{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:48:49Z","timestamp":1765486129155,"version":"3.48.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":201,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060465"],"award-info":[{"award-number":["82060465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20212ACB206023"],"award-info":[{"award-number":["20212ACB206023"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.ctarc.2025.100967","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T02:52:31Z","timestamp":1754621551000},"page":"100967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Establishment and characterization of patient-derived xenograft of scrotal Paget's disease"],"prefix":"10.1016","volume":"45","author":[{"given":"Xiongbing","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxing","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-4273","authenticated-orcid":false,"given":"Yuanqiao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ctarc.2025.100967_bib0001","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jcma.2011.05.010","article-title":"Extramammary Paget\u2019s disease of the scrotum","volume":"74","author":"Juang","year":"2011","journal-title":"J. Chin. Med. Assoc"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100967_bib0002","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ygyno.2011.03.033","article-title":"Paget\u2019s disease of the vulva: diagnosis and follow-up key to management; a retrospective study of 50 cases from Queensland","volume":"122","author":"Jones","year":"2011","journal-title":"Gynecol. Oncol"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100967_bib0003","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ygyno.2019.11.009","article-title":"Extramammary paget disease of the vulva: management and prognosis","volume":"157","author":"Nasioudis","year":"2020","journal-title":"Gynecol. Oncol"},{"issue":"2","key":"10.1016\/j.ctarc.2025.100967_bib0004","first-page":"313","article-title":"Extramammary Paget\u2019s disease: treatment, prognostic factors and outcome in 76 patients","volume":"158","author":"Hatta","year":"2008","journal-title":"Br. J. Dermatol"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100967_bib0005","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13890","article-title":"Paget\u2019s disease of scrotum and penis case report of a re-irradiation and review of the literature","volume":"33","author":"Piras","year":"2020","journal-title":"Dermatol. Ther"},{"issue":"4","key":"10.1016\/j.ctarc.2025.100967_bib0006","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1464-410X.2008.07575.x","article-title":"Penile and Scrotal Paget\u2019s disease: 130 Chinese patients with long-term follow-up","volume":"102","author":"Wang","year":"2008","journal-title":"BJU Int"},{"issue":"3","key":"10.1016\/j.ctarc.2025.100967_bib0007","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jdermsci.2016.06.004","article-title":"A proposal for a TNM staging system for extramammary Paget disease: retrospective analysis of 301 patients with invasive primary tumors","volume":"83","author":"Ohara","year":"2016","journal-title":"J. Dermatol. Sci"},{"issue":"4","key":"10.1016\/j.ctarc.2025.100967_bib0008","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1001\/jamadermatol.2024.0001","article-title":"Anatomic subtype differences in extramammary paget disease: a meta-analysis","volume":"160","author":"Kibbi","year":"2024","journal-title":"JAMA Dermatol"},{"issue":"10","key":"10.1016\/j.ctarc.2025.100967_bib0009","first-page":"4492","article-title":"Applications of photodynamic therapy in extramammary Paget\u2019s disease","volume":"13","author":"Ren","year":"2023","journal-title":"Am. J. Cancer Res"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100967_bib0010","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41392-023-01419-2","article-title":"Patient-derived xenograft models in cancer therapy: technologies and applications","volume":"8","author":"Liu","year":"2023","journal-title":"Sign. Transduct. Target Ther"},{"issue":"36","key":"10.1016\/j.ctarc.2025.100967_bib0011","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1038\/s41388-020-01404-x","article-title":"Extramammary Paget\u2019s disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity to HER2-targeted therapies","volume":"39","author":"Maeda","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.ctarc.2025.100967_bib0012","doi-asserted-by":"crossref","DOI":"10.1038\/s41416-024-02788-3","article-title":"Establishment of a trastuzumab-resistant extramammary Paget disease model: loss of PTEN as a potential mechanism","author":"Hsu","year":"2024","journal-title":"Br J. Cancer"},{"issue":"10","key":"10.1016\/j.ctarc.2025.100967_bib0013","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1007\/s00432-023-04618-0","article-title":"Selinexor demonstrates anti-tumor efficacy in paired patient-derived xenograft models and hydrogel-embedded histoculture drug sensitivity test of penile cancer","volume":"149","author":"He","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100967_bib0014","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13045-015-0156-y","article-title":"Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments","volume":"8","author":"Ye","year":"2015","journal-title":"J. Hematol. OncolJ. Hematol. Oncol"},{"issue":"2","key":"10.1016\/j.ctarc.2025.100967_bib0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1590\/abd1806-4841.20153189","article-title":"Mammary and extramammary Paget\u2019s disease","volume":"90","author":"Lopes Filho","year":"2015","journal-title":"An. Bras Dermatol"},{"issue":"4","key":"10.1016\/j.ctarc.2025.100967_bib0016","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ad.2019.09.003","article-title":"Enfermedad de Paget extramamaria","volume":"111","author":"Marcoval","year":"2020","journal-title":"Actas. Dermo-Sifiliogr\u00e1ficas"},{"issue":"5","key":"10.1016\/j.ctarc.2025.100967_bib0017","first-page":"400","article-title":"Treatment of extramammary Paget\u2032s disease: a Chinese expert consensus statement (2024)","volume":"57","author":"Chen","year":"2024","journal-title":"Chin. J. Dermatol"},{"issue":"3","key":"10.1016\/j.ctarc.2025.100967_bib0018","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejso.2011.12.008","article-title":"Invasive extramammary Paget\u2019s disease and the risk for secondary tumours in Europe","volume":"38","author":"Van Der Zwan","year":"2012","journal-title":"Eur. J. Surg Oncol. EJSO"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100967_bib0019","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13023-021-01715-6","article-title":"Prevalence of extramammary Paget\u2019s disease in urban China: a population-based study","volume":"16","author":"Yin","year":"2021","journal-title":"Orphanet. J. Rare Dis"},{"key":"10.1016\/j.ctarc.2025.100967_bib0020","article-title":"Scrotal Paget\u2019s disease associated with Human epidermal growth factor receptor 2-overexpressing metastatic apocrine carcinoma with complete response to Paclitaxel, Trastuzumab, and Pertuzumab","volume":"7","author":"Nowicka-Matus","year":"2023","journal-title":"JCO Precis. Oncol"},{"key":"10.1016\/j.ctarc.2025.100967_bib0021","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.29486","article-title":"Scrotal extramammary Paget\u2019s disease in an elderly caucasian male","author":"Barrera","year":"2022","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.ctarc.2025.100967_bib0022","first-page":"34","article-title":"Recurrent extramammary Paget\u2019s disease of the penis and scrotum: clinical analysis of 18 cases","volume":"15","author":"Li","year":"2009","journal-title":"Zhonghua Nan. Ke. Xue. Natl. J. Androl"},{"issue":"4","key":"10.1016\/j.ctarc.2025.100967_bib0023","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jamaoncol.2021.7148","article-title":"Evidence-based clinical practice guidelines for extramammary paget disease","volume":"8","author":"Kibbi","year":"2022","journal-title":"JAMA Oncol"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100967_bib0024","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/14737140.2018.1457955","article-title":"The diagnosis and management of extramammary Paget\u2019s disease","volume":"18","author":"Ito","year":"2018","journal-title":"Expert Rev. Anticancer. Ther"},{"issue":"3","key":"10.1016\/j.ctarc.2025.100967_bib0025","first-page":"1849","article-title":"Immunohistochemical detection of carcinoembryonic antigen in esophageal carcinomas: a comparison with other gastrointestinal neoplasms","volume":"22","author":"Bhatnagar","year":"2002","journal-title":"Anticancer Res"},{"issue":"9","key":"10.1016\/j.ctarc.2025.100967_bib0026","first-page":"3426","article-title":"Primary extramammary Paget\u2019s disease: a clinicopathological study of 28 cases","volume":"12","author":"Zhao","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol"},{"issue":"4","key":"10.1016\/j.ctarc.2025.100967_bib0027","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2559.2007.02633.x","article-title":"Mammary and extramammary Paget\u2019s disease: an immunohistochemical study of 83 cases","volume":"50","author":"Liegl","year":"2007","journal-title":"Histopathology"},{"issue":"5","key":"10.1016\/j.ctarc.2025.100967_bib0028","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.asjsur.2024.01.147","article-title":"A case of surgery-cured scrotal Paget\u2019s disease presenting as a huge cauliflower-like mass","volume":"47","author":"Zeng","year":"2024","journal-title":"Asian. J. Surg"},{"issue":"13","key":"10.1016\/j.ctarc.2025.100967_bib0029","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000037541","article-title":"Case report: a case of Paget disease outside the axillary breast","volume":"103","author":"Zhou","year":"2024","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.ctarc.2025.100967_bib0030","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000536654","article-title":"Extramammary Paget\u2019s Disease of the scrotal and penile: a case report and review of the literature","volume":"108","author":"Yang","year":"2024","journal-title":"Urol. Int"},{"issue":"9","key":"10.1016\/j.ctarc.2025.100967_bib0031","first-page":"810","article-title":"Clinicopathological analysis of Paget\u2019s disease of the scrotum and penis","volume":"14","author":"Wang","year":"2008","journal-title":"Zhonghua Nan Ke. Xue Natl. J. Androl"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100967_bib0032","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/tbj.13824","article-title":"A rare case of Bowen\u2019s disease of the nipple: literature review and management pathway","volume":"26","author":"Liang","year":"2020","journal-title":"Breast. J"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100967_bib0033","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2340\/00015555-0512","article-title":"p63 constitutes a useful histochemical marker for differentiation of pagetoid Bowen\u2019s disease from extramammary Paget\u2019s disease","volume":"88","author":"Memezawa","year":"2008","journal-title":"Acta. Derm. Venereol"},{"key":"10.1016\/j.ctarc.2025.100967_bib0034","article-title":"Using patient-derived xenografts to explore the efficacy of treating head-and-neck squamous cell carcinoma with Anlotinib","volume":"27","author":"Hu","year":"2021","journal-title":"Pathol. Oncol. Res. POR"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:39:49Z","timestamp":1765485589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294225001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":34,"alternative-id":["S2468294225001030"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100967","relation":{},"ISSN":["2468-2942"],"issn-type":[{"type":"print","value":"2468-2942"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment and characterization of patient-derived xenograft of scrotal Paget's disease","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100967"}}