{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:39:04Z","timestamp":1776512344537,"version":"3.51.2"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Complementary Therapies in Medicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ctim.2026.103366","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T07:44:24Z","timestamp":1774770264000},"page":"103366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy and acupoint specificity of sedative-tranquilizing acupuncture for Alzheimer\u2019s disease with sleep disorders: A three-arm randomized controlled trial protocol"],"prefix":"10.1016","volume":"98","author":[{"given":"Hang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-chun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-qin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s12877-025-06045-x","article-title":"Long-term health conditions and their impact on people with sleep disturbances and dementia[J]","volume":"5","author":"Rapaport","year":"2025","journal-title":"BMC Geriatr"},{"issue":"03","key":"10.1016\/j.ctim.2026.103366_bib2","first-page":"219","article-title":"China Alzheimer Report 2024[J]","volume":"23","author":"Wang","year":"2024","journal-title":"J Diagn Concepts & Pract"},{"issue":"01","key":"10.1016\/j.ctim.2026.103366_bib3","first-page":"68","article-title":"Research progress in correlation between sleep disorders and Alzheimer\u2032s disease in the elderly[J]","volume":"23","author":"Zhang","year":"2024","journal-title":"Chin J Mult Organ Dis Elder"},{"key":"10.1016\/j.ctim.2026.103366_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1542607","article-title":"Alzheimer's disease and insomnia: a bibliometric study and visualization analysis[J]","volume":"17","author":"Tian","year":"2025","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies[J]","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"10.1016\/j.ctim.2026.103366_bib6","first-page":"105","article-title":"Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to ClinicalApplication[J","volume":"11","author":"Jayaprakash","year":"2024","journal-title":"Chronic Dis Transl Med"},{"issue":"3","key":"10.1016\/j.ctim.2026.103366_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41593-022-01013-9","article-title":"Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18\u2009kDa translocator protein (TSPO)[J]","volume":"25","author":"Shi","year":"2022","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib8","first-page":"24927","article-title":"Zolpidem: Efficacy and Side Effects for Insomnia[J]","volume":"9","author":"Edinoff","year":"2021","journal-title":"Health Psychol Res"},{"issue":"01","key":"10.1016\/j.ctim.2026.103366_bib9","first-page":"41","article-title":"Research progress in the central mechanisms of acupuncture in treatment of insomnia with cognitive disorders based on fMRI[J]","volume":"23","author":"Zhu","year":"2025","journal-title":"Chin Imaging J Integr Tradit West Med"},{"issue":"2","key":"10.1016\/j.ctim.2026.103366_bib10","first-page":"203","article-title":"Professor WANG Fu-chun's experience of four elements of acupuncture manipulation practice]","volume":"40","author":"Zhao","year":"2020","journal-title":"Zhongguo Zhen Jiu"},{"issue":"11","key":"10.1016\/j.ctim.2026.103366_bib11","first-page":"1887","article-title":"Research Progress on Treating Insomnia with Cognitive Dysfunction in TCM[J]","volume":"28","author":"Li","year":"2022","journal-title":"J Basic Chin Med"},{"issue":"05","key":"10.1016\/j.ctim.2026.103366_bib12","first-page":"1187","article-title":"Exploring the Acupoint Selection Patterns in Acupuncture Treatment for Cognitive Impairment in Alzheimer's Disease Based on Data Mining[J]","volume":"42","author":"Zhang","year":"2025","journal-title":"J Guangzhou Univ Tradit Chin Med"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1186\/s12916-025-04255-z","article-title":"Sleep quality, APOE \u03b54, and Alzheimer's disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis[J]","volume":"23","author":"Huang","year":"2025","journal-title":"BMC Med"},{"issue":"07","key":"10.1016\/j.ctim.2026.103366_bib14","first-page":"783","article-title":"Acupuncture for Alzheimer\u2019s disease: a scoping review of clinical studies[J]","volume":"23","author":"Zhang","year":"2023","journal-title":"Chin J Evid-Based Med"},{"key":"10.1016\/j.ctim.2026.103366_bib15","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2147\/NSS.S326762","article-title":"Impact of Acupuncture on Sleep and Comorbid Symptoms for Chronic Insomnia: A Randomized Clinical Trial","volume":"13","author":"Wang","year":"2021","journal-title":"Nat Sci Sleep"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12906-020-02969-6","article-title":"Effectiveness and cerebral responses of multi-points acupuncture for primary insomnia: a preliminary randomized clinical trial and fMRI study","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Complement Med Ther"},{"issue":"10284","key":"10.1016\/j.ctim.2026.103366_bib17","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ctim.2026.103366_bib18","first-page":"560","article-title":"Chinese guideline for diagnosis and treatment of insomnia(2023)[J]","volume":"57","author":"Chinese Society of Sleep Disorders","year":"2024","journal-title":"Chin J Neurol"},{"issue":"5","key":"10.1016\/j.ctim.2026.103366_bib19","first-page":"579","article-title":"Interpretation of China national standard Nomenclature and Location of Meridian Points(GB\/T 12346-2021)","volume":"42","author":"Wu","year":"2022","journal-title":"J] Chin Acupunct & Moxibustion"},{"issue":"4","key":"10.1016\/j.ctim.2026.103366_bib20","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/jamainternmed.2016.9378","article-title":"The Long-term Effect of Acupuncture for Migraine Prophylaxis: A Randomized Clinical Trial","volume":"177","author":"Zhao","year":"2017","journal-title":"JAMA Intern Med"},{"issue":"3","key":"10.1016\/j.ctim.2026.103366_bib21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.fertnstert.2024.09.018","article-title":"Association between sleep quality and ovarian reserve in women of reproductive age: a cross-sectional study","volume":"123","author":"Lin","year":"2025","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00415-020-10381-w","article-title":"Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials","volume":"269","author":"Fatemeh","year":"2022","journal-title":"J Neurol"},{"key":"10.1016\/j.ctim.2026.103366_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106204","article-title":"Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis","volume":"179","author":"Zhang","year":"2022","journal-title":"Pharm Res"},{"issue":"9","key":"10.1016\/j.ctim.2026.103366_bib24","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jamapsychiatry.2021.1559","article-title":"Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial","volume":"78","author":"Deligiannidis","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ctim.2026.103366_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2025.102147","article-title":"Pharmacological impact on sleep architecture and polysomnographic measures in Restless Legs Syndrome: A systematic review","volume":"83","author":"Mogavero","year":"2025","journal-title":"Sleep Med Rev"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13195-023-01367-7","article-title":"Digital Clock and Recall is superior to the Mini-Mental State Examination for the detection of mild cognitive impairment and mild dementia","volume":"16","author":"Jannati","year":"2024","journal-title":"Alzheimers Res Ther"},{"issue":"4","key":"10.1016\/j.ctim.2026.103366_bib27","doi-asserted-by":"crossref","first-page":"771","DOI":"10.14283\/jpad.2023.123","article-title":"Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer's Disease","volume":"10","author":"Cohen","year":"2023","journal-title":"J Prev Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib28","doi-asserted-by":"crossref","first-page":"9164","DOI":"10.1038\/s41467-024-53299-x","article-title":"Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep in humans","volume":"15","author":"Jang","year":"2024","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ctim.2026.103366_bib29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/alz.12556","article-title":"Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer's dementia","volume":"18","author":"Frontera","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ctim.2026.103366_bib30","series-title":"A Clinical Comparison of Verum and Placebo Acupuncture in the Treatment of Primary Insomnia[D]","author":"Leung","year":"2017"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13063-018-3138-x","article-title":"Efficacy of electro-acupuncture and manual acupuncture versus sham acupuncture for knee osteoarthritis: study protocol for a randomised controlled trial","volume":"20","author":"Tu","year":"2019","journal-title":"Trials"},{"issue":"4","key":"10.1016\/j.ctim.2026.103366_bib32","first-page":"383","article-title":"Sleep-Based Interventions in Alzheimer's Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory","volume":"14","author":"Cordone","year":"2021","journal-title":"Pharm (Basel)"},{"key":"10.1016\/j.ctim.2026.103366_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.772068","article-title":"Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review","volume":"12","author":"Liu","year":"2021","journal-title":"Front Psychiatry"},{"issue":"4","key":"10.1016\/j.ctim.2026.103366_bib34","first-page":"383","article-title":"Sleep-Based Interventions in Alzheimer's Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory","volume":"14","author":"Cordone","year":"2021","journal-title":"Pharm (Basel)"},{"key":"10.1016\/j.ctim.2026.103366_bib35","article-title":"Effect and mechanism of acupuncture on Alzheimer's disease: A review","volume":"15","author":"Wu","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13058-023-01645-0","article-title":"Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial","volume":"25","author":"Zhang","year":"2023","journal-title":"Breast Cancer Res"},{"issue":"1","key":"10.1016\/j.ctim.2026.103366_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-053312","article-title":"Strengthening the quality of clinical trials of acupuncture: a guideline protocol","volume":"12","author":"He","year":"2022","journal-title":"BMJ Open"},{"issue":"12","key":"10.1016\/j.ctim.2026.103366_bib38","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrclinonc.2017.141","article-title":"Radiomics: the bridge between medical imaging and personalized medicine","volume":"14","author":"Lambin","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ctim.2026.103366_bib39","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.sleep.2021.01.053","article-title":"Can acupuncture improve objective sleep indices in patients with primary insomnia? A systematic review and meta-analysis","volume":"80","author":"Zhao","year":"2021","journal-title":"Sleep Med"}],"container-title":["Complementary Therapies in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096522992600049X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096522992600049X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:40:31Z","timestamp":1776508831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096522992600049X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"alternative-id":["S096522992600049X"],"URL":"https:\/\/doi.org\/10.1016\/j.ctim.2026.103366","relation":{},"ISSN":["0965-2299"],"issn-type":[{"value":"0965-2299","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and acupoint specificity of sedative-tranquilizing acupuncture for Alzheimer\u2019s disease with sleep disorders: A three-arm randomized controlled trial protocol","name":"articletitle","label":"Article Title"},{"value":"Complementary Therapies in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctim.2026.103366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103366"}}