{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:06:16Z","timestamp":1782882376367,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["97.2765"],"award-info":[{"award-number":["97.2765"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Clinical Practice"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ctcp.2020.101239","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T11:38:23Z","timestamp":1600429103000},"page":"101239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["The comparison of the effect of soybean and fish oil on supplementation on menopausal symptoms in postmenopausal women: A randomized, double-blind, placebo-controlled trial"],"prefix":"10.1016","volume":"41","author":[{"given":"Bahareh","family":"Purzand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Rokhgireh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoore","family":"Shabani Zanjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nooshin","family":"Eshraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdiss","family":"Mohamadianamiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Esmailzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Alkatout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Gitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Allahqoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ogc.2011.05.002","article-title":"The timing of the age at which natural menopause occurs","volume":"38","author":"Gold","year":"2011","journal-title":"Obstetr. Gynecol. Clin."},{"issue":"7","key":"10.1016\/j.ctcp.2020.101239_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jclinepi.2004.09.016","article-title":"The menopausal transition was associated in a prospective study with decreased health functioning in women who report menopausal symptoms","volume":"58","author":"Kumari","year":"2005","journal-title":"J. Clin. Epidemiol."},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ogc.2011.05.006","article-title":"Vasomotor symptoms and menopause: findings from the study of women's health across the nation","volume":"38","author":"Thurston","year":"2011","journal-title":"Obstetr. Gynecol. Clin."},{"key":"10.1016\/j.ctcp.2020.101239_bib4","series-title":"Dewhurst's Text Book of Obstetrics & Gynaecology","first-page":"479","article-title":"Menopause and the postmenopausal women","author":"Panay","year":"2007"},{"issue":"1","key":"10.1016\/j.ctcp.2020.101239_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/jmh.JMH_7_19","article-title":"Menopausal hot flashes: a concise review","volume":"10","author":"Bansal","year":"2019","journal-title":"J. Mid Life Health"},{"issue":"9","key":"10.1016\/j.ctcp.2020.101239_bib6","first-page":"FC13","article-title":"The effect of soy isoflavones on the menopause rating scale scoring in perimenopausal and postmenopausal women: a pilot study","volume":"11","author":"Ahsan","year":"2017","journal-title":"J. Clin. Diagn. Res.: J. Clin. Diagn. Res."},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00198-013-2512-5","article-title":"Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study","volume":"25","author":"Atteritano","year":"2014","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"Jama"},{"issue":"10","key":"10.1016\/j.ctcp.2020.101239_bib9","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.0001-6349.2005.00769.x","article-title":"Hot flashes revisited: pharmacological and herbal options for hot flashes management. What does the evidence tell us?","volume":"84","author":"Haimov-Kochman","year":"2005","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"2","key":"10.1016\/j.ctcp.2020.101239_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/0976-7800.76216","article-title":"Attitudes and practices of gynecologists in Jaipur toward management of menopause","volume":"1","author":"Meherishi","year":"2010","journal-title":"J. Mid Life Health"},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/gme.0b013e3181f2ea2e","article-title":"Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial","volume":"18","author":"Freeman","year":"2011","journal-title":"Menopause"},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib12","first-page":"221","article-title":"Efficacy of omega-3 on hot flush in perimenopausal women versus placebo","volume":"22","author":"Ghasemi","year":"2012","journal-title":"Med. Sci. J. Islamic Azad Univ. Tehran Med. Branch"},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.29252\/ijrm.14.3.155","article-title":"The efficacy of Iranian herbal medicines in alleviating hot flashes: a systematic review","volume":"14","author":"Ghazanfarpour","year":"2016","journal-title":"Int. J. Reprod. BioMed."},{"key":"10.1016\/j.ctcp.2020.101239_bib14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ejphar.2014.07.057","article-title":"Phytoestrogens and their effects","volume":"741","author":"Sirotkin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.ctcp.2020.101239_bib15","first-page":"2223","article-title":"Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence","volume":"83","author":"Tham","year":"1998","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"5","key":"10.1016\/j.ctcp.2020.101239_bib16","first-page":"60","article-title":"Use of medicinal plants in the treatment of premenstrual syndrome: a review","volume":"7","author":"Golmakani","year":"2011","journal-title":"J. Am. Sci."},{"issue":"1","key":"10.1016\/j.ctcp.2020.101239_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/lrb.2009.0030","article-title":"The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food products","volume":"8","author":"Barnes","year":"2010","journal-title":"Lymphatic Res. Biol."},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib18","doi-asserted-by":"crossref","first-page":"664S","DOI":"10.1093\/jn\/130.3.664S","article-title":"Soybean isoflavones as an alternative to traditional hormone replacement therapy: are we there yet?","volume":"130","author":"Burke","year":"2000","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.ctcp.2020.101239_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2217\/17455057.5.2.127","article-title":"Menopausal symptoms within a hispanic cohort: SWAN, the study of women's health across the nation","volume":"5","author":"Green","year":"2009","journal-title":"Women's Health"},{"issue":"7","key":"10.1016\/j.ctcp.2020.101239_bib20","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/gme.0b013e31821fc8e0","article-title":"The role of soy isoflavones in menopausal health: report of the north American menopause society\/wulf H. Utian translational science symposium in chicago, IL (october 2010)","volume":"18","author":"Clarkson","year":"2011","journal-title":"Menopause"},{"issue":"7","key":"10.1016\/j.ctcp.2020.101239_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19071849","article-title":"N-3 polyunsatured fatty acids in menopausal transition: a systematic review of depressive and cognitive disorders with accompanying vasomotor symptoms","volume":"19","author":"Ciappolino","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ctcp.2020.101239_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.maturitas.2004.11.002","article-title":"Polyunsaturated fatty acids (PUFAs) might reduce hot flushes: an indication from two controlled trials on soy isoflavones alone and with a PUFA supplement","volume":"51","author":"Campagnoli","year":"2005","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/nu9030298","article-title":"The relationship between fatty acids and different depression-related brain regions, and their potential role as biomarkers of response to antidepressants","volume":"9","author":"Fernandes","year":"2017","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib24","first-page":"2341","article-title":"Comparison of the effect of Omega3 and folic acid on hot flashes in menopausal women","volume":"8","author":"Jahdi","year":"2018","journal-title":"Compl. Med. J."},{"key":"10.1016\/j.ctcp.2020.101239_bib25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejogrb.2018.07.008","article-title":"Effect of omega-3 supplements on vasomotor symptoms in menopausal women: a systematic review and meta-analysis","volume":"228","author":"Mohammady","year":"2018","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"10.1016\/j.ctcp.2020.101239_bib26","first-page":"7","article-title":"Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women","volume":"6","author":"Washburn","year":"1999","journal-title":"Menopause"},{"key":"10.1016\/j.ctcp.2020.101239_bib27","series-title":"Menopause Rating Scale: Psychometric Properties of Iranian Version","author":"Jahangiry","year":"2020"},{"issue":"12","key":"10.1016\/j.ctcp.2020.101239_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/nu8120767","article-title":"Vitamin B12 among vegetarians: status, assessment and supplementation","volume":"8","author":"Rizzo","year":"2016","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.ctcp.2020.101239_bib29","doi-asserted-by":"crossref","first-page":"638","DOI":"10.12891\/ceog3237.2016","article-title":"Dental management in pregnancy: recent trends","volume":"43","author":"Vitale","year":"2016","journal-title":"Clin. Exp. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.ctcp.2020.101239_bib30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3109\/09513590.2016.1144741","article-title":"Inositol's and other nutraceuticals' synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives","volume":"32","author":"Paul","year":"2016","journal-title":"Gynecol. Endocrinol."},{"issue":"6","key":"10.1016\/j.ctcp.2020.101239_bib31","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1200\/JCO.2002.20.6.1449","article-title":"Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial","volume":"20","author":"Van Patten","year":"2002","journal-title":"J. Clin. Oncol."},{"issue":"11","key":"10.1016\/j.ctcp.2020.101239_bib32","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1634\/theoncologist.2011-0174","article-title":"Hot flashes: a review of pathophysiology and treatment modalities","volume":"16","author":"Morrow","year":"2011","journal-title":"Oncol."},{"key":"10.1016\/j.ctcp.2020.101239_bib33","series-title":"Effects of Antidepressants and Soybean Association in Depressive Menopausal Women","author":"Nina Estrella","year":"2014"},{"issue":"4","key":"10.1016\/j.ctcp.2020.101239_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1054\/plef.1999.0037","article-title":"Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis possible candidate genes","volume":"60","author":"Horrobin","year":"1999","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"18","key":"10.1016\/j.ctcp.2020.101239_bib35","first-page":"4243","article-title":"Vitamin D in human reproduction: the more, the better? An evidence-based critical appraisal","volume":"21","author":"Lagan\u00e0","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ctcp.2020.101239_bib36","doi-asserted-by":"crossref","first-page":"986281","DOI":"10.1155\/2015\/986281","article-title":"The pleiotropic effects of vitamin D in gynaecological and obstetric diseases: an overview on a hot topic","volume":"2015","author":"Colonese","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"4","key":"10.1016\/j.ctcp.2020.101239_bib37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1176\/appi.ps.52.4.529","article-title":"Fish consumption and depressive symptoms in the general population in Finland","volume":"52","author":"Tanskanen","year":"2001","journal-title":"Psychiatr. Serv."},{"issue":"9110","key":"10.1016\/j.ctcp.2020.101239_bib38","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0140-6736(05)79168-6","article-title":"Fish consumption and major depression","volume":"351","author":"Hibbeln","year":"1998","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ctcp.2020.101239_bib39","first-page":"37","article-title":"Comment on: \"Is there a role for vitamin D in human reproduction?","volume":"29","author":"Colonese","year":"2017","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"issue":"4","key":"10.1016\/j.ctcp.2020.101239_bib40","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4088\/JCP.v69n0418","article-title":"Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial","volume":"69","author":"Su","year":"2008","journal-title":"J. Clin. Psychiatr."},{"issue":"4","key":"10.1016\/j.ctcp.2020.101239_bib41","first-page":"410","article-title":"Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression","volume":"8","author":"Logan","year":"2003","journal-title":"Alternative Med. Rev."},{"issue":"3","key":"10.1016\/j.ctcp.2020.101239_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.6118\/jmm.2014.20.3.97","article-title":"Expression of ezrin in vagina cells of postmenopausal rats after dietary administration of omega-3 Fatty Acid formula","volume":"20","author":"Lee","year":"2014","journal-title":"J. Menopausal. Med."},{"issue":"1","key":"10.1016\/j.ctcp.2020.101239_bib43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fertnstert.2004.09.003","article-title":"Lack of effect of isoflavonoids on the vagina and endometrium in postmenopausal women","volume":"83","author":"Nikander","year":"2005","journal-title":"Fertil. Steril."},{"issue":"10","key":"10.1016\/j.ctcp.2020.101239_bib44","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/GME.0000000000000223","article-title":"Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis)","volume":"21","author":"Silverstein","year":"2014","journal-title":"Menopause"},{"issue":"12","key":"10.1016\/j.ctcp.2020.101239_bib45","doi-asserted-by":"crossref","first-page":"e673","DOI":"10.1161\/CIR.0000000000000709","article-title":"Omega-3 fatty acids for the management of hypertriglyceridemia: a science advisory from the American Heart Association","volume":"140","author":"Skulas-Ray","year":"2019","journal-title":"Circulation"}],"container-title":["Complementary Therapies in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744388120311142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744388120311142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:03:09Z","timestamp":1778824989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744388120311142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":45,"alternative-id":["S1744388120311142"],"URL":"https:\/\/doi.org\/10.1016\/j.ctcp.2020.101239","relation":{},"ISSN":["1744-3881"],"issn-type":[{"value":"1744-3881","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The comparison of the effect of soybean and fish oil on supplementation on menopausal symptoms in postmenopausal women: A randomized, double-blind, placebo-controlled trial","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctcp.2020.101239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101239"}}