{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:53:04Z","timestamp":1790916784340,"version":"4.1.0"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2025QC947"],"award-info":[{"award-number":["ZR2025QC947"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2025QC1383"],"award-info":[{"award-number":["ZR2025QC1383"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2025LSW038"],"award-info":[{"award-number":["ZR2025LSW038"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-6-49"],"award-info":[{"award-number":["320.6750.2024-6-49"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["LYSRMYY-KCTD-005"],"award-info":[{"award-number":["LYSRMYY-KCTD-005"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2026.101283","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:48:07Z","timestamp":1781340487000},"page":"101283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Histone methylation machinery in gliomas: From enzymatic mechanisms to inhibitor development"],"prefix":"10.1016","volume":"48","author":[{"given":"Xiaoran","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","article-title":"Glioma","volume":"10","author":"Weller","year":"2024","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0002","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41392-025-02299-4","article-title":"Glioblastoma at the crossroads: current understanding and future therapeutic horizons","volume":"10","author":"Singh","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.ctarc.2026.101283_bib0003","first-page":"12","article-title":"The epigenetic mechanisms involved in the treatment resistance of glioblastoma","volume":"8","author":"Shahani","year":"2025","journal-title":"Cancer Drug Resist."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101283_bib0004","first-page":"647","article-title":"[Elderly Glioma]","volume":"49","author":"Yamasaki","year":"2021","journal-title":"No Shinkei. Geka"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101283_bib0005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.apsb.2018.12.001","article-title":"Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy","volume":"9","author":"Jiao","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"issue":"12","key":"10.1016\/j.ctarc.2026.101283_bib0006","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/jamaoncol.2024.4361","article-title":"Efficacy of adding Veliparib to Temozolomide for patients with MGMT-methylated glioblastoma: a randomized clinical trial","volume":"10","author":"Sarkaria","year":"2024","journal-title":"JAMa Oncol."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101283_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188616","article-title":"Elucidating the mechanisms of temozolomide resistance in gliomas and the strategies to overcome the resistance","volume":"1876","author":"Tomar","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101283_bib0008","article-title":"MGMT in TMZ-based glioma therapy: multifaceted insights and clinical trial perspectives","volume":"1871","author":"Shaw","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101283_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189184","article-title":"Unraveling the mysteries of MGMT: implications for neuroendocrine tumors","volume":"1879","author":"Jiang","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"17","key":"10.1016\/j.ctarc.2026.101283_bib0010","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1158\/0008-5472.CAN-18-3394","article-title":"Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors","volume":"79","author":"Jackson","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101283_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocn.2024.110816","article-title":"Herpes zoster in patients with glioma treated with temozolomide","volume":"129","author":"Hiong","year":"2024","journal-title":"J. Clin. Neurosci."},{"issue":"44","key":"10.1016\/j.ctarc.2026.101283_bib0012","article-title":"LncRNA-mediated TPI1 and PKM2 promote self-renewal and chemoresistance in GBM","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"issue":"5","key":"10.1016\/j.ctarc.2026.101283_bib0013","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41419-024-06695-6","article-title":"Glioblastoma stem cells deliver ABCB4 transcribed by ATF3 via exosomes conferring glioblastoma resistance to temozolomide","volume":"15","author":"Xu","year":"2024","journal-title":"Cell Death. Dis."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101283_bib0014","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/s41588-021-00926-8","article-title":"Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response","volume":"53","author":"Johnson","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ctarc.2026.101283_bib0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.semcancer.2020.12.015","article-title":"Epigenetics of glioblastoma multiforme: from molecular mechanisms to therapeutic approaches","volume":"83","author":"Uddin","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101283_bib0016","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ccell.2021.01.006","article-title":"Proteogenomic and metabolomic characterization of human glioblastoma","volume":"39","author":"Wang","year":"2021","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101283_bib0017","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/EBC20253015","article-title":"Epigenetics, human imprintome, and chronic diseases","volume":"69","author":"Jirtle","year":"2025","journal-title":"Essays Biochem."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101283_bib0018","first-page":"376","article-title":"Cancer epigenetics in clinical practice","volume":"73","author":"Davalos","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101283_bib0019","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163450","article-title":"Impact of epigenetic reprogramming on antitumor immune responses in glioma","volume":"133","author":"McClellan","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"8026","key":"10.1016\/j.ctarc.2026.101283_bib0020","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/s41586-024-07751-z","article-title":"Histone serotonylation regulates ependymoma tumorigenesis","volume":"632","author":"Chen","year":"2024","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101283_bib0021","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/14737159.2026.2648127","article-title":"Artificial intelligence in cancer screening: a narrative review of current evidence and future directions","volume":"26","author":"Yazarkan","year":"2026","journal-title":"Expert. Rev. Mol. Diagn."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101283_bib0022","doi-asserted-by":"crossref","DOI":"10.1007\/s10555-026-10327-0","article-title":"Hyponatremia in cancer patients receiving immune checkpoint inhibitors: the ARON-MOUSEION-014 meta-analysis","volume":"45","author":"Vitale","year":"2026","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.ctarc.2026.101283_bib0023","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.2147\/DDDT.S560518","article-title":"Infusion-related reactions among cancer patients receiving immune checkpoint inhibitors: the ARON-MOUSEION-013 systematic review and meta-analysis","volume":"19","author":"Vitale","year":"2025","journal-title":"Drug Des Devel Ther."},{"key":"10.1016\/j.ctarc.2026.101283_bib0024","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.clnesp.2025.10.031","article-title":"Decreased appetite in cancer patients treated with immune checkpoint inhibitors (ICIs): the MOUSEION-012 systematic review and meta-analysis","volume":"70","author":"Vitale","year":"2025","journal-title":"Clin. Nutr. ESPEN."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101283_bib0025","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/1750743X.2025.2483656","article-title":"Nutritional conditions and PFS and OS in cancer immunotherapy: the MOUSEION-010 meta-analysis","volume":"17","author":"Vitale","year":"2025","journal-title":"Immunotherapy"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0026","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71746-z","article-title":"Sex differences in adverse events among cancer patients receiving immune checkpoint inhibitors: the MOUSEION-07 systematic review and meta-analysis","volume":"14","author":"Vitale","year":"2024","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101283_bib0027","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1111\/bph.16237","article-title":"Natural products modulating epigenetic mechanisms by affecting histone methylation\/demethylation: targeting cancer cells","volume":"182","author":"Dorna","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101283_bib0028","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051803","article-title":"The interplay between DNA and histone methylation: molecular mechanisms and disease implications","volume":"22","author":"Li","year":"2021","journal-title":"EMBo Rep."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101283_bib0029","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s10815-025-03577-4","article-title":"The dynamics of DNA methylation, histone methylation and acetylation during oocyte aging in mammalian species and possible interventions to regulate them","volume":"42","author":"Ozturk","year":"2025","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.ctarc.2026.101283_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108640","article-title":"Therapeutic targeting of DNA methylation alterations in cancer","volume":"258","author":"Lee","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ctarc.2026.101283_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104764","article-title":"Glioblastoma: molecular features, emerging molecular targets and novel therapeutic strategies","volume":"212","author":"Politis","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"14","key":"10.1016\/j.ctarc.2026.101283_bib0032","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.2174\/0929867328666211108105214","article-title":"Histone modifications and their role in epigenetics of cancer","volume":"29","author":"Zaib","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ctarc.2026.101283_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119504","article-title":"Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy","volume":"277","author":"Ramaiah","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0034","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13046-020-01682-z","article-title":"Histone methyltransferase and drug resistance in cancers","volume":"39","author":"Yang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101283_bib0035","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1021\/acs.analchem.2c04648","article-title":"mNeuCode empowers targeted proteome analysis of arginine dimethylation","volume":"95","author":"Wang","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ctarc.2026.101283_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2024.102153","article-title":"Role of H3K4 monomethylation in gene regulation","volume":"84","author":"Wang","year":"2024","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101283_bib0037","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41588-022-01047-6","article-title":"H3K27me3 conditions chemotolerance in triple-negative breast cancer","volume":"54","author":"Marsolier","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ctarc.2026.101283_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2023.102600","article-title":"Review: targeting EZH2 in neuroblastoma","volume":"119","author":"Gao","year":"2023","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0039","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13045-020-00937-8","article-title":"EZH2: a novel target for cancer treatment","volume":"13","author":"Duan","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101283_bib0040","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.celrep.2019.12.056","article-title":"Inhibition of EZH2 catalytic activity selectively targets a metastatic subpopulation in triple-negative breast cancer","volume":"30","author":"Yomtoubian","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0041","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12943-020-01173-x","article-title":"Verification of EZH2 as a druggable target in metastatic uveal melanoma","volume":"19","author":"Jin","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ctarc.2026.101283_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216706","article-title":"EZH2-mediated development of therapeutic resistance in cancer","volume":"586","author":"Kaur","year":"2024","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101283_bib0043","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/ijc.32360","article-title":"Polycomb complex mediated epigenetic reprogramming alters TGF-beta signaling via a novel EZH2\/miR-490\/TGIF2 axis thereby inducing migration and EMT potential in glioblastomas","volume":"145","author":"Vinchure","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ctarc.2026.101283_bib0044","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.2147\/IJN.S189871","article-title":"Targeting EZH2 for glioma therapy with a novel nanoparticle-siRNA complex","volume":"14","author":"Wang","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0045","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12943-020-01258-7","article-title":"Targeting STAT3 in cancer immunotherapy","volume":"19","author":"Zou","year":"2020","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0046","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12964-024-01642-6","article-title":"Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2\/STAT3 and NF-kappaB pathways","volume":"22","author":"Yan","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"24","key":"10.1016\/j.ctarc.2026.101283_bib0047","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29245817","article-title":"Targeting EZH2 in cancer: mechanisms, pathways, and therapeutic potential","volume":"29","author":"Gilardini Montani","year":"2024","journal-title":"Molecules."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101283_bib0048","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0246244","article-title":"EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth","volume":"16","author":"Bownes","year":"2021","journal-title":"PLoS. One"},{"issue":"22","key":"10.1016\/j.ctarc.2026.101283_bib0049","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213915","article-title":"GSK343, an inhibitor of enhancer of Zeste Homolog 2, reduces glioblastoma progression through inflammatory process modulation: focus on canonical and non-canonical NF-kappaB\/IkappaBalpha pathways","volume":"23","author":"Scuderi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0050","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1139\/bcb-2022-0224","article-title":"GSK126 an inhibitor of epigenetic regulator EZH2 suppresses cardiac fibrosis by regulating the EZH2-PAX6-CXCL10 pathway","volume":"101","author":"Aziz","year":"2023","journal-title":"Biochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101283_bib0051","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s40265-020-01288-x","article-title":"Tazemetostat: first approval","volume":"80","author":"Hoy","year":"2020","journal-title":"Drugs"},{"issue":"16","key":"10.1016\/j.ctarc.2026.101283_bib0052","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s40265-022-01800-5","article-title":"Valemetostat Tosilate: first approval","volume":"82","author":"Keam","year":"2022","journal-title":"Drugs"},{"issue":"8","key":"10.1016\/j.ctarc.2026.101283_bib0053","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1158\/0008-5472.CAN-18-2395","article-title":"EZH2 Inhibitor GSK126 suppresses antitumor immunity by driving production of myeloid-derived suppressor cells","volume":"79","author":"Huang","year":"2019","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101283_bib0054","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S1470-2045(20)30441-1","article-title":"Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial","volume":"21","author":"Morschhauser","year":"2020","journal-title":"Lancet Oncol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101283_bib0055","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S1470-2045(24)00503-5","article-title":"Valemetostat for patients with relapsed or refractory peripheral T-cell lymphoma (VALENTINE-PTCL01): a multicentre, open-label, single-arm, phase 2 study","volume":"25","author":"Zinzani","year":"2024","journal-title":"Lancet Oncol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101283_bib0056","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073911","article-title":"Dual inhibition of H3K9me2 and H3K27me3 promotes tumor cell senescence without triggering the secretion of SASP","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ctarc.2026.101283_bib0057","doi-asserted-by":"crossref","DOI":"10.35371\/aoem.2022.34.e1","article-title":"Mental health symptoms among dependent contractors in Korea: a cross-sectional study based on the Fifth Korean Working Condition Survey","volume":"34","author":"Baek","year":"2022","journal-title":"Ann. Occup. Environ. Med."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101283_bib0058","doi-asserted-by":"crossref","first-page":"359","DOI":"10.5694\/mja2.51916","article-title":"Moving breast cancer susceptibility gene testing into the mainstream","volume":"218","author":"Wong","year":"2023","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.ctarc.2026.101283_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149252","article-title":"The role of trimethylation on histone H3 lysine 27 (H3K27me3) in temozolomide resistance of glioma","volume":"1846","author":"Zhang","year":"2025","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0060","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1186\/s12913-024-11216-4","article-title":"Perceived barriers and opportunities of providing quality family planning services among Palestinian midwives, physicians and nurses in the West Bank: a qualitative study","volume":"24","author":"Hassan","year":"2024","journal-title":"BMC. Health Serv. Res."},{"key":"10.1016\/j.ctarc.2026.101283_bib0061","article-title":"Editorial: challenges and current research status of vertigo\/vestibular diseases, volume II","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Neurol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101283_bib0062","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16122175","article-title":"G9a in cancer: mechanisms, therapeutic advancements, and clinical implications","volume":"16","author":"Ni","year":"2024","journal-title":"Cancers. (Basel)"},{"key":"10.1016\/j.ctarc.2026.101283_bib0063","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-3-030-30651-9_13","article-title":"Histone modifying enzymes and chromatin modifiers in glioma pathobiology and therapy responses","volume":"1202","author":"Ciechomska","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101283_bib0064","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.12998\/wjcc.v11.i12.2811","article-title":"Open surgery: still a great option to treat patients with post-traumatic arteriovenous fistulas: a case report","volume":"11","author":"Kalinin","year":"2023","journal-title":"World J. Clin. Cases."},{"key":"10.1016\/j.ctarc.2026.101283_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110720","article-title":"Histone methyltransferase inhibitor UNC0642 promotes breast cancer cell death by upregulating TXNIP-dependent oxidative stress","volume":"385","author":"Singh","year":"2023","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0066","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1038\/s41467-025-59128-z","article-title":"Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology","volume":"16","author":"Xie","year":"2025","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.ctarc.2026.101283_bib0067","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1021\/acs.jmedchem.2c00652","article-title":"Discovery of the first-in-class G9a\/GLP covalent inhibitors","volume":"65","author":"Park","year":"2022","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101283_bib0068","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1021\/acs.jmedchem.3c02394","article-title":"Discovery of the first-in-class G9a\/GLP PROTAC Degrader","volume":"67","author":"Velez","year":"2024","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101283_bib0069","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.diii.2018.10.001","article-title":"Cutaneous necrosis after embolization of spontaneous soft-tissue hematoma of the abdominal wall","volume":"99","author":"Djaber","year":"2018","journal-title":"Diagn. Interv. ImAging"},{"issue":"45","key":"10.1016\/j.ctarc.2026.101283_bib0070","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1038\/s41388-024-03164-4","article-title":"SUV39H1 epigenetically modulates the MCPIP1-AURKA signaling axis to enhance neuroblastoma tumorigenesis","volume":"43","author":"Li","year":"2024","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.ctarc.2026.101283_bib0071","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.186344","article-title":"SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma","volume":"10","author":"Li","year":"2025","journal-title":"JCI. Insight."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0072","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41392-024-01764-w","article-title":"TGF-beta signaling in health, disease, and therapeutics","volume":"9","author":"Deng","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0073","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s13046-019-1341-6","article-title":"A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma","volume":"38","author":"Bian","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101283_bib0074","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/neuonc\/noad222","article-title":"Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201","volume":"26","author":"Xin","year":"2024","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ctarc.2026.101283_bib0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.canlet.2020.02.004","article-title":"SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth","volume":"476","author":"Lu","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ctarc.2026.101283_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174459","article-title":"Chaetocin: A review of its anticancer potentials and mechanisms","volume":"910","author":"Jiang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101283_bib0077","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/BCJ20220528","article-title":"Chaetocin disrupts the SUV39H1-HP1 interaction independent of SUV39H1 methyltransferase activity","volume":"480","author":"Han","year":"2023","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101283_bib0078","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/ATVBAHA.124.322048","article-title":"Suv39h1 Regulates phenotypic modulation of smooth muscle cells and contributes to vascular injury by repressing HIC1 transcription","volume":"45","author":"Yang","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"45","key":"10.1016\/j.ctarc.2026.101283_bib0079","doi-asserted-by":"crossref","first-page":"16831","DOI":"10.1074\/jbc.RA119.010371","article-title":"Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet","volume":"294","author":"Newhardt","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"5S","key":"10.1016\/j.ctarc.2026.101283_bib0080","first-page":"S7","article-title":"Practical opportunities for pharmacists to optimize psychotropic medication use among foster youth","volume":"60","author":"Lambert","year":"2003","journal-title":"J. Am. Pharm. Assoc."},{"key":"10.1016\/j.ctarc.2026.101283_bib0081","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12935-019-0982-z","article-title":"Histone methyltransferase SUV39H2 regulates cell growth and chemosensitivity in glioma via regulation of hedgehog signaling","volume":"19","author":"Wang","year":"2019","journal-title":"Cancer Cell Int."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101283_bib0082","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.neo.2020.06.006","article-title":"BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases","volume":"22","author":"Grigore","year":"2020","journal-title":"Neoplasia"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101283_bib0083","first-page":"2989","article-title":"Clinical significance of chromodomain helicase\/ATPase DNA binding protein 1-like and human mutL homolog 1 gene expression in cholangiocarcinoma","volume":"16","author":"Hua","year":"2018","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0084","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41420-025-02702-7","article-title":"CRISPR\/Cas9 screening identifies SUV39H2 as a key regulator of oHSV-1 resistance in oral squamous cell carcinoma","volume":"11","author":"Qiu","year":"2025","journal-title":"Cell Death. Discov."},{"issue":"25","key":"10.1016\/j.ctarc.2026.101283_bib0085","doi-asserted-by":"crossref","first-page":"22900","DOI":"10.1021\/acsnano.5c01541","article-title":"NIR-II engineered exosome nanotheranostic probes for \"oriented blasting\" in orthotopic glioblastoma","volume":"19","author":"Yu","year":"2025","journal-title":"ACS. Nano"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0086","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13148-022-01251-5","article-title":"Roles for the methyltransferase SETD8 in DNA damage repair","volume":"14","author":"Xu","year":"2022","journal-title":"Clin. Epigenetics."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101283_bib0087","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.prp.2018.01.004","article-title":"Downregulation of SETD8 by miR-382 is involved in glioma progression","volume":"214","author":"Ma","year":"2018","journal-title":"Pathol. Res. Pract."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101283_bib0088","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41419-023-06167-3","article-title":"Targeted inhibition of the methyltransferase SETD8 synergizes with the Wee1 inhibitor adavosertib in restraining glioblastoma growth","volume":"14","author":"Della Monica","year":"2023","journal-title":"Cell Death. Dis."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101283_bib0089","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/art.40042","article-title":"A dual role of upper zone of growth plate and cartilage matrix-associated protein in Human and mouse osteoarthritic cartilage: inhibition of aggrecanases and promotion of bone turnover","volume":"69","author":"Stock","year":"2017","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12957-022-02538-w","article-title":"Global analysis of miRNA-mRNA regulation pair in bladder cancer","volume":"20","author":"Fan","year":"2022","journal-title":"World J. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101283_bib0091","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.molcel.2018.04.028","article-title":"MLL4 Is required to maintain broad H3K4me3 peaks and super-enhancers at tumor suppressor genes","volume":"70","author":"Dhar","year":"2018","journal-title":"Molecular cell"},{"issue":"50","key":"10.1016\/j.ctarc.2026.101283_bib0092","doi-asserted-by":"crossref","first-page":"eabj9141","DOI":"10.1126\/sciadv.abj9141","article-title":"MLL4 mediates differentiation and tumor suppression through ferroptosis","volume":"7","author":"Egolf","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ctarc.2026.101283_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105888","article-title":"Role of NSD1 as potential therapeutic target in tumor","volume":"173","author":"Yang","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"13","key":"10.1016\/j.ctarc.2026.101283_bib0094","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.molcel.2022.04.015","article-title":"NSD1 mediates antagonism between SWI\/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition","volume":"82","author":"Drosos","year":"2022","journal-title":"Mol. Cell"},{"issue":"19-20","key":"10.1016\/j.ctarc.2026.101283_bib0095","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1101\/gad.328773.119","article-title":"Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma","volume":"33","author":"Lee","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.ctarc.2026.101283_bib0096","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12935-020-01169-z","article-title":"Circular RNA circPITX1 knockdown inhibits glycolysis to enhance radiosensitivity of glioma cells by miR-329-3p\/NEK2 axis","volume":"20","author":"Guan","year":"2020","journal-title":"Cancer Cell Int."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101283_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32366","article-title":"DNA methylation in human diseases","volume":"10","author":"Younesian","year":"2024","journal-title":"Heliyon."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0098","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41576-024-00760-8","article-title":"DNA methylation in mammalian development and disease","volume":"26","author":"Smith","year":"2025","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101283_bib0099","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.apsb.2024.01.005","article-title":"Strategies that regulate LSD1 for novel therapeutics","volume":"14","author":"Li","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ctarc.2026.101283_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217093","article-title":"Targeting LSD1 in cancer: molecular elucidation and recent advances","volume":"598","author":"Cai","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ctarc.2026.101283_bib0101","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114564","article-title":"A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors","volume":"240","author":"Dong","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101283_bib0102","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/neuonc\/noaa058","article-title":"Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma","volume":"22","author":"Bailey","year":"2020","journal-title":"Neuro Oncol."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101283_bib0103","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ccell.2019.09.005","article-title":"Re-programing chromatin with a bifunctional LSD1\/HDAC inhibitor induces therapeutic differentiation in DIPG","volume":"36","author":"Anastas","year":"2019","journal-title":"Cancer Cell"},{"issue":"36","key":"10.1016\/j.ctarc.2026.101283_bib0104","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1200\/JCO.19.03250","article-title":"First-in-Human phase I study of Iadademstat (ORY-1001): A First-in-class lysine-specific histone demethylase 1A inhibitor, in relapsed or refractory acute myeloid leukemia","volume":"38","author":"Salamero","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101283_bib0105","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/pros.24707","article-title":"Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models","volume":"84","author":"Jasmine","year":"2024","journal-title":"Prostate"},{"key":"10.1016\/j.ctarc.2026.101283_bib0106","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1170773","article-title":"Relationship between histone demethylase LSD family and development and prognosis of gastric cancer","volume":"14","author":"Dong","year":"2023","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101283_bib0107","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/s41417-024-00847-8","article-title":"Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma","volume":"31","author":"Shinjo","year":"2024","journal-title":"Cancer Gene Ther."},{"issue":"623","key":"10.1016\/j.ctarc.2026.101283_bib0108","doi-asserted-by":"crossref","first-page":"eabf7036","DOI":"10.1126\/scitranslmed.abf7036","article-title":"LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response","volume":"13","author":"Faletti","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0109","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s13577-024-01130-6","article-title":"Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy","volume":"38","author":"Seker","year":"2024","journal-title":"Hum. Cell"},{"key":"10.1016\/j.ctarc.2026.101283_bib0110","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12935-020-01177-z","article-title":"The histone demethylase JMJD2A promotes glioma cell growth via targeting akt-mTOR signaling","volume":"20","author":"Li","year":"2020","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0111","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1186\/s12951-024-02888-5","article-title":"Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway","volume":"22","author":"Xue","year":"2024","journal-title":"J. Nanobiotechnology."},{"key":"10.1016\/j.ctarc.2026.101283_bib0112","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.semcancer.2021.06.019","article-title":"Attacking the PI3K\/akt\/mTOR signaling pathway for targeted therapeutic treatment in human cancer","volume":"85","author":"Yu","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ctarc.2026.101283_bib0113","article-title":"PI3K\/Akt\/mTOR pathway and its role in cancer therapeutics: are we making headway?","volume":"12","author":"Peng","year":"2022","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101283_bib0114","first-page":"5930","article-title":"JMJD3 promotes the epithelial-mesenchymal transition and migration of glioma cells via the CXCL12\/CXCR4 axis","volume":"18","author":"Zou","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ctarc.2026.101283_bib0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neuint.2019.01.006","article-title":"The histone H3 lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1","volume":"124","author":"Sui","year":"2019","journal-title":"Neurochem. Int."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101283_bib0116","doi-asserted-by":"crossref","first-page":"17990","DOI":"10.1002\/jcp.28431","article-title":"Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells","volume":"234","author":"Sui","year":"2019","journal-title":"Journal of cellular physiology"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0117","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13148-025-01913-0","article-title":"Epigenetic editing and epi-drugs: a combination strategy to simultaneously target KDM4 as a novel anticancer approach","volume":"17","author":"Sarno","year":"2025","journal-title":"Clin. Epigenetics."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101283_bib0118","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1598","article-title":"Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicity","volume":"14","author":"Sun","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ctarc.2026.101283_bib0119","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biopha.2018.01.020","article-title":"Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1","volume":"99","author":"Dai","year":"2018","journal-title":"Biomed. PharmacOther"},{"issue":"7","key":"10.1016\/j.ctarc.2026.101283_bib0120","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1021\/acschemneuro.4c00003","article-title":"Histone lysine demethylase KDM5 inhibitor CPI-455 induces astrocytogenesis in neural stem cells","volume":"15","author":"San","year":"2024","journal-title":"ACS Chem Neurosci."},{"issue":"19","key":"10.1016\/j.ctarc.2026.101283_bib0121","doi-asserted-by":"crossref","first-page":"12979","DOI":"10.1021\/acs.jmedchem.2c00797","article-title":"Discovery of novel pyrazole-based KDM5B inhibitor TK-129 and its protective effects on myocardial remodeling and fibrosis","volume":"65","author":"Tang","year":"2022","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0122","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41392-025-02163-5","article-title":"Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation","volume":"10","author":"Zhou","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"21","key":"10.1016\/j.ctarc.2026.101283_bib0123","doi-asserted-by":"crossref","first-page":"34896","DOI":"10.18632\/oncotarget.16820","article-title":"Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells","volume":"8","author":"Banelli","year":"2017","journal-title":"Oncotarget."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101283_bib0124","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1111\/cns.14191","article-title":"G9a promotes immune suppression by targeting the Fbxw7\/Notch pathway in glioma stem cells","volume":"29","author":"Cao","year":"2023","journal-title":"CNS. Neurosci. Ther."},{"key":"10.1016\/j.ctarc.2026.101283_bib0125","article-title":"CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101283_bib0126","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/neuonc\/noad018","article-title":"Lysine-specific histone demethylase 1A (KDM1A\/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma","volume":"25","author":"Alejo","year":"2023","journal-title":"Neuro Oncol."},{"issue":"7882","key":"10.1016\/j.ctarc.2026.101283_bib0127","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41586-021-03994-2","article-title":"KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements","volume":"598","author":"Zhang","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0128","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/1874467211205010102","article-title":"Temozolomide: mechanisms of action, repair and resistance","volume":"5","author":"Zhang","year":"2012","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.ctarc.2026.101283_bib0129","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105780","article-title":"Glioblastoma multiforme (GBM): an overview of current therapies and mechanisms of resistance","volume":"171","author":"Wu","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101283_bib0130","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41419-024-06902-4","article-title":"Erianin induces ferroptosis in GSCs via REST\/LRSAM1 mediated SLC40A1 ubiquitination to overcome TMZ resistance","volume":"15","author":"Mansuer","year":"2024","journal-title":"Cell Death. Dis."},{"issue":"15","key":"10.1016\/j.ctarc.2026.101283_bib0131","doi-asserted-by":"crossref","first-page":"24518","DOI":"10.18632\/oncotarget.15543","article-title":"Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity","volume":"8","author":"Gursoy-Yuzugullu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ctarc.2026.101283_bib0132","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3389\/fphar.2018.01271","article-title":"Pre-treatment or post-treatment of Human glioma cells with BIX01294, the inhibitor of histone methyltransferase G9a, sensitizes cells to temozolomide","volume":"9","author":"Ciechomska","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101283_bib0133","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.215525","article-title":"Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability","volume":"131","author":"Zhang","year":"2018","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101283_bib0134","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11060878","article-title":"Targeting of histone demethylases KDM5A and KDM6B inhibits the proliferation of temozolomide-resistant glioblastoma cells","volume":"11","author":"Romani","year":"2019","journal-title":"Cancers. (Basel)"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0135","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13045-021-01041-1","article-title":"The emerging role of KDM5A in human cancer","volume":"14","author":"Yang","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"20","key":"10.1016\/j.ctarc.2026.101283_bib0136","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1021\/acs.accounts.5c00488","article-title":"Precision phototherapy enabled by decoding complex microenvironments","volume":"58","author":"Ding","year":"2025","journal-title":"Acc. Chem. Res."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101283_bib0137","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66247-y","article-title":"Diagnostic accuracy of artificial intelligence in detecting left ventricular hypertrophy by electrocardiograph: a systematic review and meta-analysis","volume":"14","author":"Siranart","year":"2024","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101283_bib0138","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/s41590-024-01917-7","article-title":"Author correction: distinct developmental pathways generate functionally distinct populations of natural killer cells","volume":"25","author":"Ding","year":"2024","journal-title":"Nat. Immunol."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226001942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226001942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:54:15Z","timestamp":1790913255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294226001942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":138,"alternative-id":["S2468294226001942"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101283","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone methylation machinery in gliomas: From enzymatic mechanisms to inhibitor development","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101283"}}