{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T17:51:32Z","timestamp":1747158692873,"version":"3.40.5"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.ctarc.2023.100770","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T18:31:41Z","timestamp":1696962701000},"page":"100770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Pancreatic ductal adenocarcinoma complete regression after preoperative chemotherapy: Surgical results in a small series"],"prefix":"10.1016","volume":"37","author":[{"given":"Domenico","family":"Pinelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-2580","authenticated-orcid":false,"given":"Andrea","family":"Micalef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Merelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosangela","family":"Trezzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Amaduzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Agnesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Guizzetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Camagni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Colledan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ctarc.2023.100770_bib0001","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/ags3.12288","article-title":"Pathological complete response (pCR) with or without the residual intraductal carcinoma component following preoperative treatment for pancreatic cancer: Revisiting the definition of \u201cpCR\u201d from the prognostic standpoint","volume":"3","author":"Yamada","year":"2019","journal-title":"Ann. Gastroenterol. Surg."},{"issue":"3","key":"10.1016\/j.ctarc.2023.100770_bib0002","doi-asserted-by":"crossref","first-page":"390","DOI":"10.14701\/ahbps.2021.25.3.390","article-title":"Complete response of locally advanced left-sided pancreatic cancer after modified FOLFIRINOX chemotherapy followed by conversion surgery: a case report","volume":"25","author":"Kim","year":"2021","journal-title":"Ann. Hepatobiliary Pancreat. Surg."},{"issue":"6","key":"10.1016\/j.ctarc.2023.100770_bib0003","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00262-022-03349-4","article-title":"Complete remissions following immunotherapy or immuno-oncology combinations in cancer patients: the MOUSEION-03 meta-analysis","volume":"72","author":"Santoni","year":"2023","journal-title":"Cancer Immunol. Immunother. CII,"},{"issue":"10","key":"10.1016\/j.ctarc.2023.100770_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14102429","article-title":"Immunotherapy in pancreatic cancer: why do we keep failing? A focus on tumor immune microenvironment, predictive biomarkers and treatment outcomes","volume":"14","author":"di Federico","year":"2022","journal-title":"In Cancers"},{"issue":"7","key":"10.1016\/j.ctarc.2023.100770_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ph14070677","article-title":"Hacking pancreatic cancer: present and future of personalized medicine","volume":"14","author":"di Federico","year":"2021","journal-title":"In Pharmaceuticals"},{"issue":"8","key":"10.1016\/j.ctarc.2023.100770_bib0006","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1245\/ASO.2006.08.011","article-title":"Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy","volume":"13","author":"Varadhachary","year":"2006","journal-title":"Ann. Surg. Oncol."},{"issue":"8","key":"10.1016\/j.ctarc.2023.100770_bib0007","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.6004\/jnccn.2017.0131","article-title":"Pancreatic adenocarcinoma, version 2.2017, NCCN clinical practice guidelines in oncology","volume":"15","author":"Tempero","year":"2017","journal-title":"J. Natl Compreh. Cancer Netw."},{"issue":"6","key":"10.1016\/j.ctarc.2023.100770_bib0008","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S2468-1253(18)30081-5","article-title":"Safety and efficacy of preoperative or postoperative chemotherapy for resectable pancreatic adenocarcinoma (PACT-15): a randomised, open-label, phase 2\u20133 trial","volume":"3","author":"Reni","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.ctarc.2023.100770_bib0009","first-page":"542","article-title":"Immunonutrition and prehabilitation in pancreatic cancer surgery: a new concept in the era of ERAS\u00ae and neoadjuvant treatment","volume":"49","author":"de Luca","year":"2023","journal-title":"Eur. J. Surg. Oncol. J. Eur. Soc. Surg. Oncol. Br. Assoc. Surg. Oncol."},{"issue":"3","key":"10.1016\/j.ctarc.2023.100770_bib0010","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/SLA.0000000000003468","article-title":"Survival outcomes associated with clinical and pathological response following neoadjuvant FOLFIRINOX or gemcitabine\/nab-paclitaxel chemotherapy in resected pancreatic cancer","volume":"270","author":"Macedo","year":"2019","journal-title":"Ann. Surg."},{"issue":"3","key":"10.1016\/j.ctarc.2023.100770_bib0011","doi-asserted-by":"crossref","first-page":"998","DOI":"10.4143\/crt.2015.254","article-title":"What is the ideal tumor regression grading system in rectal cancer patients after preoperative chemoradiotherapy?","volume":"48","author":"Kim","year":"2016","journal-title":"Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.ctarc.2023.100770_bib0012","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41379-020-00683-9","article-title":"Amsterdam international consensus meeting: tumor response scoring in the pathology assessment of resected pancreatic cancer after neoadjuvant therapy","volume":"34","author":"Janssen","year":"2021","journal-title":"Modern Pathol."},{"issue":"6","key":"10.1016\/j.ctarc.2023.100770_bib0013","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American joint committee on cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM","volume":"17","author":"Edge","year":"2010","journal-title":"Ann. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.ctarc.2023.100770_bib0014","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2559.2005.02176.x","article-title":"Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer","volume":"47","author":"Ryan","year":"2005","journal-title":"Histopathology"},{"issue":"12","key":"10.1016\/j.ctarc.2023.100770_bib0015","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1097\/PAS.0000000000000738","article-title":"Validation of a proposed tumor regression grading scheme for pancreatic ductal adenocarcinoma after neoadjuvant therapy as a prognostic indicator for survival","volume":"40","author":"Lee","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"issue":"1","key":"10.1016\/j.ctarc.2023.100770_bib0016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.anndiagpath.2011.08.005","article-title":"Pathologic complete response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma is associated with a better prognosis","volume":"16","author":"Zhao","year":"2012","journal-title":"Ann. Diagn. Pathol."},{"issue":"5","key":"10.1016\/j.ctarc.2023.100770_bib0017","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.pan.2018.04.010","article-title":"Pathology assessment of pancreatic cancer following neoadjuvant treatment: Time to move on","volume":"18","author":"Verbeke","year":"2018","journal-title":"Pancreatology"},{"issue":"4","key":"10.1016\/j.ctarc.2023.100770_bib0018","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3892\/or.2021.7977","article-title":"Neoadjuvant therapy for pancreatic cancer: Limitations and advances of response assessment (Review","volume":"45","author":"Xu","year":"2021","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.ctarc.2023.100770_bib0019","doi-asserted-by":"crossref","DOI":"10.1111\/ans.16665","article-title":"Pathological complete response after neoadjuvant therapy for pancreatic ductal adenocarcinoma does not equal cure","volume":"91","author":"Zhou","year":"2021","journal-title":"ANZ J. Surg."},{"issue":"1","key":"10.1016\/j.ctarc.2023.100770_bib0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/SLA.0000000000003570","article-title":"Recurrence in patients achieving pathological complete response after neoadjuvant treatment for advanced pancreatic cancer","volume":"274","author":"Blair","year":"2021","journal-title":"Ann. Surg."},{"issue":"1","key":"10.1016\/j.ctarc.2023.100770_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0000000000002672","article-title":"Is a pathological complete response following neoadjuvant chemoradiation associated with prolonged survival in patients with pancreatic cancer?","volume":"268","author":"He","year":"2018","journal-title":"Ann. Surg."},{"issue":"52","key":"10.1016\/j.ctarc.2023.100770_bib0022","doi-asserted-by":"crossref","first-page":"e2168","DOI":"10.1097\/MD.0000000000002168","article-title":"Pathological complete remission of pancreatic cancer following neoadjuvant chemoradiation therapy; not the end of battles","volume":"94","author":"Lee","year":"2015","journal-title":"Medicine"},{"issue":"10242","key":"10.1016\/j.ctarc.2023.100770_bib0023","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.ctarc.2023.100770_bib0024","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/s41591-020-1063-5","article-title":"Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies","volume":"26","author":"Nakamura","year":"2020","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.ctarc.2023.100770_bib0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/SLA.0000000000000867","article-title":"Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer","volume":"261","author":"Ferrone","year":"2015","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.ctarc.2023.100770_bib0026","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/SLA.0000000000003284","article-title":"Factors predicting response, perioperative outcomes, and survival following total neoadjuvant therapy for borderline\/locally advanced pancreatic cancer","volume":"273","author":"Truty","year":"2021","journal-title":"Ann. Surg."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294223000928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294223000928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T19:23:23Z","timestamp":1722972203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294223000928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":26,"alternative-id":["S2468294223000928"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2023.100770","relation":{},"ISSN":["2468-2942"],"issn-type":[{"type":"print","value":"2468-2942"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pancreatic ductal adenocarcinoma complete regression after preoperative chemotherapy: Surgical results in a small series","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2023.100770","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100770"}}