{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:11:57Z","timestamp":1793149917576,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.ctarc.2025.100876","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T02:22:21Z","timestamp":1738549341000},"page":"100876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The role of dietary sugars in cancer risk: A comprehensive review of current evidence"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5467-7491","authenticated-orcid":false,"given":"Nazmul","family":"Hasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Yazdanpanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbod","family":"Khaleghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash Rezazadeh","family":"Kalebasty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.ctarc.2025.100876_bib0001","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.3390\/cancers14246042","article-title":"Understanding the link between sugar and cancer: an examination of the preclinical and clinical evidence","volume":"14","author":"Epner","year":"2022","journal-title":"Cancers. (Basel)"},{"issue":"4","key":"10.1016\/j.ctarc.2025.100876_bib0002","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3390\/nu15040889","article-title":"The impact of free sugar on human health\u2014a narrative review","volume":"15","author":"Gillespie","year":"2023","journal-title":"Nutrients."},{"key":"10.1016\/j.ctarc.2025.100876_bib0003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-nutr-082117-051805","article-title":"Consumption of sugars, sugary foods, and sugary beverages in relation to cancer risk: a systematic review of longitudinal studies","volume":"38","author":"Makarem","year":"2018","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.ctarc.2025.100876_bib0004","article-title":"Interacting inflammatory and growth factor signals underlie the obesity-cancer link","author":"Lashinger","year":"2013","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.ctarc.2025.100876_bib0005","first-page":"57","article-title":"Sucrose intakes and incident colorectal cancer risk among women","volume":"41","author":"Kiran","year":"2022","journal-title":"J. Am. Nutr. Assoc."},{"issue":"3","key":"10.1016\/j.ctarc.2025.100876_bib0006","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrm2327","article-title":"Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and \u03b2-cell failure in type 2 diabetes","volume":"9","author":"Muoio","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ctarc.2025.100876_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110795","article-title":"Recent advances in fructose intake and risk of hyperuricemia","volume":"131","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ctarc.2025.100876_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00019.2009","article-title":"Metabolic effects of fructose and the worldwide increase in obesity","volume":"90","author":"Tappy","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ctarc.2025.100876_bib0009","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: progress and prospects","volume":"12","author":"Ganapathy-Kanniappan","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ctarc.2025.100876_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2021.09.010","article-title":"Molecular aspects of fructose metabolism and metabolic disease","author":"Herman","year":"2021","journal-title":"Cell Metab."},{"issue":"14","key":"10.1016\/j.ctarc.2025.100876_bib0011","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.jacc.2015.08.025","article-title":"Fructose and cardiometabolic health: what the evidence from sugar-sweetened beverages tells us","volume":"66","author":"Malik","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.ctarc.2025.100876_bib0012","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.2337\/dc10-1079","article-title":"Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis","volume":"33","author":"Malik","year":"2010","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100876_bib0013","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/advances\/nmx020","article-title":"Perspective: total, added, or free? What kind of sugars should we be talking about?","volume":"9","author":"Mela","year":"2018","journal-title":"Adv. Nutr."},{"issue":"12","key":"10.1016\/j.ctarc.2025.100876_bib0014","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.3390\/nu15122749","article-title":"Global impacts of Western diet and its effects on metabolism and health: a narrative review","volume":"15","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Nutrients."},{"key":"10.1016\/j.ctarc.2025.100876_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2022.03.007","article-title":"High fructose diet: a risk factor for immune system dysregulation","author":"Cheng","year":"2022","journal-title":"Hum. Immunol."},{"issue":"5","key":"10.1016\/j.ctarc.2025.100876_bib0016","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/ajcn\/nqaa246","article-title":"Total and added sugar intakes, sugar types, and cancer risk: results from the prospective NutriNet-Sant\u00e9 cohort","volume":"112","author":"Debras","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"issue":"3","key":"10.1016\/j.ctarc.2025.100876_bib0017","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"12","key":"10.1016\/j.ctarc.2025.100876_bib0018","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3390\/life12121992","article-title":"The insulin-like growth factor signaling pathway in breast cancer: an elusive therapeutic target","volume":"12","author":"Lee","year":"2022","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100876_bib0019","first-page":"74","article-title":"Clinical significance of serum IL-6 and TNF-\u03b1 levels in patients with metabolic syndrome","volume":"6","author":"Mohammadi","year":"2017","journal-title":"Rep. Biochem. Mol. Biol."},{"issue":"9","key":"10.1016\/j.ctarc.2025.100876_bib0020","first-page":"1000","article-title":"Concentrated sugars and incidence of prostate cancer in a prospective cohort","volume":"120","author":"Miles","year":"2018","journal-title":"Br. J. Nutr."},{"issue":"6433","key":"10.1016\/j.ctarc.2025.100876_bib0021","first-page":"1345","article-title":"High-fructose corn syrup enhances intestinal tumor growth in mice","volume":"363","author":"Goncalves","year":"2019","journal-title":"Science (1979)"},{"key":"10.1016\/j.ctarc.2025.100876_bib0022","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12937-021-00752-y","article-title":"Dietary carbohydrate quality and risk of breast cancer among women","volume":"20","author":"Sasanfar","year":"2021","journal-title":"Nutr. J."},{"key":"10.1016\/j.ctarc.2025.100876_bib0023","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13058-019-1096-1","article-title":"Associations between dietary patterns and the risk of breast cancer: a systematic review and meta-analysis of observational studies","volume":"21","author":"Xiao","year":"2019","journal-title":"Breast. Cancer Res."},{"issue":"6","key":"10.1016\/j.ctarc.2025.100876_bib0024","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1001\/jama.2023.12618","article-title":"Sugar-sweetened and artificially sweetened beverages and risk of liver cancer and chronic liver disease mortality","volume":"330","author":"Zhao","year":"2023","journal-title":"JAMa"},{"key":"10.1016\/j.ctarc.2025.100876_bib0025","series-title":"Impact of Hyperglycemia and Sugar Intake on Carcinogenesis. Impact of Hyperglycemia on Inflammation","author":"Hasan","year":"2024"},{"key":"10.1016\/j.ctarc.2025.100876_bib0026","article-title":"Nuclear imaging of glucose metabolism: beyond 18F-FDG","author":"Feng","year":"2019","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.ctarc.2025.100876_bib0027","doi-asserted-by":"crossref","first-page":"l2408","DOI":"10.1136\/bmj.l2408","article-title":"Sugary drink consumption and risk of cancer: results from NutriNet-Sant\u00e9 prospective cohort","volume":"366","author":"Chazelas","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.ctarc.2025.100876_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2009.06.020","article-title":"Inflammation and cancer: how friendly is the relationship for cancer patients?","author":"Aggarwal","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"issue":"7203","key":"10.1016\/j.ctarc.2025.100876_bib0029","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100876_bib0030","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1111\/cas.15766","article-title":"Sugar intake and colorectal cancer risk: a prospective Japanese cohort study","volume":"114","author":"Kanehara","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ctarc.2025.100876_bib0031","article-title":"Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms","volume":"2012","author":"Arcidiacono","year":"2012","journal-title":"J. Obes."},{"key":"10.1016\/j.ctarc.2025.100876_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2023.112032","article-title":"Total sugar, added sugar, fructose, and sucrose intake and all-cause, cardiovascular, and cancer mortality: a systematic review and dose-response meta-analysis of prospective cohort studies","author":"Huang","year":"2023","journal-title":"Nutrition"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100876_bib0033","first-page":"121","article-title":"Sugars in diet and risk of cancer in the NIH-AARP Diet and Health Study","volume":"129","author":"Tasevska","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.ctarc.2025.100876_bib0034","first-page":"3927","article-title":"Association between dietary sugar intake and colorectal adenoma among cancer screening examinees in Japan","volume":"111","author":"Cho","year":"2020","journal-title":"Cancer Sci."},{"issue":"7","key":"10.1016\/j.ctarc.2025.100876_bib0035","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/dc10-0666","article-title":"Diabetes and cancer: a consensus report","volume":"33","author":"Giovannucci","year":"2010","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.ctarc.2025.100876_bib0036","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","article-title":"Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease","volume":"61","author":"Softic","year":"2016","journal-title":"Dig. Dis. Sci."},{"issue":"17","key":"10.1016\/j.ctarc.2025.100876_bib0037","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.7150\/jca.46200","article-title":"Friend or foe? An unrecognized role of Uric acid in cancer development and the potential anticancer effects of uric acid-lowering drugs","volume":"11","author":"Mi","year":"2020","journal-title":"J. Cancer"},{"key":"10.1016\/j.ctarc.2025.100876_bib0038","doi-asserted-by":"crossref","unstructured":"Gupta, S., Koirala, J., Khardori, R., & Khardori, N. (2007). Infections in diabetes mellitus and hyperglycemia. Infectious disease clinics of North America. https:\/\/doi.org\/10.1016\/j.idc.2007.07.003.","DOI":"10.1016\/j.idc.2007.07.003"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100876_bib0039","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3390\/ijms20061283","article-title":"Killing mechanisms of chimeric antigen receptor (CAR) T cells","volume":"20","author":"Benmebarek","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ctarc.2025.100876_bib0040","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","article-title":"The effects of type 2 diabetes mellitus on organ metabolism and the immune system","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.ctarc.2025.100876_bib0041","first-page":"245","article-title":"American cancer society guideline for diet and physical activity for cancer prevention","volume":"70","author":"Rock","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ctarc.2025.100876_bib0042","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-11-0497","article-title":"Dual inhibition of tumor energy pathway by 2-deoxy glucose and metformin is effective against a broad spectrum of preclinical cancer models","author":"Cheong","year":"2011","journal-title":"Mol. Cancer Ther."},{"issue":"14","key":"10.1016\/j.ctarc.2025.100876_bib0043","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.3390\/ijms21145165","article-title":"Dual inhibition of CDK4\/6 and PI3K\/AKT\/mTOR signaling impairs energy metabolism in MPM cancer cells","volume":"21","author":"Bonelli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.ctarc.2025.100876_bib0044","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s42255-023-00913-9","article-title":"The glucose transporter 2 regulates CD8\u00b1 T cell function via environment sensing","volume":"5","author":"Fu","year":"2023","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.ctarc.2025.100876_bib0045","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41389-018-0036-8","article-title":"Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4","volume":"7","author":"Wang","year":"2018","journal-title":"Oncogenesis."},{"issue":"10","key":"10.1016\/j.ctarc.2025.100876_bib0046","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1158\/2326-6066.CIR-19-0904","article-title":"Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation","volume":"8","author":"Mantuano","year":"2020","journal-title":"Cancer Immunol. Res."},{"issue":"12","key":"10.1016\/j.ctarc.2025.100876_bib0047","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/mc.21922","article-title":"Hyperglycemia of tumor microenvironment modulates stage-dependent tumor progression and multidrug resistance: implication of cell survival regulatory molecules and altered glucose transport","volume":"52","author":"Vishvakarma","year":"2013","journal-title":"Mol. Carcinog."},{"issue":"7","key":"10.1016\/j.ctarc.2025.100876_bib0048","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s42255-020-0219-4","article-title":"Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction","volume":"2","author":"Wang","year":"2020","journal-title":"Nat. Metab."},{"issue":"6","key":"10.1016\/j.ctarc.2025.100876_bib0049","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3390\/cancers13061346","article-title":"Hyperglycemia-induced miR-467 drives tumor inflammation and growth in breast cancer","volume":"13","author":"Gajeton","year":"2021","journal-title":"Cancers. (Basel)"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100876_bib0050","first-page":"8536","article-title":"High glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE\u2011NOXs pathway","volume":"17","author":"Liao","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.ctarc.2025.100876_bib0051","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12966-023-01459-5","article-title":"Association of soft drinks and 100% fruit juice consumption with risk of cancer: a systematic review and dose-response meta-analysis of prospective cohort studies","volume":"20","author":"Pan","year":"2023","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"issue":"1","key":"10.1016\/j.ctarc.2025.100876_bib0052","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00018-024-05438-2","article-title":"High sugar diet promotes tumor progression paradoxically through aberrant upregulation of pepck1","volume":"81","author":"Chang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.ctarc.2025.100876_bib0053","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1007\/s00394-021-02517-z","article-title":"Types of carbohydrate intake and breast cancer survival","volume":"60","author":"Farvid","year":"2021","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"10.1016\/j.ctarc.2025.100876_bib0054","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13046-023-02765-3","article-title":"Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells","volume":"42","author":"Cui","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ctarc.2025.100876_bib0055","series-title":"Impact of Hyperglycemia on Immune Evasion and Drug Resistance","author":"Hasan","year":"2025"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225000140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225000140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T15:05:42Z","timestamp":1754060742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294225000140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":55,"alternative-id":["S2468294225000140"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100876","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of dietary sugars in cancer risk: A comprehensive review of current evidence","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100876","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100876"}}