{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:22:02Z","timestamp":1788200522583,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ctim.2019.102205","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T11:27:57Z","timestamp":1570102077000},"page":"102205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial"],"prefix":"10.1016","volume":"47","author":[{"given":"Mohammadreza","family":"Rafati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Saeedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emran","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Salehifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Mosazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monireh","family":"Maham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ctim.2019.102205_bib0005","doi-asserted-by":"crossref","first-page":"433","DOI":"10.6004\/jnccn.2017.0044","article-title":"NCCN guidelines insights: breast cancer, version 1.2017","volume":"15","author":"Gradishar","year":"2017","journal-title":"J Natl Compr Cancer Netw"},{"issue":"3","key":"10.1016\/j.ctim.2019.102205_bib0010","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/jid.2011.411","article-title":"Ionizing radiation: the good, the bad, and the ugly","volume":"132","author":"Ryan","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ctim.2019.102205_bib0015","series-title":"Toxicities of radiation treatment for breast cancer","first-page":"5","article-title":"Acute and late skin toxicity from breast radiation","author":"Sloan","year":"2019"},{"issue":"2","key":"10.1016\/j.ctim.2019.102205_bib0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13555-016-0120-y","article-title":"Acute and chronic cutaneous reactions to ionizing radiation therapy","volume":"6","author":"Bray","year":"2016","journal-title":"Dermatol Ther"},{"issue":"5","key":"10.1016\/j.ctim.2019.102205_bib0025","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctim.2019.102205_bib0030","series-title":"Acute side effects of radiation therapy: A guide to management","author":"Sourati","year":"2017"},{"issue":"12","key":"10.1016\/j.ctim.2019.102205_bib0035","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2146\/ajhp120467","article-title":"Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia","volume":"70","author":"Radvansky","year":"2013","journal-title":"Am J Health-Syst Pharm"},{"issue":"3","key":"10.1016\/j.ctim.2019.102205_bib0040","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s40257-016-0186-4","article-title":"Radiodermatitis: a review of our current understanding","volume":"17","author":"Singh","year":"2016","journal-title":"Am J Clin Dermatol"},{"issue":"10","key":"10.1016\/j.ctim.2019.102205_bib0045","first-page":"2933","article-title":"Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group","volume":"21","author":"Wong","year":"2013","journal-title":"Support Care Cancer"},{"issue":"10","key":"10.1016\/j.ctim.2019.102205_bib0050","first-page":"5343","article-title":"Topical management of acute radiation dermatitis in breast cancer patients: a systematic review and meta-analysis","volume":"37","author":"Haruna","year":"2017","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ctim.2019.102205_bib0055","series-title":"Rational use of topical corticosteroids. A treatise on topical corticosteroids in dermatology","first-page":"117","author":"D\u2019Souza","year":"2018"},{"key":"10.1016\/j.ctim.2019.102205_bib0060","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jep.2016.06.061","article-title":"Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: a review","volume":"190","author":"Gholamnezhad","year":"2016","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.ctim.2019.102205_bib0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jdds.2015.04.002","article-title":"Dermatological effects of Nigella sativa","volume":"19","author":"Aljabre","year":"2015","journal-title":"J Dermatol Dermatol Surg"},{"issue":"01\/02","key":"10.1016\/j.ctim.2019.102205_bib0070","first-page":"8","article-title":"Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects","volume":"82","author":"Amin","year":"2016","journal-title":"Planta Med"},{"issue":"1","key":"10.1016\/j.ctim.2019.102205_bib0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.intimp.2015.06.023","article-title":"Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: a comprehensive review","volume":"28","author":"Majdalawieh","year":"2015","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.ctim.2019.102205_bib0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.drudis.2013.08.021","article-title":"Thymoquinone: fifty years of success in the battle against cancer models","volume":"19","author":"Schneider-Stock","year":"2014","journal-title":"Drug Discov Today"},{"issue":"5","key":"10.1016\/j.ctim.2019.102205_bib0085","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0731-7085(98)00300-8","article-title":"High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.)","volume":"19","author":"Ghosheh","year":"1999","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ctim.2019.102205_bib0090","series-title":"The United States pharmacopeia-national formulary (USP 38-NF 33)","author":"USP","year":"2015"},{"issue":"6","key":"10.1016\/j.ctim.2019.102205_bib0095","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archderm.1988.01670060015008","article-title":"The validity and practicality of sun-reactive skin types I through VI","volume":"124","author":"Fitzpatrick","year":"1988","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.ctim.2019.102205_bib0100","series-title":"Common Terminology Criteria for Adverse Events (CTCAE)","author":"Institute","year":"2017"},{"key":"10.1016\/j.ctim.2019.102205_bib0105","series-title":"Department of dermatology CUSoM. DLQI questionnaire","year":"2019"},{"issue":"12","key":"10.1016\/j.ctim.2019.102205_bib0110","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/jdv.12033","article-title":"Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema","volume":"27","author":"Yousefi","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"11","key":"10.1016\/j.ctim.2019.102205_bib0115","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jclinepi.2005.12.020","article-title":"Recommendations for reporting randomized controlled trials of herbal interventions: explanation and elaboration","volume":"59","author":"Gagnier","year":"2006","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"10.1016\/j.ctim.2019.102205_bib0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.25251\/skin.2.1.1","article-title":"Risk factors for the development of acute radiation dermatitis in breast cancer patients","volume":"2","author":"Parker","year":"2018","journal-title":"Ski J Cutan Med"},{"issue":"4","key":"10.1016\/j.ctim.2019.102205_bib0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/09553002.2018.1440092","article-title":"Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications","volume":"94","author":"Najafi","year":"2018","journal-title":"Int J Radiat Biol"},{"issue":"6","key":"10.1016\/j.ctim.2019.102205_bib0130","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1586\/17512433.2013.841079","article-title":"Topical corticosteroid therapy for the prevention of acute radiation dermatitis: a systematic review of randomized controlled trials","volume":"6","author":"Meghrajani","year":"2013","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.ctim.2019.102205_bib0135","series-title":"Systemic side effects of topical corticosteroids. A treatise on topical corticosteroids in dermatology","first-page":"241","author":"Ghosh","year":"2018"},{"key":"10.1016\/j.ctim.2019.102205_bib0140","series-title":"Topical side effects of topical corticosteroids. A treatise on topical corticosteroids in dermatology","first-page":"251","author":"Sarkar","year":"2018"},{"issue":"9","key":"10.1016\/j.ctim.2019.102205_bib0145","doi-asserted-by":"crossref","first-page":"446","DOI":"10.12968\/ijpn.2015.21.9.446","article-title":"Topical antioxidants in radiodermatitis: a clinical review","volume":"21","author":"Kodiyan","year":"2015","journal-title":"Int J Palliat Nurs"},{"issue":"5","key":"10.1016\/j.ctim.2019.102205_bib0150","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.phymed.2013.10.023","article-title":"Radiation-modifying abilities of Nigella sativa and thymoquinone on radiation-induced nitrosative stress in the brain tissue","volume":"21","author":"Ahlatci","year":"2014","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.ctim.2019.102205_bib0155","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.prp.2016.02.017","article-title":"Protective effects of Nigella sativa on gamma radiation-induced jejunal mucosal damage in rats","volume":"212","author":"Orhon","year":"2016","journal-title":"Pathol-Res Pract"},{"issue":"3","key":"10.1016\/j.ctim.2019.102205_bib0160","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1097\/SCS.0000000000004314","article-title":"Evaluation of the effect of topical application of Nigella sativa on acute radiation-induced nasal mucositis","volume":"29","author":"\u00c7anakci","year":"2018","journal-title":"J Craniofac Surg"},{"issue":"9-10","key":"10.1016\/j.ctim.2019.102205_bib0165","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1515\/znc-2003-9-1004","article-title":"Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran","volume":"58","author":"Nickavar","year":"2003","journal-title":"Zeitschrift f\u00fcr Naturforschung C"},{"issue":"3","key":"10.1016\/j.ctim.2019.102205_bib0170","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/13880209.2014.923003","article-title":"Evaluation of p-cymene, a natural antioxidant","volume":"53","author":"de Oliveira","year":"2015","journal-title":"Pharm Biol"},{"issue":"11","key":"10.1016\/j.ctim.2019.102205_bib0175","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3109\/13880209.2014.993040","article-title":"The anti-hyperalgesic and anti-inflammatory profiles of p-cymene: evidence for the involvement of opioid system and cytokines","volume":"53","author":"de Santana","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.ctim.2019.102205_bib0180","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.biopha.2017.05.032","article-title":"Anti-inflammatory effects of trans-anethole in a mouse model of chronic obstructive pulmonary disease","volume":"91","author":"Kim","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.ctim.2019.102205_bib0185","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000093790","article-title":"Anti-inflammatory activity of thymol: Inhibitory effect on the release of human neutrophil elastase","volume":"77","author":"Braga","year":"2006","journal-title":"Pharmacology"},{"issue":"5","key":"10.1016\/j.ctim.2019.102205_bib0190","article-title":"Antioxidant activity of carvone and derivatives against superoxide ion","volume":"12","author":"Pombal","year":"2017","journal-title":"Nat Prod Commun"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096522991831238X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096522991831238X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:11:13Z","timestamp":1760807473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096522991831238X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":38,"alternative-id":["S096522991831238X"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2019.102205","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2019.102205","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102205"}}