{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:05:17Z","timestamp":1774058717992,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014869","name":"Chongqing Xinqiao Hospital, Second Affiliated Hospital of Army Medical University","doi-asserted-by":"publisher","award":["2024F042"],"award-info":[{"award-number":["2024F042"]}],"id":[{"id":"10.13039\/501100014869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2025.101064","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T06:35:02Z","timestamp":1765089302000},"page":"101064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Clinical characteristics and prognostic outcomes in KRAS-mutant non-small cell lung cancer: A real-world study with or without COPD comorbidity"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5852-2884","authenticated-orcid":false,"given":"Chen","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhoukui","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.ctarc.2025.101064_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14215430","article-title":"KRAS in NSCLC: state of the art and Future perspectives","volume":"14","author":"Cascetta","year":"2022","journal-title":"Cancers. (Basel)"},{"issue":"10378","key":"10.1016\/j.ctarc.2025.101064_bib0002","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(23)00221-0","article-title":"Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRAS(G12C) mutation: a randomised, open-label, phase 3 trial","volume":"401","author":"de Langen","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ctarc.2025.101064_bib0003","first-page":"75","article-title":"Comprehensive genetic variant analysis reveals combination of KRAS and LRP1B as a predictive biomarker of response to immunotherapy in patients with non-small cell lung cancer","volume":"44","author":"Eklund","year":"2025","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"issue":"7","key":"10.1016\/j.ctarc.2025.101064_bib0004","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1007\/s12010-023-04748-8","article-title":"An updated review on KRAS mutation in lung cancer (NSCLC) and its effects on Human health","volume":"196","author":"Ghosh","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"4","key":"10.1016\/j.ctarc.2025.101064_bib0005","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0009-9260(82)80301-2","article-title":"Computed tomography in pulmonary emphysema","volume":"33","author":"Goddard","year":"1982","journal-title":"Clin. Radiol."},{"issue":"10","key":"10.1016\/j.ctarc.2025.101064_bib0006","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1229724","article-title":"Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment","volume":"5","author":"Gong","year":"2016","journal-title":"Oncoimmunology."},{"issue":"4","key":"10.1016\/j.ctarc.2025.101064_bib0007","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.21037\/jtd.2018.03.165","article-title":"Status of coexisting chronic obstructive pulmonary disease and its clinicopathological features in patients undergoing lung cancer surgery: a cross-sectional study of 3006 cases","volume":"10","author":"Hu","year":"2018","journal-title":"J. Thorac. Dis."},{"issue":"9","key":"10.1016\/j.ctarc.2025.101064_bib0008","first-page":"2877","article-title":"K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation","volume":"31","author":"Keohavong","year":"2011","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101064_bib0009","article-title":"Clinical characteristics and outcomes in advanced KRAS-mutated NSCLC: a multicenter collaboration in Asia (ATORG-005)","volume":"3","author":"Lee","year":"2022","journal-title":"JTo Clin. Res. Rep."},{"key":"10.1016\/j.ctarc.2025.101064_bib0010","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.2147\/COPD.S328938","article-title":"Impact of chronic obstructive pulmonary disease on the mortality of patients with small cell lung cancer","volume":"16","author":"Liao","year":"2021","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.ctarc.2025.101064_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1038715","article-title":"Lung cancer patients with chronic obstructive pulmonary disease benefit from anti-PD-1\/PD-L1 therapy","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ctarc.2025.101064_bib0012","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40364-020-00199-z","article-title":"Clinical characteristics and prognostic value of the KRAS G12C mutation in Chinese non-small cell lung cancer patients","volume":"8","author":"Liu","year":"2020","journal-title":"Biomark. Res."},{"issue":"8","key":"10.1016\/j.ctarc.2025.101064_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/jpm14080839","article-title":"Is there a link between chronic obstructive pulmonary disease and lung adenocarcinoma? A clinico-pathological and molecular study","volume":"14","author":"Lunardi","year":"2024","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.ctarc.2025.101064_bib0014","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.2147\/COPD.S363482","article-title":"Molecular and clinicopathological characteristics of lung cancer concomitant chronic obstructive pulmonary disease (COPD)","volume":"17","author":"Ma","year":"2022","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"issue":"3","key":"10.1016\/j.ctarc.2025.101064_bib0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1164\/rccm.201704-0795OC","article-title":"Chronic obstructive pulmonary disease alters immune cell composition and immune checkpoint inhibitor efficacy in non-small cell lung cancer","volume":"197","author":"Mark","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101064_bib0016","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/mc.2940110108","article-title":"Ki-ras mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-initiated and butylated hydroxytoluene-promoted lung tumors in A\/J mice","volume":"11","author":"Matzinger","year":"1994","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ctarc.2025.101064_bib0017","first-page":"32","article-title":"EGFR mutant locally advanced non-small cell lung cancer is at increased risk of brain metastasis","volume":"18","author":"Mitra","year":"2019","journal-title":"Clin. Transl. Radiat. Oncol."},{"issue":"7","key":"10.1016\/j.ctarc.2025.101064_bib0018","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/0284186X.2017.1324213","article-title":"The role of comorbidity in the management and prognosis in nonsmall cell lung cancer: a population-based study","volume":"56","author":"Nilsson","year":"2017","journal-title":"Acta Oncol."},{"key":"10.1016\/j.ctarc.2025.101064_bib0019","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2147\/COPD.S104670","article-title":"Characteristics of elderly patients with COPD and newly diagnosed lung cancer, and factors associated with treatment decision","volume":"11","author":"Qin","year":"2016","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"issue":"9","key":"10.1016\/j.ctarc.2025.101064_bib0020","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.annonc.2021.06.001","article-title":"Targeting KRAS in non-small-cell lung cancer: recent progress and new approaches","volume":"32","author":"Reck","year":"2021","journal-title":"Ann. Oncol. Off. J. European Soc. Med. Oncol."},{"issue":"3","key":"10.1016\/j.ctarc.2025.101064_bib0021","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jtho.2021.10.013","article-title":"Diminished efficacy of programmed death-(Ligand)1 inhibition in STK11- and KEAP1-mutant lung adenocarcinoma is affected by KRAS mutation status","volume":"17","author":"Ricciuti","year":"2022","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.ctarc.2025.101064_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152317","article-title":"Chronic obstructive pulmonary disease is not associated with KRAS mutations in non-small cell lung cancer","volume":"11","author":"Saber","year":"2016","journal-title":"PLoS. One"},{"key":"10.1016\/j.ctarc.2025.101064_bib0023","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.lungcan.2017.07.039","article-title":"PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: a comprehensive mutational analysis from a multi-institutional cohort","volume":"112","author":"Sawa","year":"2017","journal-title":"Lung Cancer"},{"issue":"6","key":"10.1016\/j.ctarc.2025.101064_bib0024","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jtho.2025.02.025","article-title":"Can immunotherapy Be omitted in KRAS G12C-mutant lung cancer by 2025?","volume":"20","author":"Scheffler","year":"2025","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.ctarc.2025.101064_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2025.108421","article-title":"Real-world outcomes of non-small cell lung cancer patients harbouring KRAS G12C and KRAS G12D mutations","volume":"201","author":"Shahnam","year":"2025","journal-title":"Lung Cancer"},{"issue":"9","key":"10.1016\/j.ctarc.2025.101064_bib0026","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1002\/ijc.32235","article-title":"Improved treatment outcome of pembrolizumab in patients with nonsmall cell lung cancer and chronic obstructive pulmonary disease","volume":"145","author":"Shin","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.ctarc.2025.101064_bib0027","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s41591-024-02903-0","article-title":"Targeting KRAS in cancer","volume":"30","author":"Singhal","year":"2024","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ctarc.2025.101064_bib0028","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.ctarc.2025.101064_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2024.103473","article-title":"Clinical characteristic and survival outcomes of patients with advanced NSCLC according to KRAS mutational status in the French real-life ESME cohort","volume":"9","author":"Thomas","year":"2024","journal-title":"ESMo Open."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101064_bib0030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/jcp-2022-208574","article-title":"Prognostic value of KRAS mutations, TP53 mutations and PD-L1 expression among lung adenocarcinomas treated with immunotherapy","volume":"77","author":"T\u00f8nnesen","year":"2023","journal-title":"J. Clin. Pathol."},{"issue":"1","key":"10.1016\/j.ctarc.2025.101064_bib0031","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12890-024-03088-5","article-title":"Analysis of clinical characteristics and prognosis of lung cancer patients with CPFE or COPD: a retrospective study","volume":"24","author":"Wei","year":"2024","journal-title":"BMC. Pulm. Med."},{"issue":"4","key":"10.1016\/j.ctarc.2025.101064_bib0032","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/crj.13144","article-title":"The prognosis of non-small cell lung cancer combined with chronic obstructive pulmonary disease: a systematic review and meta-analysis","volume":"14","author":"Wu","year":"2020","journal-title":"Clin. Respir. J."},{"issue":"8","key":"10.1016\/j.ctarc.2025.101064_bib0033","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.21037\/tlcr-23-339","article-title":"International expert consensus on diagnosis and treatment of lung cancer complicated by chronic obstructive pulmonary disease","volume":"12","author":"Zhou","year":"2023","journal-title":"Transl. Lung Cancer Res."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246829422500200X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246829422500200X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:17:18Z","timestamp":1774055838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246829422500200X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":33,"alternative-id":["S246829422500200X"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.101064","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics and prognostic outcomes in KRAS-mutant non-small cell lung cancer: A real-world study with or without COPD comorbidity","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2025.101064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101064"}}