{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:00:25Z","timestamp":1791489625917,"version":"4.3.4"},"reference-count":166,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":257,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment and Research Communications"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.ctarc.2026.101448","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:53:53Z","timestamp":1789851233000},"page":"101448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Viral exploitation of p300\/CBP at the virus-cancer interface: Chromatin regulation, oncogenesis, immune evasion, and therapeutic targeting"],"prefix":"10.1016","volume":"49","author":[{"given":"Ali M","family":"Atoom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasur","family":"Rizaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"Polatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5850-6745","authenticated-orcid":false,"given":"Pareshkumar N.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.V.","family":"Jamuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmidhar","family":"Maharana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Bainsal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.ctarc.2026.101448_bib0001","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1101\/gad.14.13.1553","article-title":"CBP\/p300 in cell growth, transformation, and development","volume":"14","author":"Goodman","year":"2000","journal-title":"Genes Dev."},{"issue":"Pt 13","key":"10.1016\/j.ctarc.2026.101448_bib0002","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.114.13.2363","article-title":"La Thangue NB. p300\/CBP proteins: HATs for transcriptional bridges and scaffolds","volume":"114","author":"Chan","year":"2001","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0003","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1006\/viro.2001.1129","article-title":"Enhancement of the p300 histone acetyltransferase activity by HIV-1 Tat on chromatin DNA","volume":"289","author":"Deng","year":"2001","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0004","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/viro.2000.0593","article-title":"Acetylation of HIV-1 Tat by CBP\/p300 increases transcription of integrated HIV-1 genome and enhances binding to core histones","volume":"277","author":"Deng","year":"2000","journal-title":"Virology"},{"issue":"23","key":"10.1016\/j.ctarc.2026.101448_bib0005","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.95.23.13519","article-title":"HIV-1 Tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter","volume":"95","author":"Marzio","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101448_bib0006","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1021\/cr500452k","article-title":"Protein lysine acetylation by p300\/CBP","volume":"115","author":"Dancy","year":"2015","journal-title":"Chem. Rev."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101448_bib0007","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.7150\/thno.73223","article-title":"Histone acetyltransferases CBP\/p300 in tumorigenesis and CBP\/p300 inhibitors as promising novel anticancer agents","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"issue":"7337","key":"10.1016\/j.ctarc.2026.101448_bib0008","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nature09730","article-title":"Inactivating mutations of acetyltransferase genes in B-cell lymphoma","volume":"471","author":"Pasqualucci","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101448_bib0009","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/73536","article-title":"Mutations truncating the EP300 acetylase in human cancers","volume":"24","author":"Gayther","year":"2000","journal-title":"Nat. Genet."},{"issue":"18","key":"10.1016\/j.ctarc.2026.101448_bib0010","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1093\/emboj\/18.18.5061","article-title":"The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300","volume":"18","author":"Patel","year":"1999","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101448_bib0011","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/onc.2013.25","article-title":"Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma","volume":"33","author":"Xie","year":"2014","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0012","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1182\/blood.V97.7.2137","article-title":"Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein\/p300","volume":"97","author":"Mori","year":"2001","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.virol.2006.07.002","article-title":"Histone acetyltransferase activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity","volume":"354","author":"Michael","year":"2006","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0014","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1128\/MCB.01657-07","article-title":"The human T-cell leukemia virus type 1 Tax protein confers CBP\/p300 recruitment and transcriptional activation properties to phosphorylated CREB","volume":"28","author":"Geiger","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"6575","key":"10.1016\/j.ctarc.2026.101448_bib0015","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/380642a0","article-title":"Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP","volume":"380","author":"Kwok","year":"1996","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ctarc.2026.101448_bib0016","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1128\/MCB.20.10.3470-3481.2000","article-title":"Molecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2\/ATF-4","volume":"20","author":"Gachon","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0017","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1128\/MCB.17.9.5156","article-title":"Anchoring of CREB-binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation","volume":"17","author":"Giebler","year":"1997","journal-title":"Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0018","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1128\/MCB.18.9.5052","article-title":"An exposed KID-like domain in HTLV-1 Tax is responsible for recruitment of coactivators CBP\/p300","volume":"18","author":"Harrod","year":"1998","journal-title":"Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101448_bib0019","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1128\/MCB.20.10.3377-3386.2000","article-title":"Inactivation of p53 by HTLV-1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation","volume":"20","author":"Pise-Masison","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0020","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.jmb.2007.06.062","article-title":"Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP\/p300","volume":"372","author":"Ramirez","year":"2007","journal-title":"J. Mol. Biol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0021","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.onc.1204163","article-title":"HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP\/p300 coactivators","volume":"20","author":"Lin","year":"2001","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0022","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1073\/pnas.97.1.430","article-title":"Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter","volume":"97","author":"Wang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0023","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1074\/jbc.M606774200","article-title":"The hepatitis B virus X protein functionally interacts with CREB-binding protein\/p300 in the regulation of CREB-mediated transcription","volume":"282","author":"Cougot","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0024","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02155-17","article-title":"Epstein-Barr virus nuclear antigen leader protein coactivates EP300","volume":"92","author":"Wang","year":"2018","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0025","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02028-19","article-title":"B cell-specific transcription activator PAX5 recruits p300 to support EBNA1-driven transcription","volume":"94","author":"Liu","year":"2020","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0026","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/viro.2001.1103","article-title":"Intranuclear localization of the transcription coadaptor CBP\/p300 and the transcription factor RBP-Jk in relation to EBNA-2 and EBNA-5 in B lymphocytes","volume":"288","author":"Bandobashi","year":"2001","journal-title":"Virology"},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107645","article-title":"Epstein-Barr virus nuclear antigen EBNA3A modulates IRF3-dependent IFN-beta expression","volume":"300","author":"Landman","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.ctarc.2026.101448_bib0028","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1128\/MCB.20.15.5722-5735.2000","article-title":"Modulation of histone acetyltransferase activity through interaction of Epstein-Barr virus nuclear antigen 3C with prothymosin alpha","volume":"20","author":"Cotter","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101448_bib0029","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1128\/JVI.73.8.6551-6558.1999","article-title":"Epstein-Barr virus BZLF1 protein interacts physically and functionally with the histone acetylase CBP","volume":"73","author":"Adamson","year":"1999","journal-title":"J. Virol."},{"issue":"13","key":"10.1016\/j.ctarc.2026.101448_bib0030","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1128\/JVI.75.13.6228-6234.2001","article-title":"Epstein-Barr virus immediate-early protein BRLF1 interacts with CBP, promoting enhanced BRLF1 transactivation","volume":"75","author":"Swenson","year":"2001","journal-title":"J. Virol."},{"issue":"21","key":"10.1016\/j.ctarc.2026.101448_bib0031","doi-asserted-by":"crossref","first-page":"8254","DOI":"10.1128\/MCB.20.21.8254-8263.2000","article-title":"Inhibition of p300 histone acetyltransferase by viral interferon regulatory factor","volume":"20","author":"Li","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0032","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/bbrc.2000.2393","article-title":"Viral interferon regulatory factor 1 of Kaposi sarcoma-associated herpesvirus binds to and inhibits transactivation of CREB-binding protein","volume":"270","author":"Seo","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0033","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.1128\/JVI.73.9.7334-7342.1999","article-title":"Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300","volume":"73","author":"Burysek","year":"1999","journal-title":"J. Virol."},{"issue":"19","key":"10.1016\/j.ctarc.2026.101448_bib0034","doi-asserted-by":"crossref","first-page":"9509","DOI":"10.1128\/JVI.75.19.9509-9516.2001","article-title":"Kaposi sarcoma-associated herpesvirus K8 protein interacts with CBP and represses CBP-mediated transcription","volume":"75","author":"Hwang","year":"2001","journal-title":"J. Virol."},{"issue":"50","key":"10.1016\/j.ctarc.2026.101448_bib0035","doi-asserted-by":"crossref","first-page":"8272","DOI":"10.1038\/sj.onc.1208059","article-title":"The Kaposi sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor-beta signaling through interaction with CREB-binding protein","volume":"23","author":"Tomita","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ctarc.2026.101448_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198066","article-title":"p300 promotes cell proliferation through suppressing Kaposi sarcoma-associated herpesvirus reactivation in infected B-lymphoma cells","volume":"286","author":"Sun","year":"2020","journal-title":"Virus. Res."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0037","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virol.2004.06.044","article-title":"Hepatitis C virus core protein regulates p300\/CBP co-activation function: possible role in regulation of NF-AT1 transcriptional activity","volume":"328","author":"Gomez-Gonzalo","year":"2004","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.ctarc.2026.101448_bib0038","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/sj.onc.1209052","article-title":"Wu Lee YH. Hepatitis C virus core protein recruits nucleolar phosphoprotein B23 and coactivator p300 to relieve the repression effect of transcriptional factor YY1 on B23 gene expression","volume":"25","author":"Mai","year":"2006","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.ctarc.2026.101448_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/kjm2.70006","article-title":"EP300 modulates MCM8 transcription and augments the malignant phenotype of hepatitis B virus-positive hepatocellular carcinoma cells","volume":"41","author":"Xue","year":"2025","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101448_bib0040","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/hep.25849","article-title":"Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling","volume":"56","author":"Zhang","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.ctarc.2026.101448_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104069","article-title":"Safety, tolerability, and anti-fibrotic efficacy of the CBP\/beta-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: an investigator-initiated, open-label, non-randomised, multicentre, phase 1\/2a study","volume":"80","author":"Kimura","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ctarc.2026.101448_bib0042","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41598-017-00282-w","article-title":"Selective inhibitor of Wnt\/beta-catenin\/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in a mouse model","volume":"7","author":"Tokunaga","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101448_bib0043","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators p300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"issue":"6610","key":"10.1016\/j.ctarc.2026.101448_bib0044","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"issue":"6735","key":"10.1016\/j.ctarc.2026.101448_bib0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/20974","article-title":"Structure and ligand of a histone acetyltransferase bromodomain","volume":"399","author":"Dhalluin","year":"1999","journal-title":"Nature"},{"issue":"7674","key":"10.1016\/j.ctarc.2026.101448_bib0046","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nature24028","article-title":"Discovery of a selective catalytic p300\/CBP inhibitor that targets lineage-specific tumors","volume":"550","author":"Lasko","year":"2017","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.ctarc.2026.101448_bib0047","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","article-title":"An essential role for p300\/CBP in the cellular response to hypoxia","volume":"93","author":"Arany","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ctarc.2026.101448_bib0048","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ebiom.2017.08.016","article-title":"Safety, tolerability, and preliminary efficacy of the antifibrotic small molecule PRI-724, a CBP\/\u03b2-catenin inhibitor, in patients with hepatitis C virus-related cirrhosis: a single-center, open-label, dose-escalation phase 1 trial","volume":"23","author":"Kimura","year":"2017","journal-title":"EBioMedicine"},{"issue":"17","key":"10.1016\/j.ctarc.2026.101448_bib0049","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1128\/JVI.76.17.8710-8721.2002","article-title":"Down regulation of the interleukin-8 promoter by human papillomavirus type 16 E6 and E7 through effects on CREB-binding protein\/p300 and P\/CAF","volume":"76","author":"Huang","year":"2002","journal-title":"J. Virol."},{"issue":"16","key":"10.1016\/j.ctarc.2026.101448_bib0050","doi-asserted-by":"crossref","first-page":"11852","DOI":"10.1074\/jbc.275.16.11852","article-title":"p300 and p300\/CREB-binding protein-associated factor interact with HTLV-1 Tax in a multi-histone acetyltransferase\/activator-enhancer complex","volume":"275","author":"Harrod","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0051","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.virol.2008.12.043","article-title":"Acetylation of HTLV-1 Tax by p300 promotes activation of the NF-kappaB pathway","volume":"386","author":"Lodewick","year":"2009","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0052","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/MCB.22.1.127-137.2002","article-title":"p300-mediated Tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function","volume":"22","author":"Georges","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"13","key":"10.1016\/j.ctarc.2026.101448_bib0053","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1128\/MCB.22.13.4450-4462.2002","article-title":"Acetylation of nucleosomal histones by p300 facilitates transcription from a Tax-responsive HTLV-1 chromatin template","volume":"22","author":"Lu","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"21","key":"10.1016\/j.ctarc.2026.101448_bib0054","doi-asserted-by":"crossref","first-page":"10542","DOI":"10.1128\/JVI.00631-06","article-title":"Tax abolishes histone H1 repression of p300 acetyltransferase activity at the HTLV-1 promoter","volume":"80","author":"Konesky","year":"2006","journal-title":"J. Virol."},{"issue":"14","key":"10.1016\/j.ctarc.2026.101448_bib0055","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1038\/onc.2009.498","article-title":"The HTLV-1 Tax protein cooperates with phosphorylated CREB, TORC2, and p300 to activate CRE-dependent cyclin D1 transcription","volume":"29","author":"Kim","year":"2010","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.ctarc.2026.101448_bib0056","doi-asserted-by":"crossref","first-page":"15720","DOI":"10.1074\/jbc.M100131200","article-title":"Human T-cell leukemia virus type I Tax repression of p73beta is mediated through competition for the C\/H1 domain of CBP","volume":"276","author":"Lemasson","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0057","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1006\/bbrc.2000.2325","article-title":"CBP: a target molecule of HTLV-1 Tax in synoviocyte activation","volume":"269","author":"Nakazawa","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"31","key":"10.1016\/j.ctarc.2026.101448_bib0058","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1038\/sj.onc.1207719","article-title":"Utilization of the CBP but not the p300 co-activator by HTLV-2 Tax for p53 inhibition","volume":"23","author":"Meertens","year":"2004","journal-title":"Oncogene"},{"issue":"24","key":"10.1016\/j.ctarc.2026.101448_bib0059","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S0960-9822(00)80120-7","article-title":"Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity","volume":"9","author":"Ott","year":"1999","journal-title":"Curr. Biol."},{"issue":"38","key":"10.1016\/j.ctarc.2026.101448_bib0060","doi-asserted-by":"crossref","first-page":"24898","DOI":"10.1074\/jbc.273.38.24898","article-title":"Activation of integrated provirus requires histone acetyltransferase: p300 and P\/CAF are coactivators for HIV-1 Tat","volume":"273","author":"Benkirane","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0061","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013073","article-title":"HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4-positive T cells","volume":"21","author":"Lewis","year":"2025","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0062","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1073\/pnas.95.9.5281","article-title":"HIV transcriptional activation by the accessory protein Vpr is mediated by the p300 co-activator","volume":"95","author":"Felzien","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.ctarc.2026.101448_bib0063","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1093\/emboj\/17.11.3124","article-title":"Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300","volume":"17","author":"Hottiger","year":"1998","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0064","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1074\/jbc.M107848200","article-title":"Enhancement of nuclear factor-kappaB acetylation by coactivator p300 and HIV-1 Tat proteins","volume":"277","author":"Furia","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.ctarc.2026.101448_bib0065","doi-asserted-by":"crossref","first-page":"12198","DOI":"10.1128\/JVI.78.22.12198-12206.2004","article-title":"Cell-cycle arrest in G2 induces human immunodeficiency virus type 1 transcriptional activation through histone acetylation and recruitment of CBP, NF-kappaB, and c-Jun to the long terminal repeat promoter","volume":"78","author":"Thierry","year":"2004","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0066","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02224-18","article-title":"Acetylation of E2 by p300 mediates topoisomerase entry at the papillomavirus replicon","volume":"93","author":"Thomas","year":"2019","journal-title":"J. Virol."},{"issue":"21","key":"10.1016\/j.ctarc.2026.101448_bib0067","doi-asserted-by":"crossref","first-page":"11042","DOI":"10.1128\/JVI.76.21.11042-11053.2002","article-title":"Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300","volume":"76","author":"Muller","year":"2002","journal-title":"J. Virol."},{"issue":"13","key":"10.1016\/j.ctarc.2026.101448_bib0068","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1128\/JVI.74.13.5872-5879.2000","article-title":"AMF-1\/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins","volume":"74","author":"Peng","year":"2000","journal-title":"J. Virol."},{"issue":"19","key":"10.1016\/j.ctarc.2026.101448_bib0069","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1128\/JVI.74.19.9090-9098.2000","article-title":"Adeno-associated virus type 2 Rep protein inhibits human papillomavirus type 16 E2 recruitment of the transcriptional coactivator p300","volume":"74","author":"Marcello","year":"2000","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101448_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002211","article-title":"Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT\/p300 association","volume":"7","author":"Howie","year":"2011","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101448_bib0071","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1128\/MCB.23.10.3392-3404.2003","article-title":"Tax recruitment of CBP\/p300 via the KIX domain reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent","volume":"23","author":"Georges","year":"2003","journal-title":"Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101448_bib0072","doi-asserted-by":"crossref","first-page":"8252","DOI":"10.1128\/JVI.72.10.8252-8256.1998","article-title":"Interaction of HIV-1 Tat with transcriptional coactivators p300 and CREB-binding protein","volume":"72","author":"Hottiger","year":"1998","journal-title":"J. Virol."},{"issue":"19","key":"10.1016\/j.ctarc.2026.101448_bib0073","doi-asserted-by":"crossref","first-page":"9724","DOI":"10.1128\/JVI.76.19.9724-9734.2002","article-title":"Human immunodeficiency virus type 1 accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300\/CBP coactivators","volume":"76","author":"Kino","year":"2002","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101448_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111244","article-title":"CBP\/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells","volume":"27","author":"Horvath","year":"2024","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0075","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.virol.2006.10.028","article-title":"Recruitment of activated IRF-3 and CBP\/p300 to herpes simplex virus ICP0 nuclear foci: potential role in blocking IFN-\u03b2 induction","volume":"360","author":"Melroe","year":"2007","journal-title":"Virology"},{"issue":"17","key":"10.1016\/j.ctarc.2026.101448_bib0076","doi-asserted-by":"crossref","first-page":"9788","DOI":"10.1128\/JVI.01440-13","article-title":"Herpes simplex virus 1-encoded tegument protein VP16 abrogates the production of beta interferon by inhibiting NF-\u03baB activation and blocking IRF3 recruitment of its coactivator CBP","volume":"87","author":"Xing","year":"2013","journal-title":"J. Virol."},{"issue":"17","key":"10.1016\/j.ctarc.2026.101448_bib0077","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1038\/sj.emboj.7600770","article-title":"Acetylation of HIV-1 integrase by p300 regulates viral integration","volume":"24","author":"Cereseto","year":"2005","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101448_bib0078","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(00)80552-8","article-title":"A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity","volume":"96","author":"Chakravarti","year":"1999","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ctarc.2026.101448_bib0079","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.chom.2014.10.004","article-title":"Adenovirus small E1A employs the lysine acetylases p300\/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection","volume":"16","author":"Ferrari","year":"2014","journal-title":"Cell Host. Microbe"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0080","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/emboj\/17.4.1087","article-title":"Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP\/p300","volume":"17","author":"Yoneyama","year":"1998","journal-title":"EMBO J."},{"issue":"25","key":"10.1016\/j.ctarc.2026.101448_bib0081","doi-asserted-by":"crossref","first-page":"22304","DOI":"10.1074\/jbc.M200192200","article-title":"Direct involvement of CREB-binding protein\/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex","volume":"277","author":"Suhara","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101448_bib0082","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1128\/MCB.18.3.1359","article-title":"Interferon regulatory factor 3 and CREB-binding protein\/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1","volume":"18","author":"Weaver","year":"1998","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0083","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1097-2765(00)80051-9","article-title":"Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo","volume":"1","author":"Wathelet","year":"1998","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0084","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1097-2765(00)80181-1","article-title":"Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter","volume":"3","author":"Parekh","year":"1999","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0014-5793(98)00210-5","article-title":"Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene","volume":"425","author":"Sato","year":"1998","journal-title":"FEBS Lett."},{"issue":"28","key":"10.1016\/j.ctarc.2026.101448_bib0086","doi-asserted-by":"crossref","first-page":"E2621","DOI":"10.1073\/pnas.1309906110","article-title":"Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300\/CBP and STAT3","volume":"110","author":"Du","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0087","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70683","article-title":"Enhancing oncolytic adenovirus replication by early region 1A protein-mediated degradation of E1A binding protein p300","volume":"7","author":"Xiao","year":"2026","journal-title":"MedComm"},{"key":"10.1016\/j.ctarc.2026.101448_bib0088","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s11658-018-0121-1","article-title":"Latent viruses can cause disease by disrupting the competition for the limiting factor p300\/CBP","volume":"23","author":"Polansky","year":"2018","journal-title":"Cell Mol. Biol. Lett."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0089","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1615\/CritRevImmunol.v29.i2.30","article-title":"Viral mechanisms involved in the transcriptional CBP\/p300 regulation of inflammatory and immune responses","volume":"29","author":"Revilla","year":"2009","journal-title":"Crit. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.ctarc.2026.101448_bib0090","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0966-842X(00)01874-6","article-title":"Viral replication and the coactivators p300 and CBP","volume":"8","author":"Hottiger","year":"2000","journal-title":"Trends Microbiol."},{"issue":"28","key":"10.1016\/j.ctarc.2026.101448_bib0091","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1038\/sj.onc.1202766","article-title":"Tax protein of HTLV-1 inhibits CBP\/p300-mediated transcription by interfering with recruitment of CBP\/p300 onto DNA elements","volume":"18","author":"Suzuki","year":"1999","journal-title":"Oncogene"},{"issue":"14","key":"10.1016\/j.ctarc.2026.101448_bib0092","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1074\/jbc.275.14.10551","article-title":"HTLV-1 Tax represses MyoD-dependent transcription by inhibiting MyoD binding to the KIX domain of p300","volume":"275","author":"Riou","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"25","key":"10.1016\/j.ctarc.2026.101448_bib0093","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1038\/sj.onc.1202703","article-title":"Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control","volume":"18","author":"Van Orden","year":"1999","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.ctarc.2026.101448_bib0094","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/sj.onc.1203450","article-title":"HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration","volume":"19","author":"Ariumi","year":"2000","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0095","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.virol.2008.06.035","article-title":"Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP\/p300","volume":"379","author":"Zhang","year":"2008","journal-title":"Virology"},{"issue":"37","key":"10.1016\/j.ctarc.2026.101448_bib0096","doi-asserted-by":"crossref","first-page":"26321","DOI":"10.1074\/jbc.274.37.26321","article-title":"Binding of p53 to the KIX domain of CREB-binding protein: a potential link to human T-cell leukemia virus type 1-associated leukemogenesis","volume":"274","author":"Van Orden","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"35","key":"10.1016\/j.ctarc.2026.101448_bib0097","doi-asserted-by":"crossref","first-page":"23903","DOI":"10.1074\/jbc.M803116200","article-title":"An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor and the KIX domain of p300\/CBP contributes to the down-regulation of Tax-dependent viral transcription by HBZ","volume":"283","author":"Clerc","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0098","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.18632\/oncotarget.6424","article-title":"Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300\/CBP and HBO1","volume":"7","author":"Wright","year":"2016","journal-title":"Oncotarget"},{"issue":"13","key":"10.1016\/j.ctarc.2026.101448_bib0099","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1093\/nar\/gks244","article-title":"The HTLV-1-encoded protein HBZ directly inhibits the acetyltransferase activity of p300\/CBP","volume":"40","author":"Wurm","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"24","key":"10.1016\/j.ctarc.2026.101448_bib0100","doi-asserted-by":"crossref","first-page":"11988","DOI":"10.1128\/JVI.74.24.11988-11992.2000","article-title":"Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the Tax-CBP\/p300 interaction","volume":"74","author":"Robek","year":"2000","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0101","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1128\/MCB.18.4.2392","article-title":"Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB-binding protein and p300","volume":"18","author":"Bex","year":"1998","journal-title":"Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101448_bib0102","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1128\/JVI.73.8.6209-6219.1999","article-title":"The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP\/p300","volume":"73","author":"Zimmermann","year":"1999","journal-title":"J. Virol."},{"issue":"39","key":"10.1016\/j.ctarc.2026.101448_bib0103","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1038\/sj.onc.1206896","article-title":"Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300","volume":"22","author":"Bernat","year":"2003","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.ctarc.2026.101448_bib0104","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1128\/JVI.02349-08","article-title":"Transcriptional coactivators are not required for herpes simplex virus type 1 immediate-early gene expression in vitro","volume":"83","author":"Kutluay","year":"2009","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.virol.2007.11.028","article-title":"Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300\/CBP histone acetyltransferase activity","volume":"373","author":"Kutluay","year":"2008","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.ctarc.2026.101448_bib0106","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ncb2054","article-title":"miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator","volume":"12","author":"Lagos","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"19","key":"10.1016\/j.ctarc.2026.101448_bib0107","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1128\/JVI.00920-16","article-title":"Varicella-zoster virus activates CREB, and inhibition of the pCREB-p300\/CBP interaction inhibits viral replication in vitro and skin pathogenesis in vivo","volume":"90","author":"Francois","year":"2016","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101448_bib0108","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1128\/AAC.02055-15","article-title":"C646, a novel p300\/CREB-binding protein-specific inhibitor of histone acetyltransferase, attenuates influenza A virus infection","volume":"60","author":"Zhao","year":"2016","journal-title":"Antimicrob. Agents Chemother"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0109","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2023-001341","article-title":"Safety and tolerability of OP-724 in patients with haemophilia and liver cirrhosis due to HIV\/HCV coinfection: an investigator-initiated, open-label, non-randomised, single-centre, phase I study","volume":"11","author":"Kimura","year":"2024","journal-title":"BMJ Open Gastroenterol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0110","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28383","article-title":"SARS-CoV-2 infection activates CREB\/CBP in cellular cyclic AMP-dependent pathways","volume":"95","author":"Yang","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ctarc.2026.101448_bib0111","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1193320","article-title":"Machine learning on large-scale perturbation screens for SARS-CoV-2 host factors identifies \u03b2-catenin\/CBP inhibitor PRI-724 as a potent antiviral","volume":"14","author":"Kelch","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ctarc.2026.101448_bib0112","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/612823","article-title":"Disruption of HPV16-E7 by CRISPR\/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells","volume":"2014","author":"Hu","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0113","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011351","article-title":"The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression","volume":"19","author":"Wei","year":"2023","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101448_bib0114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009616","article-title":"p300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity","volume":"17","author":"Zhang","year":"2021","journal-title":"PLoS Pathog."},{"issue":"Pt 4","key":"10.1016\/j.ctarc.2026.101448_bib0115","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1099\/0022-1317-83-4-829","article-title":"Complementation of a p300\/CBP defective-binding mutant of adenovirus E1A by human papillomavirus E6 proteins","volume":"83","author":"Bernat","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ctarc.2026.101448_bib0116","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.antiviral.2015.04.013","article-title":"The hepatitis B virus core protein enhances transcription activation of CRE via the CRE\/CREB\/CBP pathway","volume":"120","author":"Xiang","year":"2015","journal-title":"Antiviral Res."},{"issue":"30","key":"10.1016\/j.ctarc.2026.101448_bib0117","doi-asserted-by":"crossref","first-page":"17666","DOI":"10.1074\/jbc.271.30.17666","article-title":"Differential interactions of the CREB\/ATF family of transcription factors with p300 and adenovirus E1A","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.ctarc.2026.101448_bib0118","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1128\/MCB.16.8.4312","article-title":"Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300","volume":"16","author":"Lee","year":"1996","journal-title":"Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.ctarc.2026.101448_bib0119","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gad.9.10.1188","article-title":"Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated p300","volume":"9","author":"Lee","year":"1995","journal-title":"Genes Dev."},{"issue":"6589","key":"10.1016\/j.ctarc.2026.101448_bib0120","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/382319a0","article-title":"A p300\/CBP-associated factor that competes with the adenoviral oncoprotein E1A","volume":"382","author":"Yang","year":"1996","journal-title":"Nature"},{"issue":"32","key":"10.1016\/j.ctarc.2026.101448_bib0121","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1038\/onc.2008.85","article-title":"The transcription-repression domain of adenovirus E1A targets p300 at the promoter","volume":"27","author":"Green","year":"2008","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0122","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/nar\/gkn1057","article-title":"Transcriptional control by adenovirus E1A conserved region 3 via p300\/CBP","volume":"37","author":"Pelka","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.ctarc.2026.101448_bib0123","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1128\/JVI.73.5.3574-3581.1999","article-title":"Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif in CBP\/p300","volume":"73","author":"OConnor","year":"1999","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0124","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1073\/pnas.93.4.1439","article-title":"E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP","volume":"93","author":"Trouche","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0125","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/j.1460-2075.1996.tb00577.x","article-title":"The SV40 large T antigen and adenovirus E1A oncoproteins interact with distinct isoforms of the transcriptional coactivator p300","volume":"15","author":"Avantaggiati","year":"1996","journal-title":"EMBO J."},{"issue":"24","key":"10.1016\/j.ctarc.2026.101448_bib0126","doi-asserted-by":"crossref","first-page":"13985","DOI":"10.1073\/pnas.93.24.13985","article-title":"Role of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejection","volume":"93","author":"Cook","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0127","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/jvi.70.1.68-77.1996","article-title":"Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis","volume":"70","author":"Shisler","year":"1996","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0128","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1023\/A:1007967009156","article-title":"Identification of specific amino acid residues of adenovirus 12 E1A involved in transformation and p300 binding","volume":"15","author":"Sawada","year":"1997","journal-title":"Virus Genes"},{"issue":"5","key":"10.1016\/j.ctarc.2026.101448_bib0129","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/sj.bjc.6603304","article-title":"Roles for the coactivators CBP and p300 and the APC\/C E3 ubiquitin ligase in E1A-dependent cell transformation","volume":"95","author":"Turnell","year":"2006","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/PGP.0b013e3181bccaec","article-title":"p300 expression is related to high-risk human papillomavirus infections and severity of cervical intraepithelial neoplasia but not to viral or disease outcomes in a longitudinal setting","volume":"29","author":"Syrj\u00e4nen","year":"2010","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.ctarc.2026.101448_bib0131","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1479-5876-9-5","article-title":"High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma","volume":"9","author":"Li","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ctarc.2026.101448_bib0132","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1479-5876-10-110","article-title":"High expression of p300 is linked to aggressive features and poor prognosis of nasopharyngeal carcinoma","volume":"10","author":"Liao","year":"2012","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.ctarc.2026.101448_bib0133","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/MCB.26.3.789-809.2006","article-title":"Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development","volume":"26","author":"Kasper","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.ctarc.2026.101448_bib0134","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1182\/blood-2010-12-326199","article-title":"HTLV-1 bZIP factor enhances TGF-beta signaling through p300 coactivator","volume":"118","author":"Zhao","year":"2011","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.ctarc.2026.101448_bib0135","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1128\/MCB.20.22.8580-8589.2000","article-title":"Distinct p300-responsive mechanisms promote caspase-dependent apoptosis by HTLV-1 Tax","volume":"20","author":"Nicot","year":"2000","journal-title":"Mol. Cell Biol."},{"issue":"16","key":"10.1016\/j.ctarc.2026.101448_bib0136","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1128\/MCB.21.16.5520-5530.2001","article-title":"The oncoprotein Tax binds the SRC-1-interacting domain of CBP\/p300 to mediate transcriptional activation","volume":"21","author":"Scoggin","year":"2001","journal-title":"Mol. Cell Biol."},{"issue":"52","key":"10.1016\/j.ctarc.2026.101448_bib0137","doi-asserted-by":"crossref","first-page":"34646","DOI":"10.1074\/jbc.273.51.34646","article-title":"The coactivator CBP stimulates human T-cell lymphotropic virus type 1 Tax transactivation in vitro","volume":"273","author":"Kashanchi","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.ctarc.2026.101448_bib0138","first-page":"49","article-title":"Transcriptional coactivator CBP facilitates transcription initiation and reinitiation of HTLV-1 and cyclin D2 promoter","volume":"2","author":"Duvall","year":"1998","journal-title":"Iran. Biomed. J."},{"issue":"23","key":"10.1016\/j.ctarc.2026.101448_bib0139","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.1073\/pnas.0800534105","article-title":"The coactivators CBP\/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoter","volume":"105","author":"Sharma","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8016","key":"10.1016\/j.ctarc.2026.101448_bib0140","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0141","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12943-024-02140-6","article-title":"Artificial intelligence alphafold model for molecular biology and drug discovery: a machine-learning-driven informatics investigation","volume":"23","author":"Guo","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0142","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.1038\/s41467-025-61618-z","article-title":"Structural host-virus interactome profiling of intact infected cells","volume":"16","author":"Bogdanow","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0143","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3390\/biom16040541","article-title":"Interactys-AI: toward AI-driven structural mapping of virus-host interfaces for antiviral repurposing and pandemic preparedness","volume":"16","author":"Poitras","year":"2026","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0144","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41467-023-44288-7","article-title":"From interaction networks to interfaces, scanning intrinsically disordered regions using AlphaFold2","volume":"15","author":"Bret","year":"2024","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.ctarc.2026.101448_bib0145","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1128\/MCB.21.21.7391-7402.2001","article-title":"Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage","volume":"21","author":"Nicot","year":"2001","journal-title":"Mol. Cell Biol."},{"issue":"14","key":"10.1016\/j.ctarc.2026.101448_bib0146","doi-asserted-by":"crossref","first-page":"9346","DOI":"10.1128\/JVI.79.14.9346-9350.2005","article-title":"Evidence for NF-kappaB- and CBP-independent repression of p53 transcriptional activity by human T-cell leukemia virus type 1 Tax in mouse embryo and primary human fibroblasts","volume":"79","author":"Miyazato","year":"2005","journal-title":"J. Virol."},{"issue":"16","key":"10.1016\/j.ctarc.2026.101448_bib0147","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1038\/sj.onc.1203536","article-title":"HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300","volume":"19","author":"Nicot","year":"2000","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0148","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1074\/jbc.M005601200","article-title":"Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent","volume":"276","author":"Pise-Masison","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.ctarc.2026.101448_bib0149","doi-asserted-by":"crossref","first-page":"9885","DOI":"10.1128\/JVI.75.20.9885-9895.2001","article-title":"HTLV-1 p30II regulates gene transcription by binding CREB-binding protein\/p300","volume":"75","author":"Zhang","year":"2001","journal-title":"J. Virol."},{"issue":"23","key":"10.1016\/j.ctarc.2026.101448_bib0150","doi-asserted-by":"crossref","first-page":"11939","DOI":"10.1128\/JVI.01356-08","article-title":"The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the HTLV-1 promoter","volume":"82","author":"Kim","year":"2008","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.ctarc.2026.101448_bib0151","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/aid.2005.21.273","article-title":"HTLV-1 accessory protein p12I modulates calcium-mediated cellular gene expression and enhances p300 expression in T lymphocytes","volume":"21","author":"Nair","year":"2005","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"14","key":"10.1016\/j.ctarc.2026.101448_bib0152","doi-asserted-by":"crossref","first-page":"12310","DOI":"10.1074\/jbc.M211167200","article-title":"Human immunodeficiency virus type 1 Tat\/coactivator acetyltransferase interactions inhibit p53 Lys-320 acetylation and p53-responsive transcription","volume":"278","author":"Harrod","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.ctarc.2026.101448_bib0153","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/glia.21038","article-title":"Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes","volume":"58","author":"Zou","year":"2010","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0154","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1159\/000088404","article-title":"p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells: association with alteration of TGF-beta and Smad signaling","volume":"102","author":"Kapasi","year":"2006","journal-title":"Nephron. Exp. Nephrol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101448_bib0155","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/JVI.02257-06","article-title":"Posttranslational acetylation of HIV-1 integrase carboxyl-terminal domain is dispensable for viral replication","volume":"81","author":"Topper","year":"2007","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101448_bib0156","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s13258-020-00938-4","article-title":"Tip60 and p300 function antagonistically in epigenetic regulation of HPV18 E6\/E7 genes in cervical cancer HeLa cells","volume":"42","author":"Lai","year":"2020","journal-title":"Genes. Genomics"},{"issue":"18","key":"10.1016\/j.ctarc.2026.101448_bib0157","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.1128\/JVI.78.18.9689-9696.2004","article-title":"VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection","volume":"78","author":"Herrera","year":"2004","journal-title":"J. Virol."},{"issue":"15","key":"10.1016\/j.ctarc.2026.101448_bib0158","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.1128\/JVI.02581-07","article-title":"Transcription factor YY1 and its associated acetyltransferases CBP and p300 interact with hepatitis delta antigens and modulate hepatitis delta virus RNA replication","volume":"82","author":"Huang","year":"2008","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.ctarc.2026.101448_bib0159","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1462-5822.2009.01340.x","article-title":"The hepatitis E virus ORF3 protein stabilizes HIF-1\u03b1 and enhances HIF-1-mediated transcriptional activity through p300\/CBP","volume":"11","author":"Moin","year":"2009","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.ctarc.2026.101448_bib0160","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fcimb.2017.00195","article-title":"AGO2 negatively regulates type I interferon signaling pathway by competition binding IRF3 with CBP\/p300","volume":"7","author":"Wang","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0161","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41564-021-01004-9","article-title":"Molecular mimicry of NF-\u03baB by vaccinia virus protein enables selective inhibition of antiviral responses","volume":"7","author":"Albarnaz","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ctarc.2026.101448_bib0162","article-title":"Echinocystic acid in Momordica charantia exosome-like nanovesicles attenuates dengue virus-induced vascular leakage-associated inflammatory mediators through macrophage metabolic reprogramming and HIF-1alpha\/p300-CBP interaction","volume":"12","author":"Liu","year":"2025","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0163","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0040013","article-title":"A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus-infected cells","volume":"4","author":"Le May","year":"2008","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.ctarc.2026.101448_bib0164","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010559","article-title":"Zika virus infection drives epigenetic modulation of immunity by the histone acetyltransferase CBP of Aedes aegypti","volume":"16","author":"Amarante","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"5-6","key":"10.1016\/j.ctarc.2026.101448_bib0165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.18632\/genesandcancer.178","article-title":"How a disruption of the competition between HIF-1 and p53 for limiting p300\/CBP by latent viruses can cause disease","volume":"9","author":"Polansky","year":"2018","journal-title":"Genes. Cancer"},{"issue":"1","key":"10.1016\/j.ctarc.2026.101448_bib0166","doi-asserted-by":"crossref","first-page":"451","DOI":"10.4049\/jimmunol.176.1.451","article-title":"The viral protein A238L inhibits TNF-alpha expression through a CBP\/p300 transcriptional coactivator pathway","volume":"176","author":"Granja","year":"2006","journal-title":"J. Immunol."}],"container-title":["Cancer Treatment and Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226003588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468294226003588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:38:53Z","timestamp":1791488333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468294226003588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":166,"alternative-id":["S2468294226003588"],"URL":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101448","relation":{},"ISSN":["2468-2942"],"issn-type":[{"value":"2468-2942","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Viral exploitation of p300\/CBP at the virus-cancer interface: Chromatin regulation, oncogenesis, immune evasion, and therapeutic targeting","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment and Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctarc.2026.101448","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101448"}}