{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:05:42Z","timestamp":1773828342968,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["SHWSRS(2023)_062"],"award-info":[{"award-number":["SHWSRS(2023)_062"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ctim.2025.103265","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:38:35Z","timestamp":1760535515000},"page":"103265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acupuncture with micro-needle for dry eye disease: A study protocol for a randomized, sham-controlled, clinical trial"],"prefix":"10.1016","volume":"95","author":[{"given":"Monica","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guancheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ctim.2025.103265_bib1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.ctim.2025.103265_bib3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.ctim.2025.103265_bib4","first-page":"46","article-title":"The research development of China dry eye epidemiology","volume":"10","author":"Wei","year":"2020","journal-title":"CHIN J OPHTHALMOL MED"},{"issue":"2","key":"10.1016\/j.ctim.2025.103265_bib5","first-page":"92","article-title":"[Curent aspects of dry eye syndrome]","volume":"115","author":"L\u00f6ffler","year":"2018","journal-title":"der Ophthalmol Z der Dtsch Ophthalmol Ges"},{"issue":"5","key":"10.1016\/j.ctim.2025.103265_bib6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/aos.14651","article-title":"Therapeutic effects of acupuncture in typical dry eye: a systematic review and meta-analysis","volume":"99","author":"Na","year":"2021","journal-title":"Acta Ophthalmol"},{"issue":"6","key":"10.1016\/j.ctim.2025.103265_bib7","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s11684-022-0923-4","article-title":"Acupuncture for the management of dry eye disease","volume":"16","author":"Prinz","year":"2022","journal-title":"Front Med"},{"issue":"7","key":"10.1016\/j.ctim.2025.103265_bib8","first-page":"721","article-title":"Acupoint catgut embedding in the treatment of dry eye with insufficient tear production: randomized controlled study","volume":"39","author":"Liu","year":"2019","journal-title":"Chin Acupunct Moxibustion"},{"issue":"9","key":"10.1016\/j.ctim.2025.103265_bib9","first-page":"709","article-title":"Evaluation of the effect of acupuncture on tear secretion in dry eye","volume":"30","author":"Wei","year":"2010","journal-title":"Chin Acupunct Moxibustion"},{"issue":"11","key":"10.1016\/j.ctim.2025.103265_bib10","first-page":"1303","article-title":"Clinical experience of high-dimensional electroacupuncture in the treatment of dry eye [ J].Chinese acupuncture","volume":"43","author":"Ning","year":"2023","journal-title":"Chin Acupunct Moxibustion"},{"issue":"11","key":"10.1016\/j.ctim.2025.103265_bib11","first-page":"1235","article-title":"Acupuncture for water - deficient dry eye: a randomized controlled trial","volume":"43","author":"Liu","year":"2023","journal-title":"Chin Acupunct Moxibustion"},{"issue":"6","key":"10.1016\/j.ctim.2025.103265_bib12","first-page":"575","article-title":"Efficacy analysis of diclofenac sodium combined with sodium hyaluronate eye drops in the treatment of dry eye after cataract surgery","volume":"38","author":"Wang","year":"2019","journal-title":"J Wannan Med Coll"},{"issue":"5","key":"10.1016\/j.ctim.2025.103265_bib13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/bjd.16442","article-title":"Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sj\u00f6gren syndrome: a double-blind randomized controlled trial","volume":"179","author":"Cifuentes","year":"2018","journal-title":"Br J Dermatol"},{"issue":"2","key":"10.1016\/j.ctim.2025.103265_bib14","first-page":"162","article-title":"Clinical observation on acupuncture treatment of liver and kidney yin deficiency type dry eye","volume":"42","author":"Sun","year":"2022","journal-title":"Chin Acupunct Moxibustion"},{"key":"10.1016\/j.ctim.2025.103265_bib15","first-page":"91","article-title":"32 cases of dry eye syndrome were treated from the neck based on the theory of ' focusing on the eye out of the item ' based on the essence and qi of the viscera","volume":"39","author":"Han","year":"2019"},{"issue":"11","key":"10.1016\/j.ctim.2025.103265_bib16","first-page":"1166","article-title":"Acupuncture eye five needle treatment of 58 cases of computer dry eye","volume":"35","author":"Wulei","year":"2015","journal-title":"Chin Acupunct Moxibustion"},{"issue":"5","key":"10.1016\/j.ctim.2025.103265_bib17","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/bjophthalmol-2017-310633","article-title":"Epidemiology of discordance between symptoms and signs of dry eye","volume":"102","author":"Ong","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"10.1016\/j.ctim.2025.103265_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13020-023-00736-6","article-title":"Clinical research progress of acupuncture in the treatment of dry eye","volume":"43","author":"Li","year":"2023","journal-title":"Mod Chin Med"},{"issue":"17","key":"10.1016\/j.ctim.2025.103265_bib19","first-page":"8642","article-title":"Dry eye disease treatment: the role of tear substitutes, their future, and an updated classification","volume":"24","author":"Barabino","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"4","key":"10.1016\/j.ctim.2025.103265_bib20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/ICU.0000000000000768","article-title":"Alternative therapies for dry eye disease","volume":"32","author":"Mittal","year":"2021","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ctim.2025.103265_bib21","unstructured":"China Branch of Asian Dry Eye Association, Ophthalmology and Lacrimal Diseases Group of Ophthalmology Professional Committee of Cross-Strait Medical and Health Exchange Association, Association OaDEGoOBoCMD. Chinese Dry Eye Expert Consensus: Treatment ( 2020). Chinese Journal of Ophthalmology. 2020;56(12):907-913. 10.3760\/cma.j.cn112142-20200925-00618."},{"issue":"9","key":"10.1016\/j.ctim.2025.103265_bib22","first-page":"945","article-title":"Clinical observation of eye acupuncture combined with conventional acupuncture in the treatment of liver and kidney yin deficiency type dry eye","volume":"39","author":"Cheng","year":"2019","journal-title":"Chin Acupunct Moxibustion"},{"key":"10.1016\/j.ctim.2025.103265_bib23","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2147\/OPTH.S175321","article-title":"Acupuncture and dry eye: current perspectives. A double-blinded randomized controlled trial and review of the literature","volume":"13","author":"Dhaliwal","year":"2019","journal-title":"Clin Ophthalmol (Auckl NZ)"},{"issue":"1","key":"10.1016\/j.ctim.2025.103265_bib24","first-page":"107","article-title":"27 cases of dry eye were treated by acupuncture at neijingming","volume":"37","author":"Zhu","year":"2017","journal-title":"Chin Acupunct Moxibustion"},{"issue":"9","key":"10.1016\/j.ctim.2025.103265_bib25","first-page":"1433","article-title":"Observation on the efficacy of electroacupuncture in the treatment of dry eye syndrome of qi and yin deficiency type","volume":"27","author":"Jiang","year":"2017","journal-title":"J Basic Chin Med"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229925001414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229925001414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:53:03Z","timestamp":1773820383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965229925001414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":24,"alternative-id":["S0965229925001414"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103265","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acupuncture with micro-needle for dry eye disease: A study protocol for a randomized, sham-controlled, clinical trial","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103265"}}