{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:53:31Z","timestamp":1790916811218,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":194,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007207","name":"Toray Industries Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2026.101328","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:50:01Z","timestamp":1784613001000},"page":"101328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association of apolipoprotein A2 isoform index with demographic, behavioral, and clinical risk factors for pancreatic ductal adenocarcinoma in a single-center observational study: considerations for development of a pancreatic cancer screening algorithm?"],"prefix":"10.1016","volume":"48","author":[{"given":"Alan H.B.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chui Mei","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Alamillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakary","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giman","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctarc.2026.101328_bib0001","article-title":"Key statistics for pancreatic cancer","year":"2026","journal-title":"American Cancer Society"},{"key":"10.1016\/j.ctarc.2026.101328_bib0002","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10689-024-00372-5","article-title":"Genetic and other risk factors for pancreatic ductal adenocarcinoma (PDAC)","volume":"23","author":"Jacobs","year":"2024","journal-title":"Fam. Cancer"},{"key":"10.1016\/j.ctarc.2026.101328_bib0003","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1053\/j.seminoncol.2016.09.002","article-title":"Familial pancreatic cancer","volume":"43","author":"Petersen","year":"2016","journal-title":"Sem. Oncol."},{"key":"10.1016\/j.ctarc.2026.101328_bib0004","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4240\/wjgs.v12.i12.468","article-title":"Carbohydrate antigen 19-9 tumor marker: past, present and future","volume":"12","author":"Lee","year":"2020","journal-title":"World J. Gastrontest. Surg."},{"key":"10.1016\/j.ctarc.2026.101328_bib0005","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/MEG.0000000000002415","article-title":"Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: a systematic review and meta-analysis","volume":"34","author":"Zhao","year":"2022","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ctarc.2026.101328_bib0006","first-page":"314","article-title":"Usefulness of carbohydrate antigen 19-9 test in healthy people and necessity of medical follow-up in individuals with elevated carbohydrate antigen 19-9","volume":"40","author":"Lee","year":"2018","journal-title":"Kor. J. Fam. Fem."},{"issue":"40","key":"10.1016\/j.ctarc.2026.101328_bib0007","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/MPA.0000000000001687","article-title":"Lewis antigen phenotype and survival of patients with pancreatic cancer","volume":"49","author":"Kwon","year":"2020","journal-title":"Pancreas"},{"key":"10.1016\/j.ctarc.2026.101328_bib0008","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.pan.2024.01.009","article-title":"The prognostic and predictive role of class III \u03b2-tubulin and hENT1 expression in patients with advanced pancreatic ductal adenocarcinoma","volume":"24","author":"Sahin","year":"2024","journal-title":"Pancreatol"},{"key":"10.1016\/j.ctarc.2026.101328_bib0009","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/epigenomes8040041","article-title":"Epigenetic landscape of DNA methylation in pancreatic ductal adenocarcinoma","volume":"8","author":"Liu","year":"2024","journal-title":"Epigen"},{"key":"10.1016\/j.ctarc.2026.101328_bib0010","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1158\/1078-0432.CCR-18-3310","article-title":"The sTRA plasma biomarker: blinded validation of improved accuracy over CA19-9 in pancreatic cancer diagnosis","volume":"25","author":"Staal","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101328_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217245","article-title":"A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone","volume":"604","author":"Haab","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ctarc.2026.101328_bib0012","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2217\/bmm-2016-0209","article-title":"Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer","volume":"10","author":"Honda","year":"2016","journal-title":"Biomark. Med."},{"key":"10.1016\/j.ctarc.2026.101328_bib0013","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00535-023-02072-w","article-title":"Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer","volume":"59","author":"Kashiro","year":"2024","journal-title":"J. Gastroenetrol."},{"key":"10.1016\/j.ctarc.2026.101328_bib0014","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/CBM-210198","article-title":"Risk stratification of pancreatic cancer by a blood test for apolipoprotein A2-isoforms","volume":"33","author":"Honda","year":"2022","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.ctarc.2026.101328_bib0015","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.3390\/diagnostics14171920","article-title":"Potential of carbohydrate antigen 19-9 and serum apolipoprotein A2-isoforms in the diagnosis of stage 0 and IA pancreatic cancer","volume":"14","author":"Hanada","year":"2024","journal-title":"Diagnosis"},{"key":"10.1016\/j.ctarc.2026.101328_bib0016","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/cancers17071071","article-title":"Evaluating the usefulness of the blood apolipoprotein A2 isoform index for pancreatic cancer diagnosis","volume":"17","author":"Shionoya","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.ctarc.2026.101328_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102193","article-title":"Blood biomarkers for differential diagnosis and early detection of pancreatic cancer","volume":"96","author":"Al-Shaheri","year":"2021","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ctarc.2026.101328_bib0018","article-title":"Metabolite biomarkers for early detection of pancreatic ductal adenocarcinoma: a systematic review","volume":"16","author":"Eze-Odurukwe","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ctarc.2026.101328_bib0019","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s00535-024-02197-6","article-title":"An integrative multi-omics analysis reveals a multi-analyte signature of pancreatic ductal adenocarcinoma in serum","volume":"60","author":"Balay","year":"2025","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ctarc.2026.101328_bib0020","first-page":"250","article-title":"Multibiomarker panel in liquid biopsy for early detection or pancreqt cancer-a comprehensive review","volume":"42","author":"Reese KL","year":"2004","journal-title":"J. Esxp. Lin. Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101328_bib0021","article-title":"A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer","volume":"12","author":"Vockorny","year":"2023","journal-title":"eLife"},{"issue":"55","key":"10.1016\/j.ctarc.2026.101328_bib0022","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1097\/MPA.0000000000002559","article-title":"Alteration of apolipoprotein A2 isoforms is associated with progression of chronic pancreatitis","volume":"55","author":"Abe","year":"2026","journal-title":"Pancreas"},{"key":"10.1016\/j.ctarc.2026.101328_bib0023","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3390\/life14080980","article-title":"Pancreatic cancer: a review of risk factors","volume":"14","author":"Grigorescu","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.ctarc.2026.101328_bib0024","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1158\/1055-9965.EPI-19-1027","article-title":"Pancreatic cancer risk in relation to lifetime smoking patterns, tobacco type, and dose\u2013response relationships","volume":"29","author":"Molina-Montes","year":"2020","journal-title":"Cancer Epidemiol. Biom. Prev."},{"issue":"26","key":"10.1016\/j.ctarc.2026.101328_bib0025","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pan.2026.01.009","article-title":"Obesity as a risk and prognostic factor for disease progression in intraductal papillary mucinous neoplasm (IPMN): a systematic review and meta-analysis","volume":"26","author":"Parhiala","year":"2026","journal-title":"Pancreatol"},{"key":"10.1016\/j.ctarc.2026.101328_bib0026","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s41431-023-01301-3","article-title":"Abdominal obesity is a more important causal risk factor for pancreatic cancer than overall obesity","volume":"31","author":"Maina","year":"2023","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ctarc.2026.101328_bib0027","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/nutrit\/nux038","article-title":"Dietary patterns and risk for pancreatic cancer: a systematic review","volume":"75","author":"Zheng","year":"2017","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.ctarc.2026.101328_bib0028","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/ijc.24997","article-title":"Can physical activity modulate pancreatic cancer risk? A systematic review and meta-analysis","volume":"126","author":"O\u2019Rorke","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ctarc.2026.101328_bib0029","first-page":"2401","article-title":"The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinoma","volume":"56","author":"Sing","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ctarc.2026.101328_bib0030","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.3390\/cancers14194684","article-title":"Risk factors for pancreatic cancer in patients with new-onset diabetes: a systematic review and meta-analysis","volume":"14","author":"Mellenthin","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.ctarc.2026.101328_bib0031","article-title":"Extraordinarily high serum CA19-9 in setting of pancreatic necrosis and underlying pancreatic adenocarcinoma: a case report","volume":"2023","author":"McConnell","year":"2023","journal-title":"J. Surg. Cases Rjad"},{"issue":"22","key":"10.1016\/j.ctarc.2026.101328_bib0032","first-page":"159","article-title":"The Pancreatic Cancer Early Detection (PRECEDE) Study is a global effort to drive early detection: baseline imaging findings in high-risk individuals","author":"Zogopoulos","year":"2024","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.ctarc.2026.101328_bib0033","series-title":"Biological Variation: From Principle to Practice","author":"Fraser","year":"2001"},{"key":"10.1016\/j.ctarc.2026.101328_bib0034","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/00365510701601699","article-title":"Biological variation and reference change values of CA 19-9, CEA, AFP in serum of healthy individuals","volume":"68","author":"Erden","year":"2008","journal-title":"Scan. J. Clin. Lab. Invest."},{"key":"10.1016\/j.ctarc.2026.101328_bib0035","doi-asserted-by":"crossref","DOI":"10.1177\/15353508241245265","article-title":"Combining nuclear medicine with other modalities: future prospect for multimodality imaging","volume":"23","author":"Archibald","year":"2024","journal-title":"Mol. Imag."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246829422600239X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S246829422600239X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:57:18Z","timestamp":1790913438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S246829422600239X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"alternative-id":["S246829422600239X"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101328","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of apolipoprotein A2 isoform index with demographic, behavioral, and clinical risk factors for pancreatic ductal adenocarcinoma in a single-center observational study: considerations for development of a pancreatic cancer screening algorithm?","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101328","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101328"}}