{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:43:36Z","timestamp":1769013816629,"version":"3.49.0"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ctim.2021.102768","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T11:30:05Z","timestamp":1629286205000},"page":"102768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Withania somnifera as a safer option to hydroxychloroquine in the chemoprophylaxis of COVID-19: Results of interim analysis"],"prefix":"10.1016","volume":"62","author":[{"given":"Arvind","family":"Chopra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayanam","family":"Srikanth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-2609","authenticated-orcid":false,"given":"Bhushan","family":"Patwardhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ctim.2021.102768_bib0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/jamainternmed.2020.6319","article-title":"Efficacy and safety of hydroxychloroquine vs placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers: A randomized clinical trial","volume":"181","author":"Abella","year":"2021","journal-title":"JAMA Intern Med"},{"issue":"21","key":"10.1016\/j.ctim.2021.102768_bib0010","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.2020.22389","article-title":"Misguided use of hydroxychloroquine for COVID-19: The infusion of politics into science","volume":"324","author":"Saag","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ctim.2021.102768_bib0015","unstructured":"ICMR Advisory on the use of Hydroxychloroquine as prophylaxis for SARS-CoV-2 infection dated May 22, 2020. Available at: https:\/\/www.icmr.gov.in\/pdf\/covid\/techdoc\/V5_Revised_advisory_on_the_use_of_HCQ_SARS_CoV2_infection.pdf. As accessed on July 6, 2021."},{"key":"10.1016\/j.ctim.2021.102768_bib0020","unstructured":"Ministry of AYUSH advisory page 8, available at https:\/\/www.ayush.gov.in\/docs\/ayurved-guidlines.pdf. As accessed on June, 15, 2021."},{"key":"10.1016\/j.ctim.2021.102768_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2020.102642","article-title":"Safety of Ashwagandha root extract: A randomized, placebo-controlled, study in healthy volunteers","volume":"57","author":"Verma","year":"2021","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.ctim.2021.102768_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/0975-9476.100168","article-title":"Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers","volume":"3","author":"Raut","year":"2012","journal-title":"J Ayurveda Integr Med"},{"key":"10.1016\/j.ctim.2021.102768_bib0035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jaim.2015.08.001","article-title":"Safety assessment of Withania somnifera extract standardized for Withaferin A: Acute and sub-acute toxicity study","volume":"7","author":"Patel","year":"2016","journal-title":"J Ayurveda Integr Med"},{"key":"10.1016\/j.ctim.2021.102768_bib0040","doi-asserted-by":"crossref","DOI":"10.1089\/acm.2020.0129","article-title":"Public health approach of ayurveda and yoga for COVID-19 prophylaxis","author":"Tillu","year":"2020","journal-title":"J Altern Complement Med"},{"key":"10.1016\/j.ctim.2021.102768_bib0045","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2006.02.016","article-title":"Selective Th1 up-regulating activity of Withania somnifera aqueous extract in an experimental system using flow cytometry","volume":"107","author":"Bani","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.ctim.2021.102768_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.623795","article-title":"Withania somnifera (L.) dunal: Opportunity for clinical repurposing in COVID-19 management","volume":"12","author":"Saggam","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ctim.2021.102768_bib0055","unstructured":"Chopra A., Tillu G., Saluja M. et al. A Study of Ashwagandha in the Prophylaxis Against COVID-19 and its Benefits on General Health in High Risk Health Care Workers: A Randomized Controlled Comparison with Hydroxychloroquine Sulphate (HCQS). Clinical Trial Registry of India. Registration Number CTRI\/2020\/08\/027163, Registered on: 14\/08\/2020. Available at http:\/\/ctri.nic.in\/Clinicaltrials\/login.php. As Accessed on July 6, 2021."}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229921001096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229921001096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T16:19:37Z","timestamp":1760804377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965229921001096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":11,"alternative-id":["S0965229921001096"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2021.102768","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Withania somnifera as a safer option to hydroxychloroquine in the chemoprophylaxis of COVID-19: Results of interim analysis","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2021.102768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102768"}}