{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:10:51Z","timestamp":1793373051831,"version":"4.5.0"},"reference-count":159,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.ctim.2023.102955","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T16:55:07Z","timestamp":1684860907000},"page":"102955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Effects of curcumin\/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose\u2013response meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"75","author":[{"given":"Mohammad Jafar","family":"Dehzad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Ghalandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moein","family":"Askarpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctim.2023.102955_bib1","doi-asserted-by":"crossref","first-page":"ITC81","DOI":"10.7326\/AITC201712050","article-title":"Dyslipidemia","volume":"167","author":"Kopin","year":"2017","journal-title":"Ann Intern Med."},{"key":"10.1016\/j.ctim.2023.102955_bib2","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1016\/j.jcjd.2017.10.019","article-title":"Committee DCCPGE. Dyslipidemia","volume":"42","author":"Mancini","year":"2018","journal-title":"Can J Diabetes"},{"key":"10.1016\/j.ctim.2023.102955_bib3","unstructured":"Pappan N., Rehman A.. Dyslipidemia. StatPearls [Internet]: StatPearls Publishing; 2022."},{"key":"10.1016\/j.ctim.2023.102955_bib4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1210\/endrev\/bnab037","article-title":"A modern approach to dyslipidemia","volume":"43","author":"Berberich","year":"2022","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ctim.2023.102955_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11100690","article-title":"Apolipoprotein B and cardiovascular disease: biomarker and potential therapeutic target","volume":"Vol 11","author":"Behbodikhah","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.ctim.2023.102955_bib6","unstructured":"Rhee E.J. , Byrne Cd Fau - Sung K.-C. , Sung K.C. The HDL cholesterol\/apolipoprotein A-I ratio: an indicator of cardiovascular disease."},{"key":"10.1016\/j.ctim.2023.102955_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017728","article-title":"Relation of different fruit and vegetable sources with incident cardiovascular outcomes: a systematic review and meta\u2010analysis of prospective cohort studies","volume":"9","author":"Zurbau","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ctim.2023.102955_bib8","first-page":"8","article-title":"The association between dietary antioxidant micronutrients and cardiovascular disease in adults in the united states: a cross-sectional study","author":"Yin","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s13679-020-00403-z","article-title":"A review of obesity, physical activity, and cardiovascular disease","volume":"9","author":"Elagizi","year":"2020","journal-title":"Curr Obes Rep"},{"key":"10.1016\/j.ctim.2023.102955_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12872-021-02106-2","article-title":"Dietary phytochemical index associated with cardiovascular risk factor in patients with type 1 diabetes mellitus","volume":"21","author":"Delshad Aghdam","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.ctim.2023.102955_bib11","doi-asserted-by":"crossref","first-page":"7656919","DOI":"10.1155\/2020\/7656919","article-title":"Biochemistry, safety, pharmacological activities, and clinical applications of turmeric: a mechanistic review","volume":"2020","author":"Ahmad","year":"2020","journal-title":"Evid-Based Complement Altern Med"},{"key":"10.1016\/j.ctim.2023.102955_bib12","first-page":"38","article-title":"WHAM evidence summary: topical turmeric for wound healing","volume":"42","author":"Haesler","year":"2022","journal-title":"World Counc Enteros Ther J"},{"key":"10.1016\/j.ctim.2023.102955_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/NT.0000000000000392","article-title":"Turmeric: potential health benefits","volume":"55","author":"Singletary","year":"2020","journal-title":"Nutr Today"},{"key":"10.1016\/j.ctim.2023.102955_bib14","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1002\/jsfa.11372","article-title":"Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability","volume":"101","author":"Abd El-Hack","year":"2021","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.ctim.2023.102955_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.14280","article-title":"Curcumin and rheumatoid arthritis: a systematic review of literature","volume":"75","author":"Pourhabibi-Zarandi","year":"2021","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.ctim.2023.102955_bib16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/ptr.6257","article-title":"Curcumin intervention for cognitive function in different types of people: a systematic review and meta-analysis","volume":"33","author":"Zhu","year":"2019","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib17","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"key":"10.1016\/j.ctim.2023.102955_bib18","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The cochrane collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.ctim.2023.102955_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.ctim.2023.102955_bib20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1751-5823.2009.00095_15.x","article-title":"Introduction to Meta-Analysis by Michael Borenstein, Larry V. Hedges, Julian P.T. Higgins, Hannah R. Rothstein","volume":"77","author":"Rosenblad","year":"2009","journal-title":"Int Stat Rev"},{"key":"10.1016\/j.ctim.2023.102955_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096411","article-title":"Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability","volume":"9","author":"Brondani","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ctim.2023.102955_bib22","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.1016\/j.clbc.2018.01.007","article-title":"Dietary inflammatory potential score and risk of breast cancer: systematic review and meta-analysis","volume":"18","author":"Zahedi","year":"2018","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.ctim.2023.102955_bib23","first-page":"15","article-title":"Assessing the influence of a single study in the meta-analysis estimate","volume":"47","author":"Tobias","year":"1999","journal-title":"Stata Tech Bull"},{"key":"10.1016\/j.ctim.2023.102955_bib24","series-title":"Economic Record","first-page":"132","article-title":"Interpreting and Visualizing Regression Models Using Stata","author":"Foster","year":"2013"},{"key":"10.1016\/j.ctim.2023.102955_bib25","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"Rating quality of evidence and strength of recommendations GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Falck-Ytter","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.ctim.2023.102955_bib26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1523-5378.2007.00497.x","article-title":"A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: Something to learn from failure?","volume":"12","author":"Di Mario","year":"2007","journal-title":"Helicobacter"},{"key":"10.1016\/j.ctim.2023.102955_bib27","first-page":"9","article-title":"Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects","author":"Wickenberg","year":"2010","journal-title":"Nutr J"},{"key":"10.1016\/j.ctim.2023.102955_bib28","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3923\/pjn.2013.842.850","article-title":"Effect of temulawak {Curcumin xanthorrhiza Roxb) extract on reduction of MDA (Malondialdehyde) levels of football athletes","volume":"12","author":"Rosidi","year":"2013","journal-title":"Pak J Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib29","first-page":"11","article-title":"Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva\u00ae): a randomised, placebo-controlled trial","author":"Drobnic","year":"2014","journal-title":"J Int Soc Sports Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib30","first-page":"469","article-title":"Effects of curcumin supplementation on exercise-induced oxidative stress in humans","volume":"35","author":"Takahashi","year":"2014","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.ctim.2023.102955_bib31","first-page":"12","article-title":"The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2\u2009h of endurance cycling","author":"Sciberras","year":"2015","journal-title":"J Int Soc Sports Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib32","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00421-015-3170-4","article-title":"Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin","volume":"115","author":"Tanabe","year":"2015","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.ctim.2023.102955_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbacli.2016.02.003","article-title":"Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin","volume":"5","author":"McFarlin","year":"2016","journal-title":"BBA Clin"},{"key":"10.1016\/j.ctim.2023.102955_bib34","first-page":"8","article-title":"Influence of curcumin supplementation on exercise-induced oxidative stress","author":"Roohi","year":"2017","journal-title":"Asian J Sports Med"},{"key":"10.1016\/j.ctim.2023.102955_bib35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.20463\/jenb.2019.0010","article-title":"Curcumin supplementation attenuates the decrease in endothelial function following eccentric exercise","volume":"23","author":"Choi","year":"2019","journal-title":"J Exerc Nutr Biochem"},{"key":"10.1016\/j.ctim.2023.102955_bib36","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.3889\/oamjms.2019.426","article-title":"Curcumin\u2019s effect \u043en COX-2 \u0430nd IL-10 serum in preeclampsia\u2019s patient undergo sectio caesarea with spinal anesthesia","volume":"7","author":"Fadinie","year":"2019","journal-title":"Open Access Maced J Med Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib37","first-page":"123","article-title":"Effect of one and five-day curcumin consumption on muscle damage indices after an eccentric exercise session in untrained young men","volume":"21","author":"Samadi","year":"2019","journal-title":"J Mil Med"},{"key":"10.1016\/j.ctim.2023.102955_bib38","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/sms.13373","article-title":"Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation","volume":"29","author":"Tanabe","year":"2019","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.ctim.2023.102955_bib39","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3177\/jnsv.65.82","article-title":"Effective timing of curcumin ingestion to attenuate eccentric exercise\u2013induced muscle soreness in men","volume":"65","author":"Tanabe","year":"2019","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1016\/j.ctim.2023.102955_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph17114088","article-title":"Effect of morning vs. Evening turmeric consumption on urine oxidative stress biomarkers in obese, middle-aged adults: A feasibility study","volume":"17","author":"Blanton","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ctim.2023.102955_bib41","first-page":"21","article-title":"The clinical effect of Nano micelles containing curcumin as a therapeutic supplement in patients with COVID-19 and the immune responses balance changes following treatment: a structured summary of a study protocol for a randomised controlled trial","author":"Hassaniazad","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.ctim.2023.102955_bib42","first-page":"36","article-title":"Effects of nanocurcumin on inflammatory factors and clinical outcomes in critically ill patients with sepsis: a pilot randomized clinical trial","author":"Karimi","year":"2020","journal-title":"Eur J Integr Med"},{"key":"10.1016\/j.ctim.2023.102955_bib43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/19390211.2018.1515142","article-title":"Effects of curcumin on the oxidative stress response to a dual stress challenge in trained men","volume":"17","author":"McAllister","year":"2020","journal-title":"J Diet Suppl"},{"key":"10.1016\/j.ctim.2023.102955_bib44","first-page":"21","article-title":"Effects of curcumin-piperine co-supplementation on clinical signs, duration, severity, and inflammatory factors in patients with COVID-19: a structured summary of a study protocol for a randomised controlled trial","author":"Miryan","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.ctim.2023.102955_bib45","first-page":"89","article-title":"Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients","author":"Valizadeh","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.ctim.2023.102955_bib46","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s40200-019-00451-w","article-title":"Therapeutic effects of supplementation with Curcuminoids in critically ill patients receiving enteral nutrition: a randomized controlled trial protocol","volume":"19","author":"Zahedi","year":"2020","journal-title":"J Diabetes Metab Disord"},{"key":"10.1016\/j.ctim.2023.102955_bib47","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/jmf.2020.0074","article-title":"Acute effects of turmeric extracts on knee joint pain: a pilot, randomized controlled trial","volume":"24","author":"Calder\u00f3n-P\u00e9rez","year":"2021","journal-title":"J Med Food"},{"key":"10.1016\/j.ctim.2023.102955_bib48","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1002\/ptr.7294","article-title":"A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients","volume":"35","author":"Hassaniazad","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib49","article-title":"Short term, oral supplementation with optimized curcumin does not impair performance improvements associated with high intensity interval training","author":"Kisiolek","year":"2021","journal-title":"J Diet Suppl"},{"key":"10.1016\/j.ctim.2023.102955_bib50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/19390211.2020.1796885","article-title":"Curcumin improves delayed onset muscle soreness and postexercise lactate accumulation","volume":"18","author":"Mallard","year":"2021","journal-title":"J Diet Suppl"},{"key":"10.1016\/j.ctim.2023.102955_bib51","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1002\/ptr.7004","article-title":"Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial","volume":"35","author":"Saber-Moghaddam","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib52","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1055\/s-0040-1720969","article-title":"Curcumin's effect on inflammatory response following percutaneous coronary intervention in adult patients with stable coronary heart disease","volume":"30","author":"Silalahi","year":"2021","journal-title":"Int J Angiol"},{"key":"10.1016\/j.ctim.2023.102955_bib53","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1002\/jcp.30233","article-title":"Immunomodulatory effects of nanocurcumin on Th17 cell responses in mild and severe COVID-19 patients","volume":"236","author":"Tahmasebi","year":"2021","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ctim.2023.102955_bib54","first-page":"276","article-title":"Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2","author":"Tahmasebi","year":"2021","journal-title":"Life Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib55","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1002\/ptr.7179","article-title":"Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial","volume":"35","author":"Zahedi","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib56","doi-asserted-by":"crossref","first-page":"216","DOI":"10.5530\/pj.2022.14.27","article-title":"The effect of curcumin and virgin coconut oil towards cytokines levels in covid-19 patients at universitas sebelas maret hospital, Surakarta, Indonesia","volume":"14","author":"Hartono","year":"2022","journal-title":"Pharmacogn J"},{"key":"10.1016\/j.ctim.2023.102955_bib57","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/ptr.7374","article-title":"Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: a randomized double-blind placebo-controlled trial","volume":"36","author":"Honarkar Shafie","year":"2022","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib58","first-page":"14","article-title":"Co-administration of iron and bioavailable curcumin reduces levels of systemic markers of inflammation and oxidative stress in a placebo-controlled randomised study","author":"Lorinczova","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2023.102955_bib59","doi-asserted-by":"crossref","first-page":"66","DOI":"10.18585\/inabj.v14i1.1734","article-title":"Curcumin's antioxidant properties in stable coronary artery disease patients undergoing percutaneous coronary intervention: a randomized controlled trial","volume":"14","author":"Silalahi","year":"2022","journal-title":"Indones Biomed J"},{"key":"10.1016\/j.ctim.2023.102955_bib60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3923\/jms.2013.10.18","article-title":"Safety of garlic (Allium sativum) and turmeric (curcuma domestica) extract in comparison with simvastatin on improving lipid profile in dyslipidemia patients","volume":"13","author":"Sukandar","year":"2013","journal-title":"J Med Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib61","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1177\/0003319714568792","article-title":"Effect of a natural supplement containing curcuma longa, guggul, and chlorogenic acid in patients with metabolic syndrome","volume":"66","author":"Patti","year":"2015","journal-title":"Angiology"},{"key":"10.1016\/j.ctim.2023.102955_bib62","first-page":"8","article-title":"Curcumin and Boswellia serrata modulate the glyco-oxidative status and lipo-oxidation in master athletes","author":"Chilelli","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2023.102955_bib63","first-page":"389","article-title":"Study the effects of anti-inflammatory curcumex capsules containing three plants (ginger, curcumin and black pepper) in patients with active Rheumatoid Arthritis","volume":"7","author":"Hemmati","year":"2016","journal-title":"IIOAB J"},{"key":"10.1016\/j.ctim.2023.102955_bib64","first-page":"321","article-title":"The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study","volume":"52","author":"Sterzi","year":"2016","journal-title":"Eur J Phys Rehabil Med"},{"key":"10.1016\/j.ctim.2023.102955_bib65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejogrb.2016.10.018","article-title":"Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women","volume":"207","author":"Torella","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ctim.2023.102955_bib66","first-page":"147","article-title":"Curcumin and piperine supplementation and recovery following exercise induced muscle damage: a randomized controlled trial","volume":"16","author":"Delecroix","year":"2017","journal-title":"J Sports Sci Med"},{"key":"10.1016\/j.ctim.2023.102955_bib67","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.5114\/amsad.2018.79597","article-title":"Effects of a nutraceutical combination of fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia: an 8-week, open-label, single-arm pilot study","volume":"3","author":"Biagi","year":"2018","journal-title":"Arch Med Sci Atheroscler Dis"},{"key":"10.1016\/j.ctim.2023.102955_bib68","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/bfm.2018.0159","article-title":"Effects of fenugreek, ginger, and turmeric supplementation on human milk volume and nutrient content in breastfeeding mothers: A randomized double-blind controlled trial","volume":"13","author":"Bumrungpert","year":"2018","journal-title":"Breastfeed Med"},{"key":"10.1016\/j.ctim.2023.102955_bib69","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.phymed.2018.01.014","article-title":"Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols: a randomized, placebo controlled trial","volume":"42","author":"Derosa","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ctim.2023.102955_bib70","doi-asserted-by":"crossref","first-page":"766","DOI":"10.21037\/jgo.2019.03.07","article-title":"A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study","volume":"10","author":"Hatab","year":"2019","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.ctim.2023.102955_bib71","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12094-018-1950-0","article-title":"A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study","volume":"21","author":"Mart\u00ednez","year":"2019","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.ctim.2023.102955_bib72","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.2147\/CIA.S223805","article-title":"Recovery of bone and muscle mass in patients with chronic kidney disease and iron overload on hemodialysis and taking combined supplementation with curcumin and resveratrol","volume":"14","author":"Ortiz","year":"2019","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.ctim.2023.102955_bib73","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clnesp.2019.09.011","article-title":"A combined effect of Cavacurcumin, Eicosapentaenoic acid (Omega-3s), Astaxanthin and Gamma \u2013linoleic acid (Omega-6) (CEAG) in healthy volunteers- a randomized, double-blind, placebo-controlled study","volume":"35","author":"Birudaraju","year":"2020","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.ctim.2023.102955_bib74","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2147\/DMSO.S232791","article-title":"An evaluation of a nutraceutical with berberine, curcumin, inositol, banaba and chromium picolinate in patients with fasting dysglycemia","volume":"13","author":"Derosa","year":"2020","journal-title":"Diabetes, Metab Syndr Obes: Targets Ther"},{"key":"10.1016\/j.ctim.2023.102955_bib75","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.13057\/biodiv\/d210560","article-title":"Effectiveness of anemia herbal formula containing curcuma zanthorrhiza, Elephantopus scaber and Amaranthus tricolor in iron deficiency anemia patients","volume":"21","author":"Fitriani","year":"2020","journal-title":"Biodiversitas"},{"key":"10.1016\/j.ctim.2023.102955_bib76","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/ptr.6671","article-title":"Herbal formulation \u201cturmeric extract, black pepper, and ginger\u201d versus Naproxen for chronic knee osteoarthritis: a randomized, double-blind, controlled clinical trial","volume":"34","author":"Heidari-Beni","year":"2020","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib77","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1039\/C9FO02424G","article-title":"Consumption of a green tea extract-curcumin drink decreases blood urea nitrogen and redox iron in \u03b2-thalassemia patients","volume":"11","author":"Koonyosying","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.ctim.2023.102955_bib78","first-page":"22","article-title":"A presurgical study of curcumin combined with anthocyanin supplements in patients with colorectal adenomatous polyps","author":"Briata","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib79","first-page":"804","article-title":"The effects of livercare tablet [Combination of milk thistle, dandelion, barberry, tumeric (Curcumin), and artichoke] in prevention of anti-tuberculosis drugs-induced hepatotoxicity: a randomized controlled clinical trial","volume":"38","author":"Yazdani","year":"2021","journal-title":"J Isfahan Med Sch"},{"key":"10.1016\/j.ctim.2023.102955_bib80","first-page":"887","article-title":"Effect of oral curcumin administration on insulin resistance, serum resistin and fetuin-A in obese children: randomized placebo-controlled study","volume":"5","author":"Ismail","year":"2014","journal-title":"Res J Pharm, Biol Chem Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib81","first-page":"1891","article-title":"Impact of curcumin intake on gluco-insulin homeostasis, leptin and adiponectin in obese subjects","volume":"7","author":"Ismail","year":"2016","journal-title":"Res J Pharm, Biol Chem Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib82","first-page":"238","article-title":"Curcuma longa L. ameliorates asthma control in children and adolescents: a randomized, double-blind, controlled trial","author":"Manarin","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.ctim.2023.102955_bib83","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1590\/1516-3180.2018.0454120419","article-title":"Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial","volume":"137","author":"Saraf-Bank","year":"2019","journal-title":"Sao Paulo Med J"},{"key":"10.1016\/j.ctim.2023.102955_bib84","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/ptr.6370","article-title":"Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: a randomized placebo-controlled clinical trial","volume":"33","author":"Saraf-Bank","year":"2019","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib85","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.phrs.2007.09.013","article-title":"Curcumin effects on blood lipid profile in a 6-month human study","volume":"56","author":"Baum","year":"2007","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.ctim.2023.102955_bib86","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/00365599.2011.585622","article-title":"Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-\u03b2 and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study","volume":"45","author":"Khajehdehi","year":"2011","journal-title":"Scand J Urol Nephrol"},{"key":"10.1016\/j.ctim.2023.102955_bib87","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.nutres.2012.09.002","article-title":"Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women","volume":"32","author":"Akazawa","year":"2012","journal-title":"Nutr Res"},{"key":"10.1016\/j.ctim.2023.102955_bib88","first-page":"11","article-title":"Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people","author":"Disilvestro","year":"2012","journal-title":"Nutr J"},{"key":"10.1016\/j.ctim.2023.102955_bib89","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/ajh.2012.24","article-title":"Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: Pilot study","volume":"25","author":"Sugawara","year":"2012","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.ctim.2023.102955_bib90","first-page":"13","article-title":"The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study","author":"Kim","year":"2013","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.ctim.2023.102955_bib91","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ptr.4715","article-title":"Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial","volume":"27","author":"Mohammadi","year":"2013","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib92","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jnutbio.2013.09.013","article-title":"Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial","volume":"25","author":"Chuengsamarn","year":"2014","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.ctim.2023.102955_bib93","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s40620-014-0039-2","article-title":"Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial","volume":"27","author":"Pakfetrat","year":"2014","journal-title":"J Nephrol"},{"key":"10.1016\/j.ctim.2023.102955_bib94","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1055\/s-0034-1389986","article-title":"Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: positive results of a randomized double-blind placebo-controlled trial","volume":"65","author":"Panahi","year":"2014","journal-title":"Drug Res"},{"key":"10.1016\/j.ctim.2023.102955_bib95","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/ptr.5197","article-title":"Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial","volume":"28","author":"Yang","year":"2014","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib96","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ctim.2015.01.008","article-title":"Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial","volume":"23","author":"Amin","year":"2015","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.ctim.2023.102955_bib97","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12291-014-0436-2","article-title":"Efficacy of turmeric as adjuvant therapy in type 2 diabetic patients","volume":"30","author":"Maithili Karpaga Selvi","year":"2015","journal-title":"Indian J Clin Biochem"},{"key":"10.1016\/j.ctim.2023.102955_bib98","first-page":"479","article-title":"The effect of curcumin on some of traditional and non-traditional cardiovascular risk factors: a pilot randomized, double-blind, placebo-controlled trial","volume":"14","author":"Mirzabeigi","year":"2015","journal-title":"Iran J Pharm Res"},{"key":"10.1016\/j.ctim.2023.102955_bib99","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2147\/COPD.S104490","article-title":"Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD","volume":"11","author":"Funamoto","year":"2016","journal-title":"Int J COPD"},{"key":"10.1016\/j.ctim.2023.102955_bib100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1053\/j.jrn.2016.01.013","article-title":"The effect of dietary supplementation with curcumin on redox status and Nrf2 activation in patients with nondiabetic or diabetic proteinuric chronic kidney disease: A pilot study","volume":"26","author":"Jim\u00e9nez-Osorio","year":"2016","journal-title":"J Ren Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib101","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/mnfr.201501034","article-title":"Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals","volume":"60","author":"Kocher","year":"2016","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.ctim.2023.102955_bib102","first-page":"567","article-title":"The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial","volume":"6","author":"Rahimi","year":"2016","journal-title":"Avicenna J Phytomed"},{"key":"10.1016\/j.ctim.2023.102955_bib103","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/ptr.5659","article-title":"Treatment of non-alcoholic fatty liver disease with curcumin: a randomized placebo-controlled trial","author":"Rahmani","year":"2016","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib104","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1089\/jmf.2017.3930","article-title":"A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study","volume":"20","author":"Amalraj","year":"2017","journal-title":"J Med Food"},{"key":"10.1016\/j.ctim.2023.102955_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctim.2017.05.006","article-title":"Curcuminoids modify lipid profile in type 2 diabetes mellitus: a randomized controlled trial","volume":"33","author":"Panahi","year":"2017","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.ctim.2023.102955_bib106","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1055\/s-0043-100019","article-title":"Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial","volume":"67","author":"Panahi","year":"2017","journal-title":"Drug Res"},{"key":"10.1016\/j.ctim.2023.102955_bib107","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.metabol.2017.12.009","article-title":"Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial","volume":"82","author":"Ferguson","year":"2018","journal-title":"Metab: Clin Exp"},{"key":"10.1016\/j.ctim.2023.102955_bib108","first-page":"330","article-title":"The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: a randomized, placebo-controlled clinical trial","volume":"8","author":"Javandoost","year":"2018","journal-title":"Avicenna J Phytomed"},{"key":"10.1016\/j.ctim.2023.102955_bib109","first-page":"2018","article-title":"A novel curcumin-galactomannoside complex delivery system improves hepatic function markers in chronic alcoholics: a double-blinded, randomized, placebo-controlled study","author":"Krishnareddy","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.ctim.2023.102955_bib110","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00580-017-2624-y","article-title":"Evaluation of the effects of curcumin in patients with metabolic syndrome","volume":"27","author":"Saberi-Karimian","year":"2018","journal-title":"Comp Clin Pathol"},{"key":"10.1016\/j.ctim.2023.102955_bib111","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/NHA-170029","article-title":"Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults","volume":"4","author":"Santos-Parker","year":"2018","journal-title":"Nutr Healthy Aging"},{"key":"10.1016\/j.ctim.2023.102955_bib112","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/ptr.6312","article-title":"Effect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients","volume":"33","author":"Adab","year":"2019","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib113","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/ptr.6328","article-title":"The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial","volume":"33","author":"Adibian","year":"2019","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib114","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.nut.2019.01.002","article-title":"Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: a double-blinded, randomized, controlled trial","volume":"62","author":"Campbell","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.ctim.2023.102955_bib115","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/s41430-018-0386-5","article-title":"A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial","volume":"73","author":"Chashmniam","year":"2019","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib116","first-page":"2019","article-title":"Effects of highly absorbable curcumin in patients with impaired glucose tolerance and non-insulin-dependent diabetes mellitus","author":"Funamoto","year":"2019","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.ctim.2023.102955_bib117","first-page":"16","article-title":"Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): A double-blind randomized placebo-controlled clinical trial","author":"Jazayeri-Tehrani","year":"2019","journal-title":"Nutr Metab"},{"key":"10.1016\/j.ctim.2023.102955_bib118","doi-asserted-by":"crossref","first-page":"183","DOI":"10.15403\/jgld-179","article-title":"Effect of phytosomal curcumin on circulating levels of adiponectin and leptin in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial","volume":"28","author":"Mirhafez","year":"2019","journal-title":"J Gastrointest Liver Dis"},{"key":"10.1016\/j.ctim.2023.102955_bib119","first-page":"19","article-title":"Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial","author":"Saadati","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.ctim.2023.102955_bib120","first-page":"19","article-title":"Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV\/AIDS: a randomized controlled trial","author":"Silva","year":"2019","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.ctim.2023.102955_bib121","first-page":"47","article-title":"The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight\/obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial","author":"Sohaei","year":"2019","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.ctim.2023.102955_bib122","first-page":"18","article-title":"Curcumin and\/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial","author":"Thota","year":"2019","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.ctim.2023.102955_bib123","first-page":"11","article-title":"Hot water extract of Curcuma longa L. Improves serum inflammatory markers and general health in subjects with overweight or prehypertension\/mild hypertension: a randomized, double-blind, placebo-controlled trial","author":"Uchio","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2023.102955_bib124","first-page":"77","article-title":"Curcumin as a major active component of turmeric attenuates proteinuria in patients with overt diabetic nephropathy","volume":"24","author":"Vanaie","year":"2019","journal-title":"J Res Med Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib125","first-page":"52","article-title":"The effects of nano-curcumin supplementation on serum level of hs-CRP, adhesion molecules, and lipid profiles in hemodialysis patients, a randomized controlled clinical trial","volume":"14","author":"Afshar","year":"2020","journal-title":"Iran J Kidney Dis"},{"key":"10.1016\/j.ctim.2023.102955_bib126","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1016\/j.clnu.2020.03.007","article-title":"Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: a pilot randomized, double-blind, controlled study","volume":"39","author":"Alvarenga","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib127","first-page":"22","article-title":"The effects of curcumin supplementation added to diet on anthropometric and biochemical status in women with polycystic ovary syndrome: a randomized, placebo-controlled trial","author":"Asan","year":"2020","journal-title":"Prog Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib128","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00394-019-01916-7","article-title":"Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial","volume":"59","author":"Cicero","year":"2020","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib129","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7570\/jomes19055","article-title":"The effect of curcumin supplementation and aerobic training on anthropometric indices, serum lipid profiles, C-Reactive protein and insulin resistance in overweight women: a randomized, double-blind, placebo-controlled trial","volume":"29","author":"Dolati","year":"2020","journal-title":"J Obes Metab Syndr"},{"key":"10.1016\/j.ctim.2023.102955_bib130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.clnesp.2020.01.005","article-title":"Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Jamilian","year":"2020","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.ctim.2023.102955_bib131","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.numecd.2019.12.010","article-title":"Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: a randomized controlled trial","volume":"30","author":"Kuszewski","year":"2020","journal-title":"Nutr, Metab Cardiovasc Dis"},{"key":"10.1016\/j.ctim.2023.102955_bib132","first-page":"12","article-title":"Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome","author":"Osali","year":"2020","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.ctim.2023.102955_bib133","first-page":"49","article-title":"Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: a randomized controlled trial","author":"Saberi-Karimian","year":"2020","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.ctim.2023.102955_bib134","first-page":"290","article-title":"The effects of nano-curcumin on metabolic status in patients with diabetes on hemodialysis, a randomized, double blind, placebo-controlled trial","volume":"14","author":"Shafabakhsh","year":"2020","journal-title":"Iran J Kidney Dis"},{"key":"10.1016\/j.ctim.2023.102955_bib135","first-page":"21","article-title":"A double-blind randomized controlled trial of curcumin for improvement in glycemic status, lipid profile and systemic inflammation in \u03b2-thalassemia major","author":"Tamaddoni","year":"2020","journal-title":"J Herb Med"},{"key":"10.1016\/j.ctim.2023.102955_bib136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-64872-5_1","article-title":"The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial","volume":"Vol 1308","author":"Alidadi","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ctim.2023.102955_bib137","first-page":"110","article-title":"The effect of curcumin-black pepper on body fat composition and lipid levels in overweight male adults","volume":"10","author":"Alqahtani","year":"2021","journal-title":"Int J Med Res Health Sci"},{"key":"10.1016\/j.ctim.2023.102955_bib138","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/19390211.2020.1757798","article-title":"Effect of curcumin on serum urate in asymptomatic hyperuricemia: a randomized placebo-controlled trial","volume":"18","author":"Bupparenoo","year":"2021","journal-title":"J Diet Suppl"},{"key":"10.1016\/j.ctim.2023.102955_bib139","first-page":"111","article-title":"How combined and separate aerobic training and turmeric supplementation alter lipid profile and glycemic status? a clinical trial in middle-aged females with type 2 diabetes and hyperlipidemia","volume":"15","author":"Darmian","year":"2021","journal-title":"Int Cardiovasc Res J"},{"key":"10.1016\/j.ctim.2023.102955_bib140","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.2174\/22123873MTEzBMDAb5","article-title":"Curcumin nanomicelle improves lipid profile, stress oxidative factors and inflammatory markers in patients undergoing coronary elective an-gioplasty; a randomized clinical trial","volume":"21","author":"Helli","year":"2021","journal-title":"Endocr, Metab Immune Disord - Drug Targets"},{"key":"10.1016\/j.ctim.2023.102955_bib141","first-page":"13","article-title":"The effect of turmeric on lipid profile, malondialdehyde, liver echogenicity and enzymes among patients with nonalcoholic fatty liver disease: a randomized double blind clinical trial","author":"jarhahzadeh","year":"2021","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.ctim.2023.102955_bib142","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1002\/ptr.7136","article-title":"The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A phase 2 randomized, placebo-controlled trial with a multi-arm, parallel-group design","volume":"35","author":"Karandish","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib143","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/ptr.6957","article-title":"The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial","volume":"35","author":"Mokhtari","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/j.ctim.2023.102955_bib144","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1080\/09637486.2021.1885015","article-title":"Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial","volume":"72","author":"Neta","year":"2021","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib145","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1080\/07315724.2020.1823909","article-title":"Cost-effectiveness of passion fruit albedo versus turmeric in the glycemic and lipaemic control of people with type 2 diabetes: randomized clinical trial","volume":"40","author":"Sousa","year":"2021","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib146","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1089\/jmf.2020.4778","article-title":"The efficacy of the novel bioavailable curcumin (cureit) in the management of sarcopenia in healthy elderly subjects: a randomized, placebo-controlled, double-blind clinical study","volume":"24","author":"Varma","year":"2021","journal-title":"J Med Food"},{"key":"10.1016\/j.ctim.2023.102955_bib147","first-page":"22","article-title":"Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study","author":"Arabnezhad","year":"2022","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.ctim.2023.102955_bib148","first-page":"14","article-title":"Curcumin and zinc co-supplementation along with a loss-weight diet can improve lipid profiles in subjects with prediabetes: a multi-arm, parallel-group, randomized, double-blind placebo-controlled phase 2 clinical trial","author":"Karandish","year":"2022","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.ctim.2023.102955_bib149","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10071015","article-title":"The effects of nano-curcumin supplementation on risk factors for cardiovascular disease: a grade-assessed systematic review and meta-analysis of clinical trials","volume":"Vol 10","author":"Ashtary-Larky","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ctim.2023.102955_bib150","first-page":"89","article-title":"The independent relationship between triglycerides and coronary heart disease","volume":"5","author":"Morrison","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.ctim.2023.102955_bib151","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1080\/13813455.2020.1779309","article-title":"Curcumin and blood lipid levels: an updated systematic review and meta-analysis of randomised clinical trials","volume":"128","author":"Saeedi","year":"2022","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.ctim.2023.102955_bib152","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.2174\/1381612824666180828162053","article-title":"The effects of curcumin on glycemic control and lipid profiles among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials","volume":"24","author":"Tabrizi","year":"2018","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ctim.2023.102955_bib153","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020684","article-title":"Effects of curcumin on glycemic control and lipid profile in polycystic ovary syndrome: systematic review with meta-analysis and trial sequential analysis","volume":"Vol 13","author":"Chien","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2023.102955_bib154","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020404","article-title":"Potential therapeutic effects of curcumin on glycemic and lipid profile in uncomplicated type 2 diabetes\u2014a meta-analysis of randomized controlled trial","volume":"Vol 13","author":"Altobelli","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2023.102955_bib155","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/advances\/nmz021","article-title":"A systematic review and meta-analysis of randomized controlled trials on the effects of turmeric and curcuminoids on blood lipids in adults with metabolic diseases","volume":"10","author":"Yuan","year":"2019","journal-title":"Adv Nutr"},{"key":"10.1016\/j.ctim.2023.102955_bib156","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejmech.2018.12.016","article-title":"The therapeutic potential of curcumin: a review of clinical trials","volume":"163","author":"Salehi","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.ctim.2023.102955_bib157","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jcp.25756","article-title":"Curcumin as a potential candidate for treating hyperlipidemia: a review of cellular and metabolic mechanisms","volume":"233","author":"Panahi","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ctim.2023.102955_bib158","first-page":"5","article-title":"Effects of curcumin on ion channels and transporters","author":"Zhang","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.ctim.2023.102955_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111214","article-title":"Curcumin and cardiovascular diseases: focus on cellular targets and cascades","volume":"136","author":"Pourbagher-Shahri","year":"2021","journal-title":"Biomed Pharmacother"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229923000420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229923000420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:18:23Z","timestamp":1760807903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965229923000420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":159,"alternative-id":["S0965229923000420"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2023.102955","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of curcumin\/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose\u2013response meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2023.102955","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102955"}}