{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:17:57Z","timestamp":1770563877038,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ctro.2020.11.016","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T13:31:35Z","timestamp":1607002295000},"page":"86-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["1.5\u00a0T MR-linac planning study to compare two different strategies of rectal boost irradiation"],"prefix":"10.1016","volume":"26","author":[{"given":"Pierluigi","family":"Bonomo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Lo Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Nachbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Boeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergios","family":"Gatidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Zips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Thorwarth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihan","family":"Gani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctro.2020.11.016_b0005","unstructured":"National Comprehensive Cancer Network. Rectal Cancer (Version 4.2020). May 25, 2020]; Available from: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/rectal.pdf."},{"issue":"9","key":"10.1016\/j.ctro.2020.11.016_b0010","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1470-2045(10)70172-8","article-title":"Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data","volume":"11","author":"Maas","year":"2010","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2020.11.016_b0015","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0360-3016(02)02764-5","article-title":"Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients","volume":"53","author":"Valentini","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ctro.2020.11.016_b0020","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ijrobp.2004.11.017","article-title":"The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer","volume":"62","author":"Vecchio","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ctro.2020.11.016_b0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijrobp.2007.12.019","article-title":"Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients","volume":"72","author":"Capirci","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ctro.2020.11.016_b0030","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.ijrobp.2005.09.020","article-title":"Prognostic factors for disease-free survival in patients with T3\u20134 or N+ rectal cancer treated with preoperative chemoradiation therapy, surgery, and intraoperative irradiation","volume":"64","author":"D\u00edaz-Gonz\u00e1lez","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10139","key":"10.1016\/j.ctro.2020.11.016_b0035","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/S0140-6736(18)31078-X","article-title":"Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study","volume":"391","author":"van der Valk","year":"2018","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ctro.2020.11.016_b0040","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ejso.2005.05.004","article-title":"Quality of life and functional outcome following anterior or abdominoperineal resection for rectal cancer","volume":"31","author":"Guren","year":"2005","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2020.11.016_b0045","doi-asserted-by":"crossref","DOI":"10.1097\/SLA.0b013e3181485617","article-title":"A randomized multicenter trial to compare long-term functional outcome, quality of life, and complications of surgical procedures for low rectal cancers","volume":"246","author":"Fazio","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.ctro.2020.11.016_b0050","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fonc.2019.00318","article-title":"Organ Preservation in Rectal Cancer: The Patients' Perspective","volume":"9","author":"Gani","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.ctro.2020.11.016_b0055","first-page":"9","article-title":"Organ preservation in rectal cancer - Challenges and future strategies","volume":"3","author":"Gani","year":"2017","journal-title":"Clin Transl Radiat Oncol"},{"issue":"2","key":"10.1016\/j.ctro.2020.11.016_b0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/02656736.2015.1117661","article-title":"Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer","volume":"32","author":"Gani","year":"2016","journal-title":"Int J Hyperthermia"},{"issue":"1","key":"10.1016\/j.ctro.2020.11.016_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2014.08.035","article-title":"Impact of radiotherapy boost on pathological complete response in patients with locally advanced rectal cancer: a systematic review and meta-analysis","volume":"113","author":"Burbach","year":"2014","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2020.11.016_b0070","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ijrobp.2005.08.012","article-title":"Preoperative radiation with concurrent chemotherapy for resectable rectal cancer: effect of dose escalation on pathologic complete response, local recurrence-free survival, disease-free survival, and overall survival","volume":"64","author":"Wiltshire","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ctro.2020.11.016_b0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijrobp.2012.05.017","article-title":"Radiation dose-response model for locally advanced rectal cancer after preoperative chemoradiation therapy","volume":"85","author":"Appelt","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ctro.2020.11.016_b0080","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.ijrobp.2010.12.063","article-title":"Value of diffusion-weighted magnetic resonance imaging for prediction and early assessment of response to neoadjuvant radiochemotherapy in rectal cancer: preliminary results","volume":"82","author":"Lambrecht","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.ctro.2020.11.016_b0085","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/0284186X.2017.1400689","article-title":"Tumor volume regression during preoperative chemoradiotherapy for rectal cancer: a prospective observational study with weekly MRI","volume":"57","author":"Van den Begin","year":"2018","journal-title":"Acta Oncol"},{"issue":"23","key":"10.1016\/j.ctro.2020.11.016_b0090","doi-asserted-by":"crossref","first-page":"L41","DOI":"10.1088\/1361-6560\/aa9517","article-title":"First patients treated with a 1.5 T MRI-Linac: clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment","volume":"62","author":"Raaymakers","year":"2017","journal-title":"Phys Med Biol"},{"issue":"7","key":"10.1016\/j.ctro.2020.11.016_b0095","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/1878-0261.12751","article-title":"Image guidance in radiation therapy for better cure of cancer","volume":"14","author":"Gr\u00e9goire","year":"2020","journal-title":"Mol Oncol"},{"key":"10.1016\/j.ctro.2020.11.016_b0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.phro.2020.09.007","article-title":"Quantitative magnetic resonance imaging on hybrid magnetic resonance linear accelerators: Perspective on technical and clinical validation","volume":"16","author":"Thorwarth","year":"2020","journal-title":"Physics and Imaging in Radiation Oncology"},{"key":"10.1016\/j.ctro.2020.11.016_b0105","volume":"Vol. 649","author":"Edge","year":"2010"},{"key":"10.1016\/j.ctro.2020.11.016_b0110","first-page":"66","article-title":"Online MR guided radiotherapy for rectal cancer","volume":"18","author":"Gani","year":"2019","journal-title":"New opportunities. Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ctro.2020.11.016_b0115","first-page":"54","article-title":"Adaptive radiotherapy: The Elekta Unity MR-linac concept","volume":"18","author":"Winkel","year":"2019","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ctro.2020.11.016_b0120","first-page":"80","article-title":"MR-guided radiotherapy in rectal cancer: First clinical experience of an innovative technology","volume":"18","author":"Chiloiro","year":"2019","journal-title":"Clin Transl Radiat Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2020.11.016_b0125","doi-asserted-by":"crossref","first-page":"e353","DOI":"10.1016\/j.ijrobp.2012.01.023","article-title":"Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas","volume":"83","author":"Gay","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ctro.2020.11.016_b0130","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ijrobp.2005.10.002","article-title":"Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer","volume":"64","author":"Peeters","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.ctro.2020.11.016_b0135","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ijrobp.2020.01.003","article-title":"Derivation of Dose\/Volume Constraints for the Anorectum from Clinician- and Patient-Reported Outcomes in the CHHiP Trial of Radiation Therapy Fractionation","volume":"106","author":"Wilkins","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ctro.2020.11.016_b0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2009.08.004","article-title":"Dose-volume effects for normal tissues in external radiotherapy: pelvis","volume":"93","author":"Fiorino","year":"2009","journal-title":"Radiother Oncol"},{"issue":"3 Suppl","key":"10.1016\/j.ctro.2020.11.016_b0145","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.ijrobp.2009.03.078","article-title":"Radiation dose-volume effects in radiation-induced rectal injury","volume":"76","author":"Michalski","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2020.11.016_b0150","doi-asserted-by":"crossref","unstructured":"Hospers, G., R.R. Bahadoer, E.A. Dijkstra, B.v. Etten, C. Marijnen, H. Putter, et al., Short-course radiotherapy followed by chemotherapy before TME in locally advanced rectal cancer: The randomized RAPIDO trial. Journal of Clinical Oncology, 2020. 38(15_suppl): p. 4006-4006.","DOI":"10.1200\/JCO.2020.38.15_suppl.4006"},{"key":"10.1016\/j.ctro.2020.11.016_b0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.radonc.2020.03.011","article-title":"Compliance and tolerability of short-course radiotherapy followed by preoperative chemotherapy and surgery for high-risk rectal cancer - Results of the international randomized RAPIDO-trial","volume":"147","author":"van der Valk","year":"2020","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2020.11.016_b0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.clon.2019.07.009","article-title":"Intensity-Modulated Radiotherapy With a Simultaneous Integrated Boost in Rectal Cancer","volume":"32","author":"Owens","year":"2020","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ctro.2020.11.016_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2020.06.013","article-title":"Efficacy of dose-escalated chemoradiation on complete tumour response in patients with locally advanced rectal cancer (RECTAL-BOOST); a phase 2 randomised controlled trial","author":"Couwenberg","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"#cr-split#-10.1016\/j.ctro.2020.11.016_b0170.1","unstructured":"ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 Feb 29-. Identifier NCT04095299. Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients (WW3)"},{"key":"#cr-split#-10.1016\/j.ctro.2020.11.016_b0170.2","unstructured":"2019 Sep 17 [cited 2020 Nov 26]. Available from: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04095299#contacts"},{"key":"10.1016\/j.ctro.2020.11.016_b0175","unstructured":"ISRCTN registry [Internet]. London: BMC. ISRCTN16158514. APHRODITE - A phase II trial of higher radiotherapy dose in the eradication of early rectal cancer; 2019 Oct 17 [cited 2020 Nov 26]. Available from: http:\/\/www.isrctn.com\/ISRCTN16158514"},{"issue":"3","key":"10.1016\/j.ctro.2020.11.016_b0180","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijrobp.2019.10.046","article-title":"Long-Term Patient-Reported Outcomes After High-Dose Chemoradiation Therapy for Nonsurgical Management of Distal Rectal Cancer","volume":"106","author":"Dizdarevic","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"10.1016\/j.ctro.2020.11.016_b0185","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s12094-017-1627-0","article-title":"Fecal incontinence and radiation dose on anal sphincter in patients with locally advanced rectal cancer (LARC) treated with preoperative chemoradiotherapy: a retrospective, single-institutional study","volume":"19","author":"Arias","year":"2017","journal-title":"Clin Transl Oncol"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630820301038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630820301038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:08:03Z","timestamp":1762502883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630820301038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":38,"alternative-id":["S2405630820301038"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2020.11.016","relation":{},"ISSN":["2405-6308"],"issn-type":[{"value":"2405-6308","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1.5\u00a0T MR-linac planning study to compare two different strategies of rectal boost irradiation","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2020.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}]}}