{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:47:41Z","timestamp":1788497261499,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ctim.2019.102283","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T19:51:36Z","timestamp":1576612296000},"page":"102283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"48","author":[{"given":"Mohammad","family":"Jalali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Mahmoodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-1984","authenticated-orcid":false,"given":"Zahra","family":"Mosallanezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hadi","family":"Imanieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Parisa","family":"Moosavian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctim.2019.102283_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41430-018-0386-5","article-title":"A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial","author":"Chashmniam","year":"2019","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"10.1016\/j.ctim.2019.102283_bib0010","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ptr.6270","article-title":"Does turmeric\/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials","volume":"33","author":"Goodarzi","year":"2019","journal-title":"Phytother Res"},{"issue":"1","key":"10.1016\/j.ctim.2019.102283_bib0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.imr.2018.07.004","article-title":"Efficacy of curcumin\/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: a systematic review of randomized controlled trials","volume":"8","author":"Mansour-Ghanaei","year":"2019","journal-title":"Integr Med Res"},{"issue":"12","key":"10.1016\/j.ctim.2019.102283_bib0020","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1002\/jcb.27371","article-title":"Impact of curcumin on sirtuins: a review","volume":"119","author":"Zendedel","year":"2018","journal-title":"J Cell Biochem"},{"issue":"1","key":"10.1016\/j.ctim.2019.102283_bib0025","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.18549\/PharmPract.2019.1.1350","article-title":"The impact of turmeric or its curcumin extract on nonalcoholic fatty liver disease: a systematic review of clinical trials","volume":"17","author":"White","year":"2019","journal-title":"Pharm Pract (Granada)"},{"issue":"7","key":"10.1016\/j.ctim.2019.102283_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/nu10070855","article-title":"Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective","volume":"10","author":"Farzaei","year":"2018","journal-title":"Nutrients"},{"issue":"27","key":"10.1016\/j.ctim.2019.102283_bib0035","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.2174\/1381612824666180828162053","article-title":"The effects of curcumin on glycemic control and lipid profiles among patients with metabolic syndrome and related disorders: a systematic review and metaanalysis of randomized controlled trials","volume":"24","author":"Tabrizi","year":"2018","journal-title":"Curr Pharm Des"},{"issue":"12","key":"10.1016\/j.ctim.2019.102283_bib0040","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.4158\/EP14421.RA","article-title":"Proinflammatory and antiinflammatory attributes of fetuin-a: a novel hepatokine modulating cardiovascular and glycemic outcomes in metabolic syndrome","volume":"20","author":"Mukhopadhyay","year":"2014","journal-title":"Endocr Pract"},{"issue":"5","key":"10.1016\/j.ctim.2019.102283_bib0045","first-page":"581","article-title":"Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity","volume":"56","author":"Kalpana","year":"2004","journal-title":"Pol J Pharmacol"},{"issue":"2","key":"10.1016\/j.ctim.2019.102283_bib0050","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jcp.27096","article-title":"Evidence of curcumin and curcumin analogue effects in skin diseases: a narrative review","volume":"234","author":"Panahi","year":"2019","journal-title":"J Cell Physiol"},{"issue":"6","key":"10.1016\/j.ctim.2019.102283_bib0055","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/ptr.6037","article-title":"Effects of curcumin consumption on human chronic diseases: a narrative review of the most recent clinical data","volume":"32","author":"Mantzorou","year":"2018","journal-title":"Phytother Res"},{"issue":"7","key":"10.1016\/j.ctim.2019.102283_bib0060","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1080\/10408398.2017.1396201","article-title":"Lipid-modifying activity of curcuminoids: a systematic review and meta-analysis of randomized controlled trials","volume":"59","author":"Simental-Mendia","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"5","key":"10.1016\/j.ctim.2019.102283_bib0065","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.ctim.2014.07.006","article-title":"Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial","volume":"22","author":"Panahi","year":"2014","journal-title":"Complement Ther Med"},{"issue":"3","key":"10.1016\/j.ctim.2019.102283_bib0070","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12072-018-9910-x","article-title":"The effects of curcumin on the metabolic parameters of non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials","volume":"13","author":"Wei","year":"2019","journal-title":"Hepatol Int"},{"issue":"1","key":"10.1016\/j.ctim.2019.102283_bib0075","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1038\/s41598-017-06220-0","article-title":"Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats","volume":"7","author":"Tranchida","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ctim.2019.102283_bib0080","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/FJC.0000000000000406","article-title":"Curcumin lowers serum lipids and uric acid in subjects with nonalcoholic fatty liver disease: a randomized controlled trial","volume":"68","author":"Panahi","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"issue":"12","key":"10.1016\/j.ctim.2019.102283_bib0085","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/mnfr.201100440","article-title":"Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism","volume":"55","author":"Shin","year":"2011","journal-title":"Mol Nutr Food Res."},{"issue":"5","key":"10.1016\/j.ctim.2019.102283_bib0090","first-page":"567","article-title":"The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial","volume":"6","author":"Rahimi","year":"2016","journal-title":"Avicenna J Phytomed"},{"issue":"3","key":"10.1016\/j.ctim.2019.102283_bib0095","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ptr.4715","article-title":"Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial","volume":"27","author":"Mohammadi","year":"2013","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2019.102283_bib0100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.15403\/jgld-179","article-title":"Effect of phytosomal curcumin on circulating levels of Adiponectin and leptin in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial","volume":"28","author":"Mirhafez","year":"2019","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1016\/j.ctim.2019.102283_bib0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12986-019-0331-1","article-title":"Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial","volume":"16","author":"Jazayeri-Tehrani","year":"2019","journal-title":"Nutr Metab (Lond)"},{"issue":"4","key":"10.1016\/j.ctim.2019.102283_bib0110","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1055\/s-0043-100019","article-title":"Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial","volume":"67","author":"Panahi","year":"2017","journal-title":"Drug Res (Stuttg)"},{"key":"10.1016\/j.ctim.2019.102283_bib0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.phrs.2017.02.008","article-title":"Effects of curcumin on HDL functionality","volume":"119","author":"Ganjali","year":"2017","journal-title":"Pharmacol Res"},{"issue":"6","key":"10.1016\/j.ctim.2019.102283_bib0120","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.phrs.2007.09.013","article-title":"Curcumin effects on blood lipid profile in a 6-month human study","volume":"56","author":"Baum","year":"2007","journal-title":"Pharmacol Res"},{"issue":"12","key":"10.1016\/j.ctim.2019.102283_bib0125","first-page":"1770","article-title":"Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind","volume":"28","author":"Yang","year":"2014","journal-title":"Placebo-Controlled Trial."},{"issue":"4","key":"10.1016\/j.ctim.2019.102283_bib0130","first-page":"201","article-title":"The effect of curcumin on lipid level in patients with acute coronary syndrome","volume":"40","author":"Alwi","year":"2008","journal-title":"Acta Med Indones"},{"issue":"4","key":"10.1016\/j.ctim.2019.102283_bib0135","first-page":"273","article-title":"Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers","volume":"36","author":"Soni","year":"1992","journal-title":"Indian J Physiol Pharmacol"},{"issue":"11","key":"10.1016\/j.ctim.2019.102283_bib0140","doi-asserted-by":"crossref","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ctim.2019.102283_bib0145","series-title":"Appendix: Jadad scale for reporting randomized controlled trials.","first-page":"237","author":"Halpern","year":"2005"},{"issue":"9","key":"10.1016\/j.ctim.2019.102283_bib0150","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/ptr.5659","article-title":"Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial","volume":"30","author":"Rahmani","year":"2016","journal-title":"Phytother Res"},{"issue":"Suppl 1","key":"10.1016\/j.ctim.2019.102283_bib0155","first-page":"S8","article-title":"Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease","volume":"11","author":"Saadati","year":"2018","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"3","key":"10.1016\/j.ctim.2019.102283_bib0160","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41430-018-0382-9","article-title":"The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease","volume":"73","author":"Saadati","year":"2019","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"10.1016\/j.ctim.2019.102283_bib0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12876-019-1055-4","article-title":"Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial","volume":"19","author":"Saadati","year":"2019","journal-title":"BMC Gastroenterol"},{"issue":"11","key":"10.1016\/j.ctim.2019.102283_bib0170","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3109\/10715762.2013.837577","article-title":"Special issue on \u201cOxidative stress and redox signaling in the gastrointestinal tract and related organs\u201d for Free Radical Research Involvement of free radicals and oxidative stress in NAFLD\/NASH","volume":"47","author":"Sumida","year":"2013","journal-title":"Free Radic Res"},{"issue":"1","key":"10.1016\/j.ctim.2019.102283_bib0175","first-page":"22","article-title":"Nutritional and health benefits of curcumin","volume":"6","author":"Jovi\u010di\u0107","year":"2017","journal-title":"Hrana u zdravlju i bolesti: znanstveno-stru\u010dni \u010dasopis za nutricionizam i dijetetiku"},{"issue":"10","key":"10.1016\/j.ctim.2019.102283_bib0180","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods6100092","article-title":"Curcumin: a review of its\u2019 effects on human health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"issue":"4","key":"10.1016\/j.ctim.2019.102283_bib0185","first-page":"324","article-title":"Ameliorative effects of curcumin against sodium fluoride-induced hepatotoxicity","volume":"17","author":"Moghaddam","year":"2015","journal-title":"Prog Food Nutr Sci"},{"issue":"10","key":"10.1016\/j.ctim.2019.102283_bib0190","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/jcm7100298","article-title":"A meta-analysis of the clinical use of curcumin for irritable bowel syndrome (IBS)","volume":"7","author":"Ng","year":"2018","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.ctim.2019.102283_bib0195","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12937-017-0293-y","article-title":"Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials","volume":"16","author":"Qin","year":"2017","journal-title":"Nutr J"},{"issue":"1","key":"10.1016\/j.ctim.2019.102283_bib0200","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10787-016-0301-4","article-title":"Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial","volume":"25","author":"Panahi","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ctim.2019.102283_bib0205","first-page":"1","article-title":"The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and dose-response meta-analysis of randomized controlled trials","author":"Mousavi","year":"2018","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"3","key":"10.1016\/j.ctim.2019.102283_bib0210","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ptr.4715","article-title":"Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial","volume":"27","author":"Mohammadi","year":"2013","journal-title":"Phytother Res"},{"issue":"4","key":"10.1016\/j.ctim.2019.102283_bib0215","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ptr.5779","article-title":"Effects of curcumin on serum vitamin E concentrations in individuals with metabolic syndrome","volume":"31","author":"Mohammadi","year":"2017","journal-title":"Phytother Res"},{"issue":"5","key":"10.1016\/j.ctim.2019.102283_bib0220","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1159\/000354516","article-title":"Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK\/uncoupling protein 2 pathway","volume":"32","author":"Pu","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.ctim.2019.102283_bib0225","first-page":"10","article-title":"The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials","author":"Akbari","year":"2019","journal-title":"Front Pharmacol"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229919313780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229919313780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:12:27Z","timestamp":1760807547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965229919313780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":45,"alternative-id":["S0965229919313780"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2019.102283","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2019.102283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102283"}}