{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:31:46Z","timestamp":1772559106692,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ctim.2025.103266","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:38:33Z","timestamp":1760535513000},"page":"103266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3562-8302","authenticated-orcid":false,"given":"Melika Jafari","family":"Dehnayebi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouya","family":"Zeidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-4972","authenticated-orcid":false,"given":"Soheila","family":"Shamsikhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-0646","authenticated-orcid":false,"given":"Mehdi","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1191-1091","authenticated-orcid":false,"given":"Mehdi","family":"Safarabadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctim.2025.103266_bib1","author":"Halma","year":"2024","journal-title":"Herbal Medicine for Hypertension: A Review of Potential Therapeutics"},{"issue":"3","key":"10.1016\/j.ctim.2025.103266_bib2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.61132\/obat.v2i3.398","article-title":"Peran ekstrak tanaman herbal dalam mengendalikan tekanan darah pada penderita hipertensi","volume":"2","author":"Sari","year":"2024","journal-title":"OBAT J Ris Ilmu Farm Dan Kesehat"},{"issue":"228","key":"10.1016\/j.ctim.2025.103266_bib3","first-page":"22","article-title":"The effect of islamic self-care model on blood pressure and medication compliance in the elderly with hypertension: a randomized controlled trial","volume":"33","author":"Jahanbakhsh","year":"2024","journal-title":"J Mazandaran Univ Med Sci"},{"issue":"1","key":"10.1016\/j.ctim.2025.103266_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.advnut.2023.09.011","article-title":"The role of diet in the prevention of hypertension and management of blood pressure: an umbrella review of meta-analyses of interventional and observational studies","volume":"15","author":"Aljuraiban","year":"2024","journal-title":"Adv Nutr"},{"issue":"12","key":"10.1016\/j.ctim.2025.103266_bib5","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.1002\/ptr.7251","article-title":"Effect of melissa officinalis on systolic and diastolic blood pressures in essential hypertension: a double-blind crossover clinical trial","volume":"35","author":"Shekarriz","year":"2021","journal-title":"Phytother Res"},{"issue":"12","key":"10.1016\/j.ctim.2025.103266_bib6","article-title":"An exploration of dietary strategies for hypertension management: a narrative review","volume":"15","author":"Altawili","year":"2023","journal-title":"Cureus"},{"issue":"9","key":"10.1016\/j.ctim.2025.103266_bib7","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1002\/ptr.7187","article-title":"The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: a randomized controlled trial","volume":"35","author":"Malekahmadi","year":"2021","journal-title":"Phytother Res"},{"issue":"1","key":"10.1016\/j.ctim.2025.103266_bib8","article-title":"Utilization of complementary and alternative medicine among patients with cardiovascular disease in Iran: a cross-sectional study","volume":"9","author":"Mohammad","year":"2024","journal-title":"Tradit Integr Med"},{"key":"10.1016\/j.ctim.2025.103266_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.eujim.2022.102179","article-title":"Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: a double-blind, randomized, controlled trial","volume":"55","author":"Hajibeygi","year":"2022","journal-title":"Eur J Integr Med"},{"issue":"1","key":"10.1016\/j.ctim.2025.103266_bib10","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1080\/10942912.2020.1833916","article-title":"Effects of Momordica charantia L on blood pressure: a systematic review and meta- analysis of randomized clinical trials","volume":"23","author":"Jandari","year":"2020","journal-title":"Int J Food Prop"},{"key":"10.1016\/j.ctim.2025.103266_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2024.103058","article-title":"A. Effectiveness of herbs taken concurrently with antihypertensive drugs in managing hypertension and lipid outcomes. A systematic review and meta-analysis","author":"Francis","year":"2024","journal-title":"Complement Ther Med"},{"issue":"6","key":"10.1016\/j.ctim.2025.103266_bib12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.explore.2023.04.003","article-title":"Effect of stachys lavandulifolia on occupational stress in emergency medical technicians","volume":"19","author":"Jadidi","year":"2023","journal-title":"Explore"},{"issue":"1","key":"10.1016\/j.ctim.2025.103266_bib13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/AIHB.AIHB_31_18","article-title":"An analgesic effect of stachys lavandulifolia in patients with migraine: a double-blind randomised clinical trial study","volume":"9","author":"Ashtiani","year":"2019","journal-title":"Adv Hum Biol"},{"issue":"1","key":"10.1016\/j.ctim.2025.103266_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.34172\/japid.2023.003","article-title":"Evaluation of the effect of echium amoenum on pain control after clinical crown lengthening surgery","volume":"15","author":"Ghasemi","year":"2023","journal-title":"J Adv Periodo Implant Dent"},{"issue":"1","key":"10.1016\/j.ctim.2025.103266_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12906-020-03084-2","article-title":"Effectiveness of echium amoenum on premenstrual syndrome: a randomized, double-blind, controlled trial","volume":"20","author":"Farahmand","year":"2020","journal-title":"BMC Complement Med Ther"},{"issue":"1","key":"10.1016\/j.ctim.2025.103266_bib16","first-page":"53","article-title":"Eachium amoenum as a functional food ingredient","volume":"9","author":"Torabi-Toran-Pashtoshti","year":"2022","journal-title":"Ecophysiol Phytochem Med Aromat Plants"},{"key":"10.1016\/j.ctim.2025.103266_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.hermed.2023.100751","article-title":"Therapeutic applications of lemon balm (Melissa officinalis) for obstetrics and gynecological health issues: a systematic review","author":"Alimoradi","year":"2023","journal-title":"J Herb Med"},{"issue":"2","key":"10.1016\/j.ctim.2025.103266_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.31083\/j.fbs1402016","article-title":"An updated review on the properties of Melissa officinalis L.: not exclusively anti-anxiety","volume":"14","author":"Zam","year":"2022","journal-title":"Front Biosci (Sch Ed)"},{"key":"10.1016\/j.ctim.2025.103266_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.661778","article-title":"Melissa officinalis L. as a nutritional strategy for cardioprotection","volume":"12","author":"Draginic","year":"2021","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.ctim.2025.103266_bib20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3945\/jn.109.115097","article-title":"Hibiscus sabdariffa L. Tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults","volume":"140","author":"McKay","year":"2010","journal-title":"J Nutr"},{"issue":"6","key":"10.1016\/j.ctim.2025.103266_bib21","first-page":"107","article-title":"Effects of hibiscus subdariffa on albuminuria and hypertension in patients with diabetic nephropathy","volume":"14","author":"Najarzade","year":"2016","journal-title":"Tolooebehdasht"},{"key":"10.1016\/j.ctim.2025.103266_bib22","unstructured":"Arab Nejad Z., Hejazi S. A Study on the Effects of Echium amoenum and Dried Lime (Citrus aurantifolia) Decoction on Blood Pressure and Heart Rate. 2015. \u3008https:\/\/www.sid.ir\/fa\/seminar\/ViewPaper.aspx?ID=86019\u3009."}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229925001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965229925001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:20:51Z","timestamp":1772554851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965229925001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":22,"alternative-id":["S0965229925001426"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103266","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2025.103266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103266"}}