{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:13:46Z","timestamp":1762503226915,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ctro.2021.08.002","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T02:17:57Z","timestamp":1628648277000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Long-term outcomes of an esophagus-preserving chemoradiotherapy strategy for patients with endoscopically unresectable stage I thoracic esophageal squamous cell carcinoma"],"prefix":"10.1016","volume":"30","author":[{"given":"Tatsuya","family":"Suwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Negoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusako","family":"Kusumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kadokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rihito","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshishige","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mizowaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ctro.2021.08.002_b0005","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/1878-0261.12458","article-title":"Early detection and therapeutics","volume":"13","author":"Januszewicz","year":"2019","journal-title":"Mol Oncol"},{"issue":"6","key":"10.1016\/j.ctro.2021.08.002_b0010","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/1097-0142(19950915)76:6<928::AID-CNCR2820760604>3.0.CO;2-5","article-title":"Successful screening for early esophageal cancer in alcoholics using endoscopy and mucosa iodine staining","volume":"76","author":"Yokoyama","year":"1995","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.ctro.2021.08.002_b0015","doi-asserted-by":"crossref","first-page":"523","DOI":"10.5946\/ce.2014.47.6.523","article-title":"Lymph node metastases in esophageal carcinoma: an endoscopist's view","volume":"47","author":"Cho","year":"2014","journal-title":"Clin Endosc"},{"issue":"5","key":"10.1016\/j.ctro.2021.08.002_b0020","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1200\/JCO.2002.20.5.1167","article-title":"INT 0123 (Radiation Therapy Oncology Group 94\u201305) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy","volume":"20","author":"Minsky","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctro.2021.08.002_b0025","doi-asserted-by":"crossref","unstructured":"Igaki H, Kato H, Tachimori Y, Daiko H, Fukaya M, Yajima S, et al. Clinicopathologic characteristics and survival of patients with clinical Stage I squamous cell carcinomas of the thoracic esophagus treated with three-field lymph node dissection. Eur J Cardio-thoracic Surgery. 2001;20:1089-94.","DOI":"10.1016\/S1010-7940(01)01003-X"},{"issue":"2","key":"10.1016\/j.ctro.2021.08.002_b0030","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s10388-016-0531-y","article-title":"Comprehensive registry of esophageal cancer in Japan, 2009","volume":"13","author":"Tachimori","year":"2016","journal-title":"Esophagus"},{"issue":"10","key":"10.1016\/j.ctro.2021.08.002_b0035","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/jjco\/hyp069","article-title":"A phase II trial of chemoradiotherapy for stage I esophageal squamous cell carcinoma: Japan Clinical Oncology Group Study (JCOG9708)","volume":"39","author":"Kato","year":"2009","journal-title":"Jpn J Clin Oncol"},{"issue":"5","key":"10.1016\/j.ctro.2021.08.002_b0040","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s10147-016-0963-3","article-title":"Comparison between surgery and definitive chemoradiotherapy for patients with resectable esophageal squamous cell carcinoma: a propensity score analysis","volume":"21","author":"Nomura","year":"2016","journal-title":"Int J Clin Oncol"},{"issue":"4","key":"10.1016\/j.ctro.2021.08.002_b0045","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.ijrobp.2005.10.015","article-title":"Treatment results of chemoradiotherapy for clinical stage I (T1N0M0) esophageal carcinoma","volume":"64","author":"Yamada","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ctro.2021.08.002_b0050","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0360-3016(99)00171-6","article-title":"Comparison between chemoradiation protocol intended for organ preservation and conventional surgery for clinical T1\u2013T2 esophageal carcinoma","volume":"45","author":"Murakami","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.ctro.2021.08.002_b0055","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0360-3016(97)00900-0","article-title":"Neoadjuvant concurrent chemoradiotherapy followed by definitive high-dose radiotherapy or surgery for operable thoracic esophageal carcinoma","volume":"40","author":"Murakami","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ctro.2021.08.002_b0060","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/cncr.10233","article-title":"Ten-year survival with chemotherapy and radiotherapy in patients with squamous cell carcinoma of the esophagus","volume":"94","author":"Bidoli","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ctro.2021.08.002_b0065","first-page":"1623","article-title":"Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85\u201301)","volume":"281","author":"Cooper","year":"1999","journal-title":"Radiat Therapy Oncol Group JAMA"},{"issue":"3","key":"10.1016\/j.ctro.2021.08.002_b0070","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/jso.22096","article-title":"Ten-year survival of esophageal cancer after an en-bloc esophagectomy","volume":"105","author":"Oezcelik","year":"2012","journal-title":"J Surg Oncol"},{"issue":"2","key":"10.1016\/j.ctro.2021.08.002_b0075","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/jso.21953","article-title":"Long-term survival after esophagectomy for early esophageal squamous cell carcinoma in Linxian","volume":"104","author":"Song","year":"2011","journal-title":"China J Surg Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2021.08.002_b0080","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1245\/s10434-013-3372-0","article-title":"T1 squamous cell carcinoma of the esophagus: long-term outcomes and prognostic factors after esophagectomy","volume":"21","author":"Tanaka","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2021.08.002_b0085","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.ctro.2021.08.002_b0090","doi-asserted-by":"crossref","unstructured":"Kumabe A, Fukada J, Kota R, Koike N, Shiraishi Y, Seki S, et al. Long-term results of concurrent chemoradiotherapy with daily-low-dose continuous infusion of 5-fluorouracil and cisplatin (LDFP) for Stage I-II esophageal carcinoma. Dis Esophagus. 2018;31.","DOI":"10.1093\/dote\/dox138"},{"issue":"3","key":"10.1016\/j.ctro.2021.08.002_b0095","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijrobp.2010.06.033","article-title":"Phase II study of chemoradiotherapy with 5-fluorouracil and cisplatin for Stage II-III esophageal squamous cell carcinoma: JCOG trial (JCOG 9906)","volume":"81","author":"Kato","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2021.08.002_b0100","doi-asserted-by":"crossref","unstructured":"Tahara M, Ohtsu A, Hironaka S, Boku N, Ishikura S, Miyata Y, et al. Clinical impact of criteria for complete response (CR) of primary site to treatment of esophageal cancer. Japanese J Clin Oncol. 2005;35:316\u201323.","DOI":"10.1093\/jjco\/hyi095"},{"issue":"13","key":"10.1016\/j.ctro.2021.08.002_b0105","doi-asserted-by":"crossref","first-page":"22135","DOI":"10.18632\/oncotarget.14029","article-title":"A multicenter phase II study of salvage photodynamic therapy using talaporfin sodium (ME2906) and a diode laser (PNL6405EPG) for local failure after chemoradiotherapy or radiotherapy for esophageal cancer","volume":"8","author":"Yano","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.ctro.2021.08.002_b0110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0360-3016(01)01686-8","article-title":"Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation","volume":"51","author":"Petersen","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ctro.2021.08.002_b0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0167-8140(94)90100-7","article-title":"Impact of overall treatment time of fractionated irradiation on local control of human FaDu squamous cell carcinoma in nude mice","volume":"32","author":"Baumann","year":"1994","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.1016\/j.ctro.2021.08.002_b0120","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.surg.2008.06.026","article-title":"Use of (18)F-fluorodeoxyglucose-positron emission tomography to evaluate responses to neo-adjuvant chemotherapy for primary tumor and lymph node metastasis in esophageal squamous cell carcinoma","volume":"144","author":"Makino","year":"2008","journal-title":"Surgery"},{"issue":"12","key":"10.1016\/j.ctro.2021.08.002_b0125","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1245\/s10434-011-1732-1","article-title":"FDG-PET parameters as prognostic factor in esophageal cancer patients: a review","volume":"18","author":"Omloo","year":"2011","journal-title":"Ann Surg Oncol"},{"issue":"14","key":"10.1016\/j.ctro.2021.08.002_b0130","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1200\/JCO.2003.03.055","article-title":"Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus","volume":"21","author":"Ishikura","year":"2003","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.ctro.2021.08.002_b0135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00535-006-1771-8","article-title":"Late toxicity in complete response cases after definitive chemoradiotherapy for esophageal squamous cell carcinoma","volume":"41","author":"Kumekawa","year":"2006","journal-title":"J Gastroenterol"},{"issue":"1","key":"10.1016\/j.ctro.2021.08.002_b0140","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijrobp.2008.10.075","article-title":"Late toxicity after definitive concurrent chemoradiotherapy for thoracic esophageal carcinoma","volume":"75","author":"Morota","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2021.08.002_b0145","doi-asserted-by":"crossref","unstructured":"Hulshof M, Geijsen ED, Rozema T, Oppedijk V, Buijsen J, Neelis KJ, et al. Randomized study on dose escalation in definitive chemoradiation for patients with locally advanced esophageal cancer (ARTDECO Study). J Clin Oncol. 2021:JCO2003697.","DOI":"10.1200\/JCO.20.03697"},{"issue":"5","key":"10.1016\/j.ctro.2021.08.002_b0150","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<988::AID-CNCR7>3.0.CO;2-U","article-title":"A phase I\/II study of external beam radiation, brachytherapy, and concurrent chemotherapy for patients with localized carcinoma of the esophagus (Radiation Therapy Oncology Group Study 9207): final report","volume":"88","author":"Gaspar","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ctro.2021.08.002_b0155","doi-asserted-by":"crossref","unstructured":"Ito H, Itasaka S, Sakanaka K, Araki N, Mizowaki T, Hiraoka M. Long-term complications of definitive chemoradiotherapy for esophageal cancer using the classical method. J Radiat Res. 2017;58:106-13.","DOI":"10.1093\/jrr\/rrw078"},{"key":"10.1016\/j.ctro.2021.08.002_b0160","doi-asserted-by":"crossref","first-page":"vi51","DOI":"10.1093\/annonc\/mdt342","article-title":"Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Stahl","year":"2013","journal-title":"Ann Oncol"},{"issue":"10","key":"10.1016\/j.ctro.2021.08.002_b0165","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/jjco\/hyp078","article-title":"Gastrointestinal Oncology Study Group of Japan Clinical Oncology G. A phase II trial of combined treatment of endoscopic mucosal resection and chemoradiotherapy for clinical stage I esophageal carcinoma: Japan Clinical Oncology Group Study JCOG0508","volume":"39","author":"Kurokawa","year":"2009","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.ctro.2021.08.002_b0170","doi-asserted-by":"crossref","unstructured":"Kato K, Igaki H, Ito Y et al. Parallel-group controlled trial of esophagectomy versus chemoradiotherapy in patients with clinical stage I esophageal carcinoma (JCOG0502). J Clin Oncol 2019; 37(4_suppl):7.","DOI":"10.1200\/JCO.2019.37.4_suppl.7"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630821000719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630821000719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:09:05Z","timestamp":1762502945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630821000719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":34,"alternative-id":["S2405630821000719"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2021.08.002","relation":{},"ISSN":["2405-6308"],"issn-type":[{"type":"print","value":"2405-6308"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term outcomes of an esophagus-preserving chemoradiotherapy strategy for patients with endoscopically unresectable stage I thoracic esophageal squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2021.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}]}}