{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:35:03Z","timestamp":1773930903835,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017291","name":"Zhongshan Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024B1096"],"award-info":[{"award-number":["2024B1096"]}],"id":[{"id":"10.13039\/501100017291","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018571","name":"Specific Research Project of Guangxi for Research Bases and Talents","doi-asserted-by":"publisher","award":["GuiKe AD24999032"],"award-info":[{"award-number":["GuiKe AD24999032"]}],"id":[{"id":"10.13039\/501100018571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["GuiKe AB24010096"],"award-info":[{"award-number":["GuiKe AB24010096"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060006"],"award-info":[{"award-number":["82060006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160002"],"award-info":[{"award-number":["82160002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460008"],"award-info":[{"award-number":["82460008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160014"],"award-info":[{"award-number":["82160014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2025.101052","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:08:57Z","timestamp":1764432537000},"page":"101052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Serum ZFPL1 as a clinical biomarker for diagnosis, progression tracking, and treatment response in lung cancer"],"prefix":"10.1016","volume":"46","author":[{"given":"Teng","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8136-4014","authenticated-orcid":false,"given":"Honglin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoni","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanjie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biwen","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ctarc.2025.101052_bib0001","first-page":"505","article-title":"An update on the immune landscape in lung and head and neck cancers","volume":"70","author":"Carlisle","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"13","key":"10.1016\/j.ctarc.2025.101052_bib0002","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21134569","article-title":"Genetic markers in lung cancer diagnosis: a review","volume":"21","author":"Wadowska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ctarc.2025.101052_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8030414","article-title":"Are there new biomarkers in tissue and liquid biopsies for the early detection of non-small cell lung cancer?","volume":"8","author":"Calabrese","year":"2019","journal-title":"J. Clin. Med."},{"issue":"10066","key":"10.1016\/j.ctarc.2025.101052_bib0004","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0140-6736(16)30958-8","article-title":"Lung cancer: current therapies and new targeted treatments","volume":"389","author":"Hirsch","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ctarc.2025.101052_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2019.111416","article-title":"Recent advances in biosensor for detection of lung cancer biomarkers","volume":"141","author":"Yang","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101052_bib0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/acs.jproteome.6b00559","article-title":"Serum protein markers for the early detection of lung cancer: a focus on autoantibodies","volume":"16","author":"Broodman","year":"2017","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.ctarc.2025.101052_bib0007","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/thoraxjnl-2015-207140","article-title":"UK lung cancer RCT pilot screening trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening","volume":"71","author":"Field","year":"2016","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.ctarc.2025.101052_bib0008","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtho.2015.11.011","article-title":"Comparative study of autoantibody responses between lung adenocarcinoma and benign pulmonary nodules","volume":"11","author":"Wang","year":"2016","journal-title":"J. Thorac. Oncol."},{"issue":"12","key":"10.1016\/j.ctarc.2025.101052_bib0009","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.4014\/jmb.1609.09021","article-title":"Structural analyses of zinc finger domains for specific interactions with DNA","volume":"26","author":"Eom","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.ctarc.2025.101052_bib0010","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2017.71","article-title":"Zinc-finger proteins in health and disease","volume":"3","author":"Cassandri","year":"2017","journal-title":"Cell Death Discov."},{"issue":"31","key":"10.1016\/j.ctarc.2025.101052_bib0011","doi-asserted-by":"crossref","first-page":"51946","DOI":"10.18632\/oncotarget.17393","article-title":"The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer","volume":"8","author":"Ashraf","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.ctarc.2025.101052_bib0012","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026245","article-title":"Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: progress and Challenges","volume":"7","author":"Wang","year":"2017","journal-title":"Cold. Spring. Harb. Perspect. Med."},{"issue":"16","key":"10.1016\/j.ctarc.2025.101052_bib0013","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1038\/onc.2016.377","article-title":"ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma","volume":"36","author":"Hazawa","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.ctarc.2025.101052_bib0014","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gene.2018.07.053","article-title":"RING domain of zinc finger protein like 1 is essential for cell proliferation in endometrial cancer cell line RL95-2","volume":"677","author":"Cai","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.ctarc.2025.101052_bib0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gene.2018.07.053","article-title":"RING domain of zinc finger protein like 1 is essential for cell proliferation in endometrial cancer cell line RL95-2","volume":"677","author":"Cai","year":"2018","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.ctarc.2025.101052_bib0016","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.3892\/mmr.2017.6300","article-title":"Knockdown of ZFPL1 results in increased autophagy and autophagy\u2011related cell death in NCI\u2011N87 and BGC\u2011823 human gastric carcinoma cell lines","volume":"15","author":"Xie","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.ctarc.2025.101052_bib0017","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2023.5486","article-title":"Zinc finger protein\u2011like 1 is a novel neuroendocrine biomarker for prostate cancer","volume":"62","author":"Masud","year":"2023","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101052_bib0018","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The eighth edition lung cancer stage classification","volume":"151","author":"Detterbeck","year":"2017","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.ctarc.2025.101052_bib0019","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0169-5002(02)00072-7","article-title":"Staging small cell lung cancer: veterans administration lung study group versus international association for the study of lung Cancer\u2013what limits limited disease?","volume":"37","author":"Micke","year":"2002","journal-title":"Lung Cancer"},{"issue":"9","key":"10.1016\/j.ctarc.2025.101052_bib0020","first-page":"805","article-title":"[Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2024 edition)]","volume":"46","year":"2024","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"issue":"1","key":"10.1016\/j.ctarc.2025.101052_bib0021","first-page":"2","article-title":"Cancer incidence and mortality in China, 2015","volume":"1","author":"Zhang","year":"2021","journal-title":"J. Natl. Cancer Cent."},{"key":"10.1016\/j.ctarc.2025.101052_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116787","article-title":"Considerations regarding the selection, sampling, extraction, analysis, and modelling of biomarkers in exhaled breath for early lung cancer screening","volume":"260","author":"Lundberg","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"8077","key":"10.1016\/j.ctarc.2025.101052_bib0023","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41586-025-09234-1","article-title":"WSTF nuclear autophagy regulates chronic but not acute inflammation","volume":"644","author":"Wang","year":"2025","journal-title":"Nature"},{"issue":"36","key":"10.1016\/j.ctarc.2025.101052_bib0024","doi-asserted-by":"crossref","first-page":"32063","DOI":"10.1021\/acsnano.4c16049","article-title":"An aggrecanase-responsive delivery hydrogel system of miRNA-17 facilitates microfracture-mediated articular cartilage regeneration by reprogramming hostile inflammatory niche","volume":"19","author":"Gao","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ctarc.2025.101052_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1626082","article-title":"Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies?","volume":"16","author":"Kumar","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101052_bib0026","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4314\/ejhs.v24i1.2","article-title":"Evaluation of clinical and pathological response after two cycles of neoadjuvant chemotherapy on Sudanese patients with locally advanced breast cancer","volume":"24","author":"Alawad","year":"2014","journal-title":"Ethiop. J. Health Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101052_bib0027","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00330-022-08994-y","article-title":"Quantitative CT evaluation after two cycles of induction chemotherapy to predict prognosis of patients with locally advanced oesophageal squamous cell carcinoma before undergoing definitive chemoradiotherapy\/radiotherapy","volume":"33","author":"Yan","year":"2023","journal-title":"Eur. Radiol."},{"issue":"12","key":"10.1016\/j.ctarc.2025.101052_bib0028","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/MNM.0b013e32834a8341","volume":"32","author":"Yang","year":"2011","journal-title":"Nucl. Med. Commun."},{"issue":"6","key":"10.1016\/j.ctarc.2025.101052_bib0029","first-page":"886","article-title":"[Diagnostic value of serum tumor markers CEA, CYFRA21-1, SCCAg, NSE and ProGRP for lung cancers of different pathological types]","volume":"42","author":"Gao","year":"2022","journal-title":"Nan. Fang. Yi. Ke Da Xue Xue Bao"},{"issue":"10","key":"10.1016\/j.ctarc.2025.101052_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102731","article-title":"Chaperone-mediated autophagy markers LAMP2A and HSPA8 in advanced non-small cell lung cancer after neoadjuvant therapy","volume":"10","author":"Losmanova","year":"2021","journal-title":"Cells"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225001881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294225001881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:45:59Z","timestamp":1773920759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294225001881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":30,"alternative-id":["S2468294225001881"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.101052","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum ZFPL1 as a clinical biomarker for diagnosis, progression tracking, and treatment response in lung cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.101052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101052"}}