{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:16Z","timestamp":1791489676516,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004252","name":"Qatar University","doi-asserted-by":"publisher","award":["QUST-CHS-2026-601"],"award-info":[{"award-number":["QUST-CHS-2026-601"]}],"id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004252","name":"Qatar University","doi-asserted-by":"publisher","award":["QUCG-CHS-25\/26-716"],"award-info":[{"award-number":["QUCG-CHS-25\/26-716"]}],"id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2026.101401","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:46:39Z","timestamp":1788223599000},"page":"101401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MIF \u2212173 G>C polymorphism as a context-dependent modifier of solid cancer risk: A meta-analysis"],"prefix":"10.1016","volume":"49","author":[{"given":"Rand","family":"Hamdan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran","family":"Zein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joud","family":"Naser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalal","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan H.","family":"Abunada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saja A.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashael","family":"Al-Shafai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-956X","authenticated-orcid":false,"given":"Atiyeh M.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8705-0198","authenticated-orcid":false,"given":"Amal","family":"Al-Haidose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctarc.2026.101401_bib0001","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/14728222.2019.1656718","article-title":"Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus","volume":"23","author":"Bilsborrow","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ctarc.2026.101401_bib0002","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"Calandra","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0003","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/qjmed\/hcq148","article-title":"Inflammation and cancer: macrophage migration inhibitory factor (MIF)\u2013the potential missing link","volume":"103","author":"Conroy","year":"2010","journal-title":"QJM Mon. J. Assoc. Physicians"},{"key":"10.1016\/j.ctarc.2026.101401_bib0004","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005475","article-title":"OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases","volume":"10","author":"Thiele","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ctarc.2026.101401_bib0005","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/j.febslet.2009.07.058","article-title":"A functional heteromeric MIF receptor formed by CD74 and CXCR4","volume":"583","author":"Schwartz","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ctarc.2026.101401_bib0006","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1038\/s41467-020-19764-z","article-title":"Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting","volume":"11","author":"Kontos","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ctarc.2026.101401_bib0007","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/14728222.2019.1656718","article-title":"Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus","volume":"23","author":"Bilsborrow","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ctarc.2026.101401_bib0008","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/qjmed\/hcq148","article-title":"Inflammation and cancer: macrophage migration inhibitory factor (MIF)\u2013the potential missing link","volume":"103","author":"Conroy","year":"2010","journal-title":"QJM Mon. J. Assoc. Physicians"},{"key":"10.1016\/j.ctarc.2026.101401_bib0009","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005475","article-title":"OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases","volume":"10","author":"Thiele","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ctarc.2026.101401_bib0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fgene.2018.00055","article-title":"Macrophage migration inhibitory factor -173 G\/C polymorphism: a global meta-analysis across the disease spectrum","volume":"9","author":"Illescas","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.ctarc.2026.101401_bib0011","article-title":"Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src\/PI3K\/myosin II pathway","volume":"35","author":"Ives","year":"2021","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0012","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.drudis.2021.03.012","article-title":"Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation","volume":"26","author":"Osipyan","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ctarc.2026.101401_bib0013","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3390\/cancers11101430","article-title":"Macrophage migration inhibitory factor is a molecular determinant of the anti-EGFR monoclonal antibody cetuximab resistance in Human colorectal cancer cells","volume":"11","author":"Russo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ctarc.2026.101401_bib0014","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/cncr.20818","article-title":"Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma","volume":"103","author":"Hira","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.ctarc.2026.101401_bib0015","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/cncr.10354","article-title":"Macrophage migration inhibitory factor evaluation compared with prostate specific antigen as a biomarker in patients with prostate carcinoma","volume":"94","author":"Meyer-Siegler","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ctarc.2026.101401_bib0016","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF03401765","article-title":"Involvement of macrophage migration inhibitory factor (MIF) in the mechanism of tumor cell growth","volume":"4","author":"Takahashi","year":"1998","journal-title":"Mol. Med."},{"key":"10.1016\/j.ctarc.2026.101401_bib0017","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ijc.11287","article-title":"Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma","volume":"107","author":"Ren","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ctarc.2026.101401_bib0018","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/cancers11040529","article-title":"Role of macrophage migration inhibitory factor (MIF) in melanoma","volume":"11","author":"Soumoy","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ctarc.2026.101401_bib0019","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1471-2407-9-230","article-title":"Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer","volume":"9","author":"Verjans","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ctarc.2026.101401_bib0020","doi-asserted-by":"crossref","DOI":"10.1111\/eci.70132","article-title":"Metabolic dysfunction-associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: a deadly triad","volume":"56","author":"Caturano","year":"2026","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.ctarc.2026.101401_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2025.102881","article-title":"Dynamics of resistance to immunotherapy and TKI in patients with advanced renal cell carcinoma","volume":"133","author":"Santoni","year":"2025","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ctarc.2026.101401_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108024","article-title":"Macrophage migration inhibitory factor (MIF): a multifaceted cytokine regulated by genetic and physiological strategies","volume":"233","author":"Sumaiya","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ctarc.2026.101401_bib0023","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1007\/s10620-016-4322-z","article-title":"A macrophage migration inhibitory factor polymorphism is associated with autoimmune Hepatitis severity in US and Japanese patients","volume":"61","author":"Assis","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ctarc.2026.101401_bib0024","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41598-017-00299-1","article-title":"Association between the MIF-173G\/C polymorphism and serum MIF levels with pulmonary tuberculosis: a meta-analysis","volume":"7","author":"Tong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ctarc.2026.101401_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23209","article-title":"Association of the genetic variants (-794 CATT5-8 and -173 G >C) of macrophage migration inhibitory factor (MIF) with higher soluble levels of MIF and TNF\u03b1 in women with breast cancer","volume":"34","author":"Avalos-Navarro","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.ctarc.2026.101401_bib0026","doi-asserted-by":"crossref","first-page":"135.24","DOI":"10.4049\/jimmunol.202.Supp.135.24","article-title":"MIF functional polymorphisms (\u2212794 CATT5\u20138 and \u2212173 G>C) in Basal cell carcinoma in western Mexican population","volume":"202","author":"Alvarado","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2022.153850","article-title":"Correlation of MIF-AS1 polymorphisms with the risk and prognosis of gastric cancer","volume":"233","author":"Ni","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.ctarc.2026.101401_bib0028","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.2252","article-title":"Haplotypes of [-794(CATT)5\u20138\/-173G>C] MIF gene polymorphisms and its soluble levels in cutaneous squamous cell carcinoma in western Mexican population","volume":"11","author":"Guevara-Guti\u00e9rrez","year":"2023","journal-title":"Mol. Genet. Genomic Med."},{"key":"10.1016\/j.ctarc.2026.101401_bib0029","first-page":"601","article-title":"The association between the migration inhibitory factor -173G\/C polymorphism and cancer risk: a meta-analysis","volume":"8","author":"Zhang","year":"2015","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.ctarc.2026.101401_bib0030","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ctarc.2026.101401_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"The PRISMA Group, preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101401_bib0032","first-page":"329","article-title":"The Landscape of Randomized Controlled Trials for Behavioral Health-Focused Psychosocial Interventions for Youth in the Juvenile Legal System: A Systematic Review","volume":"32","author":"Sheerin","year":"2025","journal-title":"Clin. Psychol. (New York)."},{"key":"10.1016\/j.ctarc.2026.101401_bib0033","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12863-015-0211-2","article-title":"Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool","volume":"16","author":"Sohani","year":"2015","journal-title":"BMC Genet"},{"key":"10.1016\/j.ctarc.2026.101401_bib0034","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jclinepi.2018.01.013","article-title":"GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences\u2014Risk of bias and indirectness","volume":"111","author":"Zhang","year":"2019","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0035","doi-asserted-by":"crossref","DOI":"10.5505\/tjo.2020.2186","article-title":"The MIF rs755622 variant may increase susceptibility of breast cancer but not gastrointestinal cancer in a Turkish population","author":"Pehlivan","year":"2020","journal-title":"Turk. J. Oncol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0036","first-page":"223","article-title":"Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis","volume":"19","author":"Arisawa","year":"2008","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ctarc.2026.101401_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155806","article-title":"The influence of interleukin-6, interleukin-8, interleukin-10, interleukin-17, TNF-A, MIF, STAT3 on lung cancer risk in Moroccan population","volume":"151","author":"Kaanane","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.ctarc.2026.101401_bib0038","first-page":"55","article-title":"Genetic variants of the MIF gene and susceptibility of rectal cancer","volume":"Volume 14","author":"Chuo","year":"2021","journal-title":"Pharmacogenomics Pers. Med."},{"key":"10.1016\/j.ctarc.2026.101401_bib0039","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3892\/ol.2021.12810","article-title":"MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma","volume":"22","author":"Qin","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ctarc.2026.101401_bib0040","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jso.21304","article-title":"The association between MIF-173 G>C polymorphism and prostate cancer in southern Chinese","volume":"100","author":"Ding","year":"2009","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.mgene.2019.100605","article-title":"Association of the IL-17A rs2275913 and MIF rs755622 polymorphisms with the risk of gastric and colorectal cancer","volume":"22","author":"Moundir","year":"2019","journal-title":"Meta Gene."},{"key":"10.1016\/j.ctarc.2026.101401_bib0042","first-page":"189","article-title":"The -173 G\/C polymorphism of the promoter region macrophage migration inhibitory factor gene is not associated with incidence of pulmonary hamartoma","volume":"58","author":"Kaznowska","year":"2007","journal-title":"Pol. J. Pathol. Off. J. Pol. Soc. Pathol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0043","first-page":"41","article-title":"Haplotypes of (-794(CATT)5-8\/-173G>C) MIF gene polymorphisms and its soluble levels in basal cell carcinoma in western Mexican population","volume":"69","author":"Guevara-Guti\u00e9rrez","year":"2021","journal-title":"J. Investig. Med. Off. Publ. Am. Fed. Clin. Res."},{"key":"10.1016\/j.ctarc.2026.101401_bib0044","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10549-024-07393-9","article-title":"The clinical signature of genetic variants and serum levels of macrophage migration inhibitory factor in Egyptian breast cancer patients","volume":"208","author":"Seliem","year":"2024","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.ctarc.2026.101401_bib0045","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10238-016-0439-9","article-title":"Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women","volume":"17","author":"Lin","year":"2017","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.ctarc.2026.101401_bib0046","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cyto.2012.07.015","article-title":"Gastric cancer susceptibility in gastric cancer relatives: attributable risks of macrophage migration inhibitory factor promoter polymorphism and Helicobacter pylori","volume":"60","author":"Li","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.ctarc.2026.101401_bib0047","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3892\/ol.2011.409","article-title":"Correlation of macrophage migration inhibitory factor gene polymorphism with the risk of early-stage cervical cancer and lymphatic metastasis","volume":"2","author":"Wu","year":"2011","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ctarc.2026.101401_bib0048","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1007\/s11033-011-1075-9","article-title":"Macrophage migration inhibitory factor gene -173G>C polymorphism and risk of bladder cancer in southeast China: a case-control analysis","volume":"39","author":"Yuan","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ctarc.2026.101401_bib0049","first-page":"32","article-title":"Association of macrophage inhibitory factor -173 gene polymorphism with biological behavior of prostate cancer","volume":"16","author":"Razzaghi","year":"2019","journal-title":"Urol. J."},{"key":"10.1016\/j.ctarc.2026.101401_bib0050","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003729","article-title":"Macrophage migration inhibitory factor polymorphism and the risk of ulcerative colitis and Crohn\u2019s disease in Asian and European populations: a meta-analysis","volume":"3","author":"Hao","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.ctarc.2026.101401_bib0051","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1323423","article-title":"Impact of the MIF -173G\/C variant on cardiovascular disease risk: a meta-analysis of 9047 participants","volume":"11","author":"Fouda","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ctarc.2026.101401_bib0052","first-page":"15949","article-title":"The MIF -173G\/C gene polymorphism increase gastrointestinal cancer and hematological malignancy risk: evidence from a meta-analysis and FPRP test","volume":"8","author":"Tong","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.ctarc.2026.101401_bib0053","first-page":"4597","article-title":"Contribution of macrophage migration inhibitory factor -173G\/C gene polymorphism to the risk of cancer in Chinese population, Asian Pac","volume":"16","author":"Wang","year":"2015","journal-title":"J. Cancer Prev. APJCP"},{"key":"10.1016\/j.ctarc.2026.101401_bib0054","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"Calandra","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ctarc.2026.101401_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2119\/molmed.2008.00107","article-title":"Macrophage migration inhibitory factor promotes colorectal cancer","volume":"15","author":"He","year":"2009","journal-title":"Mol. Med."},{"key":"10.1016\/j.ctarc.2026.101401_bib0056","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098656","article-title":"Chronic macrophage migration inhibitory factor exposure induces mesenchymal epithelial transition and promotes gastric and colon cancers","volume":"9","author":"Morris","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ctarc.2026.101401_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2056085","article-title":"Macrophage migration inhibitory factor promotes the interaction between the tumor, macrophages, and T cells to regulate the progression of chemically induced colitis-associated colorectal cancer","volume":"2019","author":"Pacheco-Fern\u00e1ndez","year":"2019","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.ctarc.2026.101401_bib0058","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41392-024-02097-4","article-title":"Digestive cancers: mechanisms, therapeutics and management","volume":"10","author":"Zhan","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ctarc.2026.101401_bib0059","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.3390\/ijms24076834","article-title":"A basic review on estrogen receptor signaling pathways in breast cancer","volume":"24","author":"Clusan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ctarc.2026.101401_bib0060","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.3892\/ijo.2015.3185","article-title":"Macrophage migration inhibitory factor involvement in breast cancer (Review)","volume":"47","author":"Richard","year":"2015","journal-title":"Int. J. Oncol."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226003126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226003126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:46:52Z","timestamp":1791488812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294226003126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":60,"alternative-id":["S2468294226003126"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101401","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MIF \u2212173 G>C polymorphism as a context-dependent modifier of solid cancer risk: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101401"}}