias","volume":"15","author":"Kamitsuji","year":"2008","journal-title":"Cell death and differentiation"},{"issue":"5","key":"10.1016\/j.ctarc.2022.100512_bib0073","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1172\/JCI35660","article-title":"Targeting autophagy potentiates tyrosine kinase inhibitor\u2013induced cell death in Philadelphia chromosome\u2013positive cells, including primary CML stem cells","volume":"119","author":"Bellodi","year":"2009","journal-title":"The Journal of clinical investigation"},{"issue":"7","key":"10.1016\/j.ctarc.2022.100512_bib0074","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.4161\/auto.5.7.9509","article-title":"Targeted therapies and autophagy: new insights from chronic myeloid leukemia","volume":"5","author":"Salomoni","year":"2009","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ajh.21914","article-title":"Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment","volume":"86","author":"Crowley","year":"2011","journal-title":"American journal of hematology"},{"issue":"17","key":"10.1016\/j.ctarc.2022.100512_bib0076","doi-asserted-by":"crossref","first-page":"28063","DOI":"10.18632\/oncotarget.14188","article-title":"A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR\/ERK signaling pathway","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0077","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.celrep.2016.12.061","article-title":"Targeted inhibition of EGFR and glutaminase induces metabolic crisis in EGFR mutant lung cancer","volume":"18","author":"Momcilovic","year":"2017","journal-title":"Cell reports"},{"key":"10.1016\/j.ctarc.2022.100512_bib0078","doi-asserted-by":"crossref","first-page":"37594","DOI":"10.1038\/srep37594","article-title":"Autophagy is required for PDAC glutamine metabolism","volume":"6","author":"Seo","year":"2016","journal-title":"Scientific reports"},{"issue":"14","key":"10.1016\/j.ctarc.2022.100512_bib0079","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1158\/0008-5472.CAN-13-0080","article-title":"Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism","volume":"73","author":"Fendt","year":"2013","journal-title":"Cancer research"},{"issue":"22","key":"10.1016\/j.ctarc.2022.100512_bib0080","doi-asserted-by":"crossref","first-page":"10976","DOI":"10.1158\/0008-5472.CAN-07-2667","article-title":"Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma","volume":"67","author":"Halder","year":"2007","journal-title":"Cancer research"},{"key":"10.1016\/j.ctarc.2022.100512_bib0081","series-title":"Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells","author":"Vidal","year":"2013"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0082","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40425-016-0119-z","article-title":"From bench to bedside a comprehensive review of pancreatic cancer immunotherapy","volume":"4","author":"Kunk","year":"2016","journal-title":"Journal for immunotherapy of cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0083","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2015.09.001","article-title":"Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity","volume":"163","author":"Serrels","year":"2015","journal-title":"Cell"},{"issue":"7520","key":"10.1016\/j.ctarc.2022.100512_bib0084","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature13541","article-title":"Endothelial\u2013cell FAK targeting sensitizes tumours to DNA\u2013damaging therapy","volume":"514","author":"Tavora","year":"2014","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0085","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1158\/1535-7163.MCT-11-0261","article-title":"Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment","volume":"10","author":"Stokes","year":"2011","journal-title":"Molecular cancer therapeutics"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0086","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40425-017-0217-6","article-title":"FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer","volume":"5","author":"Symeonides","year":"2017","journal-title":"Journal for immunotherapy of cancer"},{"key":"10.1016\/j.ctarc.2022.100512_bib0087","series-title":"Abstract CT118: Phase I study of defactinib combined with pembrolizumab and gemcitabine in patients with advanced cancer: Experiences of pancreatic ductal adenocarcinoma (PDAC) patients","author":"Wang-Gillam","year":"2020"},{"issue":"9","key":"10.1016\/j.ctarc.2022.100512_bib0088","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4161\/cbt.8.9.8246","article-title":"Sunitinib and PF-562,271 (FAK\/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model","volume":"8","author":"Bagi","year":"2009","journal-title":"Cancer biology & therapy"},{"key":"10.1016\/j.ctarc.2022.100512_bib0089","series-title":"Methods and compositions for treating abnormal cell growth","author":"Xu","year":"2015"},{"issue":"7","key":"10.1016\/j.ctarc.2022.100512_bib0090","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1158\/1535-7163.MCT-08-1169","article-title":"Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy","volume":"8","author":"Ding","year":"2009","journal-title":"Molecular cancer therapeutics"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0091","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bcp.2014.12.003","article-title":"Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells","volume":"93","author":"Martin","year":"2015","journal-title":"Biochemical pharmacology"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0092","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1182\/blood-2006-10-050260","article-title":"Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl\u2013mediated drug resistance","volume":"110","author":"Carew","year":"2007","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0093","first-page":"201","article-title":"Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance","volume":"2","author":"Carew","year":"2008","journal-title":"Biologics: targets & therapy"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0094","first-page":"4345","article-title":"Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells","volume":"17","author":"Gao","year":"2018","journal-title":"Molecular medicine reports"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0095","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/cdd.2017.41","article-title":"mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism","volume":"24","author":"Lampada","year":"2017","journal-title":"Cell Death Differ"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0096","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/EBC20170091","article-title":"Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking","volume":"61","author":"Fraser","year":"2017","journal-title":"Essays in biochemistry"},{"issue":"23","key":"10.1016\/j.ctarc.2022.100512_bib0097","doi-asserted-by":"crossref","first-page":"8991","DOI":"10.3390\/ijms21238991","article-title":"Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance","volume":"21","author":"Xu","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0098","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0099","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","article-title":"Defining the role of mTOR in cancer","volume":"12","author":"Guertin","year":"2007","journal-title":"Cancer cell"},{"issue":"26","key":"10.1016\/j.ctarc.2022.100512_bib0100","doi-asserted-by":"crossref","first-page":"20109","DOI":"10.1074\/jbc.M110.121699","article-title":"Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly","volume":"285","author":"Kaizuka","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"7432","key":"10.1016\/j.ctarc.2022.100512_bib0101","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"mTOR is a key modulator of ageing and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0102","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0277-5379(83)90012-3","article-title":"Human brain tumor xenografts in nude mice as a chemotherapy model","volume":"19","author":"Houchens","year":"1983","journal-title":"European Journal of Cancer and Clinical Oncology"},{"issue":"6594","key":"10.1016\/j.ctarc.2022.100512_bib0103","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/382822a0","article-title":"Dimeric ligands define a role for transcriptional activation domains in reinitiation","volume":"382","author":"Ho","year":"1996","journal-title":"Nature"},{"issue":"1-4","key":"10.1016\/j.ctarc.2022.100512_bib0104","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12154-008-0003-5","article-title":"Rapamycin and mTOR kinase inhibitors","volume":"1","author":"Ballou","year":"2008","journal-title":"Journal of chemical biology"},{"issue":"5","key":"10.1016\/j.ctarc.2022.100512_bib0105","doi-asserted-by":"crossref","first-page":"725","DOI":"10.4161\/auto.5.5.8504","article-title":"Rapamycin inhibits mTORC1, but not completely","volume":"5","author":"Thoreen","year":"2009","journal-title":"Autophagy"},{"issue":"19","key":"10.1016\/j.ctarc.2022.100512_bib0106","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1158\/0008-5472.CAN-08-1385","article-title":"NVP-BEZ235, a dual PI3K\/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations","volume":"68","author":"Serra","year":"2008","journal-title":"Cancer research"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0107","doi-asserted-by":"crossref","first-page":"34IN5","DOI":"10.1593\/neo.111512","article-title":"The dual PI3K\/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM-and DNA-PKCs-mediated DNA damage responses","volume":"14","author":"Mukherjee","year":"2012","journal-title":"Neoplasia"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0108","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/jcb.23405","article-title":"The efficacy of a novel, dual PI3K\/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer","volume":"113","author":"Awasthi","year":"2012","journal-title":"Journal of cellular biochemistry"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0109","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3892\/ijo.2014.2505","article-title":"NVP-BEZ235, a dual PI3K\/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells","volume":"45","author":"Moon","year":"2014","journal-title":"International journal of oncology"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0110","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1182\/blood-2009-07-235747","article-title":"Dual targeting of the PI3K\/Akt\/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia","volume":"115","author":"Roccaro","year":"2010","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.ctarc.2022.100512_bib0111","doi-asserted-by":"crossref","first-page":"e46726","DOI":"10.1371\/journal.pone.0046726","article-title":"Utility of a PI3K\/mTOR inhibitor (NVP-BEZ235) for thyroid cancer therapy","volume":"7","author":"Lin","year":"2012","journal-title":"PloS one"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0112","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3390\/cancers7020763","article-title":"Mechanisms of acquired resistance to ALK inhibitors and the rationale for treating ALK-positive lung cancer","volume":"7","author":"Isozaki","year":"2015","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.ctarc.2022.100512_bib0113","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.ctarc.2022.100512_bib0114","doi-asserted-by":"crossref","unstructured":"Cheng, Y., et\u00a0al., MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Molecular cancer therapeutics, 2011: p. molcanther. 0606.2011.","DOI":"10.1158\/1535-7163.MCT-11-0606"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0115","doi-asserted-by":"crossref","first-page":"e18691","DOI":"10.1371\/journal.pone.0018691","article-title":"EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells","volume":"6","author":"Han","year":"2011","journal-title":"PloS one"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0116","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.canlet.2011.07.002","article-title":"Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: a beneficial strategy to combat non-small cell lung cancer","volume":"310","author":"Gorzalczany","year":"2011","journal-title":"Cancer letters"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0117","doi-asserted-by":"crossref","first-page":"e1536","DOI":"10.1038\/cddis.2014.500","article-title":"Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1-and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells","volume":"5","author":"Babcook","year":"2014","journal-title":"Cell death & disease"},{"issue":"32","key":"10.1016\/j.ctarc.2022.100512_bib0118","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.1000248107","article-title":"Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)","volume":"107","author":"Gupta","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"120","key":"10.1016\/j.ctarc.2022.100512_bib0119","doi-asserted-by":"crossref","first-page":"120ra17","DOI":"10.1126\/scitranslmed.3003316","article-title":"Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers","volume":"4","author":"Katayama","year":"2012","journal-title":"Science translational medicine"},{"issue":"12","key":"10.1016\/j.ctarc.2022.100512_bib0120","first-page":"5077","article-title":"Autophagy: novel action of panitumumab in colon cancer","volume":"29","author":"Giannopoulou","year":"2009","journal-title":"Anticancer research"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0121","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1756283X13498660","article-title":"Panitumumab in the management of patients with KRAS wild-type metastatic colorectal cancer","volume":"7","author":"Hocking","year":"2014","journal-title":"Therapeutic advances in gastroenterology"},{"issue":"14","key":"10.1016\/j.ctarc.2022.100512_bib0122","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.4161\/cbt.22002","article-title":"EGFR tyrosine kinase inhibition induces autophagy in cancer cells","volume":"13","author":"Fung","year":"2012","journal-title":"Cancer biology & therapy"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0123","doi-asserted-by":"crossref","first-page":"139","DOI":"10.12717\/DR.2017.21.2.139","article-title":"Metformin Synergistically Potentiates the Antitumor Effects of Imatinib in Colorectal Cancer Cells","volume":"21","author":"Lee","year":"2017","journal-title":"Development & Reproduction"},{"issue":"8","key":"10.1016\/j.ctarc.2022.100512_bib0124","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.4161\/auto.29264","article-title":"Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed\/refractory myeloma","volume":"10","author":"Vogl","year":"2014","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10637-014-0177-3","article-title":"A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer","volume":"33","author":"Bendell","year":"2015","journal-title":"Investigational new drugs"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0126","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.chest.2019.05.038","article-title":"Alterations in polyamine metabolism in patients with lymphangioleiomyomatosis and tuberous sclerosis complex 2-deficient cells","volume":"156","author":"Tang","year":"2019","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0127","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s10637-015-0314-7","article-title":"A phase I study of selumetinib (AZD6244\/ARRY-142866), a MEK1\/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer","volume":"34","author":"Deming","year":"2016","journal-title":"Investigational new drugs"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0128","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clbc.2019.08.004","article-title":"Phase 1 Study of Erlotinib and Metformin in Metastatic Triple-Negative Breast Cancer","volume":"20","author":"Fenn","year":"2020","journal-title":"Clinical breast cancer"},{"key":"10.1016\/j.ctarc.2022.100512_bib0129","unstructured":"Vidal, G., et\u00a0al. Efficacy and safety of CB-839, a small molecule inhibitor of glutaminase, in combination with paclitaxel in patients with advanced triple negative breast cancer (TNBC): Initial findings from a multicenter, open-label phase 2 study. in Conference Record of the Cancer Research. 2019."},{"key":"10.1016\/j.ctarc.2022.100512_bib0130","first-page":"BCBCR","article-title":"Everolimus in the treatment of metastatic breast cancer","volume":"9","author":"Royce","year":"2015","journal-title":"Breast cancer: basic and clinical research"},{"issue":"10","key":"10.1016\/j.ctarc.2022.100512_bib0131","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/s41416-019-0452-3","article-title":"A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours","volume":"120","author":"Mak","year":"2019","journal-title":"British journal of cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0132","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3233\/KCA-180043","article-title":"The \u2018Achilles Heel'of metabolism in renal cell carcinoma: glutaminase inhibition as a rational treatment strategy","volume":"3","author":"Hoerner","year":"2019","journal-title":"Kidney Cancer"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0133","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.clgc.2017.03.004","article-title":"Comprehensive analysis of survival outcomes in non\u2013clear cell renal cell carcinoma patients treated in clinical trials","volume":"15","author":"de Velasco","year":"2017","journal-title":"Clinical genitourinary cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0134","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1947601909358324","article-title":"Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors","volume":"1","author":"Wu","year":"2010","journal-title":"Genes & cancer"},{"issue":"49","key":"10.1016\/j.ctarc.2022.100512_bib0135","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1038\/onc.2008.250","article-title":"Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530","volume":"27","author":"Chang","year":"2008","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0136","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.canlet.2011.06.034","article-title":"Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2","volume":"310","author":"Ahn","year":"2011","journal-title":"Cancer letters"},{"issue":"41","key":"10.1016\/j.ctarc.2022.100512_bib0137","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1038\/sj.onc.1202957","article-title":"Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells","volume":"18","author":"Agochiya","year":"1999","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.ctarc.2022.100512_bib0138","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/(SICI)1097-0142(19991015)86:6<1551::AID-CNCR23>3.0.CO;2-P","article-title":"Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma","volume":"86","author":"Judson","year":"1999","journal-title":"Cancer"},{"issue":"51","key":"10.1016\/j.ctarc.2022.100512_bib0139","doi-asserted-by":"crossref","first-page":"20302","DOI":"10.1073\/pnas.0710091104","article-title":"Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression","volume":"104","author":"Lahlou","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molcel.2007.11.031","article-title":"Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation","volume":"29","author":"Lim","year":"2008","journal-title":"Molecular cell"},{"issue":"8","key":"10.1016\/j.ctarc.2022.100512_bib0141","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/jcs.00373","article-title":"Focal adhesion kinase: the first ten years","volume":"116","author":"Parsons","year":"2003","journal-title":"Journal of cell science"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0142","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/path.3018","article-title":"Focal adhesion kinase and tumour angiogenesis","volume":"226","author":"Lechertier","year":"2012","journal-title":"The Journal of pathology"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0143","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2407-14-237","article-title":"Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer","volume":"14","author":"Alexopoulou","year":"2014","journal-title":"BMC Cancer"},{"issue":"17","key":"10.1016\/j.ctarc.2022.100512_bib0144","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1158\/0008-5472.CAN-18-3934","article-title":"Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861","volume":"79","author":"Pedrosa","year":"2019","journal-title":"Cancer Research"},{"issue":"9","key":"10.1016\/j.ctarc.2022.100512_bib0145","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1091\/mbc.e02-05-0295","article-title":"Regulation of focal adhesion kinase by a novel protein inhibitor FIP200","volume":"13","author":"Abbi","year":"2002","journal-title":"Molecular biology of the cell"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0146","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1083\/jcb.200712064","article-title":"FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells","volume":"181","author":"Hara","year":"2008","journal-title":"The Journal of cell biology"},{"issue":"10","key":"10.1016\/j.ctarc.2022.100512_bib0147","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.15252\/emmm.201606907","article-title":"Endothelial FAK is required for tumour angiogenesis","volume":"8","author":"Tavora","year":"2016","journal-title":"EMBO molecular medicine"},{"key":"10.1016\/j.ctarc.2022.100512_bib0148","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/ncomms2212","article-title":"The Hedgehog signalling pathway regulates autophagy","volume":"3","author":"Jimenez-Sanchez","year":"2012","journal-title":"Nature communications"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0149","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12943-016-0509-3","article-title":"Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment","volume":"15","author":"Hanna","year":"2016","journal-title":"Molecular cancer"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0150","first-page":"105","article-title":"Autophagy accompanied with bisdemethoxycurcumin-induced apoptosis in non-small cell lung cancer cells","volume":"28","author":"XU","year":"2015","journal-title":"Biomedical and Environmental Sciences"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0151","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3892\/or.2013.2881","article-title":"Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells","volume":"31","author":"Xu","year":"2014","journal-title":"Oncology reports"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0152","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4161\/15548627.2014.994368","article-title":"Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia","volume":"11","author":"Zeng","year":"2015","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0153","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1756-8722-6-77","article-title":"Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs","volume":"6","author":"Ahmad","year":"2013","journal-title":"Journal of hematology & oncology"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0154","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbcan.2010.07.003","article-title":"Autophagy is a therapeutic target in anticancer drug resistance","volume":"1806","author":"Chen","year":"2010","journal-title":"Biochimica et Biophysica Acta (BBA)-Reviews on Cancer"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0155","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbrc.2012.12.120","article-title":"Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells","volume":"431","author":"Humbert","year":"2013","journal-title":"Biochemical and biophysical research communications"},{"key":"10.1016\/j.ctarc.2022.100512_bib0156","series-title":"Seminars in Cancer Biology","article-title":"Recent progress of autophagy signaling in tumor microenvironment and its targeting for possible cancer therapeutics","author":"Mukhopadhyay","year":"2021"},{"issue":"8","key":"10.1016\/j.ctarc.2022.100512_bib0157","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: a new therapeutic target in cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends in biochemical sciences"},{"issue":"8","key":"10.1016\/j.ctarc.2022.100512_bib0158","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1753-4887.1990.tb02967.x","article-title":"Is glutamine a conditionally essential amino acid?","volume":"48","author":"Lacey","year":"1990","journal-title":"Nutrition reviews"},{"issue":"19","key":"10.1016\/j.ctarc.2022.100512_bib0159","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.4161\/cc.9.19.13302","article-title":"Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?","volume":"9","author":"Dang","year":"2010","journal-title":"Cell cycle"},{"issue":"7","key":"10.1016\/j.ctarc.2022.100512_bib0160","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nbt.2285","article-title":"Therapeutic targets in cancer cell metabolism and autophagy","volume":"30","author":"Cheong","year":"2012","journal-title":"Nature biotechnology"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0161","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bbrc.2005.03.159","article-title":"The serine\/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2","volume":"331","author":"Palmada","year":"2005","journal-title":"Biochemical and biophysical research communications"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0162","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0006-291X(03)00921-5","article-title":"Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB","volume":"306","author":"Boehmer","year":"2003","journal-title":"Biochemical and biophysical research communications"},{"issue":"8","key":"10.1016\/j.ctarc.2022.100512_bib0163","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ncb2536","article-title":"Modulation of glutamine metabolism by the PI (3) K-PKB-FOXO network regulates autophagy","volume":"14","author":"Van Der Vos","year":"2012","journal-title":"Nature cell biology"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0164","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","article-title":"Bidirectional transport of amino acids regulates mTOR and autophagy","volume":"136","author":"Nicklin","year":"2009","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.ctarc.2022.100512_bib0165","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.4161\/cbt.12.12.18671","article-title":"Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance","volume":"12","author":"Ko","year":"2011","journal-title":"Cancer biology & therapy"},{"issue":"3","key":"10.1016\/j.ctarc.2022.100512_bib0166","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1042\/BJ20070039","article-title":"Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1, 2, 4-thiadiazol-2-yl) ethyl sulfide (BPTES)","volume":"406","author":"Robinson","year":"2007","journal-title":"Biochemical Journal"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0167","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2011.12.009","article-title":"Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells","volume":"15","author":"Le","year":"2012","journal-title":"Cell metabolism"},{"issue":"4","key":"10.1016\/j.ctarc.2022.100512_bib0168","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/1535-7163.MCT-13-0870","article-title":"Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer","volume":"13","author":"Gross","year":"2014","journal-title":"Molecular cancer therapeutics"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0169","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1182\/blood-2015-01-621870","article-title":"Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition","volume":"126","author":"Jacque","year":"2015","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0170","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1172\/JCI75836","article-title":"Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis","volume":"125","author":"Xiang","year":"2015","journal-title":"The Journal of clinical investigation"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0171","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccell.2014.12.006","article-title":"Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth","volume":"27","author":"Jin","year":"2015","journal-title":"Cancer cell"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0172","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nature cell biology"},{"issue":"35","key":"10.1016\/j.ctarc.2022.100512_bib0173","doi-asserted-by":"crossref","first-page":"23225","DOI":"10.1074\/jbc.M109.005280","article-title":"The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R","volume":"284","author":"Zhong","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.ctarc.2022.100512_bib0174","doi-asserted-by":"crossref","unstructured":"Vidoni, C., et\u00a0al., Epigenetic control of autophagy in women's tumors: role of non-coding RNAs. Journal of Cancer Metastasis and Treatment, 2021. 7.","DOI":"10.20517\/2394-4722.2020.95"},{"issue":"10","key":"10.1016\/j.ctarc.2022.100512_bib0175","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.4251\/wjgo.v13.i10.1244","article-title":"Role of autophagy in gastric carcinogenesis","volume":"13","author":"Papaefthymiou","year":"2021","journal-title":"World Journal of Gastrointestinal Oncology"},{"issue":"11","key":"10.1016\/j.ctarc.2022.100512_bib0176","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.3390\/nu13113714","article-title":"Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates","volume":"13","author":"Omari","year":"2021","journal-title":"Nutrients"},{"issue":"16","key":"10.1016\/j.ctarc.2022.100512_bib0177","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1021\/acs.jmedchem.1c00579","article-title":"Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery","volume":"64","author":"Li","year":"2021","journal-title":"Journal of Medicinal Chemistry"},{"issue":"7","key":"10.1016\/j.ctarc.2022.100512_bib0178","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1093\/hmg\/ddt583","article-title":"Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients","volume":"23","author":"Liao","year":"2014","journal-title":"Human molecular genetics"},{"issue":"17","key":"10.1016\/j.ctarc.2022.100512_bib0179","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1038\/s41388-018-0664-7","article-title":"CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion, and lung metastasis of human bladder cancer (BC) cells","volume":"38","author":"Zhu","year":"2019","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.ctarc.2022.100512_bib0180","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4252\/wjsc.v13.i6.542","article-title":"Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells","volume":"13","author":"Mandhair","year":"2021","journal-title":"World journal of stem cells"},{"issue":"2","key":"10.1016\/j.ctarc.2022.100512_bib0181","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.gene.2016.05.036","article-title":"Aberrant methylation of ATG2B, ATG4D, ATG9A and ATG9B CpG island promoter is associated with decreased mRNA expression in sporadic breast carcinoma","volume":"590","author":"Zhang","year":"2016","journal-title":"Gene"},{"issue":"32","key":"10.1016\/j.ctarc.2022.100512_bib0182","doi-asserted-by":"crossref","first-page":"22306","DOI":"10.1074\/jbc.M114.567032","article-title":"Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth","volume":"289","author":"Shukla","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-10-98","article-title":"Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors","volume":"10","author":"Li","year":"2010","journal-title":"BMC cancer"},{"issue":"9","key":"10.1016\/j.ctarc.2022.100512_bib0184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-018-0930-1","article-title":"Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells","volume":"9","author":"Kim","year":"2018","journal-title":"Cell death & disease"},{"issue":"4","key":"10.1016\/j.ctarc.2022.100512_bib0185","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1080\/15548627.2018.1548547","article-title":"HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells","volume":"15","author":"Sharif","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.ctarc.2022.100512_bib0186","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.canlet.2017.12.005","article-title":"HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH\/Gli1 signaling pathway","volume":"415","author":"Yang","year":"2018","journal-title":"Cancer letters"},{"key":"10.1016\/j.ctarc.2022.100512_bib0187","doi-asserted-by":"crossref","unstructured":"Patra, S., et\u00a0al., Vorinostat in autophagic cell death: A critical insight into autophagy-mediated, -associated and -dependent cell death for cancer prevention. Drug Discovery Today, 2021.","DOI":"10.1016\/j.drudis.2021.08.004"},{"issue":"5","key":"10.1016\/j.ctarc.2022.100512_bib0188","doi-asserted-by":"crossref","first-page":"544","DOI":"10.4161\/cbt.2.5.454","article-title":"Induction of apoptosis in BCR\/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF\/MEK\/ERK and JNK pathways","volume":"2","author":"Yu","year":"2003","journal-title":"Cancer biology & therapy"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0189","doi-asserted-by":"crossref","first-page":"134","DOI":"10.7150\/ijbs.50773","article-title":"The emerging roles of autophagy-related microRNAs in cancer","volume":"17","author":"Shan","year":"2021","journal-title":"International Journal of Biological Sciences"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12929-021-00715-9","article-title":"Regulation of autophagy by microRNAs in human breast cancer","volume":"28","author":"Chong","year":"2021","journal-title":"Journal of Biomedical Science"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0191","first-page":"239","article-title":"LncRNA MALAT1 potentiates autophagy\u2011associated cisplatin resistance by regulating the microRNA\u201130b\/autophagy\u2011related gene 5 axis in gastric cancer","volume":"54","author":"Xi","year":"2019","journal-title":"International journal of oncology"},{"key":"10.1016\/j.ctarc.2022.100512_bib0192","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/bs.acr.2018.02.003","article-title":"Acquired resistance to drugs targeting tyrosine kinases","volume":"138","author":"Rosenzweig","year":"2018","journal-title":"Advances in cancer research"},{"issue":"7782","key":"10.1016\/j.ctarc.2022.100512_bib0193","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ctarc.2022.100512_bib0194","doi-asserted-by":"crossref","first-page":"e838","DOI":"10.1038\/cddis.2013.350","article-title":"Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment","volume":"4","author":"Sui","year":"2013","journal-title":"Cell Death & Disease"},{"issue":"1","key":"10.1016\/j.ctarc.2022.100512_bib0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40880-017-0219-2","article-title":"Autophagy and multidrug resistance in cancer","volume":"36","author":"Li","year":"2017","journal-title":"Chinese Journal of Cancer"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294222000041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294222000041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:10:57Z","timestamp":1778893857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294222000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":195,"alternative-id":["S2468294222000041"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2022.100512","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy Modulation and Cancer Combination Therapy: A Smart Approach in Cancer Therapy","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2022.100512","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100512"}}