{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:48:34Z","timestamp":1765486114734,"version":"3.48.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":237,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.ctarc.2025.100983","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T16:00:07Z","timestamp":1756224007000},"page":"100983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Advancements in nasopharyngeal carcinoma radiotherapy: Dosimetric evaluation of arc therapy with hippocampal sparing"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-5143","authenticated-orcid":false,"given":"Fadila","family":"Kouhen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak","family":"Chahid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanae El","family":"Gouache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Errafiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhak","family":"Maghous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctarc.2025.100983_bib0001","doi-asserted-by":"crossref","DOI":"10.2196\/49968","article-title":"Nasopharyngeal cancer incidence and mortality in 185 countries in 2020 and the projected burden in 2040: population-based global epidemiological profiling","volume":"9","author":"Zhang","year":"2023","journal-title":"JMIR Public Health Surveill."},{"key":"10.1016\/j.ctarc.2025.100983_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2024.107008","article-title":"Current state, challenges, and future perspective of adaptive radiotherapy: a narrative review of nasopharyngeal carcinoma","volume":"158","author":"Zhou","year":"2024","journal-title":"Oral Oncol."},{"issue":"1","key":"10.1016\/j.ctarc.2025.100983_bib0003","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1186\/s12967-023-04673-8","article-title":"Precision medicine in nasopharyngeal carcinoma: comprehensive review of past, present, and future prospect","volume":"21","author":"Siak","year":"2023","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.ctarc.2025.100983_bib0004","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","article-title":"Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized intergroup study 0099","volume":"16","author":"Al-Sarraf","year":"1998","journal-title":"J. Clin. Oncol."},{"issue":"27","key":"10.1016\/j.ctarc.2025.100983_bib0005","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.1200\/JCO.2005.16.790","article-title":"Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer\/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety","volume":"23","author":"Wee","year":"2005","journal-title":"J. Clin. Oncol."},{"issue":"1\u20132","key":"10.1016\/j.ctarc.2025.100983_bib0006","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.canrad.2021.08.009","article-title":"Radiotherapy for nasopharyngeal cancer","volume":"26","author":"Blanchard","year":"2022","journal-title":"Cancer RadiOther"},{"issue":"24","key":"10.1016\/j.ctarc.2025.100983_bib0007","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000015951","article-title":"Oncologic outcomes of IMRT versus CRT for nasopharyngeal carcinoma: a meta-analysis","volume":"98","author":"Luo","year":"2019","journal-title":"Medicine"},{"issue":"22","key":"10.1016\/j.ctarc.2025.100983_bib0008","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1200\/JCO.2008.19.9109","article-title":"Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225","volume":"27","author":"Lee","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.ctarc.2025.100983_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219611","article-title":"The effectiveness of intensity-modulated radiation therapy versus 2D-RT for the treatment of nasopharyngeal carcinoma: a systematic review and meta-analysis","volume":"14","author":"Du","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ctarc.2025.100983_bib0010","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.radonc.2011.11.017","article-title":"Volumetric modulated arc therapy for nasopharyngeal carcinoma: a dosimetric comparison with TomoTherapy and step-and-shoot IMRT","volume":"104","author":"Lu","year":"2012","journal-title":"RadiOther Oncol."},{"issue":"1","key":"10.1016\/j.ctarc.2025.100983_bib0011","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jmir.2022.10.195","article-title":"Dosimetric comparison between Intensity Modulated Radiation Therapy (IMRT) vs dual arc Volumetric Arc Therapy (VMAT) for nasopharyngeal cancer (NPC): systematic review and meta-analysis","volume":"54","author":"Chen","year":"2023","journal-title":"J. Med. ImAging Radiat. Sci."},{"issue":"1037","key":"10.1016\/j.ctarc.2025.100983_bib0012","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20130474","article-title":"Evaluation of hippocampus dose for patients undergoing intensity-modulated radiotherapy for nasopharyngeal carcinoma","volume":"87","author":"Khodayari","year":"2014","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.ctarc.2025.100983_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110143","article-title":"Multi-domain neurocognitive impairment following definitive intensity-modulated radiotherapy for nasopharyngeal cancer: a cross-sectional study","volume":"193","author":"Chow","year":"2024","journal-title":"RadiOther Oncol."},{"issue":"3","key":"10.1016\/j.ctarc.2025.100983_bib0014","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ijrobp.2023.04.030","article-title":"Sustained preservation of cognition and prevention of patient-reported symptoms with hippocampal avoidance during whole-brain radiation therapy for brain metastases: final results of NRG oncology CC001","volume":"117","author":"Gondi","year":"2023","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.ctarc.2025.100983_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.714709","article-title":"Hippocampus-avoidance whole-brain radiation therapy is efficient in the long-term preservation of hippocampal volume","volume":"11","author":"Popp","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.ctarc.2025.100983_bib0016","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/neuonc\/noaa193","article-title":"Hippocampal avoidance whole-brain radiotherapy without memantine in preserving neurocognitive function for brain metastases: a phase II blinded randomized trial","volume":"23","author":"Yang","year":"2021","journal-title":"Neuro Oncol."},{"issue":"34","key":"10.1016\/j.ctarc.2025.100983_bib0017","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1200\/JCO.2014.57.2909","article-title":"Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial","volume":"32","author":"Gondi","year":"2014","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.ctarc.2025.100983_bib0018","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1200\/JCO.19.02767","article-title":"for NRG oncology. Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: phase III trial NRG Oncology CC001","volume":"38","author":"Brown","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ctarc.2025.100983_bib0019","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fnhum.2014.00742","article-title":"The role of the hippocampus in flexible cognition and social behavior","volume":"8","author":"Rubin","year":"2014","journal-title":"Front. Hum. Neurosci."},{"issue":"11","key":"10.1016\/j.ctarc.2025.100983_bib0020","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/nn.4661","article-title":"Viewpoints: how the hippocampus contributes to memory, navigation and cognition","volume":"20","author":"Lisman","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.ctarc.2025.100983_bib0021","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1667\/RR14289.S1","article-title":"Modeling impaired hippocampal neurogenesis after radiation exposure","volume":"185","author":"Cacao","year":"2016","journal-title":"Radiat. Res."},{"issue":"6","key":"10.1016\/j.ctarc.2025.100983_bib0022","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1667\/RR14569.1","article-title":"Modeling heavy-ion impairment of hippocampal neurogenesis after acute and fractionated irradiation","volume":"186","author":"Cacao","year":"2016","journal-title":"Radiat. Res."},{"issue":"6","key":"10.1016\/j.ctarc.2025.100983_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.13587","article-title":"Dosimetric feasibility of hippocampal avoidance whole brain radiotherapy with an MRI-guided linear accelerator","volume":"23","author":"Graham","year":"2022","journal-title":"J. Appl. Clin. Med. Phys."},{"issue":"2","key":"10.1016\/j.ctarc.2025.100983_bib0024","article-title":"Advancing beyond the hippocampus to preserve cognition for patients with brain metastases: dosimetric results from a phase 2 trial of memory-avoidance whole brain radiation therapy","volume":"9","author":"Perlow","year":"2023","journal-title":"Adv. Radiat. Oncol."},{"issue":"22","key":"10.1016\/j.ctarc.2025.100983_bib0025","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1200\/JCO.2008.19.9109","article-title":"Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225","volume":"27","author":"Lee","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.ctarc.2025.100983_bib0026","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1470-2045(11)70303-5","article-title":"Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial","volume":"13","author":"Lee","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ctarc.2025.100983_bib0027","article-title":"Comparison of conventional and hippocampus-sparing radiotherapy in nasopharyngeal carcinoma: in silico study and systematic review","volume":"46","author":"Peternel","year":"2024","journal-title":"Clin. Transl. Radiat. Oncol."},{"issue":"6\u20137","key":"10.1016\/j.ctarc.2025.100983_bib0028","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.canrad.2017.08.108","volume":"21","author":"G\u00e9rard","year":"2017","journal-title":"Cancer RadiOther"},{"issue":"6","key":"10.1016\/j.ctarc.2025.100983_bib0029","article-title":"Association of pretreatment hippocampal volume with neurocognitive function in patients treated with hippocampal avoidance whole brain radiation therapy for brain metastases: secondary analysis of NRG oncology\/RTOG 0933","volume":"7","author":"Abraham","year":"2021","journal-title":"Adv. Radiat. Oncol."},{"issue":"2","key":"10.1016\/j.ctarc.2025.100983_bib0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","article-title":"Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study","volume":"29","author":"Kocher","year":"2011","journal-title":"J. Clin. Oncol."},{"issue":"11","key":"10.1016\/j.ctarc.2025.100983_bib0031","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/neuonc\/noaa076","article-title":"Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors","volume":"22","author":"Goda","year":"2020","journal-title":"Neuro Oncol."},{"issue":"2","key":"10.1016\/j.ctarc.2025.100983_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090007","article-title":"Evaluation of the dosimetric feasibility of hippocampal sparing intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma","volume":"9","author":"Han","year":"2014","journal-title":"PLoS. One"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225001194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225001194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:39:45Z","timestamp":1765485585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294225001194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":32,"alternative-id":["S2468294225001194"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100983","relation":{},"ISSN":["2468-2942"],"issn-type":[{"type":"print","value":"2468-2942"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancements in nasopharyngeal carcinoma radiotherapy: Dosimetric evaluation of arc therapy with hippocampal sparing","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.100983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100983"}}