{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:37:48Z","timestamp":1791520668575,"version":"4.3.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Clinical Practice"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ctcp.2025.102019","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:10:17Z","timestamp":1756743017000},"page":"102019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Siguan points-based acupuncture treatment for migraine: A systematic review with meta-analysis of clinical efficacy and neurovascular regulatory effects"],"prefix":"10.1016","volume":"61","author":[{"given":"Xu-ran","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ying","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-heng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao-jiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-qiu","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kegang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10258","key":"10.1016\/j.ctcp.2025.102019_bib1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ctcp.2025.102019_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41582-022-00763-1","article-title":"Global epidemiology of migraine and its implications for public health and health policy","volume":"19","author":"Steiner","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s10194-024-01740-3","article-title":"Societal and economic burden of migraine in Spain: results from the 2020 national Health and wellness Survey","volume":"25","author":"Garc\u00eda-Azor\u00edn","year":"2024","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s10194-019-1062-4","article-title":"Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature","volume":"20","author":"Takeshima","year":"2019","journal-title":"J. Headache Pain"},{"issue":"5","key":"10.1016\/j.ctcp.2025.102019_bib5","doi-asserted-by":"crossref","first-page":"E187","DOI":"10.1503\/cmaj.221607","article-title":"Pharmacologic prevention of migraine","volume":"195","author":"Tzankova","year":"2023","journal-title":"Can. Med. Assoc. J."},{"issue":"5","key":"10.1016\/j.ctcp.2025.102019_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2165\/11630590-000000000-00000","article-title":"Taking the negative view of current migraine treatments: the unmet needs","volume":"26","author":"Tfelt-Hansen","year":"2012","journal-title":"CNS Drugs"},{"issue":"18","key":"10.1016\/j.ctcp.2025.102019_bib7","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1212\/WNL.0000000000207677","article-title":"Beyond the guidelines: a narrative review of treatments on the horizon for migraine in children and adolescents","volume":"101","author":"VanderPluym","year":"2023","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.ctcp.2025.102019_bib8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1177\/0333102416678382","article-title":"Persistence and switching patterns of oral migraine prophylactic medications among patients with chronic migraine: a retrospective claims analysis","volume":"37","author":"Hepp","year":"2017","journal-title":"Cephalalgia"},{"issue":"6","key":"10.1016\/j.ctcp.2025.102019_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1177\/0333102414547138","article-title":"Adherence to oral migraine-preventive medications among patients with chronic migraine","volume":"35","author":"Hepp","year":"2015","journal-title":"Cephalalgia"},{"issue":"9","key":"10.1016\/j.ctcp.2025.102019_bib10","doi-asserted-by":"crossref","DOI":"10.1177\/03331024241269735","article-title":"International Headache society global practice recommendations for preventive pharmacological treatment of migraine","volume":"44","author":"Puledda","year":"2024","journal-title":"Cephalalgia"},{"issue":"10","key":"10.1016\/j.ctcp.2025.102019_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11916-020-00899-z","article-title":"Efficacy and feasibility of behavioral treatments for migraine, headache, and pain in the acute care setting","volume":"24","author":"Vekhter","year":"2020","journal-title":"Curr. Pain Headache Rep."},{"issue":"8","key":"10.1016\/j.ctcp.2025.102019_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11916-023-01120-7","article-title":"Acupuncture for the treatment of migraine: an overview of systematic reviews","volume":"27","author":"Guo","year":"2023","journal-title":"Curr. Pain Headache Rep."},{"key":"10.1016\/j.ctcp.2025.102019_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e5765","article-title":"Guideline Development Group, diagnosis and management of headaches in young people and adults: summary of NICE guidance","volume":"345","author":"Carville","year":"2012","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.ctcp.2025.102019_bib14","first-page":"9","article-title":"A new interpretation of \"Opening Siguan\" based on the theory of \"Opening and Closing\"","volume":"43","author":"Qian","year":"2024","journal-title":"J Anhui Univ Chin Med."},{"issue":"4","key":"10.1016\/j.ctcp.2025.102019_bib15","first-page":"95","article-title":"Exploration of Siguan points","volume":"39","author":"Zhou","year":"2023","journal-title":"J Clin Acupunct Moxib"},{"issue":"10","key":"10.1016\/j.ctcp.2025.102019_bib16","first-page":"947","article-title":"Treatment of migraine by acupuncture at siguan points combined with gallbladder meridian points: a randomized controlled trial","volume":"34","author":"Lin","year":"2014","journal-title":"Chin. Acupunct. Moxibustion"},{"issue":"7","key":"10.1016\/j.ctcp.2025.102019_bib17","first-page":"808","article-title":"Clinical study on acupuncture at the six mind-calming acupoints plus the siguan points for migraine","volume":"35","author":"Zhang","year":"2016","journal-title":"Shanghai J Acupunct Moxib."},{"issue":"9","key":"10.1016\/j.ctcp.2025.102019_bib18","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1007\/s10072-022-06201-w","article-title":"The safety of acupuncture for migraine prevention during pregnancy","volume":"43","author":"Allais","year":"2022","journal-title":"Neurol. Sci."},{"issue":"2","key":"10.1016\/j.ctcp.2025.102019_bib19","first-page":"129","article-title":"Acupuncture at siguan points in the treatment of migraine and its influence on nitric oxide level","volume":"12","author":"Zou","year":"2003","journal-title":"J. Emerg. Tradit. Chin. Med."},{"issue":"8","key":"10.1016\/j.ctcp.2025.102019_bib20","first-page":"1205","article-title":"Mechanism of acupuncture and moxibustion at siguan points for migraine based on nuclear transcription factor-kappa B signaling pathway","volume":"15","author":"Liang","year":"2020","journal-title":"World Chin Med"},{"issue":"4","key":"10.1016\/j.ctcp.2025.102019_bib21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/bmjebm-2022-112135","article-title":"Acupuncture for acute migraine attacks in adults: a systematic review and meta-analysis","volume":"28","author":"Wang","year":"2023","journal-title":"BMJ Evid-Based Med"},{"issue":"2","key":"10.1016\/j.ctcp.2025.102019_bib22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/head.13723","article-title":"Systematic review: acupuncture vs standard pharmacological therapy for migraine prevention","volume":"60","author":"Zhang","year":"2020","journal-title":"Headache"},{"key":"10.1016\/j.ctcp.2025.102019_bib23","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache classification committee of the international headache society (IHS), the international classification of headache disorders","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"key":"10.1016\/j.ctcp.2025.102019_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001218.pub2","article-title":"Acupuncture for migraine prophylaxis","volume":"1","author":"Linde","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ctcp.2025.102019_bib26","series-title":"Guidelines for Clinical Research on New Chinese Medicinal Drugs (Trial Implementation)","first-page":"108","year":"2002"},{"key":"10.1016\/j.ctcp.2025.102019_bib27","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","first-page":"205","article-title":"Assessing risk of bias in a randomized trial","author":"Higgins","year":"2019"},{"key":"10.1016\/j.ctcp.2025.102019_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.eujim.2024.102405","article-title":"Pueraria Lobata radix (ge gen)-containing traditional Chinese medicine prescriptions for the treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"71","author":"Wang","year":"2024","journal-title":"Eur J Integr Med."},{"issue":"2","key":"10.1016\/j.ctcp.2025.102019_bib29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/sim.6342","article-title":"Statistical methods for dealing with publication bias in meta-analysis","volume":"34","author":"Jin","year":"2015","journal-title":"Stat. Med."},{"issue":"23","key":"10.1016\/j.ctcp.2025.102019_bib30","article-title":"The trim-and-fill method for publication bias: practical guidelines and recommendations based on a large database of meta-analyses","volume":"98","author":"Shi","year":"2019","journal-title":"Medicine (Baltim.)"},{"issue":"4","key":"10.1016\/j.ctcp.2025.102019_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE guidelines: 3. Rating the quality of evidence","volume":"64","author":"Balshem","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.ctcp.2025.102019_bib32","article-title":"Moxibustion for alleviating chemotherapy-induced gastrointestinal adverse effects: a systematic review of randomized controlled trials","volume":"46","author":"Yao","year":"2022","journal-title":"Compl. Ther. Clin. Pract."},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12874-017-0315-7","article-title":"Trial sequential analysis in systematic reviews with meta-analysis","volume":"17","author":"Wetterslev","year":"2017","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.ctcp.2025.102019_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112760","article-title":"Efficacy and safety of moxibustion as a complementary and alternative therapy for asthma: a systematic review and meta-analysis","volume":"139","author":"Deng","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ctcp.2025.102019_bib35","series-title":"Clinical Observation on the Combination of Acupuncture for Purging Liver Method with Flunarizine Hydrochloride Capsules in the Treatment of Migraine with Hyperactive Liver Yang","author":"Bai","year":"2023"},{"issue":"5","key":"10.1016\/j.ctcp.2025.102019_bib36","first-page":"498","article-title":"Electroacupuncture at siguan points for migraine of liver yang hyperactivity: a randomized controlled trial","volume":"42","author":"Cai","year":"2022","journal-title":"Chin. Acupunct. Moxibustion"},{"key":"10.1016\/j.ctcp.2025.102019_bib37","series-title":"Clinical Study of Lai's Tongyuan Therapy in the Treatment of Migraine Without Aura with Excessive Rising of Liver Yang","author":"Chen","year":"2017"},{"issue":"9","key":"10.1016\/j.ctcp.2025.102019_bib38","first-page":"3","article-title":"Observation of therapeutic effect of acupuncture on migraine and its influence on cerebral blood flow","volume":"26","author":"Dai","year":"2007","journal-title":"Shanghai J Acupunct Moxib."},{"issue":"9","key":"10.1016\/j.ctcp.2025.102019_bib39","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1046\/j.1526-4610.2002.02203.x","article-title":"Acupuncture in the prophylactic treatment of migraine without aura: a comparison with flunarizine","volume":"42","author":"Allais","year":"2002","journal-title":"Headache"},{"key":"10.1016\/j.ctcp.2025.102019_bib40","series-title":"Clinical Study on Acupuncture, the First Three of Needle Therapy for liver-yang-hyperactivity Migraine","author":"Guan","year":"2015"},{"issue":"5","key":"10.1016\/j.ctcp.2025.102019_bib41","first-page":"48","article-title":"Acupuncture at siguan points to treat 36 cases of migraine","volume":"31","author":"Ha","year":"2013","journal-title":"Xinjiang J Tradit Chin Med."},{"key":"10.1016\/j.ctcp.2025.102019_bib42","series-title":"Clinical Effect of electro-acupuncture on Pain Intensity of Migraine","author":"Jin","year":"2019"},{"key":"10.1016\/j.ctcp.2025.102019_bib43","article-title":"Clinical study on the treatment of migraine with hyperactivity of liver yang by means of \u201cPing Wan Li Zhi\u201d acupuncture manipulation","author":"Li","year":"2017","journal-title":"M.Sc. Thesis Yunnan University of Traditional Chinese Medicine,"},{"issue":"11","key":"10.1016\/j.ctcp.2025.102019_bib44","first-page":"733","article-title":"32 cases of migraine treated by acupuncture at siguan points","volume":"29","author":"Li","year":"2010","journal-title":"Shanghai J Acupunct Moxib"},{"key":"10.1016\/j.ctcp.2025.102019_bib45","series-title":"Clinical Research of Slow Twisting Insertion Needle Therapy on Migraine Without Aura","author":"Liao","year":"2012"},{"issue":"4","key":"10.1016\/j.ctcp.2025.102019_bib46","first-page":"24","article-title":"Treatment of 32 cases of migraine without aura by acupuncture at siguan points, acad J shanghai univ tradit","volume":"16","author":"Ni","year":"2002","journal-title":"Chin. Med."},{"key":"10.1016\/j.ctcp.2025.102019_bib47","article-title":"Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: a multicentre, randomized clinical trial","volume":"368","author":"Xu","year":"2020","journal-title":"BMJ"},{"issue":"17","key":"10.1016\/j.ctcp.2025.102019_bib48","first-page":"307","article-title":"Observation on the curative effect of acupuncture on migraine without aura","volume":"6","author":"Sun","year":"2016","journal-title":"J Front Med"},{"key":"10.1016\/j.ctcp.2025.102019_bib49","series-title":"Clinical Observation on the short-term and long-term Curative Effect of Electroacupuncture at Siguan Points in the Treatment of Migraine Without Aura","author":"Yang","year":"2006"},{"issue":"10","key":"10.1016\/j.ctcp.2025.102019_bib50","first-page":"1971","article-title":"Effect of acupuncture in migraine patients and its influence on serum MMP-2 activity","volume":"42","author":"Zeng","year":"2015","journal-title":"Liaoning J Tradit Chin Med"},{"key":"10.1016\/j.ctcp.2025.102019_bib51","series-title":"The Clinical Study of Acupuncture for the Prophylaxis of Migraine Without Aura","author":"Zhang","year":"2018"},{"key":"10.1016\/j.ctcp.2025.102019_bib52","series-title":"Clinical Study on Acupuncture in the Treatment of Migraine Without Aura","author":"Zhang","year":"2019"},{"key":"10.1016\/j.ctcp.2025.102019_bib53","series-title":"Therapeutic Effects of Different Acupuncture Methods in the Treatment of Migraine Without Aura: a Clinical Trial","author":"Zhou","year":"2018"},{"issue":"5","key":"10.1016\/j.ctcp.2025.102019_bib54","first-page":"31","article-title":"Estimation of sample size in systematic review and meta-analysis: trial sequential","volume":"20","author":"Xia","year":"2013","journal-title":"Mod Chin Clin Med."},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s10194-025-01998-1","article-title":"Migraine with and without aura-two distinct entities? A narrative review","volume":"26","author":"Grodzka","year":"2025","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.ctcp.2025.102019_bib56","series-title":"Acupuncture and Moxibustion","year":"2017"},{"key":"10.1016\/j.ctcp.2025.102019_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6879076","article-title":"Acupuncture point \"hegu\" (LI4) is close to the vascular branch from the superficial branch of the radial nerve","author":"Umemoto","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.ctcp.2025.102019_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6760958","article-title":"A part of the medial branch of the deep peroneal nerve distributes the dorsal pedis artery, and its distribution area is close to the acupuncture point LR3 (taichong)","author":"Umemoto","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib59","article-title":"Neuropeptide initiated mast cell activation by transcutaneous electrical acupoint stimulation of acupoint LI4 in rats","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ctcp.2025.102019_bib60","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jchemneu.2015.06.002","article-title":"Local cutaneous nerve terminal and mast cell responses to manual acupuncture in the acupoint LI4 area of the rats","volume":"68","author":"Wu","year":"2015","journal-title":"J. Chem. Neuroanat."},{"issue":"9","key":"10.1016\/j.ctcp.2025.102019_bib61","doi-asserted-by":"crossref","first-page":"8343","DOI":"10.3390\/ijms24098343","article-title":"Experimental and clinical investigation of cytokines in migraine: a narrative review","volume":"24","author":"Yamanaka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ctcp.2025.102019_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1084362","article-title":"Activation likelihood estimation identifies brain regions activated during puncturing at hegu in healthy volunteers: a meta-analysis","volume":"16","author":"Gao","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ctcp.2025.102019_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/585493","article-title":"Specific correlation between the hegu point (LI4) and the orofacial part: evidence from an fMRI study","author":"Kong","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"issue":"6","key":"10.1016\/j.ctcp.2025.102019_bib64","first-page":"451","article-title":"Dynamic functional connectivity analysis of taichong (LR3) acupuncture effects in various brain regions","volume":"7","author":"Qiu","year":"2012","journal-title":"Neural Regen Res"},{"issue":"6","key":"10.1016\/j.ctcp.2025.102019_bib65","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/acupmed-2015-010901","article-title":"Blockade of the brachial plexus abolishes activation of specific brain regions by electroacupuncture at LI4: a functional MRI study","volume":"33","author":"Gu","year":"2015","journal-title":"Acupunct. Med."},{"key":"10.1016\/j.ctcp.2025.102019_bib66","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/103491","article-title":"An fMRI study of neuronal specificity in acupuncture: the multiacupoint siguan and its sham point","author":"Shan","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.ctcp.2025.102019_bib67","article-title":"The central mechanisms of electroacupuncture at LR3 in the treatment of spontaneous hypertension: a PET and mRNA transcriptome study","volume":"11","author":"Li","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib68","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11655-007-0010-3","article-title":"Study on the regulatory effect of electro-acupuncture on hegu point (LI4) in cerebral response with functional magnetic resonance imaging","volume":"13","author":"Wang","year":"2007","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.ctcp.2025.102019_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1511183","article-title":"Effects of acupuncture at the taichong (LIV3) and hegu (LI4) points on functional connectivity with the retrosplenial cortex in patients with alzheimer's disease","volume":"18","author":"Wang","year":"2025","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ctcp.2025.102019_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/729091","article-title":"Correlation between the effects of acupuncture at taichong (LR3) and functional brain areas: a resting-state functional magnetic resonance imaging study using true versus sham acupuncture","author":"Wu","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"issue":"8","key":"10.1016\/j.ctcp.2025.102019_bib71","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1177\/1533317514536600","article-title":"Acupuncture stimulation of taichong (Liv3) and hegu (LI4) modulates the default mode network activity in alzheimer's disease","volume":"29","author":"Liang","year":"2014","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib72","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s10194-018-0876-9","article-title":"Exploration of intrinsic brain activity in migraine with and without comorbid depression","volume":"19","author":"Ma","year":"2018","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.ctcp.2025.102019_bib73","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8876873","article-title":"Effect of acupuncture stimulation of hegu (LI4) and taichong (LR3) on the resting-state networks in alzheimer's disease: beyond the default mode network","author":"Ji","year":"2021","journal-title":"Neural Plast."},{"issue":"6","key":"10.1016\/j.ctcp.2025.102019_bib74","doi-asserted-by":"crossref","first-page":"90","DOI":"10.21010\/ajtcam.v13i6.14","article-title":"Imaging of brain function based on the analysis of functional connectivity-imaging analysis of brain function by fMRI after acupuncture at LR3 in healthy individuals","volume":"13","author":"Zheng","year":"2016","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib75","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s10194-020-01111-8","article-title":"From transformation to chronification of migraine: pathophysiological and clinical aspects","volume":"21","author":"Torres-Ferr\u00fas","year":"2020","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.ctcp.2025.102019_bib76","doi-asserted-by":"crossref","DOI":"10.1093\/ecam\/neq073","article-title":"Assessing the effects of acupuncture by comparing needling the hegu acupoint and needling nearby nonacupoints by spectral analysis of microcirculatory laser doppler signals","author":"Hsiu","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"10.1016\/j.ctcp.2025.102019_bib77","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.eujim.2009.04.003","article-title":"Effects of electro-acupuncture at LI4 with deqi compared to sham acupuncture on blood flow in the middle cerebral artery of healthy subjects","volume":"1","author":"Wei","year":"2009","journal-title":"Eur J Integr Med"},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib78","first-page":"32","article-title":"Comparative analysis of photoplethysmography under pulsed magnetic field and low-level laser stimulus: motivation for blood flow increase using stimulus on acupoint LI4 (hegu)","volume":"19","author":"Kim","year":"2014","journal-title":"Jpn. Mag."},{"issue":"2","key":"10.1016\/j.ctcp.2025.102019_bib79","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/s19020394","article-title":"Cortical network response to acupuncture and the effect of the hegu point: an fNIRS study","volume":"19","author":"Fernandez Rojas","year":"2019","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.ctcp.2025.102019_bib80","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3294273","article-title":"Changes in mitochondria-related gene expression upon acupuncture at LR3 in the D-galactosamine-induced liver damage rat model","author":"Lee","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"issue":"10","key":"10.1016\/j.ctcp.2025.102019_bib81","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s12031-021-01844-4","article-title":"Effect of electroacupuncture at siguan acupoints on expression of BDNF and TrkB proteins in the hippocampus of post-stroke depression rats","volume":"71","author":"Kang","year":"2021","journal-title":"J. Mol. Neurosci."},{"issue":"18","key":"10.1016\/j.ctcp.2025.102019_bib82","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.3390\/ijms20184471","article-title":"Distal electroacupuncture at the LI4 acupoint reduces CFA-Induced inflammatory pain via the brain TRPV1 signaling pathway","volume":"20","author":"Yen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib83","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s10194-025-02044-w","article-title":"The role and interaction of hypothalamic-related neurotransmitters in migraine","volume":"26","author":"Salinas-Abarca","year":"2025","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.ctcp.2025.102019_bib84","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00415-019-09510-x","article-title":"Acupuncture versus propranolol in migraine prophylaxis: an indirect treatment comparison meta-analysis","volume":"267","author":"Chen","year":"2020","journal-title":"J. Neurol."},{"issue":"7","key":"10.1016\/j.ctcp.2025.102019_bib85","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neurol.2021.07.009","article-title":"Revised guidelines of the French headache society for the diagnosis and management of migraine in adults. Part 3: non-pharmacological treatment","volume":"177","author":"Demarquay","year":"2021","journal-title":"Rev Neurol-France."},{"issue":"7","key":"10.1016\/j.ctcp.2025.102019_bib86","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/head.14744","article-title":"The 2023 protocol for update to acute treatment of adults with migraine in the emergency department: the American headache society evidence assessment of parenteral pharmacotherapies","volume":"64","author":"Robblee","year":"2024","journal-title":"Headache"},{"issue":"2","key":"10.1016\/j.ctcp.2025.102019_bib87","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s40120-020-00216-1","article-title":"Acupuncture and its role in the treatment of migraine headaches","volume":"9","author":"Urits","year":"2020","journal-title":"Neurol Ther"}],"container-title":["Complementary Therapies in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744388125000842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1744388125000842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:21:34Z","timestamp":1772893294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1744388125000842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":87,"alternative-id":["S1744388125000842"],"URL":"https:\/\/doi.org\/10.1016\/j.ctcp.2025.102019","relation":{},"ISSN":["1744-3881"],"issn-type":[{"value":"1744-3881","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Siguan points-based acupuncture treatment for migraine: A systematic review with meta-analysis of clinical efficacy and neurovascular regulatory effects","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Clinical Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctcp.2025.102019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102019"}}