{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:26:17Z","timestamp":1786987577928,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ctim.2019.01.014","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T19:12:22Z","timestamp":1548270742000},"page":"81-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses\u2014A systematic review"],"prefix":"10.1016","volume":"43","author":[{"given":"Karsten","family":"M\u00fcnstedt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctim.2019.01.014_bib0005","first-page":"102","article-title":"Herpes zoster and postherpetic neuralgia: Diagnosis and therapeutic considerations","volume":"11","author":"Roxas","year":"2006","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.ctim.2019.01.014_bib0010","article-title":"Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012","volume":"10","author":"Looker","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ctim.2019.01.014_bib0015","article-title":"Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012","volume":"10","author":"Looker","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ctim.2019.01.014_bib0020","first-page":"213","article-title":"Varicella-zoster virus: Pathogenesis, incidence patterns and vaccination programs","volume":"68","author":"Gabutti","year":"2016","journal-title":"Minerva Pediatr"},{"issue":"2 Suppl","key":"10.1016\/j.ctim.2019.01.014_bib0025","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1590\/0001-3765201520140701","article-title":"Efficacy of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of herpes labialis: A systematic review","volume":"87","author":"Rosa","year":"2015","journal-title":"An Acad Bras Cienc"},{"key":"10.1016\/j.ctim.2019.01.014_bib0030","first-page":"93","article-title":"Natural remedies for Herpes simplex","volume":"11","author":"Gaby","year":"2006","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.ctim.2019.01.014_bib0035","first-page":"373","article-title":"Combined herbal preparation for topical treatment of Herpes labialis","volume":"8","author":"Saller","year":"2001","journal-title":"Forsch Komplementarmed Klass Naturheilkd"},{"key":"10.1016\/j.ctim.2019.01.014_bib0040","first-page":"1011","article-title":"A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus","volume":"23","author":"Lopez","year":"2009","journal-title":"In Vivo"},{"key":"10.1016\/j.ctim.2019.01.014_bib0045","doi-asserted-by":"crossref","first-page":"CR215","DOI":"10.12659\/MSM.882621","article-title":"Intravenous vitamin C in the treatment of shingles: Results of a multicenter prospective cohort study","volume":"18","author":"Schencking","year":"2012","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.ctim.2019.01.014_bib0050","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/jac\/48.3.450","article-title":"Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis","volume":"48","author":"Carson","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ctim.2019.01.014_bib0055","first-page":"49","article-title":"A randomized clinical trial on the treatment of oral herpes with topical zinc oxide\/glycine","volume":"7","author":"Godfrey","year":"2001","journal-title":"Altern Ther Health Med"},{"key":"10.1016\/j.ctim.2019.01.014_bib0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s15006-012-0991-5","article-title":"Aktuelle Medizin Sprechstunde Naturheilkunde. Herpes simplex \u2013 Herpes zoster [Naturopathy consultation. Herpes simplex - herpes zoster]","volume":"154","author":"Kraft","year":"2012","journal-title":"MMW Fortschr Med"},{"key":"10.1016\/j.ctim.2019.01.014_bib0065","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8025752","article-title":"External use of propolis for oral, skin, and genital diseases: A systematic review and meta-analysis","volume":"2017","author":"Sung","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.ctim.2019.01.014_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.curtheres.2017.10.004","article-title":"Comparative study with a lip balm containing 0.5% propolis special extract GH 2002 versus 5% aciclovir cream in patients with herpes labialis in the papular\/erythematous stage: A single-blind, randomized, two-arm study","volume":"88","author":"Arenberger","year":"2017","journal-title":"Curr Ther Res Clin Exp"},{"key":"10.1016\/j.ctim.2019.01.014_bib0075","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4236\/health.2011.31010","article-title":"Efficacy and tolerability of propolis special extract GH 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study","volume":"3","author":"Holcov\u00e1","year":"2011","journal-title":"Health"},{"issue":"November","key":"10.1016\/j.ctim.2019.01.014_bib0080","article-title":"Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage) : Randomized, controlled double-blind study","author":"Jautov\u00e1","year":"2018","journal-title":"Wien Med Wochenschr"},{"key":"10.1016\/j.ctim.2019.01.014_bib0085","first-page":"47","article-title":"Antiviral activities of honey, royal jelly, and acyclovir against HSV-1","volume":"26","author":"Hashemipour","year":"2014","journal-title":"Wounds"},{"key":"10.1016\/j.ctim.2019.01.014_bib0090","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.phymed.2014.04.026","article-title":"Chemical composition of Propolis extract ACF\u00ae and activity against herpes simplex virus","volume":"21","author":"Bankova","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ctim.2019.01.014_bib0095","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s12275-016-6376-1","article-title":"Inhibitory effects of bee venom and its components against viruses in vitro and in vivo","volume":"54","author":"Uddin","year":"2016","journal-title":"J Microbiol"},{"key":"10.1016\/j.ctim.2019.01.014_bib0100","first-page":"733","article-title":"Antiviral activity of propolis special extract GH 2002 against Varicella zoster virus in vitro","volume":"73","author":"Labsk\u00e1","year":"2018","journal-title":"Pharmazie"},{"key":"10.1016\/j.ctim.2019.01.014_bib0105","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.phymed.2009.07.006","article-title":"Mechanism of herpes simplex virus type 2 suppression by propolis extracts","volume":"17","author":"Nolkemper","year":"2010","journal-title":"Phytomedicine"},{"issue":"December","key":"10.1016\/j.ctim.2019.01.014_bib0110","article-title":"Acyclovir and propolis: which have a best anti HSV-1 effect?","volume":"01","author":"Eslami","year":"2015","journal-title":"J Pure Appl Microbiol; The Free Library"},{"key":"10.1016\/j.ctim.2019.01.014_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.ctim.2019.01.014_bib0120","first-page":"MT94","article-title":"Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions","volume":"10","author":"Al-Waili","year":"2004","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.ctim.2019.01.014_bib0125","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.aimed.2014.09.001","article-title":"Randomised controlled trial of topical kanuka honey for the treatment of cold sores","volume":"1","author":"Fingleton","year":"2014","journal-title":"Adv Integr Med"},{"key":"10.1016\/j.ctim.2019.01.014_bib0130","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.amjoto.2018.09.007","article-title":"Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial","volume":"39","author":"Abdel-Naby Awad","year":"2018","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.ctim.2019.01.014_bib0135","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-017766","article-title":"Pharmacy Research Network. Protocol for a randomised controlled trial of 90% kanuka honey versus 5% aciclovir for the treatment of herpes simplex labialis in the community setting","volume":"7","author":"Semprini","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.ctim.2019.01.014_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0944-7113(00)80014-8","article-title":"A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV)","volume":"7","author":"Vynograd","year":"2000","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ctim.2019.01.014_bib0145","first-page":"203","article-title":"The effects of Herstat (3% propolis ointment ACF) application in cold sores: a double-blind placebo-controlled clinical trial","volume":"4","author":"Hoheisel","year":"2001","journal-title":"J Drug Assess"},{"key":"10.1016\/j.ctim.2019.01.014_bib0150","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.4236\/health.2017.910097","article-title":"Clinical study: lotion containing propolis special extract GH 2002 0.5% vs. placebo as on-top treatment of herpes zoster","volume":"9","author":"Tomanova","year":"2017","journal-title":"Health"},{"key":"10.1016\/j.ctim.2019.01.014_bib0155","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1089\/acm.2013.0130","article-title":"Bee venom treatment for refractory postherpetic neuralgia: A case report","volume":"20","author":"Lee","year":"2014","journal-title":"J Altern Complement Med"},{"key":"10.1016\/j.ctim.2019.01.014_bib0160","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00115550-200711000-00014","article-title":"Bee stings--a remedy for postherpetic neuralgia? A case report","volume":"32","author":"Janik","year":"2007","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.ctim.2019.01.014_bib0165","doi-asserted-by":"crossref","first-page":"79","DOI":"10.17305\/bjbms.2006.3128","article-title":"Efficacy in treatment of cervical HRHPV infection by combination of beta interferon, and herbal therapy in woman with different cervical lesions","volume":"6","author":"Iljazovi\u0107","year":"2006","journal-title":"Bosn J Basic Med Sci"},{"key":"10.1016\/j.ctim.2019.01.014_bib0170","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1365-4632.2009.04184.x","article-title":"Propolis as an alternative treatment for cutaneous warts","volume":"48","author":"Zedan","year":"2009","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ctim.2019.01.014_bib0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijgo.2005.01.033","article-title":"Propolis solution for the treatment of chronic vaginitis","volume":"89","author":"Imhof","year":"2005","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ctim.2019.01.014_bib0180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0944-7113(99)80013-0","article-title":"Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis","volume":"6","author":"Koytchev","year":"1999","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ctim.2019.01.014_bib0185","doi-asserted-by":"crossref","DOI":"10.17795\/jjnpp-26160","article-title":"Therapeutic effect of melissa gel and 5% acyclovir cream in Recurrent Herpes Labialis: A double-blind randomized clinical trial","volume":"10","author":"Ahadian","year":"2015","journal-title":"Jundishapur J Nat Pharm Prod"},{"key":"10.1016\/j.ctim.2019.01.014_bib0190","first-page":"294","article-title":"Aloe vera extract 0.5% in hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. A placebo-controlled, double-blind, comparative study","volume":"7","author":"Syed","year":"1996","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.ctim.2019.01.014_bib0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/09546639709160279","article-title":"Management of genital herpes in men with 0.5% Aloe vera extract in a hydrophilic cream: A placebo-controlled double-blind study","volume":"8","author":"Syed","year":"1997","journal-title":"J Dermatolog Treat"},{"issue":"298-300","key":"10.1016\/j.ctim.2019.01.014_bib0200","first-page":"304","article-title":"Lysine for management of herpes labialis","volume":"58","author":"Tomblin","year":"2001","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.ctim.2019.01.014_bib0205","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1258\/0956462011916947","article-title":"Does the extract of the plant Echinacea purpurea influence the clinical course of recurrent genital herpes?","volume":"12","author":"Vonau","year":"2001","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.ctim.2019.01.014_bib0210","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s10103-018-2542-5","article-title":"Efficacy of low-level laser therapy in management of recurrent herpes labialis: A systematic review","volume":"33","author":"Al-Maweri","year":"2018","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.ctim.2019.01.014_bib0215","first-page":"695","article-title":"Antimicrobial activity of propolis special extract GH 2002 against multidrug-resistant clinical isolates","volume":"68","author":"Astani","year":"2013","journal-title":"Pharmazie"},{"key":"10.1016\/j.ctim.2019.01.014_bib0220","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ctcp.2018.11.016","article-title":"Honey in the management of side effects of radiotherapy- or radio\/chemotherapy-induced oral mucositis. A systematic review","volume":"34","author":"M\u00fcnstedt","year":"2019","journal-title":"Complement Ther Clin Pract"},{"key":"10.1016\/j.ctim.2019.01.014_bib0225","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/tropej\/fmx092","article-title":"Global Health Journal Club: Is honey effective as a treatment for chemotherapy-induced mucositis in paediatric oncology patients?","volume":"64","author":"Friend","year":"2018","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.ctim.2019.01.014_bib0230","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/coa.12792","article-title":"Role of honey after tonsillectomy: A systematic review and meta-analysis of randomised controlled trials","volume":"42","author":"Lal","year":"2017","journal-title":"Clin Otolaryngol"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229919300275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229919300275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:09:29Z","timestamp":1760807369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965229919300275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":46,"alternative-id":["S0965229919300275"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2019.01.014","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses\u2014A systematic review","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2019.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}