{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:59:15Z","timestamp":1790913555203,"version":"4.1.0"},"reference-count":148,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2026.101341","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:53:18Z","timestamp":1786135998000},"page":"101341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CRISPR-Cas9 gene editing approaches in colorectal cancer: Current progress and future prospects"],"prefix":"10.1016","volume":"48","author":[{"given":"Mohadeseh","family":"Hassannia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Amirifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ctarc.2026.101341_bib0001","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/cac2.12197","article-title":"Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in","volume":"41","author":"Qiu","year":"2021","journal-title":"Cancer Commun."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0002","first-page":"233","article-title":"Colorectal cancer statistics","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0003","first-page":"9","article-title":"Molecular genetics of colorectal cancer","volume":"27","author":"Bogaert","year":"2014","journal-title":"Ann. Gastroenterol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0004","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","article-title":"Development and applications of CRISPR-Cas9 for genome engineering","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ctarc.2026.101341_bib0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/archdischild-2016-310459","article-title":"What is CRISPR\/Cas9?","volume":"101","author":"Redman","year":"2016","journal-title":"Arch. Dis. Child.-Edu. Pract."},{"issue":"18","key":"10.1016\/j.ctarc.2026.101341_bib0006","doi-asserted-by":"crossref","first-page":"9872","DOI":"10.3390\/ijms22189872","article-title":"Points of view on the tools for genome\/gene editing","volume":"22","author":"Chuang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101341_bib0007","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/genes8120399","article-title":"Genome editing tools in plants","volume":"8","author":"Mohanta","year":"2017","journal-title":"Genes"},{"issue":"11","key":"10.1016\/j.ctarc.2026.101341_bib0008","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101341_bib0009","doi-asserted-by":"crossref","first-page":"219","DOI":"10.61186\/ibj.27.5.219","article-title":"CRISPR-Cas technology as a revolutionary genome editing tool: mechanisms and biomedical applications","volume":"27","author":"Ebrahimi","year":"2023","journal-title":"Iran. Biomed. J."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0010","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nbt.2909","article-title":"Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification","volume":"32","author":"Guilinger","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0011","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12943-020-01156-y","article-title":"Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance","volume":"19","author":"Pothuraju","year":"2020","journal-title":"Mol Cancer."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0012","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41579-019-0299-x","article-title":"Evolutionary classification of CRISPR\u2013Cas systems: a burst of class 2 and derived variants","volume":"18","author":"Makarova","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ctarc.2026.101341_bib0013","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mib.2017.05.008","article-title":"Diversity, classification and evolution of CRISPR-Cas systems","volume":"37","author":"Koonin","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101341_bib0014","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1093\/gbe\/evx192","article-title":"Mobile genetic elements and evolution of CRISPR-Cas systems: all the way there and back","volume":"9","author":"Koonin","year":"2017","journal-title":"Genome Biol. Evol."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101341_bib0015","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tree.2008.06.005","article-title":"Origins and evolution of eukaryotic RNA interference","volume":"23","author":"Shabalina","year":"2008","journal-title":"Trends. Ecol. Evol."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0016","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12033-022-00567-0","article-title":"A review on the mechanism and applications of CRISPR\/Cas9\/Cas12\/Cas13\/Cas14 proteins utilized for genome engineering","volume":"65","author":"Hillary","year":"2023","journal-title":"Mol. Biotechnol."},{"issue":"5819","key":"10.1016\/j.ctarc.2026.101341_bib0017","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.1138140","article-title":"CRISPR provides acquired resistance against viruses in prokaryotes","volume":"315","author":"Barrangou","year":"2007","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0018","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.str.2009.03.019","article-title":"Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense","volume":"17","author":"Wiedenheft","year":"2009","journal-title":"Structure"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0019","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ncomms1937","article-title":"Molecular memory of prior infections activates the CRISPR\/Cas adaptive bacterial immunity system","volume":"3","author":"Datsenko","year":"2012","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0020","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1365-2958.2010.07465.x","article-title":"A dual function of the CRISPR\u2013Cas system in bacterial antivirus immunity and DNA repair","volume":"79","author":"Babu","year":"2011","journal-title":"Mol. Microbiol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101341_bib0021","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1093\/nar\/gks216","article-title":"Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli","volume":"40","author":"Yosef","year":"2012","journal-title":"Nucleic. Acids. Res."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101341_bib0022","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nsmb.3289","article-title":"Protecting genome integrity during CRISPR immune adaptation","volume":"23","author":"Wright","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"7600","key":"10.1016\/j.ctarc.2026.101341_bib0023","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature17945","article-title":"The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA","volume":"532","author":"Fonfara","year":"2016","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0024","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2015.09.038","article-title":"Cpf1 Is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system","volume":"163","author":"Zetsche","year":"2015","journal-title":"Cell"},{"issue":"6387","key":"10.1016\/j.ctarc.2026.101341_bib0025","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.aar6245","article-title":"CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity","volume":"360","author":"Chen","year":"2018","journal-title":"Science"},{"issue":"7340","key":"10.1016\/j.ctarc.2026.101341_bib0026","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nature09886","article-title":"CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III","volume":"471","author":"Deltcheva","year":"2011","journal-title":"Nat"},{"issue":"7624","key":"10.1016\/j.ctarc.2026.101341_bib0027","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature19802","article-title":"Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection","volume":"538","author":"East-Seletsky","year":"2016","journal-title":"Nat"},{"issue":"7640","key":"10.1016\/j.ctarc.2026.101341_bib0028","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature21059","article-title":"New CRISPR\u2013Cas systems from uncultivated microbes","volume":"542","author":"Burstein","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0029","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2016.12.031","article-title":"Two distant catalytic sites are responsible for C2c2 RNase activities","volume":"168","author":"Liu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ctarc.2026.101341_bib0030","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ejphar.2019.04.042","article-title":"Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: a promising approach for gene therapy of beta thalassemia disease","volume":"854","author":"Khosravi","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ctarc.2026.101341_bib0031","article-title":"Expression analysis data of BCL11A and \u03b3-globin genes in KU812 and KG-1 cell lines after CRISPR\/Cas9-mediated BCL11A enhancer deletion","volume":"28","author":"Khosravi","year":"2019","journal-title":"Data Brief."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0032","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.cell.2016.04.003","article-title":"Crystal structure of Cpf1 in complex with guide RNA and target DNA","volume":"165","author":"Yamano","year":"2016","journal-title":"Cell"},{"issue":"7519","key":"10.1016\/j.ctarc.2026.101341_bib0033","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature13579","article-title":"Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease","volume":"513","author":"Anders","year":"2014","journal-title":"Nature"},{"issue":"6096","key":"10.1016\/j.ctarc.2026.101341_bib0034","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek","year":"2012","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.ctarc.2026.101341_bib0035","first-page":"2333","article-title":"Insert, remove or replace: a highly advanced genome editing system using CRISPR\/Cas9","author":"Ceasar","year":"1863","journal-title":"Biochim. Biophys. Acta (BBA)-Molecular Cell Res."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0036","first-page":"1559","article-title":"Genome editing: a perspective on the application of CRISPR\/Cas9 to study human diseases","volume":"43","author":"Garza-Elizondo","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"6121","key":"10.1016\/j.ctarc.2026.101341_bib0037","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"issue":"39","key":"10.1016\/j.ctarc.2026.101341_bib0038","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1208507109","article-title":"Cas9\u2013crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria","volume":"109","author":"Gasiunas","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0039","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2013.06.044","article-title":"CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes","volume":"154","author":"Gilbert","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ctarc.2026.101341_bib0040","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00471","article-title":"RNA-programmed genome editing in human cells","volume":"2","author":"Jinek","year":"2013","journal-title":"Elife"},{"issue":"6121","key":"10.1016\/j.ctarc.2026.101341_bib0041","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","article-title":"RNA-guided human genome engineering via Cas9","volume":"339","author":"Mali","year":"2013","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.ctarc.2026.101341_bib0042","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0043","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tig.2021.02.008","article-title":"DNA repair pathway choices in CRISPR-Cas9-mediated genome editing","volume":"37","author":"Xue","year":"2021","journal-title":"Trends. Genet."},{"issue":"6320","key":"10.1016\/j.ctarc.2026.101341_bib0044","doi-asserted-by":"crossref","DOI":"10.1126\/science.aah7111","article-title":"CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells","volume":"355","author":"Liu","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0045","first-page":"12","article-title":"Challenges of CRISPR\/Cas9 applications for long non-coding RNA genes","volume":"45","author":"Goyal","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101341_bib0046","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1101\/gr.179044.114","article-title":"Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE-and CRISPR\/Cas9-based transcriptional activators","volume":"25","author":"Polstein","year":"2015","journal-title":"Genome Res."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101341_bib0047","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nmeth.2600","article-title":"RNA-guided gene activation by CRISPR-Cas9\u2013based transcription factors","volume":"10","author":"Perez-Pinera","year":"2013","journal-title":"Nat. Methods"},{"issue":"10","key":"10.1016\/j.ctarc.2026.101341_bib0048","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nmeth.2598","article-title":"CRISPR RNA-guided activation of endogenous human genes","volume":"10","author":"Maeder","year":"2013","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0049","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nmeth.3312","article-title":"Highly efficient Cas9-mediated transcriptional programming","volume":"12","author":"Chavez","year":"2015","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0050","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","article-title":"Genome-scale CRISPR-mediated control of gene repression and activation","volume":"159","author":"Gilbert","year":"2014","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0051","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2014.09.039","article-title":"A protein-tagging system for signal amplification in gene expression and fluorescence imaging","volume":"159","author":"Tanenbaum","year":"2014","journal-title":"Cell"},{"issue":"7536","key":"10.1016\/j.ctarc.2026.101341_bib0052","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature14136","article-title":"Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex","volume":"517","author":"Konermann","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ctarc.2026.101341_bib0053","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ccell.2015.10.002","article-title":"Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis","volume":"28","author":"Anderson","year":"2015","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0054","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molcel.2017.09.029","article-title":"Methods and applications of CRISPR-mediated base editing in eukaryotic genomes","volume":"68","author":"Hess","year":"2017","journal-title":"Mol. Cell"},{"issue":"7603","key":"10.1016\/j.ctarc.2026.101341_bib0055","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature17946","article-title":"Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage","volume":"533","author":"Komor","year":"2016","journal-title":"Nature"},{"issue":"6275","key":"10.1016\/j.ctarc.2026.101341_bib0056","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1126\/science.aad8282","article-title":"Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage","volume":"351","author":"Jiang","year":"2016","journal-title":"Science"},{"issue":"7785","key":"10.1016\/j.ctarc.2026.101341_bib0057","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","article-title":"Search-and-replace genome editing without double-strand breaks or donor DNA","volume":"576","author":"Anzalone","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0058","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2013.03.002","article-title":"Lessons from the cancer genome","volume":"153","author":"Garraway","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ctarc.2026.101341_bib0059","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1148412","article-title":"Application of CRISPR-Cas9 gene editing technology in basic research, diagnosis and treatment of colon cancer","volume":"14","author":"Meng","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0060","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.celrep.2016.09.079","article-title":"A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia","volume":"17","author":"Tzelepis","year":"2016","journal-title":"Cell Rep."},{"issue":"6166","key":"10.1016\/j.ctarc.2026.101341_bib0061","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.1246981","article-title":"Genetic screens in human cells using the CRISPR-Cas9 system","volume":"343","author":"Wang","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ctarc.2026.101341_bib0062","article-title":"KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer","volume":"6","author":"Krall","year":"2017","journal-title":"Elife"},{"issue":"7669","key":"10.1016\/j.ctarc.2026.101341_bib0063","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature23477","article-title":"Identification of essential genes for cancer immunotherapy","volume":"548","author":"Patel","year":"2017","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0064","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2019.07.019","article-title":"Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint blockade","volume":"178","author":"Benci","year":"2019","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0065","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1158\/2326-6066.CIR-18-0500","article-title":"A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients","volume":"7","author":"Cursons","year":"2019","journal-title":"Cancer Immunol. Res."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101341_bib0066","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1016\/j.celrep.2019.08.017","article-title":"Natural killer cells suppress T cell-associated tumor immune evasion","volume":"28","author":"Freeman","year":"2019","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101341_bib0067","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/s41588-021-00889-w","article-title":"Genome-scale screens identify factors regulating tumor cell responses to natural killer cells","volume":"53","author":"Sheffer","year":"2021","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0068","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nbt.3836","article-title":"In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis","volume":"35","author":"Roper","year":"2017","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0069","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s13046-023-02901-z","article-title":"CRISPR\/Cas9: a powerful tool in colorectal cancer research","volume":"42","author":"Hu","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0071","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/BC20040094","article-title":"Wnt, stem cells and cancer in the intestine","volume":"97","author":"Pinto","year":"2005","journal-title":"Biol. Cell"},{"issue":"17","key":"10.1016\/j.ctarc.2026.101341_bib0072","first-page":"4682","article-title":"Ras oncogenes in human cancer: a review","volume":"49","author":"Bos","year":"1989","journal-title":"Cancer Res."},{"issue":"7407","key":"10.1016\/j.ctarc.2026.101341_bib0073","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","year":"2012","journal-title":"Nature"},{"issue":"7407","key":"10.1016\/j.ctarc.2026.101341_bib0074","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Network","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0075","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yexcr.2018.11.002","article-title":"FAPP2 promotes tumor cell growth in human colon cancer through activation of wnt signaling","volume":"374","author":"Chen","year":"2019","journal-title":"Exp Cell Res [Internet]"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0076","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.bbrc.2016.11.154","article-title":"Par3L enhances colorectal cancer cell survival by inhibiting Lkb1\/AMPK signaling pathway","volume":"482","author":"Li","year":"2017","journal-title":"Biochem. Biophys. Res. Commun. [Internet]"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0081","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/cells9020308","article-title":"uPAR knockout results in a deep glycolytic and OXPHOS reprogramming in melanoma and colon carcinoma cell lines","volume":"9","author":"Biagioni","year":"2020","journal-title":"Cells"},{"issue":"48","key":"10.1016\/j.ctarc.2026.101341_bib0082","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.1038\/s41388-021-01882-7","article-title":"CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer","volume":"40","author":"Gao","year":"2021","journal-title":"Oncogene [Internet]"},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0083","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41416-021-01681-7","article-title":"The CBS-H2S axis promotes liver metastasis of colon cancer by upregulating VEGF through AP-1 activation","volume":"126","author":"Guo","year":"2022","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0084","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000477484","article-title":"Aldolase B overexpression is associated with poor prognosis and promotes tumor progression by epithelial-mesenchymal transition in colorectal adenocarcinoma","volume":"42","author":"Li","year":"2017","journal-title":"Cell Physiol. Biochem."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0085","article-title":"Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress","volume":"8","author":"Xia","year":"2017","journal-title":"Cell Death Dis. [Internet]"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0093","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12964-017-0192-z","article-title":"CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the wnt\/beta-catenin signaling pathway","volume":"15","author":"Li","year":"2017","journal-title":"Cell Commun. Signal [Internet]"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0094","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3390\/cancers14030671","article-title":"Loss of neuropilin-2 in murine mesenchymal-like colon cancer organoids causes mesenchymal-to-epithelial transition and an acquired dependency on insulin-receptor signaling and autophagy","volume":"14","author":"Poghosyan","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"11","key":"10.1016\/j.ctarc.2026.101341_bib0095","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3390\/cells8111343","article-title":"Absence of the Tks4 scaffold protein induces epithelial-mesenchymal transition-like changes in human colon cancer cells","volume":"8","author":"Szeder","year":"2019","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0099","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1158\/1541-7786.MCR-20-0867","article-title":"AP-2\u03b1 regulates S-phase and is a marker for sensitivity to PI3K inhibitor buparlisib in colon cancer","volume":"19","author":"Beck","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101341_bib0100","article-title":"PUM1 is overexpressed in colon cancer cells with acquired resistance to cetuximab","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"37","key":"10.1016\/j.ctarc.2026.101341_bib0097","doi-asserted-by":"crossref","first-page":"60575","DOI":"10.18632\/oncotarget.11169","article-title":"Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells","volume":"7","author":"Hosain","year":"2016","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0101","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1021\/acs.molpharmaceut.0c00961","article-title":"Tumor-associated macrophages promote oxaliplatin resistance via METTL3-mediated m 6 A of TRAF5 and necroptosis in colorectal cancer","volume":"18","author":"Lan","year":"2021","journal-title":"Mol. Pharm. [Internet]"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0102","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41388-021-02077-w","article-title":"Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer","volume":"41","author":"Yu","year":"2022","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.ctarc.2026.101341_bib0108","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1089\/jir.2021.0078","article-title":"Engineering NK-92 cell by upregulating CXCR2 and IL-2 via CRISPR-Cas9 improves its antitumor effects as cellular immunotherapy for human colon cancer","volume":"41","author":"Gao","year":"2021","journal-title":"J. Interf. Cytokine Res."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0119","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.bbrc.2019.04.190","article-title":"The SNP of rs6854845 suppresses transcription via the DNA looping structure alteration of super-enhancer in colon cells","volume":"514","author":"Cong","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0118","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neo.2018.01.003","article-title":"Single nucleotide polymorphism facilitated down-regulation of the cohesin stromal antigen-1: implications for colorectal cancer racial disparities","volume":"20","author":"Datta","year":"2018","journal-title":"Neoplasia"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0117","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1158\/1055-9965.EPI-19-1116","article-title":"Genetic predisposition to colon and rectal adenocarcinoma is mediated by a super-enhancer polymorphism coactivating CD9 and PLEKHG6","volume":"29","author":"Ke","year":"2020","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0116","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1038\/ncomms6114","article-title":"Functional annotation of colon cancer risk SNPs","volume":"5","author":"Yao","year":"2014","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101341_bib0120","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-021-01595-7","article-title":"Enhancement of Apo2L\/TRAIL signaling pathway receptors by the activation of Klotho gene with CRISPR\/Cas9 in Caco-2 colon cancer cells","volume":"38","author":"Gunes","year":"2021","journal-title":"Med. Oncol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0121","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1158\/1541-7786.MCR-16-0361","article-title":"CRISPR knockout of the HuR gene causes a xenograft lethal phenotype","volume":"15","author":"Lal","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101341_bib0122","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2147\/OTT.S225556","article-title":"Cas9 mediated correction of \u03b2-catenin mutation and restoring the expression of protein phosphorylation in colon cancer HCT-116 cells decrease cell proliferation in vitro and hamper tumor growth in mice in vivo","volume":"13","author":"Li","year":"2020","journal-title":"Onco Targets. Ther."},{"key":"10.1016\/j.ctarc.2026.101341_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2022.198979","article-title":"Construction of an IL12 and CXCL11 armed oncolytic herpes simplex virus using the CRISPR\/Cas9 system for colon cancer treatment","volume":"323","author":"Zhang","year":"2023","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0126","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41388-020-01523-5","article-title":"Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth","volume":"40","author":"Li","year":"2021","journal-title":"Oncogene"},{"issue":"46","key":"10.1016\/j.ctarc.2026.101341_bib0077","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.18632\/oncotarget.27804","article-title":"Intracellular hyaluronic acid-binding protein 4 (HABP4): a candidate tumor suppressor in colorectal cancer","volume":"11","author":"Melo-Hanchuk","year":"2020","journal-title":"Oncotarget."},{"issue":"37","key":"10.1016\/j.ctarc.2026.101341_bib0078","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1038\/s41388-020-01416-7","article-title":"Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer","volume":"39","author":"Cai","year":"2020","journal-title":"Oncogene"},{"issue":"22","key":"10.1016\/j.ctarc.2026.101341_bib0079","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1802902115","article-title":"PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids","volume":"115","author":"Liu","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0080","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-022-01518-8","article-title":"Current applications and future perspective of CRISPR\/Cas9 gene editing in cancer","volume":"21","author":"Wang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"41","key":"10.1016\/j.ctarc.2026.101341_bib0086","doi-asserted-by":"crossref","first-page":"15947","DOI":"10.1074\/jbc.RA118.004180","article-title":"Double genetic disruption of lactate dehydrogenases A and B is required to ablate the \u201cWarburg effect\u201d restricting tumor growth to oxidative metabolism","volume":"293","author":"\u017ddralevi\u0107","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0087","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193560","article-title":"Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0088","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1158\/0008-5472.CAN-15-1512","article-title":"NADPH oxidase 1 activity and ROS generation are regulated by Grb2\/Cbl-mediated proteasomal degradation of NoxO1 in colon cancer cells","volume":"76","author":"Joo","year":"2016","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101341_bib0089","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1038\/s41419-017-0006-7","article-title":"ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line","volume":"8","author":"Nishi","year":"2017","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101341_bib0090","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.21873\/anticanres.14649","article-title":"Overexpression of pyruvate carboxylase is correlated with colorectal cancer progression and supports growth of invasive colon cancer HT-29 cell line","volume":"40","author":"Ngamkham","year":"2020","journal-title":"Anticancer Res."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0091","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ccell.2019.01.005","article-title":"Aging-like spontaneous epigenetic silencing facilitates wnt activation, stemness, and BrafV600E-induced tumorigenesis","volume":"35","author":"Tao","year":"2019","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0092","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/jcsm.12346","article-title":"Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice","volume":"9","author":"Kandarian","year":"2018","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"12","key":"10.1016\/j.ctarc.2026.101341_bib0096","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1158\/1535-7163.MCT-18-1225","article-title":"Hyaluronic acid binding to TLR4 promotes proliferation and blocks apoptosis in colon cancer","volume":"18","author":"Makkar","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ctarc.2026.101341_bib0098","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15945","article-title":"R-spondin chromosome rearrangements drive wnt-dependent tumour initiation and maintenance in the intestine","volume":"8","author":"Han","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0103","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-022-01290-y","article-title":"Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer","volume":"14","author":"Zhou","year":"2022","journal-title":"Clin. Epigenetics"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0104","first-page":"3769","article-title":"Identification of \u03b2-catenin target genes in colorectal cancer by interrogating gene fitness screening data","volume":"18","author":"Zhao","year":"2019","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101341_bib0105","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.celrep.2017.06.061","article-title":"A role for mitochondrial translation in promotion of viability in K-Ras mutant cells","volume":"20","author":"Martin","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0106","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/cr.2016.142","article-title":"CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells","volume":"27","author":"Liu","year":"2017","journal-title":"Cell Res."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101341_bib0107","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41577-019-0221-9","article-title":"Defining \u2018T cell exhaustion\u2019","volume":"19","author":"Blank","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101341_bib0109","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1038\/s41423-021-00749-x","article-title":"Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors","volume":"18","author":"Wang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ctarc.2026.101341_bib0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40425-017-0222-9","article-title":"Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer","volume":"5","author":"Hege","year":"2017","journal-title":"J. Immunother. Cancer."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0111","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.100978","article-title":"12P CRISPR\/Cas9-induced knock-out of DGK\u03b1\u03b6 in TAG-72 CAR-T cells improves function and persistence in ovarian cancer","volume":"8","author":"Evtimov","year":"2023","journal-title":"ESMo Open."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101341_bib0112","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1002\/cam4.2361","article-title":"Significantly increased anti-tumor activity of carcinoembryonic antigen-specific chimeric antigen receptor T cells in combination with recombinant human IL-12","volume":"8","author":"Chi","year":"2019","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0113","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001688","article-title":"Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function","volume":"9","author":"Kumar","year":"2021","journal-title":"J. ImmunOther. Cancer"},{"issue":"12","key":"10.1016\/j.ctarc.2026.101341_bib0114","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1084\/jem.20150304","article-title":"Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance","volume":"212","author":"Palmer","year":"2015","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0115","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1158\/0008-5472.CAN-06-3977","article-title":"Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling","volume":"67","author":"Zhao","year":"2007","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101341_bib0124","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/s41416-022-01916-1","article-title":"Neuropeptide Y, a paracrine factor secreted by cancer cells, is an independent regulator of angiogenesis in colon cancer","volume":"127","author":"Chakroborty","year":"2022","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0125","doi-asserted-by":"crossref","first-page":"9384","DOI":"10.1038\/s41598-017-09976-7","article-title":"Hypoxia-inducible ERO1\u03b1 promotes cancer progression through modulation of integrin-\u03b21 modification and signalling in HCT116 colorectal cancer cells","volume":"7","author":"Takei","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0127","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jcmgh.2018.08.005","article-title":"NHE8 deficiency promotes colitis-associated cancer in mice via expansion of Lgr5-expressing cells","volume":"7","author":"Xu","year":"2019","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101341_bib0128","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.neo.2018.03.001","article-title":"Novel regulatory roles of Wnt1 in infection-associated colorectal cancer","volume":"20","author":"Wang","year":"2018","journal-title":"Neoplasia"},{"issue":"7789","key":"10.1016\/j.ctarc.2026.101341_bib0129","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-1844-5","article-title":"Somatic inflammatory gene mutations in human ulcerative colitis epithelium","volume":"577","author":"Nanki","year":"2020","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ctarc.2026.101341_bib0130","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/biot.201400046","article-title":"CRISPR\/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox","volume":"9","author":"Sen\u00eds","year":"2014","journal-title":"Biotechnol. J."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0131","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78450-8","article-title":"Efficient viral delivery of Cas9 into human safe harbor","volume":"10","author":"Hayashi","year":"2020","journal-title":"Sci. Rep."},{"issue":"47","key":"10.1016\/j.ctarc.2026.101341_bib0132","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc9450","article-title":"CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy","volume":"6","author":"Rosenblum","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ctarc.2026.101341_bib0133","article-title":"CRISPR\/Cas: Advances, Limitations, and Applications for Precision Cancer Research","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Med. (Lausanne)."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101341_bib0134","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.apsb.2021.05.020","article-title":"In vivo delivery of CRISPR-Cas9 therapeutics: progress and challenges","volume":"11","author":"Behr","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101341_bib0135","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3390\/cancers14040947","article-title":"Current Status of CRISPR\/Cas9 Application in Clinical Cancer Research: Opportunities and Challenges","volume":"14","author":"Rafii","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.ctarc.2026.101341_bib0136","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/mt.2010.35","article-title":"Frequent endonuclease cleavage at off-target locations in vivo","volume":"18","author":"Petek","year":"2010","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101341_bib0137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-018-4561-9","article-title":"UDiTaS\u2122, A genome editing detection method for indels and genome rearrangements","volume":"19","author":"Giannoukos","year":"2018","journal-title":"BMC Genomics."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0138","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41591-018-0049-z","article-title":"CRISPR\u2013Cas9 genome editing induces a p53-mediated DNA damage response","volume":"24","author":"Haapaniemi","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.ctarc.2026.101341_bib0139","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1038\/s41467-021-26788-6","article-title":"A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing","volume":"12","author":"Sinha","year":"2021","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0140","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41588-020-0623-4","article-title":"Cas9 activates the p53 pathway and selects for p53-inactivating mutations","volume":"52","author":"Enache","year":"2020","journal-title":"Nat. Genet."},{"issue":"17","key":"10.1016\/j.ctarc.2026.101341_bib0141","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.3390\/ijms21176240","article-title":"CRISPR-Cas9 DNA Base-Editing and Prime-Editing","volume":"21","author":"Kantor","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101341_bib0142","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nmeth.4327","article-title":"CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations","volume":"14","author":"Kuscu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ctarc.2026.101341_bib0143","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.803252","article-title":"Strategies for high-efficiency mutation using the CRISPR\/Cas system","volume":"9","author":"Feng","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0144","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nbt.2808","article-title":"Improving CRISPR-Cas nuclease specificity using truncated guide RNAs","volume":"32","author":"Fu","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101341_bib0145","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nchembio.2559","article-title":"Partial DNA-guided Cas9 enables genome editing with reduced off-target activity","volume":"14","author":"Yin","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ctarc.2026.101341_bib0146","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1143157","article-title":"Off-target effects in CRISPR\/Cas9 gene editing","volume":"11","author":"Guo","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ctarc.2026.101341_bib0147","article-title":"Repair of double-strand breaks induced by CRISPR\u2013Cas9 leads to large deletions and complex rearrangements","volume":"36","author":"Kosicki","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101341_bib0148","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nmeth.4293","article-title":"Unexpected mutations after CRISPR\u2013Cas9 editing in vivo","volume":"14","author":"Schaefer","year":"2017","journal-title":"Nat. Methods"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226002522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226002522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:48:42Z","timestamp":1790912922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294226002522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":148,"alternative-id":["S2468294226002522"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101341","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CRISPR-Cas9 gene editing approaches in colorectal cancer: Current progress and future prospects","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101341","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101341"}}