{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:26:29Z","timestamp":1786987589682,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["21YF1447300"],"award-info":[{"award-number":["21YF1447300"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015796","name":"Shanghai Lingjun Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["23ZR1456300"],"award-info":[{"award-number":["23ZR1456300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ctim.2025.103259","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:38:32Z","timestamp":1760535512000},"page":"103259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effectiveness of 10.6-\u03bcm laser therapy for diabetic peripheral neuropathy: A double-blind, randomized controlled trial"],"prefix":"10.1016","volume":"95","author":[{"given":"Yue","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zouqin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0760-2891","authenticated-orcid":false,"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10353","key":"10.1016\/j.ctim.2025.103259_bib1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0140-6736(22)01472-6","volume":"400","author":"Tesfaye","year":"2022","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ctim.2025.103259_bib2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/jns.12457","article-title":"Phase 2a randomized controlled study investigating the safety and efficacy of PDA-002 in diabetic peripheral neuropathy","volume":"26","author":"Gibbons","year":"2021","journal-title":"J Peripher Nerv Syst"},{"issue":"7","key":"10.1016\/j.ctim.2025.103259_bib3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/dme.13630","article-title":"One-stop microvascular screening service: an effective model for the early detection of diabetic peripheral neuropathy and the high-risk foot","volume":"35","author":"Binns-Hall","year":"2018","journal-title":"Diabet Med"},{"issue":"6","key":"10.1016\/j.ctim.2025.103259_bib4","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neuron.2017.02.005","article-title":"New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain","volume":"93","author":"Feldman","year":"2017","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.ctim.2025.103259_bib5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41574-021-00496-z","article-title":"Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy","volume":"17","author":"Sloan","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ctim.2025.103259_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.934020","article-title":"Determinants of diabetic peripheral neuropathy and their clinical significance: a retrospective cohort study","volume":"13","author":"Cheng","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib7","first-page":"S11","article-title":"Standards of medical care in diabetes--2012","volume":"35 1","author":"American Diabetes Association","year":"2012","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.ctim.2025.103259_bib8","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1089\/acm.2020.0068","article-title":"Efficacy and safety of mecobalamin on peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials","volume":"26","author":"Sawangjit","year":"2020","journal-title":"J Alter Complement Med"},{"key":"10.1016\/j.ctim.2025.103259_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.813210","article-title":"Status of analgesic drugs and quality of life results for diabetic peripheral neuropathy in China","volume":"12","author":"Lian","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ctim.2025.103259_bib10","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.2147\/DDDT.S168878","article-title":"Alpha lipoic acid combined with epalrestat: a therapeutic option for patients with diabetic peripheral neuropathy","volume":"12","author":"Wang","year":"2018","journal-title":"Drug Des Dev Ther"},{"issue":"20","key":"10.1016\/j.ctim.2025.103259_bib11","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1212\/WNL.0000000000003882","article-title":"Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life: a systematic review","volume":"88","author":"Waldfogel","year":"2017","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/0309364614542266","article-title":"Treatment of painful diabetic peripheral neuropathy","volume":"39","author":"Rosenberg","year":"2015","journal-title":"Prosthet Orthot Int"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1212\/CON.0000000000000825","article-title":"Autonomic peripheral neuropathy","volume":"26","author":"Freeman","year":"2020","journal-title":"Continuum (Minneap Minn)"},{"key":"10.1016\/j.ctim.2025.103259_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1281485","article-title":"Acupuncture for painful diabetic peripheral neuropathy: a systematic review and meta-analysis","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.ctim.2025.103259_bib15","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s12010-019-03052-8","article-title":"Therapeutic effects of moxibustion simultaneously targeting Nrf2 and NF-\u03baB in diabetic peripheral neuropathy","volume":"189","author":"Li","year":"2019","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.ctim.2025.103259_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.748193","article-title":"Advances about immunoinflammatory pathogenesis and treatment in diabetic peripheral neuropathy","volume":"12","author":"Xue","year":"2021","journal-title":"Front Pharm"},{"issue":"5","key":"10.1016\/j.ctim.2025.103259_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ctim.2010.07.001","article-title":"Adverse events of moxibustion: a systematic review","volume":"18","author":"Park","year":"2010","journal-title":"Complement Ther Med"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jare.2011.02.009","article-title":"Effect of low level laser therapy on neurovascular function of diabetic peripheral neuropathy","volume":"3","author":"Yamany","year":"2012","journal-title":"J Adv Res"},{"issue":"6","key":"10.1016\/j.ctim.2025.103259_bib19","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3390\/jcm9061724","article-title":"Photobiomodulation-underlying mechanism and clinical applications","volume":"9","author":"Dompe","year":"2020","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.ctim.2025.103259_bib20","doi-asserted-by":"crossref","DOI":"10.3171\/FOC.2009.26.2.E8","article-title":"Phototherapy in peripheral nerve regeneration: from basic science to clinical study","volume":"26","author":"Rochkind","year":"2009","journal-title":"Neurosurg Focus"},{"issue":"2","key":"10.1016\/j.ctim.2025.103259_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1142\/S0192415X08005722","article-title":"Infrared radiation spectrum of acupuncture point on patients with coronary heart disease","volume":"36","author":"Shen","year":"2008","journal-title":"Am J Chin Med"},{"issue":"3","key":"10.1016\/j.ctim.2025.103259_bib22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ctim.2005.09.003","article-title":"An infrared radiation study of the biophysical characteristics of traditional moxibustion","volume":"14","author":"Shen","year":"2006","journal-title":"Complement Ther Med"},{"issue":"2","key":"10.1016\/j.ctim.2025.103259_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/pho.2005.23.191","article-title":"Evaluation of facial thermographic changes before and after low-level laser irradiation","volume":"23","author":"Makihara","year":"2005","journal-title":"Photomed Laser Surg"},{"issue":"7","key":"10.1016\/j.ctim.2025.103259_bib24","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1089\/photob.2021.0030","article-title":"Comparison of 10.6\u2009\u03bcm laser moxibustion with traditional moxibustion in knee osteoarthritic therapy: a randomized noninferiority clinical trial","volume":"39","author":"Fang","year":"2021","journal-title":"hotobiomodul Photomed Laser Surg"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib25","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.2337\/dc21-S011","article-title":"11. Microvascular complications and foot care: standards of medical care in Diabetes-2021","volume":"44","author":"American Diabetes Association","year":"2021","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.ctim.2025.103259_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2349","article-title":"Zinc deficiency correlates with severity of diabetic polyneuropathy","volume":"11","author":"Hussein","year":"2021","journal-title":"Brain Behav"},{"issue":"8","key":"10.1016\/j.ctim.2025.103259_bib27","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s11655-019-2714-6","article-title":"CO2 laser moxibustion for knee osteoarthritis: study protocol for a multicenter, Double-blind, randomized controlled trial","volume":"26","author":"Guo","year":"2020","journal-title":"Chin J Integr Med"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13063-021-05901-6","article-title":"10.6-\u03bcm infrared laser as adjuvant therapy for diabetic peripheral neuropathy: study protocol for a double-blind, randomized controlled trial","volume":"23","author":"Lin","year":"2022","journal-title":"Trials"},{"key":"10.1016\/j.ctim.2025.103259_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2673105","article-title":"Translation and psychometric properties of the arabic version of michigan neuropathy screening instrument in type 2 diabetes","volume":"2019","author":"Mohammad","year":"2019","journal-title":"J Diabetes Res"},{"issue":"5","key":"10.1016\/j.ctim.2025.103259_bib30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2337\/dc21-1074","article-title":"Risk factors for diabetic peripheral neuropathy in adolescents and young adults with type 2 diabetes: results from the TODAY study","volume":"45","author":"TODAY Study Group","year":"2021","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.diabres.2014.09.060","article-title":"Association of sleep quality and quality of life in type 2 diabetes mellitus: a cross-sectional study in China","volume":"107","author":"Lou","year":"2015","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2337\/dc21-1276","article-title":"Diabetic peripheral neuropathy and urological complications in type 1 diabetes: findings from the epidemiology of diabetes interventions and complications study","volume":"45","author":"Pop-Busui","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ctim.2025.103259_bib33","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.2147\/IDR.S365371","article-title":"Linezolid-Associated neuropathy in patients with MDR\/XDR tuberculosis in shenzhen, China","volume":"15","author":"Zhang","year":"2022","journal-title":"Infect Drug Resist"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-000991","article-title":"Glucose time in range and peripheral neuropathy in type 2 diabetes mellitus and chronic kidney disease","volume":"8","author":"Mayeda","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12902-023-01486-0","article-title":"Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial","volume":"23","author":"Hassanzadeh","year":"2023","journal-title":"BMC Endocr Disord"},{"issue":"3","key":"10.1016\/j.ctim.2025.103259_bib36","first-page":"245","article-title":"Acupotomy combined with metformin hydrochloride tablet for type 2 diabetes mellitus and its effect on serum inflammatory factors","volume":"44","author":"Zhu","year":"2024","journal-title":"Zhongguo Zhen Jiu"},{"issue":"3","key":"10.1016\/j.ctim.2025.103259_bib37","first-page":"523","article-title":"Factors associated with quality of life in 747 patients with type 2 diabetes in Tongzhou District and Shunyi District of Beijing","volume":"53","author":"Fan","year":"2021","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.ctim.2025.103259_bib38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.diabres.2017.06.017","article-title":"Effectiveness and feasibility of nailfold microcirculation test to screen for diabetic peripheral neuropathy","volume":"131","author":"Hu","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12906-024-04375-8","article-title":"Electroacupuncture efficacy in diabetic polyneuropathy: study protocol for a double-blinded randomized controlled multicenter clinical trial","volume":"24","author":"P\u00e9rez Hern\u00e1ndez","year":"2024","journal-title":"BMC Complement Med Ther"},{"issue":"7","key":"10.1016\/j.ctim.2025.103259_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18184","article-title":"Sudomotor dysfunction in diabetic peripheral neuropathy (DPN) and its testing modalities: a literature review","volume":"9","author":"Akbar","year":"2023","journal-title":"Heliyon"},{"issue":"12","key":"10.1016\/j.ctim.2025.103259_bib41","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3390\/metabo11120806","article-title":"Hemorheological parameters in diabetic patients: role of glucose lowering therapies","volume":"11","author":"Biro","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.ctim.2025.103259_bib42","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3389\/fphys.2019.01329","article-title":"Blood rheology: key parameters, impact on blood flow, role in sickle cell disease and effects of exercise","volume":"10","author":"Nader","year":"2019","journal-title":"Front Physiol"},{"issue":"13","key":"10.1016\/j.ctim.2025.103259_bib43","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.bpj.2021.05.013","article-title":"In silico biophysics and hemorheology of blood hyperviscosity syndrome","volume":"120","author":"Javadi","year":"2021","journal-title":"Biophys J"},{"issue":"2","key":"10.1016\/j.ctim.2025.103259_fur1","first-page":"113","article-title":"Effect of moxibustion at \u201cZusanli\u201d(ST36) on metabolites of gastric tissue in rats with chronic atrophic gastritis based on metabonomics","volume":"44","author":"Liu","year":"2019","journal-title":"Zhen Ci Yan Jiu"},{"issue":"4","key":"10.1016\/j.ctim.2025.103259_fur2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12576-017-0547-7","article-title":"Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice","volume":"68","author":"Lee","year":"2018","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.ctim.2025.103259_fur3","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2024.105586","article-title":"Acupuncture for senile insomnia: a systematic review of acupuncture point","volume":"127","author":"Lu","year":"2024","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.ctim.2025.103259_fur4","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.2147\/IJGM.S441978","article-title":"A study on the regularity of acupoint match based on association rules with SP6 as the main acupoint and its clinical application","volume":"16","author":"Cheng","year":"2023","journal-title":"Int J Gen Med"},{"issue":"1","key":"10.1016\/j.ctim.2025.103259_fur5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s40001-022-00795-9","article-title":"Research on electroacupuncture parameters for knee osteoarthritis based on data mining","volume":"27","author":"Cai","year":"2022","journal-title":"Eur J Med Res"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229925001359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229925001359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:42:52Z","timestamp":1773834172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965229925001359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"alternative-id":["S0965229925001359"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103259","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of 10.6-\u03bcm laser therapy for diabetic peripheral neuropathy: A double-blind, randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103259"}}