{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:45:24Z","timestamp":1792215924453,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ctim.2025.103132","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T12:18:30Z","timestamp":1737980310000},"page":"103132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Therapeutic effects of probiotics on symptoms of irritability\/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials"],"prefix":"10.1016","volume":"89","author":[{"given":"Ping-Wen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chia-Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk-Kwan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Shian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hsiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chuan","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctim.2025.103132_bib1","first-page":"170","article-title":"Probiotics for gastrointestinal conditions: a summary of the evidence","volume":"96","author":"Wilkins","year":"2017","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.ctim.2025.103132_bib2","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.21037\/apm-20-1365","article-title":"A narrative review of relationship between gut microbiota and neuropsychiatric disorders: mechanisms and clinical application of probiotics and prebiotics","volume":"10","author":"Yang","year":"2021","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.ctim.2025.103132_bib3","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ctim.2025.103132_bib4","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.molmed.2018.06.008","article-title":"The impact of systemic inflammation on neurodevelopment","volume":"24","author":"Jiang","year":"2018","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ctim.2025.103132_bib5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/1756-185X.12333","article-title":"Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double-blind clinical trial","volume":"17","author":"Alipour","year":"2014","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.ctim.2025.103132_bib6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.chc.2020.02.005","article-title":"Gastrointestinal issues and autism spectrum disorder","volume":"29","author":"Madra","year":"2020","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"10.1016\/j.ctim.2025.103132_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030521","article-title":"Autism spectrum disorders and the gut microbiota","volume":"11","author":"Fattorusso","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2025.103132_bib8","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-2528","article-title":"Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit\/hyperactivity disorder in children and adolescents","volume":"144","author":"Wolraich","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.ctim.2025.103132_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jama.2022.23661","article-title":"Autism spectrum disorder: a review","volume":"329","author":"Hirota","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.ctim.2025.103132_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.5005\/jp-journals-10018-1384","article-title":"Emerging role and place of probiotics in the management of pediatric neurodevelopmental disorders","volume":"12","author":"Khanna","year":"2022","journal-title":"Eur J Hepato-Gastroenterol"},{"key":"10.1016\/j.ctim.2025.103132_bib11","series-title":"The American Psychiatric Publishing textbook of neuropsychiatry and behavioral neurosciences","first-page":"1045","article-title":"Neuropsychiatric disorders of childhood and adolescence","author":"Teicher","year":"2008"},{"key":"10.1016\/j.ctim.2025.103132_bib12","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1007\/s10803-020-04627-9","article-title":"Assessing irritability in children with autism spectrum disorder using the affective reactivity index","volume":"51","author":"Kalvin","year":"2021","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.ctim.2025.103132_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12888-022-03818-1","article-title":"Investigating the associations between irritability and hot and cool executive functioning in those with ADHD","volume":"22","author":"Colonna","year":"2022","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.ctim.2025.103132_bib14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neurenf.2022.05.007","article-title":"Irritability in an open-door pediatric psychiatric emergency service in a middle-income country","volume":"70","author":"Lobato Machado","year":"2022","journal-title":"Neuropsychiatr De l\u2032Enfance Et De l\u2032Adolesc"},{"key":"10.1016\/j.ctim.2025.103132_bib15","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaac.2013.05.006","article-title":"The role of emotion regulation in autism spectrum disorder","volume":"52","author":"Mazefsky","year":"2013","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.ctim.2025.103132_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/nu15061415","article-title":"Effects of probiotics on autism spectrum disorder in children: a systematic review and meta-analysis of clinical trials","volume":"15","author":"He","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2025.103132_bib17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1089\/cap.2018.0156","article-title":"Probiotics for gastrointestinal symptoms and quality of life in autism: a placebo-controlled pilot trial","volume":"29","author":"Arnold","year":"2019","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.ctim.2025.103132_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/13623613221082710","article-title":"A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism","volume":"27","author":"Billeci","year":"2023","journal-title":"Autism"},{"key":"10.1016\/j.ctim.2025.103132_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051552","article-title":"Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: a randomized, double-blinded, placebo-controlled pilot trial","volume":"13","author":"Kong","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2025.103132_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.rasd.2023.102256","article-title":"Probiotic intervention in young children with autism spectrum disorder in Taiwan: a randomized, double-blinded, placebo-controlled trial","volume":"109","author":"Liu","year":"2023","journal-title":"Res Autism Spectr Disord"},{"key":"10.1016\/j.ctim.2025.103132_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040820","article-title":"Effects of Lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: a randomized, double-blind, placebo-controlled trial","volume":"11","author":"Liu","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ctim.2025.103132_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.550593","article-title":"Effects of probiotic supplementation on gastrointestinal, sensory and core symptoms in autism spectrum disorders: a randomized controlled trial","volume":"11","author":"Santocchi","year":"2020","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.ctim.2025.103132_bib23","doi-asserted-by":"crossref","first-page":"5192","DOI":"10.1038\/s41598-023-30909-0","article-title":"Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder","volume":"13","author":"Schmitt","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.ctim.2025.103132_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104784","article-title":"Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder","volume":"157","author":"Wang","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.ctim.2025.103132_bib25","first-page":"486","article-title":"Probiotics drive gut microbiome triggering emotional brain signatures","volume":"9","author":"Bagga","year":"2018","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ctim.2025.103132_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fpsyt.2019.00164","article-title":"Effects of probiotics on cognitive reactivity, mood, and sleep quality","volume":"10","author":"Marotta","year":"2019","journal-title":"Front Psychiatry"},{"issue":"1","key":"10.1016\/j.ctim.2025.103132_bib27","doi-asserted-by":"crossref","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1016\/j.ctim.2025.103132_bib28","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: the kappa statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem Med (Zagreb)"},{"key":"10.1016\/j.ctim.2025.103132_bib29","series-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins","year":"2019"},{"key":"10.1016\/j.ctim.2025.103132_bib30","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.ctim.2025.103132_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2020.05.056","article-title":"Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder - A double-blind randomized controlled trial","volume":"89","author":"Skott","year":"2020","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ctim.2025.103132_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2017-000176","article-title":"Probiotics, prematurity and neurodevelopment: follow-up of a randomised trial","volume":"1","author":"Jacobs","year":"2017","journal-title":"BMJ Paediatr Open"},{"key":"10.1016\/j.ctim.2025.103132_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1323511","article-title":"Effects of probiotics on neurocognitive outcomes in infants and young children: a meta-analysis","volume":"11","author":"Lin","year":"2023","journal-title":"Front Public Health"},{"key":"10.1016\/j.ctim.2025.103132_bib34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1176\/appi.ajp.2013.13070966","article-title":"Emotion dysregulation in attention deficit hyperactivity disorder","volume":"171","author":"Shaw","year":"2014","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.ctim.2025.103132_bib35","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1469-7610.2012.02600.x","article-title":"Severe mood problems in adolescents with autism spectrum disorder","volume":"53","author":"Simonoff","year":"2012","journal-title":"J Child Psychol Psychiatry, Allied Discip"},{"key":"10.1016\/j.ctim.2025.103132_bib36","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41593-023-01361-0","article-title":"Multi-level analysis of the gut\u2013brain axis shows autism spectrum disorder-associated molecular and microbial profiles","volume":"26","author":"Morton","year":"2023","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ctim.2025.103132_bib37","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ctim.2025.103132_bib38","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1079\/BJN2003896","article-title":"Antioxidative probiotic fermented goats' milk decreases oxidative stress-mediated atherogenicity in human subjects","volume":"90","author":"Kullisaar","year":"2003","journal-title":"Br J Nutr"},{"key":"10.1016\/j.ctim.2025.103132_bib39","series-title":"Advances in Neurotoxicology","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/bs.ant.2018.03.002","article-title":"Chapter Eight - Neurodevelopment: Inflammation Matters","author":"Davis","year":"2018"},{"key":"10.1016\/j.ctim.2025.103132_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2023.1111349","article-title":"Systematic review of probiotics as an adjuvant treatment for psychiatric disorders","volume":"17","author":"Forth","year":"2023","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.ctim.2025.103132_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.14742","article-title":"The relationship between irritability and autism symptoms in children with ASD in COVID-19 home confinement period","volume":"75","author":"T\u00fcrko\u011flu","year":"2021","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.ctim.2025.103132_bib42","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/jcpp.13053","article-title":"Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability","volume":"60","author":"Eyre","year":"2019","journal-title":"J Child Psychol Psychiatry, Allied Discip"},{"key":"10.1016\/j.ctim.2025.103132_bib43","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.foodres.2006.11.007","article-title":"In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal mucus","volume":"40","author":"Collado","year":"2007","journal-title":"Food Res Int"},{"key":"10.1016\/j.ctim.2025.103132_bib44","article-title":"Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: an updated meta-analysis","volume":"12","author":"Chang","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.ctim.2025.103132_bib45","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41390-018-0211-9","article-title":"Effect of prebiotic and probiotic supplementation on neurodevelopment in preterm very low birth weight infants: findings from a meta-analysis","volume":"87","author":"Upadhyay","year":"2020","journal-title":"Pediatr Res"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096522992500007X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096522992500007X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:38:49Z","timestamp":1741685929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096522992500007X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":45,"alternative-id":["S096522992500007X"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103132","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic effects of probiotics on symptoms of irritability\/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103132"}}