{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:53:40Z","timestamp":1790916820331,"version":"4.1.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":208,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2026.101344","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:06:28Z","timestamp":1785542788000},"page":"101344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Recent advances in biomarkers, artificial intelligence, and targeted therapeutic strategies in breast cancer: Current progress and future perspectives"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4842-0813","authenticated-orcid":false,"given":"Divya","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peeyush","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4666-0119","authenticated-orcid":false,"given":"Kaushalendra Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niharika","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4290-6526","authenticated-orcid":false,"given":"Anadi","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctarc.2026.101344_bib0001","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ctarc.2026.101344_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155509","article-title":"Advancements of gene therapy in cancer treatment: a comprehensive review","volume":"261","author":"Mohd Abas","year":"2024","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0003","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s12672-026-04894-5","article-title":"Emerging nanoimmunotherapeutic strategies for breast cancer","volume":"17","author":"Panzade","year":"2026","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0004","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2147\/BCTT.S432526","article-title":"Breast cancer: an overview of current therapeutic strategies, challenge, and perspectives","volume":"Volume 15","author":"Wang","year":"2023","journal-title":"Breast Canc. Targ. Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.clbc.2026.07.026","article-title":"Incidence, risk factors, and survival implications of immune-related adverse events in patients with metastatic breast cancer","author":"Baclig","year":"2026","journal-title":"Clin. Breast. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0006","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71746-z","article-title":"Sex differences in adverse events among cancer patients receiving immune checkpoint inhibitors: the MOUSEION-07 systematic review and meta-analysis","volume":"14","author":"Vitale","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ctarc.2026.101344_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1622954","article-title":"Global burden and projections of breast cancer incidence and mortality to 2050: a comprehensive analysis of GLOBOCAN data","volume":"13","author":"Freihat","year":"2025","journal-title":"Front. Public Health"},{"key":"10.1016\/j.ctarc.2026.101344_bib0008","series-title":"2021 7th International Conference on Advanced Computing and Communication Systems (ICACCS)","first-page":"227","article-title":"Introduction to breast cancer and awareness","volume":"1","author":"Das","year":"2021"},{"key":"10.1016\/j.ctarc.2026.101344_bib0009","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2147\/BCTT.S432526","article-title":"Breast cancer: an overview of current therapeutic strategies, challenge, and perspectives","volume":"Volume 15","author":"Wang","year":"2023","journal-title":"Breast Canc. Targ. Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0010","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3390\/ijms27052109","article-title":"The future of breast cancer treatment: from conventional wisdom to nanotechnology-enabled precision","volume":"27","author":"Kimta","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ctarc.2026.101344_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2025.103023","article-title":"Datopotamab deruxtecan: rational strategies, novel advancements, challenges, and future perspectives","volume":"140","author":"Di Lauro","year":"2025","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ctarc.2026.101344_bib0012","doi-asserted-by":"crossref","unstructured":"Subhy Alsheikhly A, Ahmed Subhy Alsheikhly M. A comprehensive review of breast cancer and the latest advancement in diagnosis and treatment 2025. https:\/\/doi.org\/10.5772\/INTECHOPEN.1008946.","DOI":"10.5772\/intechopen.1008946"},{"key":"10.1016\/j.ctarc.2026.101344_bib0013","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/jnci\/94.8.606","article-title":"Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies","volume":"94","author":"Key","year":"2002","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ctarc.2026.101344_bib0014","article-title":"Breast cancer: a review of risk factors and diagnosis","volume":"103","author":"Obeagu","year":"2024","journal-title":"Medicine (United States)"},{"key":"10.1016\/j.ctarc.2026.101344_bib0015","first-page":"3201","article-title":"Breast cancer risk from modifiable and non-modifiable risk factors among women in Southeast Asia: a meta-analysis","volume":"18","author":"Nindrea","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.ctarc.2026.101344_bib0016","doi-asserted-by":"crossref","DOI":"10.1155\/ijbc\/1986406","article-title":"Advancements in nanoparticle-based therapies for breast cancer: current trends and future prospects","volume":"2026","author":"Matalqah","year":"2026","journal-title":"Int. J. Breast. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0017","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2174\/0113892010303244240718075729","article-title":"Recent advances in immunotherapy and targeted therapy of triple negative breast cancer","volume":"26","author":"Shewale","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0018","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/14737140.2025.2610263","article-title":"Elacestrant in metastatic breast cancer: current advancements and future perspectives","volume":"26","author":"Sahin","year":"2026","journal-title":"Expert. Rev. AntiCancer Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0019","first-page":"515","article-title":"A fully-integrated analog machine learning classifier for breast cancer classification","volume":"9","author":"Chandrasekaran","year":"2020","journal-title":"Electronics (Basel)"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0020","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s12672-026-05010-3","article-title":"A review of application of artificial intelligence in breast cancer detection and treatment","volume":"17","author":"Siddiqui","year":"2026","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.632079","article-title":"Advanced approaches to breast cancer classification and diagnosis","volume":"11","author":"Zubair","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0022","doi-asserted-by":"crossref","first-page":"140","DOI":"10.52403\/ijhsr.20221018","article-title":"Breast cancer classification: a review","volume":"12","author":"Das","year":"2022","journal-title":"Int. J. Health Sci. Res. (WwwIjhsrOrg)"},{"key":"10.1016\/j.ctarc.2026.101344_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.120030","article-title":"An overview about biomarkers in breast cancer: insights into the diagnostic and prognostic significance","volume":"567","author":"Emanuelle Pereira Santos","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ctarc.2026.101344_bib0024","first-page":"1","article-title":"Biomarkers in breast cancer: where are we and where are we going?","volume":"71","author":"Duffy","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.ctarc.2026.101344_bib0025","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/ijms22041656","article-title":"Estrogen receptor beta: the promising biomarker and potential target in metastases","volume":"22","author":"Bo\u017eovi\u0107","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ctarc.2026.101344_bib0026","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2147\/DDDT.S336643","article-title":"The role of progesterone receptors in breast cancer","volume":"Volume 16","author":"Li","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0027","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clbc.2025.10.006","article-title":"High thymidine kinase 1 activity linked to poor breast cancer survival: a systematic review and meta-analysis","volume":"26","author":"Li","year":"2026","journal-title":"Clin. Breast. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0028","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(09)70262-1","article-title":"Ki67 in breast cancer: prognostic and predictive potential","volume":"11","author":"Yerushalmi","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0029","article-title":"From mutation to treatment: the dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review","volume":"46","author":"Georgy","year":"2026","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.ctarc.2026.101344_bib0030","article-title":"Human epidermal growth factor receptor 2 (HER2) expression dynamics between diagnosis and recurrence in patients with breast cancer using artificial intelligence and electronic health records: the RosHER study","volume":"7","author":"L\u00f3pez-Miranda","year":"2025","journal-title":"ESMO Real World Data Digit. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120678","article-title":"TP53 apoptosis biomarkers in breast cancer","volume":"579","author":"Rafeeq","year":"2026","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ctarc.2026.101344_bib0032","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1158\/1078-0432.CCR-13-2661","article-title":"Molecular pathways: intercellular PTEN and the potential of PTEN restoration Therapy","volume":"20","author":"Hopkins","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101344_bib0033","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1158\/1078-0432.CCR-20-2859","article-title":"STK11\/LKB1 mutations in NSCLC are associated with KEAP1\/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition","volume":"27","author":"Sitthideatphaiboon","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101344_bib0034","article-title":"The role of the CDH1 gene in the pathogenesis and progression of lobular breast cancer","volume":"17","author":"Mitchell","year":"2025","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0035","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0036","article-title":"From mutation to treatment: the dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review","volume":"46","author":"Georgy","year":"2026","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.ctarc.2026.101344_bib0037","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/jimaging6100105","article-title":"Applications of computational methods in Biomedical Breast Cancer Imaging diagnostics: a review","volume":"6","author":"Aruleba","year":"2020","journal-title":"J. ImAging"},{"key":"10.1016\/j.ctarc.2026.101344_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.bspc.2026.109911","article-title":"Robust multi-phase framework for breast cancer detection and classification using mammogram images with stacked ensemble learning","volume":"119","author":"Thakur","year":"2026","journal-title":"Biomed. Signal. Process. Control"},{"key":"10.1016\/j.ctarc.2026.101344_bib0039","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/17434440.2019.1610387","article-title":"Artificial Intelligence (AI) for the early detection of breast cancer: a scoping review to assess AI\u2019s potential in breast screening practice","volume":"16","author":"Houssami","year":"2019","journal-title":"Expert. Rev. Med. Devices"},{"key":"10.1016\/j.ctarc.2026.101344_bib0040","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4048\/jbc.2023.26.e45","article-title":"Artificial intelligence in breast cancer diagnosis and personalized medicine","volume":"26","author":"Ahn","year":"2023","journal-title":"J. Breast. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1587517","article-title":"Advances in breast cancer diagnosis: a comprehensive review of imaging, biosensors, and emerging wearable technologies","volume":"15","author":"Khan","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2024.111457","article-title":"Artificial intelligence for breast cancer detection: technology, challenges, and prospects","volume":"175","author":"D\u00edaz","year":"2024","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0043","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/17434440.2019.1610387","article-title":"Artificial Intelligence (AI) for the early detection of breast cancer: a scoping review to assess AI\u2019s potential in breast screening practice","volume":"16","author":"Houssami","year":"2019","journal-title":"Expert. Rev. Med. Devices"},{"key":"10.1016\/j.ctarc.2026.101344_bib0044","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-022-01509-z","article-title":"Artificial intelligence in mammographic phenotyping of breast cancer risk: a narrative review","volume":"24","author":"Gastounioti","year":"2022","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101344_bib0045","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3390\/cancers17020197","article-title":"Harnessing artificial intelligence to enhance global breast cancer care: a scoping review of applications, outcomes, and challenges","volume":"17","author":"Chia","year":"2025","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ctarc.2026.101344_bib0046","article-title":"Breast cancer prediction using machine learning classification algorithms","volume":"11","author":"La Moglia","year":"2025","journal-title":"Intell. Base. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0047","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/jpm11020061","article-title":"Breast cancer type classification using machine learning","volume":"11","author":"Wu","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0048","doi-asserted-by":"crossref","unstructured":"Huang S-C, Jensen M, Yeung-Levy S, Lungren MP, Poon H, Chaudhari AS. Multimodal Foundation Models for Medical Imaging - A systematic review and implementation guidelines n.d. https:\/\/doi.org\/10.1101\/2024.10.23.24316003.","DOI":"10.1101\/2024.10.23.24316003"},{"key":"10.1016\/j.ctarc.2026.101344_bib0050","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1016\/j.ultrasmedbio.2025.11.123","article-title":"A multimodal diagnostic model for breast cancer invasiveness based on ultrasound imaging and serum biomarkers","volume":"51","author":"ZHAI","year":"2025","journal-title":"Ultrasound. Med. Biol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0051","article-title":"A deep learning-based multimodal medical imaging model for breast cancer screening","volume":"15","author":"Chen","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ctarc.2026.101344_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.110466","article-title":"Multimodal deep learning for enhanced breast cancer diagnosis on sonography","volume":"194","author":"Wei","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0053","doi-asserted-by":"crossref","DOI":"10.1051\/matecconf\/201927702035","article-title":"Deep learning review and discussion of its future development","volume":"277","author":"Hao","year":"2019","journal-title":"MATEC Web Conf."},{"key":"10.1016\/j.ctarc.2026.101344_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.imu.2023.101317","article-title":"Deep learning algorithms for the early detection of breast cancer: a comparative study with traditional machine learning","volume":"41","author":"Gonzales Martinez","year":"2023","journal-title":"Inform. Med. Unlock."},{"key":"10.1016\/j.ctarc.2026.101344_bib0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1109\/MWC.001.2000374","article-title":"Deep-learning-empowered breast cancer auxiliary diagnosis for 5GB remote E-health","volume":"28","author":"Yu","year":"2021","journal-title":"IEEE Wirel. Commun."},{"key":"10.1016\/j.ctarc.2026.101344_bib0056","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-bioeng-071516-044442","article-title":"Deep learning in medical image analysis","volume":"19","author":"Shen","year":"2017","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.ctarc.2026.101344_bib0057","article-title":"A review paper on breast cancer detection using Deep Learning","volume":"1022","author":"Tan","year":"2021","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"10.1016\/j.ctarc.2026.101344_bib0058","doi-asserted-by":"crossref","DOI":"10.1098\/rsta.2019.0054","article-title":"Machine learning and big scientific data","volume":"378","author":"Hey","year":"2020","journal-title":"Philos. Trans. R. Soc. A"},{"key":"10.1016\/j.ctarc.2026.101344_bib0059","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2147\/BCTT.S432526","article-title":"Breast cancer: an overview of current therapeutic strategies, challenge, and perspectives","volume":"Volume 15","author":"Wang","year":"2023","journal-title":"Breast Canc. Targ. Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0277-9536(99)00106-9","article-title":"Patient assertiveness and physician decision-making among older breast cancer patients","volume":"49","author":"Krupat","year":"1999","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0061","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10549-011-1891-6","article-title":"Locoregional recurrence after breast cancer surgery: a systematic review by receptor phenotype","volume":"133","author":"Lowery","year":"2012","journal-title":"Breast. Cancer Res. Treat."},{"key":"10.1016\/j.ctarc.2026.101344_bib0062","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.sap.0000183791.51843.40","article-title":"Breast reduction as an alternative treatment option for early breast cancer in women with macromastia","volume":"56","author":"Thornton","year":"2006","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.ctarc.2026.101344_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2023.102670","article-title":"Current and emerging treatment approaches for hormone receptor-positive\/human epidermal growth factor receptor 2-negative metastatic breast cancer","volume":"123","author":"Jhaveri","year":"2024","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ctarc.2026.101344_bib0065","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.5858\/arpa.2018-0902-SA","article-title":"Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists Clinical Practice Guideline focused update","volume":"142","author":"Wolff","year":"2018","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0066","unstructured":"Martins SC, Aparecida M, Ara\u00fajo M, Joana, Mendes De Moura P, Anna;, et al. Hormone Therapy and Breast Cancer: a literature review about the influence of hormonal treatment on neoplastic development n.d. https:\/\/doi.org\/10.5935\/2238-3182.20210037."},{"key":"10.1016\/j.ctarc.2026.101344_bib0067","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.70166","article-title":"Targeting estrogen pathways in breast cancer: a review of current therapies and emerging strategies","volume":"44","author":"Dabhi","year":"2026","journal-title":"Cell Biochem. Funct."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0068","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41523-023-00523-4","article-title":"An emerging generation of endocrine therapies in breast cancer: a clinical perspective","volume":"9","author":"Patel","year":"2023","journal-title":"NPJ Breast. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0069","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.mce.2013.08.001","article-title":"Breast cancer: current and future endocrine therapies","volume":"382","author":"Palmieri","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0070","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3390\/medicina61071280","article-title":"Current endocrine therapy in hormone-receptor-positive breast cancer: from tumor biology to the rationale for therapeutic tunning","volume":"61","author":"Burciu","year":"2025","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.ctarc.2026.101344_bib0071","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.3390\/cancers13225643","article-title":"Endocrine treatment for breast cancer patients revisited\u2014History, standard of care, and possibilities of improvement","volume":"13","author":"Nabieva","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ctarc.2026.101344_bib0072","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/2231-4040.72251","article-title":"Various types and management of breast cancer: an overview","volume":"1","author":"Sharma","year":"2010","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.ctarc.2026.101344_bib0073","article-title":"An update on breast cancer chemotherapy-associated toxicity and their management approaches","volume":"9","author":"Langeh","year":"2023","journal-title":"Health Sci. Rev."},{"key":"10.1016\/j.ctarc.2026.101344_bib0074","unstructured":"Breast Cancer Therapies: A Review | Asian Pacific Journal of Cancer Biology n.d. https:\/\/waocp.com\/journal\/index.php\/apjcb\/article\/view\/1100 (accessed May 26, 2026)."},{"key":"10.1016\/j.ctarc.2026.101344_bib0075","article-title":"Neoadjuvant chemotherapy for breast cancer: an evaluation of its efficacy and research progress","volume":"13","author":"Chen","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0076","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3892\/or_00000963","article-title":"Chemotherapy for breast cancer (Review)","volume":"24","author":"Hassan","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ctarc.2026.101344_bib0077","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21037\/pcm-20-69","article-title":"A narrative review of chemotherapy in advanced triple negative breast cancer","volume":"4","author":"Romero Lagunes","year":"2021","journal-title":"Precis. Cancer Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0078","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20211033","article-title":"Understanding breast cancer as a global health concern","volume":"95","author":"Wilkinson","year":"2022","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0079","article-title":"An update on breast cancer chemotherapy-associated toxicity and their management approaches","volume":"9","author":"Langeh","year":"2023","journal-title":"Health Sci. Rev."},{"key":"10.1016\/j.ctarc.2026.101344_bib0080","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2147\/BCTT.S184710","article-title":"Immunotherapy for the treatment of breast cancer: emerging new data","volume":"Volume 11","author":"Mina","year":"2019","journal-title":"Breast Canc. Targ. Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0081","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.752689","article-title":"Editorial: immunotherapy as an evolving approach for the treatment of breast cancer","volume":"11","author":"Tolba","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0082","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2147\/BCTT.S482504","article-title":"Recent advances in immunotherapy for breast cancer: a review","volume":"Volume 16","author":"Wen","year":"2024","journal-title":"Breast Canc. Targ. Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0083","first-page":"1350","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"1979","journal-title":"Science (1979)"},{"key":"10.1016\/j.ctarc.2026.101344_bib0084","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.3390\/ijms21145009","article-title":"Immunotherapies and combination strategies for immuno-oncology","volume":"21","author":"Barbari","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0085","article-title":"Recent advances in immunotherapy for breast cancer","volume":"16","author":"Guo","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0086","article-title":"A review of the advancements in targeted therapies for breast cancer","volume":"15","author":"Jallah","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.ctarc.2026.101344_bib0087","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5306\/wjco.v8.i2.120","article-title":"Targeted therapies in breast cancer: new challenges to fight against resistance","volume":"8","author":"Masoud","year":"2017","journal-title":"World J. Clin. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0088","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.18632\/oncotarget.3296","article-title":"Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer","volume":"6","author":"Leung","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ctarc.2026.101344_bib0089","doi-asserted-by":"crossref","first-page":"345","DOI":"10.21037\/apm-25-30","article-title":"New progress and challenges of targeted therapies for breast cancer","volume":"14","author":"Wang","year":"2025","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0090","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.940055","article-title":"Editorial: cancer treatment and early detection targeting HER receptors","volume":"9","author":"Cai","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ctarc.2026.101344_bib0091","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.70166","article-title":"Targeting estrogen pathways in breast cancer: a review of current therapies and emerging strategies","volume":"44","author":"Dabhi","year":"2026","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.ctarc.2026.101344_bib0092","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116615","article-title":"Targeting the crosstalk between estrogen receptors and membrane growth factor receptors in breast cancer treatment: advances and opportunities","volume":"175","author":"Yan","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ctarc.2026.101344_bib0093","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20211033","article-title":"Understanding breast cancer as a global health concern","volume":"95","author":"Wilkinson","year":"2022","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0094","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.breast.2013.09.006","article-title":"Co-targeting estrogen receptor and HER2 pathways in breast cancer","volume":"23","author":"Mehta","year":"2014","journal-title":"Breast"},{"key":"10.1016\/j.ctarc.2026.101344_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115209","article-title":"Targeted therapy for breast cancer: an overview of drug classes and outcomes","volume":"204","author":"Jacobs","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0096","doi-asserted-by":"crossref","unstructured":"Jallah JK, Dweh TJ, Anjankar A, Palma O. A review of the advancements in targeted therapies for breast cancer 2023. https:\/\/doi.org\/10.7759\/cureus.47847.","DOI":"10.7759\/cureus.47847"},{"key":"10.1016\/j.ctarc.2026.101344_bib0097","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/bcr27","article-title":"Gene therapy for carcinoma of the breast pro-apoptotic gene therapy","volume":"2","author":"G\u00f3mez-Navarro","year":"1999","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101344_bib0098","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/7651_2020_284","article-title":"GMP-compliant adenoviral vectors for gene therapy","volume":"2286","author":"Arjmand","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0099","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/7651_2020_284","article-title":"GMP-compliant adenoviral vectors for gene therapy","volume":"2286","author":"Arjmand","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0100","first-page":"209","article-title":"Current status of gene therapy for breast cancer: progress and challenges","volume":"7","author":"McCrudden","year":"2014","journal-title":"Appl. Clin. Genet."},{"key":"10.1016\/j.ctarc.2026.101344_bib0101","article-title":"Genetic advancements in breast cancer treatment: a review","volume":"16","author":"Shokoohi","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0102","article-title":"Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology","volume":"11","author":"Youssef","year":"2024","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.ctarc.2026.101344_bib0103","doi-asserted-by":"crossref","first-page":"30675","DOI":"10.18632\/oncotarget.5169","article-title":"Progresses towards safe and efficient gene therapy vectors","volume":"6","author":"Chira","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0104","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12672-025-01884-x","article-title":"Genetic advancements in breast cancer treatment: a review","volume":"16","author":"Shokoohi","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0105","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.3390\/molecules28031498","article-title":"A review of different types of liposomes and their advancements as a form of gene therapy treatment for breast cancer","volume":"28","author":"Tseu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ctarc.2026.101344_bib0106","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/sj.cgt.7700929","article-title":"Gene therapy for carcinoma of the breast","volume":"13","author":"Stoff-Khalili","year":"2006","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0107","doi-asserted-by":"crossref","DOI":"10.1016\/j.senol.2025.100683","article-title":"Understanding the prospective of gene therapy for the treatment of breast cancer","volume":"38","author":"Ritika","year":"2025","journal-title":"Revista de Senolog\u00eda y Patolog\u00eda Mamaria"},{"key":"10.1016\/j.ctarc.2026.101344_bib0108","doi-asserted-by":"crossref","DOI":"10.15761\/FNN.1000S2003","article-title":"Suicide gene therapy: a promising approach towards gene delivery","volume":"5","author":"Panghal","year":"2019","journal-title":"Front. Nanosci. Nanotech."},{"key":"10.1016\/j.ctarc.2026.101344_bib0109","first-page":"45","article-title":"Suicide gene therapy for breast cancer with a suicide-inducing vector carrying the mammaglobin-1 promoter","volume":"30","author":"Ghanbariasad","year":"2018","journal-title":"Minerva Biotech."},{"key":"10.1016\/j.ctarc.2026.101344_bib0110","first-page":"1413","article-title":"Nanoparticles for death-induced gene therapy in cancer (Review)","volume":"17","author":"Roacho-Perez","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ctarc.2026.101344_bib0111","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/bcr3413","article-title":"Delivery of gene silencing agents for breast cancer therapy","volume":"15","author":"Shen","year":"2013","journal-title":"Breast. Cancer Res."},{"key":"10.1016\/j.ctarc.2026.101344_bib0112","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.2174\/0929867325666180403141554","article-title":"Gene silencing strategies in cancer therapy: an update for drug resistance","volume":"26","author":"Naghizadeh","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ctarc.2026.101344_bib0113","doi-asserted-by":"crossref","first-page":"98","DOI":"10.54254\/2753-8818\/2025.LD26514","article-title":"Applications of three gene engineering mechanisms in breast cancer therapy","volume":"129","author":"Tian","year":"2025","journal-title":"Theor. Nat. Sci."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101344_bib0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2325\/jbcs.13.8","article-title":"Gene therapy for breast cancer. \u2014 Review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital","volume":"13","author":"Takahashi","year":"2006","journal-title":"Breast. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0117","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.clbc.2024.12.020","article-title":"Low dose Tamoxifen for breast cancer prevention: a real-world experience","volume":"25","author":"Patel","year":"2025","journal-title":"Clin. Breast. Cancer"},{"key":"10.1016\/j.ctarc.2026.101344_bib0118","article-title":"Paclitaxel for breast cancer therapy: a review on effective drug combination modalities and nano drug delivery platforms","volume":"95","author":"Kaveh Zenjanab","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0119","article-title":"Exceptional response to Pembrolizumab in metastatic ER+\/HER2\u2212 breast cancer with liver metastases: a case report and literature review","volume":"2025","author":"Celi","year":"2025","journal-title":"Case Rep. Oncol. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109805","article-title":"Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy: a systematic review and meta-analysis","volume":"186","author":"Salvestrini","year":"2023","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0121","first-page":"167","article-title":"Olaparib: a novel therapy for metastatic breast cancer in patients with a BRCA1\/2 mutation","volume":"10","author":"Caulfield","year":"2019","journal-title":"J. Adv. Pract. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0122","first-page":"186","article-title":"A breakthrough in advanced breast cancer therapy","volume":"7","author":"Parab","year":"2024","journal-title":"Int. Res. J. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2024.103853","article-title":"Safety profile of sacituzumab govitecan in patients with breast cancer: a systematic review and meta-analysis","volume":"79","author":"Dacoregio","year":"2025","journal-title":"The Breast"},{"key":"10.1016\/j.ctarc.2026.101344_bib0124","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/14656566.2020.1838485","article-title":"An evaluation of palbociclib as a breast cancer treatment option: a current update","volume":"22","author":"Gallanis","year":"2021","journal-title":"Expert. Opin. PharmacOther"},{"key":"10.1016\/j.ctarc.2026.101344_bib0125","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1097\/MS9.0000000000002730","article-title":"Advancements in breast cancer management: a comprehensive review of ribociclib combined with endocrine therapy","volume":"86","author":"Qureshi","year":"2024","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.ctarc.2026.101344_bib0126","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1056\/NEJMoa2214131","article-title":"Capivasertib in hormone receptor\u2013Positive advanced breast cancer","volume":"388","author":"Turner","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0127","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/MS9.0000000000004417","article-title":"Imlunestrant in ER+ advanced breast cancer \u2013 bridging innovation and clinical reality","volume":"88","author":"Khalid","year":"2026","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.ctarc.2026.101344_bib0128","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/S1470-2045(24)00387-5","article-title":"Camizestrant, a next-generation oral SERD, versus fulvestrant in post-menopausal women with oestrogen receptor-positive, HER2-negative advanced breast cancer (SERENA-2): a multi-dose, open-label, randomised, phase 2 trial","volume":"25","author":"Oliveira","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0129","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/14737140.2025.2610263","article-title":"Elacestrant in metastatic breast cancer: current advancements and future perspectives","volume":"26","author":"Sahin","year":"2026","journal-title":"Expert. Rev. AntiCancer Ther."},{"key":"10.1016\/j.ctarc.2026.101344_bib0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21037\/tbcr-21-27","article-title":"Role of abemaciclib in primary breast cancer: a narrative review of MonarchE","volume":"3","author":"Takahashi","year":"2022","journal-title":"Transl. Breast Canc. Res."},{"key":"10.1016\/j.ctarc.2026.101344_bib0131","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2023.100969","article-title":"Alpelisib for treatment of patients with PIK3CA-related overgrowth spectrum (PROS)","volume":"25","author":"Canaud","year":"2023","journal-title":"Genet. Med."},{"key":"10.1016\/j.ctarc.2026.101344_bib0132","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/COC.0000000000001209","article-title":"Inavolisib for HR-positive, HER2-negative advanced breast cancer: clinical trials and patient access implication","volume":"48","author":"Arabshomali","year":"2025","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.ctarc.2026.101344_bib0134","doi-asserted-by":"crossref","first-page":"26085","DOI":"10.1021\/acs.jmedchem.5c02137","article-title":"Discovery of Atirmociclib (PF-07220060): a potent and selective CDK4 inhibitor","volume":"68","author":"Gallego","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ctarc.2026.101344_bib0135","article-title":"Everolimus in the treatment of metastatic breast cancer","volume":"9","author":"Royce","year":"2015","journal-title":"Breast. Canc. (Auckl.)"}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226002558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226002558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:02:32Z","timestamp":1790913752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294226002558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":130,"alternative-id":["S2468294226002558"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101344","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances in biomarkers, artificial intelligence, and targeted therapeutic strategies in breast cancer: Current progress and future perspectives","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101344"}}