{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:59:06Z","timestamp":1790913546600,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":147,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2026.101268","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:13:44Z","timestamp":1780013624000},"page":"101268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Investigation of the relationship between autophagy and Warburg effect in osteosarcoma cells: An in vitro study"],"prefix":"10.1016","volume":"48","author":[{"given":"Mehran","family":"Molavand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Majidinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Valizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azita","family":"Asadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariush","family":"Shanehbandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-2637","authenticated-orcid":false,"given":"Mostafa","family":"Vaghari-Tabari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-1527","authenticated-orcid":false,"given":"Bahman","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctarc.2026.101268_bib0001","doi-asserted-by":"crossref","first-page":"vii320","DOI":"10.1093\/annonc\/mdq276","article-title":"Osteosarcoma","volume":"21","author":"Ritter","year":"2010","journal-title":"Ann. Oncol."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101268_bib0002","first-page":"990","article-title":"Primary osteosarcoma in elderly patients: A report of three cases","volume":"18","author":"Xu","year":"2019","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0003","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41572-022-00409-y","article-title":"Osteosarcoma","volume":"8","author":"Beird","year":"2022","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101268_bib0004","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3390\/jcm14062024","article-title":"Prognostic Factors in High Grade Osteosarcoma Patients Who Received Neoadjuvant Therapy and Subsequently Underwent Surgery: Data from the Turkish Oncology Group","volume":"14","author":"Sever","year":"2025","journal-title":"J. Clin. Med."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101268_bib0005","first-page":"705","article-title":"Osteosarcoma: a review of diagnosis, management, and treatment strategies","volume":"8","author":"Geller","year":"2010","journal-title":"Clin. Adv. Hematol. Oncol."},{"key":"10.1016\/j.ctarc.2026.101268_bib0006","doi-asserted-by":"crossref","DOI":"10.1177\/15330338221124696","article-title":"Current Status and Prospects of Clinical Treatment of Osteosarcoma","volume":"21","author":"Jiang","year":"2022","journal-title":"Technol. Cancer Res. Treat."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101268_bib0007","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3390\/ph18040520","article-title":"Advancements in Osteosarcoma Therapy: Overcoming Chemotherapy Resistance and Exploring Novel Pharmacological Strategies","volume":"18","author":"Zhra","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ctarc.2026.101268_bib0008","series-title":"StatPearls","article-title":"Osteosarcoma (Osteogenic Sarcoma)","author":"Greenwood","year":"2025"},{"issue":"24","key":"10.1016\/j.ctarc.2026.101268_bib0009","first-page":"405","article-title":"The diagnosis and treatment of osteosarcoma and Ewing\u2019s sarcoma in children and adolescents","volume":"120","author":"Zarghooni","year":"2023","journal-title":"Dtsch. \u00c4rztebl. Int."},{"issue":"14","key":"10.1016\/j.ctarc.2026.101268_bib0010","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.12998\/wjcc.v7.i14.1753","article-title":"Current status of the adjuvant therapy in uterine sarcoma: A literature review","volume":"7","author":"Rizzo","year":"2019","journal-title":"World J. Clin. Cases."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101268_bib0011","first-page":"12","article-title":"Impact of Chemotherapy in the Adjuvant Setting of Early Stage Uterine Leiomyosarcoma: A Systematic Review and Updated Meta-Analysis","author":"Rizzo","year":"2020","journal-title":"Cancers. (Basel)"},{"issue":"8","key":"10.1016\/j.ctarc.2026.101268_bib0012","first-page":"12","article-title":"Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile","author":"Astolfi","year":"2020","journal-title":"Cancers. (Basel)"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0013","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71746-z","article-title":"Sex differences in adverse events among cancer patients receiving immune checkpoint inhibitors: the MOUSEION-07 systematic review and meta-analysis","volume":"14","author":"Vitale","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ctarc.2026.101268_bib0014","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.2147\/DDDT.S560518","article-title":"Infusion-Related Reactions Among Cancer Patients Receiving Immune Checkpoint Inhibitors: The ARON-MOUSEION-013 Systematic Review and Meta-Analysis","volume":"19","author":"Vitale","year":"2025","journal-title":"Drug Devel. Ther."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101268_bib0015","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1002\/jcp.30721","article-title":"DNA damage response signaling pathways as important targets for combination therapy and chemotherapy sensitization in osteosarcoma","volume":"237","author":"Alemi","year":"2022","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ctarc.2026.101268_bib0016","series-title":"Autophagy: Biology and Diseases: Technology and Methodology","first-page":"3","article-title":"The classification and basic processes of autophagy","author":"Nie","year":"2021"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1272\/jnms.JNMS.2024_91-102","article-title":"Molecular mechanisms of macroautophagy, microautophagy, and chaperone-mediated autophagy","volume":"91","author":"Yamamoto","year":"2024","journal-title":"J. Nippon. Med. Sch."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101268_bib0018","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s12032-024-02513-3","article-title":"Regulation of autophagy by non-coding RNAs in human glioblastoma","volume":"41","author":"Molavand","year":"2024","journal-title":"Med. Oncol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101268_bib0019","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s11684-022-0919-0","article-title":"Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma","volume":"16","author":"Wang","year":"2022","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.gendis.2023.04.015","article-title":"Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword","volume":"11","author":"Zhang","year":"2024","journal-title":"Genes. Dis."},{"key":"10.1016\/j.ctarc.2026.101268_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217161","article-title":"Platelets promote primary hepatocellular carcinoma metastasis through TGF-\u03b21-mediated cancer cell autophagy","volume":"600","author":"Lu","year":"2024","journal-title":"Cancer Lett."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101268_bib0022","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.3390\/cancers12123675","article-title":"Autophagy in Osteosarcoma Cancer Stem Cells Is Critical Process which Can Be Targeted by the Antipsychotic Drug Thioridazine","volume":"12","author":"Camuzard","year":"2020","journal-title":"Cancers. (Basel)"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0023","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bcp.2014.07.006","article-title":"Autophagy: an adaptive metabolic response to stress shaping the antitumor immunity","volume":"92","author":"Viry","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101268_bib0024","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg Effect: How Does it Benefit Cancer Cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/j.ctarc.2026.101268_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110488","article-title":"The Warburg effect in osteoporosis: Cellular signaling and epigenetic regulation of energy metabolic events to targeting the osteocalcin for phenotypic alteration","volume":"100","author":"Vadivalagan","year":"2022","journal-title":"Cell Signal."},{"issue":"22","key":"10.1016\/j.ctarc.2026.101268_bib0026","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.3390\/cells13221924","article-title":"Emerging Role of Extracellular pH in Tumor Microenvironment as a Therapeutic Target for Cancer Immunotherapy","volume":"13","author":"Rahman","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.ctarc.2026.101268_bib0027","article-title":"Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101268_bib0028","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2016.10.015","article-title":"Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells","volume":"24","author":"Scott","year":"2016","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101268_bib0029","first-page":"16","article-title":"Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic\/Anabolic Pathways to Promote Tumor Growth","author":"Mathew","year":"2024","journal-title":"Cancers. (Basel)"},{"issue":"2 Pt A","key":"10.1016\/j.ctarc.2026.101268_bib0030","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ctarc.2026.101268_bib0031","article-title":"The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer","volume":"10-2020","author":"Yang","year":"2020","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101268_bib0032","doi-asserted-by":"crossref","first-page":"775","DOI":"10.7150\/ijbs.26077","article-title":"Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition","volume":"14","author":"Feng","year":"2018","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0033","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/genes16010014","article-title":"Lactate Promotes Hypoxic Granulosa Cells\u2019 Autophagy by Activating the HIF-1\u03b1\/BNIP3\/Beclin-1 Signaling Axis","volume":"16","author":"Pan","year":"2025","journal-title":"Genes. (Basel)"},{"key":"10.1016\/j.ctarc.2026.101268_bib0034","article-title":"Hypoxia and Selective Autophagy in Cancer Development and Therapy","volume":"6-2018","author":"Daskalaki","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ctarc.2026.101268_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2025.104989","article-title":"The interplay involving oxidative stress and autophagy: Mechanisms, implications, and therapeutic opportunities","volume":"143","author":"Gouda","year":"2025","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.ctarc.2026.101268_bib0036","article-title":"Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox","volume":"12-2022","author":"Hasan","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ctarc.2026.101268_bib0037","article-title":"Enhancing Doxorubicin Sensitivity in Osteosarcoma Cancer Cells: Unveiling the Role of Resveratrol-Induced Oxidative DNA Damage","author":"Bazavar","year":"2025","journal-title":"Drug Res."},{"key":"10.1016\/j.ctarc.2026.101268_bib0038","series-title":"2-Deoxy-D-Glucose: A Glycolysis Inhibitor in the Treatment of Cancer, in 2-Deoxy-D-Glucose: Chemistry and Biology","first-page":"203","author":"Poorani","year":"2024"},{"issue":"8","key":"10.1016\/j.ctarc.2026.101268_bib0039","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101268_bib0040","first-page":"473","article-title":"Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent","volume":"12","author":"Geng","year":"2010","journal-title":"Neuro Oncol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0041","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41420-022-01074-6","article-title":"The combination of hydroxychloroquine and 2-deoxyglucose enhances apoptosis in breast cancer cells by blocking protective autophagy and sustaining endoplasmic reticulum stress","volume":"8","author":"Zhou","year":"2022","journal-title":"Cell Death. Discov."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101268_bib0042","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/s41401-021-00612-9","article-title":"Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin","volume":"42","author":"Huang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0043","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010234","article-title":"2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents","volume":"21","author":"Pajak","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101268_bib0044","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy."},{"key":"10.1016\/j.ctarc.2026.101268_bib0045","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3390\/cells9020380","article-title":"Silencing of PARP2 Blocks Autophagic Degradation","volume":"9","author":"Jank\u00f3","year":"2020","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.ctarc.2026.101268_bib0046","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.freeradbiomed.2010.01.016","article-title":"Regulation of glycolysis and expression of glucose metabolism-related genes by reactive oxygen species in contracting skeletal muscle cells","volume":"48","author":"Pinheiro","year":"2010","journal-title":"Free Radical Biol. Med."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101268_bib0047","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.7150\/ijbs.101921","article-title":"Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K\/AKT Pathway and the Warburg Effect","volume":"21","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101268_bib0048","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.7150\/ijbs.91492","article-title":"Histone lactylation: from tumor lactate metabolism to epigenetic regulation","volume":"20","author":"Yu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0049","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12964-025-02366-x","article-title":"Lactylation modification of HIF-1\u03b1 enhances its stability by blocking VHL recognition","volume":"23","author":"Li","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101268_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202300292","article-title":"HIF-1\u03b1 contributes to hypoxia-induced VSMC proliferation and migration by regulating autophagy in type A aortic dissection","volume":"8","author":"Huang","year":"2024","journal-title":"Adv. Biol."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101268_bib0051","first-page":"473","article-title":"Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent","volume":"12","author":"Geng","year":"2010","journal-title":"Neuro-Oncol."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101268_bib0052","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3390\/cells1030284","article-title":"Regulation of the autophagic bcl-2\/beclin 1 interaction","volume":"1","author":"Decuypere","year":"2012","journal-title":"Cells"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226001796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226001796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:48:50Z","timestamp":1790912930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294226001796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":52,"alternative-id":["S2468294226001796"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101268","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the relationship between autophagy and Warburg effect in osteosarcoma cells: An in vitro study","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101268"}}