{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:12:18Z","timestamp":1787973138386,"version":"build-2784847793"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":186,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007368","name":"Fondazione Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CUP I53C22000780001"],"award-info":[{"award-number":["CUP I53C22000780001"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["ECS00000017"],"award-info":[{"award-number":["ECS00000017"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["134\/202"],"award-info":[{"award-number":["134\/202"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.ctarc.2025.100961","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:20:21Z","timestamp":1751887221000},"page":"100961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Mitigating the side effects of conventional radiotherapy: deep examination of the FLASH effect on human healthy bronchial epithelial cell line"],"prefix":"10.1016","volume":"44","author":[{"given":"Francesca","family":"Del Debbio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sofia","family":"Bertilacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cavalieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7778-3839","authenticated-orcid":false,"given":"Giovanni","family":"Gadducci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gonnelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Cella","family":"Zanacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2257-5177","authenticated-orcid":false,"given":"Benedetta","family":"Noferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Catanzariti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"De Felice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-602X","authenticated-orcid":false,"given":"Chiara","family":"Giacomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Di Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-8949","authenticated-orcid":false,"given":"Eleonora","family":"Da Pozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Paiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Capaccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctarc.2025.100961_bib0001","first-page":"1","article-title":"Heterogeneity of lung cancer: the histopathological diversity and tumour classification in the artificial intelligence era","author":"Ramos","year":"2025","journal-title":"Pathobiology"},{"key":"10.1016\/j.ctarc.2025.100961_bib0002","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000032899","article-title":"Non-small cell lung cancer (NSCLC): a review of risk factors, diagnosis, and treatment","volume":"102","author":"Alduais","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ctarc.2025.100961_bib0003","doi-asserted-by":"crossref","first-page":"833","DOI":"10.5306\/wjco.v12.i10.833","article-title":"Postoperative radiotherapy in resected non-small cell lung cancer: the never-ending story","volume":"12","author":"Serrano","year":"2021","journal-title":"WJCO"},{"key":"10.1016\/j.ctarc.2025.100961_bib0004","doi-asserted-by":"crossref","first-page":"307","DOI":"10.21037\/tlcr-22-108","article-title":"Exploration of radiation-induced lung injury, from mechanism to treatment: a narrative review","volume":"11","author":"Yan","year":"2022","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.ctarc.2025.100961_bib0005","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.3390\/cancers13194985","article-title":"Vimentin is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis","volume":"13","author":"Usman","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ctarc.2025.100961_bib0006","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/acead0","article-title":"A diamond detector based dosimetric system for instantaneous dose rate measurements in FLASH electron beams","volume":"68","author":"Marinelli","year":"2023","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008973","article-title":"Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice","volume":"6","author":"Favaudon","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ctarc.2025.100961_bib0008","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2019.06.019","article-title":"Treatment of a first patient with FLASH-radiotherapy","volume":"139","author":"Bourhis","year":"2019","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0009","article-title":"FLASH radiotherapy: history and future","volume":"11","author":"Lin","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fphy.2023.1201708","article-title":"An insight into hypothesized biological mechanisms contributing to the Flash effect","volume":"11","author":"Del Debbio","year":"2023","journal-title":"Front. Phys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0011","doi-asserted-by":"crossref","first-page":"S3383","DOI":"10.1016\/S0167-8140(24)03110-4","article-title":"3027: beam monitoring and instantaneous dose-rate measurements with SiC detectors for FLASH radiotherapy","volume":"194","author":"Milluzzo","year":"2024","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmp.2024.103360","article-title":"Plastic scintillator-based dosimeters for ultra-high dose rate (UHDR) electron radiotherapy","volume":"121","author":"Ciarrocchi","year":"2024","journal-title":"Physica Medica"},{"key":"10.1016\/j.ctarc.2025.100961_bib0013","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.3390\/app13052986","article-title":"First characterization of novel silicon carbide detectors with ultra-high dose rate electron beams for FLASH radiotherapy","volume":"13","author":"Romano","year":"2023","journal-title":"Appl. Sci."},{"key":"10.1016\/j.ctarc.2025.100961_bib0014","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejmp.2022.11.001","article-title":"A new calculation method for the free electron fraction of an ionization chamber in the ultra-high-dose-per-pulse regimen","volume":"103","author":"Di Martino","year":"2022","journal-title":"Physica Medica"},{"key":"10.1016\/j.ctarc.2025.100961_bib0015","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1002\/mp.17172","article-title":"Comprehensive dosimetric characterization of novel silicon carbide detectors with UHDR electron beams for FLASH radiotherapy","volume":"51","author":"Milluzzo","year":"2024","journal-title":"Med. Phys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fphy.2020.570697","article-title":"FLASH radiotherapy with electrons: issues related to the production, monitoring, and dosimetric characterization of the beam","volume":"8","author":"Di Martino","year":"2020","journal-title":"Front. Phys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fphy.2023.1268310","article-title":"Architecture, flexibility and performance of a special electron linac dedicated to Flash radiotherapy research: electronFlash with a triode gun of the centro pisano flash radiotherapy (CPFR)","volume":"11","author":"Di Martino","year":"2023","journal-title":"Front. Phys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0018","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ctarc.2025.100961_bib0019","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/jcmm.17682","article-title":"Intermittent hypoxia treatments cause cellular priming in human microglia","volume":"27","author":"De Felice","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ctarc.2025.100961_bib0020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/pharmaceutics16020278","article-title":"Oxaliplatin(IV) prodrugs functionalized with gemcitabine and capecitabine induce blockage of colorectal cancer cell growth\u2014An investigation of the activation mechanism and their nanoformulation","volume":"16","author":"Marotta","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ctarc.2025.100961_bib0021","doi-asserted-by":"crossref","first-page":"23127","DOI":"10.1021\/acsomega.2c00816","article-title":"Human microglia extracellular vesicles derived from different microglia cell lines: similarities and differences","volume":"7","author":"Ceccarelli","year":"2022","journal-title":"ACS. Omega"},{"key":"10.1016\/j.ctarc.2025.100961_bib0022","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00018-024-05544-1","article-title":"18 kDa TSPO targeting drives polarized human microglia towards a protective and restorative neurosteroidome profile","volume":"82","author":"Germelli","year":"2025","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ctarc.2025.100961_bib0023","series-title":"Proteomic Profiling: Methods and Protocols","first-page":"443","article-title":"Western Blotting using In-gel protein labeling as a normalization control: advantages of stain-free technology","author":"Neris","year":"2021"},{"key":"10.1016\/j.ctarc.2025.100961_bib0024","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3390\/jpm10040171","article-title":"Comparison of clonogenic survival data obtained by pre- and post-irradiation methods","volume":"10","author":"Oike","year":"2020","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.ctarc.2025.100961_bib0025","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/S0167-8140(17)30474-7","article-title":"OC-0030: in vitro study of FLASH vs. conventional dose-rate irradiation: cell viability and DNA damage repair","volume":"123","author":"Beddok","year":"2017","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0026","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ijrobp.2021.01.050","article-title":"Multicellular spheroids as In vitro models of oxygen depletion during FLASH irradiation","volume":"110","author":"Khan","year":"2021","journal-title":"Int. J. Radiat. Oncol.*Biol.*Phys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0027","article-title":"Initial experience with an electron FLASH research extension (FLEX) for the Clinac system","volume":"25","author":"Oh","year":"2024","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0028","doi-asserted-by":"crossref","DOI":"10.1667\/RADE-21-00181.1","article-title":"Mitochondrial damage response and fate of normal cells exposed to FLASH irradiation with protons","volume":"197","author":"Guo","year":"2022","journal-title":"Radiat. Res."},{"key":"10.1016\/j.ctarc.2025.100961_bib0029","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1158\/1078-0432.CCR-19-1440","article-title":"FLASH irradiation spares lung progenitor cells and limits the incidence of radio-induced senescence","volume":"26","author":"Fouillade","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ctarc.2025.100961_bib0030","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3390\/genes12121882","article-title":"DNA damage responses during the cell cycle: insights from model organisms and beyond","volume":"12","author":"Clay","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.ctarc.2025.100961_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1247268","article-title":"Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy","volume":"14","author":"Zheng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0032","doi-asserted-by":"crossref","first-page":"25946","DOI":"10.1073\/pnas.2019057117","article-title":"Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species","volume":"117","author":"Montay-Gruel","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"key":"10.1016\/j.ctarc.2025.100961_bib0033","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.radonc.2009.06.005","article-title":"2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of akt and DNA-PKcs activities","volume":"92","author":"Florczak","year":"2009","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2024.100113","article-title":"The role of p21 in cellular senescence and aging-related diseases","volume":"47","author":"Yan","year":"2024","journal-title":"Mol. Cells"},{"key":"10.1016\/j.ctarc.2025.100961_bib0035","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling","volume":"29","author":"Engeland","year":"2022","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.ctarc.2025.100961_bib0036","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s12276-020-0384-2","article-title":"ROS in cancer therapy: the bright side of the moon","volume":"52","author":"Perillo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ctarc.2025.100961_bib0037","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1667\/RR3432.1","article-title":"Cell cycle effects of radiation on human bronchial epithelium and lung carcinoma cells in monolayer cultures and a three-dimensional co-culture system","volume":"164","author":"Edelmann","year":"2005","journal-title":"Rare"},{"key":"10.1016\/j.ctarc.2025.100961_bib0038","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/biology10020111","article-title":"Investigation of DNA damage and cell-cycle distribution in human peripheral blood lymphocytes under exposure to high doses of proton radiotherapy","volume":"10","author":"Miszczyk","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.ctarc.2025.100961_bib0039","article-title":"A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.ctarc.2025.100961_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00411-024-01102-2","article-title":"Radiation therapy-induced normal tissue damage: involvement of EMT pathways and role of FLASH-RT in reducing toxicities","volume":"64","author":"Srinivasan","year":"2025","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0041","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23790","article-title":"Epithelial\u2013mesenchymal transition in chemoradiation-induced lung damage: mechanisms and potential treatment approaches","volume":"38","author":"Saadh","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0042","article-title":"PM014 attenuates radiation-induced pulmonary fibrosis via regulating NF-kB and TGF-b1\/NOX4 pathways","volume":"10","author":"Park","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ctarc.2025.100961_bib0043","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.canlet.2015.02.019","article-title":"The nuclear factor \u03bab pathway: a link to the immune system in the radiation response","volume":"368","author":"Hellweg","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ctarc.2025.100961_bib0044","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2019.06.006","article-title":"Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation","volume":"139","author":"Simmons","year":"2019","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0045","first-page":"138","article-title":"Comparison of intratumor and local immune response between MV X-ray FLASH and conventional radiotherapies","volume":"38","author":"Zhu","year":"2022","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0046","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.radonc.2021.11.004","article-title":"First demonstration of the FLASH effect with ultrahigh dose rate high-energy X-rays","volume":"166","author":"Gao","year":"2022","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0047","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.radonc.2019.02.009","article-title":"Biological effects in normal cells exposed to FLASH dose rate protons","volume":"139","author":"Buonanno","year":"2019","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2025.100961_bib0048","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.ijrobp.2024.01.224","article-title":"FLASH proton radiation therapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease","volume":"119","author":"Kim","year":"2024","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ctarc.2025.100961_bib0049","first-page":"1","article-title":"Low\u2011dose X\u2011ray irradiation induces morphological changes and cytoskeleton reorganization in osteoblasts","volume":"20","author":"Huang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ctarc.2025.100961_bib0050","series-title":"Bioengineering (ENBENG), 2017 IEEE 5th Portuguese Meeting","article-title":"Effects of high energy X-rays on cell morphology and functions","author":"Panzetta","year":"2017"},{"key":"10.1016\/j.ctarc.2025.100961_bib0051","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/wrr.12920","article-title":"Vimentin regulates the assembly and function of matrix adhesions","volume":"29","author":"Ostrowska-Podhorodecka","year":"2021","journal-title":"Wound Repair. Regen."},{"key":"10.1016\/j.ctarc.2025.100961_bib0052","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200453","article-title":"Ionizing radiation induces epithelial\u2013mesenchymal transition in human bronchial epithelial cells","volume":"40","author":"Tang","year":"2020","journal-title":"Biosci. Rep."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225000978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225000978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T21:16:14Z","timestamp":1756934174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294225000978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":52,"alternative-id":["S2468294225000978"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100961","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitigating the side effects of conventional radiotherapy: deep examination of the FLASH effect on human healthy bronchial epithelial cell line","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100961"}}