{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:14:46Z","timestamp":1762503286039,"version":"build-2065373602"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["3R01DE028290-02S1"],"award-info":[{"award-number":["3R01DE028290-02S1"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["5K12CA088084"],"award-info":[{"award-number":["5K12CA088084"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ctro.2023.100669","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:02:17Z","timestamp":1692417737000},"page":"100669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Systematic Review of Genetic Polymorphisms Associated with Acute Pain Induced by Radiotherapy for Head and Neck Cancers"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-4635","authenticated-orcid":false,"given":"Vivian","family":"Salama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-3151","authenticated-orcid":false,"given":"Yimin","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-980X","authenticated-orcid":false,"given":"Jillian","family":"Rigert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-3994","authenticated-orcid":false,"given":"Clifton D.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Shete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0005","first-page":"7","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3857\/roj.2013.31.1.1","article-title":"Comparison of survival rates between patients treated with conventional radiotherapy and helical tomotherapy for head and neck cancer","volume":"31","author":"Kong","year":"2013","journal-title":"Radiat Oncol J"},{"issue":"19","key":"10.1016\/j.ctro.2023.100669_b0015","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.ctro.2023.100669_b0020","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.ctro.2023.100669_b0025","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/sajc.sajc_264_17","article-title":"Burden of acute toxicities in head-and-neck radiation therapy: A single-institutional experience","volume":"8","author":"Muzumder","year":"2019","journal-title":"South Asian J Cancer"},{"issue":"10","key":"10.1016\/j.ctro.2023.100669_b0030","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/hed.20602","article-title":"Measuring head and neck cancer symptom burden: The development and validation of the M. D Anderson Symptom Inventory, head and neck module","volume":"29","author":"Rosenthal","year":"2007","journal-title":"Head Neck-J Sci Spec"},{"issue":"8","key":"10.1016\/j.ctro.2023.100669_b0035","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/annonc\/mdp001","article-title":"Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes","volume":"20","author":"Breivik","year":"2009","journal-title":"Ann Oncol"},{"issue":"4","key":"10.1016\/j.ctro.2023.100669_b0040","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4103\/IJPC.IJPC_57_19","article-title":"Emergency Department Visits by Head-and-Neck Cancer Patients","volume":"25","author":"Malik","year":"2019","journal-title":"Indian J Palliat Care"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0045","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jpainsymman.2014.07.007","article-title":"Avoidable and unavoidable visits to the emergency department among patients with advanced cancer receiving outpatient palliative care","volume":"49","author":"Delgado-Guay","year":"2015","journal-title":"J Pain Symptom Manage"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0050","doi-asserted-by":"crossref","first-page":"e190979","DOI":"10.1001\/jamanetworkopen.2019.0979","article-title":"Analysis of Diagnoses, Symptoms, Medications, and Admissions Among Patients With Cancer Presenting to Emergency Departments","volume":"2","author":"Caterino","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"6","key":"10.1016\/j.ctro.2023.100669_b0055","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/hed.24748","article-title":"Cohort study of oncologic emergencies in patients with head and neck cancer","volume":"39","author":"Reyes-Gibby","year":"2017","journal-title":"Head Neck"},{"issue":"12","key":"10.1016\/j.ctro.2023.100669_b0060","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1001\/jamaoto.2013.853","article-title":"Predictors of pain among patients with head and neck cancer","volume":"138","author":"Shuman","year":"2012","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.semradonc.2008.09.006","article-title":"Strategies for managing radiation-induced mucositis in head and neck cancer","volume":"19","author":"Rosenthal","year":"2009","journal-title":"Semin Radiat Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0070","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1186\/s12885-021-09024-8","article-title":"Variations in pain prevalence, severity, and analgesic use by duration of survivorship: a cross-sectional study of 505 post-treatment head and neck cancer survivors","volume":"21","author":"Ren","year":"2021","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0075","first-page":"e743","article-title":"Prolonged Opioid Dependence Following Post-Operative Head and Neck Radiation Therapy","volume":"102","author":"Smith","year":"2018","journal-title":"ASTRO"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0080","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0194599818808513","article-title":"Short- and Long-term Opioid Use in Patients with Oral and Oropharynx Cancer","volume":"160","author":"McDermott","year":"2019","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.ctro.2023.100669_b0085","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4103\/IJPC.IJPC_145_17","article-title":"Analgesic and Opioid Use in Pain Associated with Head-and-Neck Radiation Therapy","volume":"24","author":"Muzumder","year":"2018","journal-title":"Indian J Palliat Care"},{"issue":"8","key":"10.1016\/j.ctro.2023.100669_b0090","doi-asserted-by":"crossref","first-page":"e2013605","DOI":"10.1001\/jamanetworkopen.2020.13605","article-title":"National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States","volume":"3","author":"Jairam","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"4","key":"10.1016\/j.ctro.2023.100669_b0095","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1667\/RR14721.1","article-title":"Low-Energy Ion-Species-Dependent Induction of DNA Double-Strand Breaks: Ion Energy and Fluence Thresholds","volume":"188","author":"Thopan","year":"2017","journal-title":"Radiat Res"},{"issue":"2","key":"10.1016\/j.ctro.2023.100669_b0100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/09553007814550011","article-title":"Gamma-ray induced double-strand breaks in DNA resulting from randomly-inflicted single-strand breaks: temporal local denaturation, a new radiation phenomenon?","volume":"33","author":"Van Der Schans","year":"1978","journal-title":"Int J Radiat Biol Relat Stud Phys Chem Med"},{"issue":"11","key":"10.1016\/j.ctro.2023.100669_b0105","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.2174\/1389450111009011352","article-title":"Modifying radiation damage","volume":"11","author":"Kim","year":"2010","journal-title":"Curr Drug Targets"},{"issue":"100","key":"10.1016\/j.ctro.2023.100669_b0110","doi-asserted-by":"crossref","first-page":"20140783","DOI":"10.1098\/rsif.2014.0783","article-title":"Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields","volume":"11","author":"Saha","year":"2014","journal-title":"J R Soc Interface"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s004410000188","article-title":"Radiation-induced apoptosis","volume":"301","author":"Verheij","year":"2000","journal-title":"Cell Tissue Res"},{"issue":"8","key":"10.1016\/j.ctro.2023.100669_b0120","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1667\/RR3196","article-title":"A sense of danger from radiation","volume":"162","author":"McBride","year":"2004","journal-title":"Radiat Res"},{"issue":"2","key":"10.1016\/j.ctro.2023.100669_b0130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1634\/theoncologist.7-2-136","article-title":"The effect of nonmalignant systemic disease on tolerance to radiation therapy","volume":"7","author":"Chon","year":"2002","journal-title":"Oncologist"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0135","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s12325-021-01640-x","article-title":"Radiotherapy-Specific Chronic Pain Syndromes in the Cancer Population: An Evidence-Based Narrative Review","volume":"38","author":"Karri","year":"2021","journal-title":"Adv Ther"},{"key":"10.1016\/j.ctro.2023.100669_b0140","unstructured":"Lai Y-H. Mechanisms and Models of Pain in Head and Neck Cancer Irradiation. PHD Dissertation, Raleigh, North Carolina, 2020. 2020."},{"issue":"11","key":"10.1016\/j.ctro.2023.100669_b0145","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.ctro.2023.100669_b0150","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/j.pain.0000000000000507","article-title":"Do we need a third mechanistic descriptor for chronic pain states?","volume":"157","author":"Kosek","year":"2016","journal-title":"Pain"},{"issue":"11","key":"10.1016\/j.ctro.2023.100669_b0155","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","article-title":"Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing","volume":"25","author":"Chamberlain","year":"2007","journal-title":"Stem Cells"},{"issue":"10","key":"10.1016\/j.ctro.2023.100669_b0160","first-page":"391","article-title":"Radioprotection with cytokines\u2013learning from nature to cope with radiation damage","volume":"3","author":"Neta","year":"1991","journal-title":"Cancer Cells"},{"issue":"8","key":"10.1016\/j.ctro.2023.100669_b0165","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1073\/pnas.0306734101","article-title":"IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium","volume":"101","author":"Egan","year":"2004","journal-title":"PNAS"},{"issue":"6","key":"10.1016\/j.ctro.2023.100669_b0170","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1667\/RR3031.1","article-title":"Cytokines in radiobiological responses: a review","volume":"178","author":"Schaue","year":"2012","journal-title":"Radiat Res"},{"key":"10.1016\/j.ctro.2023.100669_b0175","doi-asserted-by":"crossref","unstructured":"Muanza TM, Cotrim AP, McAuliffe M, Sowers AL, Baum BJ, Cook JA, Feldchtein F, Amazeen P, Coleman CN, Mitchell JB. Evaluation of radiation-induced oral mucositis by optical coherence tomography. Clin Cancer Res. 2005;11(14):5121-7.","DOI":"10.1158\/1078-0432.CCR-05-0403"},{"key":"10.1016\/j.ctro.2023.100669_b0180","first-page":"89","article-title":"Radiation-Induced Oral Mucositis. Front","volume":"7","author":"Maria","year":"2017","journal-title":"Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/j.soncn.2003.10.003","article-title":"Pathobiology of mucositis","volume":"20","author":"Sonis","year":"2004","journal-title":"Semin Oncol Nurs"},{"key":"10.1016\/j.ctro.2023.100669_b0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1758-3284-1-26","article-title":"Neuropathic and nociceptive pain in head and neck cancer patients receiving radiation therapy","volume":"1","author":"Epstein","year":"2009","journal-title":"Head Neck Oncol"},{"key":"10.1016\/j.ctro.2023.100669_b0195","article-title":"Physiology, Nociceptive Pathways","author":"Kendroud","year":"2022","journal-title":"StatPearls Treasure Island (FL)"},{"key":"10.1016\/j.ctro.2023.100669_b0200","article-title":"Pain Principles","author":"Dafny","year":"2020","journal-title":"Neuroscience online"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0205","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0306-4522(95)00343-H","article-title":"Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain","volume":"70","author":"Abbadie","year":"1996","journal-title":"Neuroscience"},{"issue":"20","key":"10.1016\/j.ctro.2023.100669_b0210","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1523\/JNEUROSCI.17-20-08049.1997","article-title":"Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation","volume":"17","author":"Abbadie","year":"1997","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0215","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0304-3959(80)90088-3","article-title":"Effects of substance P on nociceptive and non-nociceptive trigeminal brain stem neurons","volume":"8","author":"Henry","year":"1980","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.ctro.2023.100669_b0220","first-page":"121","article-title":"Perineural invasion in head and neck cancers - a review","volume":"7","author":"Frunza","year":"2014","journal-title":"J Med Life"},{"issue":"9","key":"10.1016\/j.ctro.2023.100669_b0225","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrc2468","article-title":"Hypoxia, HIF1 and glucose metabolism in the solid tumour","volume":"8","author":"Denko","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ctro.2023.100669_b0230","unstructured":"IASP. IASP Task Force on Taxonomy . Classification of Chronic Pain. Second. Seattle: IASP Press; 1994. [Google Scholar]."},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0235","first-page":"1","article-title":"Role of p53 in Anticancer Drug Treatment- and Radiation-Induced Injury in Normal Small Intestine","volume":"9","author":"Jin","year":"2012","journal-title":"Cancer Biol Med"},{"issue":"7","key":"10.1016\/j.ctro.2023.100669_b0240","doi-asserted-by":"crossref","first-page":"e0180396","DOI":"10.1371\/journal.pone.0180396","article-title":"Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis","volume":"12","author":"Reyes-Gibby","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ctro.2023.100669_b0245","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3389\/fgene.2018.00320","article-title":"Bioinformatics Analysis Identifies p53 as a Candidate Prognostic Biomarker for Neuropathic Pain","volume":"9","author":"Gao","year":"2018","journal-title":"Front Genet"},{"issue":"11","key":"10.1016\/j.ctro.2023.100669_b0250","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.pmrj.2011.08.535","article-title":"Radiation fibrosis syndrome: neuromuscular and musculoskeletal complications in cancer survivors","volume":"3","author":"Stubblefield","year":"2011","journal-title":"PM R"},{"key":"10.1016\/j.ctro.2023.100669_b0255","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2016.04.041","article-title":"Genetic predictors of human chronic pain conditions","volume":"338","author":"Zorina-Lichtenwalter","year":"2016","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.ctro.2023.100669_b0260","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tig.2012.02.004","article-title":"Pain genetics: past, present and future","volume":"28","author":"Mogil","year":"2012","journal-title":"Trends Genet"},{"issue":"8","key":"10.1016\/j.ctro.2023.100669_b0265","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S1470-2045(08)70197-9","article-title":"Molecular epidemiology, cancer-related symptoms, and cytokines pathway","volume":"9","author":"Reyes-Gibby","year":"2008","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0270","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijrobp.2018.01.054","article-title":"Machine Learning on a Genome-wide Association Study to Predict Late Genitourinary Toxicity After Prostate Radiation Therapy","volume":"101","author":"Lee","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2023.100669_b0275","unstructured":"GeneCards THGD. https:\/\/www.genecards.org\/."},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0280","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"CP in Bioinformatics"},{"issue":"7","key":"10.1016\/j.ctro.2023.100669_b0285","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/s41416-021-01670-w","article-title":"A genome-wide association study of radiotherapy induced toxicity in head and neck cancer patients identifies a susceptibility locus associated with mucositis","volume":"126","author":"Schack","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ctro.2023.100669_b0290","first-page":"1205","article-title":"Associations of GWAS-Identified Risk Loci with Progression, Efficacy and Toxicity of Radiotherapy of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy","volume":"14","author":"Li","year":"2021","journal-title":"Pharmgenomics Pers Med"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0295","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-020-02390-0","article-title":"Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis","volume":"18","author":"Yang","year":"2020","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.ctro.2023.100669_b0300","first-page":"531","volume":"28","author":"Mlak","year":"2020","journal-title":"Support Care Cancer"},{"issue":"5","key":"10.1016\/j.ctro.2023.100669_b0305","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/hed.26083","article-title":"Prospective evaluation of XRCC-1 Arg194Trp polymorphism as bio-predictor for clinical outcome in locally advanced laryngeal cancer undergoing cisplatin-based chemoradiation","volume":"42","author":"Raturi","year":"2020","journal-title":"Head Neck"},{"issue":"12","key":"10.1016\/j.ctro.2023.100669_b0310","doi-asserted-by":"crossref","first-page":"e1030","DOI":"10.1002\/mgg3.1030","article-title":"Potentially functional variants of autophagy-related genes are associated with the efficacy and toxicity of radiotherapy in patients with nasopharyngeal carcinoma","volume":"7","author":"Yang","year":"2019","journal-title":"Mol Genet Genomic Med"},{"issue":"3-4","key":"10.1016\/j.ctro.2023.100669_b0315","first-page":"37","article-title":"XRCC1 (rs25487) polymorphism is associated with severe oral mucositis and poor treatment response after radiotherapy for oropharyngeal carcinoma. Oral","volume":"3","author":"Gupta","year":"2019","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0320","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12253-017-0227-1","article-title":"Polymorphism of Promoter Region of TNFRSF1A Gene (-610 T > G) as a Novel Predictive Factor for Radiotherapy Induced Oral Mucositis in HNC Patients","volume":"24","author":"Brzozowska","year":"2018","journal-title":"Pathol Oncol Res"},{"issue":"8","key":"10.1016\/j.ctro.2023.100669_b0325","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/hed.25154","article-title":"Polymorphism of regulatory region of GHRL gene (-2531C>T) as a promising predictive factor for radiotherapy-induced oral mucositis in patients with head neck cancer","volume":"40","author":"Brzozowska","year":"2018","journal-title":"Head Neck"},{"issue":"51","key":"10.1016\/j.ctro.2023.100669_b0330","doi-asserted-by":"crossref","first-page":"29644","DOI":"10.18632\/oncotarget.25662","article-title":"Polymorphism of regulatory region of APEH gene (c.-521G>C, rs4855883) as a relevant predictive factor for radiotherapy induced oral mucositis and overall survival in head neck cancer patients","volume":"9","author":"Brzozowska","year":"2018","journal-title":"Oncotarget"},{"issue":"15","key":"10.1016\/j.ctro.2023.100669_b0335","doi-asserted-by":"crossref","first-page":"25334","DOI":"10.18632\/oncotarget.15835","article-title":"The impacts of single nucleotide polymorphisms in genes of cell cycle and NF-kB pathways on the efficacy and acute toxicities of radiotherapy in patients with nasopharyngeal carcinoma","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.ctro.2023.100669_b0340","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/1440-1681.12738","article-title":"Impact of polymorphisms in angiogenesis-related genes on clinical outcomes of radiotherapy in patients with nasopharyngeal carcinoma","volume":"44","author":"Ma","year":"2017","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"38","key":"10.1016\/j.ctro.2023.100669_b0345","doi-asserted-by":"crossref","first-page":"63026","DOI":"10.18632\/oncotarget.18450","article-title":"Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy","volume":"8","author":"Le","year":"2017","journal-title":"Oncotarget"},{"issue":"50","key":"10.1016\/j.ctro.2023.100669_b0350","doi-asserted-by":"crossref","first-page":"82528","DOI":"10.18632\/oncotarget.12754","article-title":"Genetic polymorphisms of Wnt\/beta-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma","volume":"7","author":"Yu","year":"2016","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0355","doi-asserted-by":"crossref","first-page":"e89079","DOI":"10.1371\/journal.pone.0089079","article-title":"Polymorphisms in radio-responsive genes and its association with acute toxicity among head and neck cancer patients","volume":"9","author":"Venkatesh","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0360","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3109\/09553002.2014.873558","article-title":"Acute oral mucositis in nasopharyngeal carcinoma patients treated with radiotherapy: association with genetic polymorphism in DNA DSB repair genes","volume":"90","author":"Ren","year":"2014","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ctro.2023.100669_b0365","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1748-717X-8-31","article-title":"XRCC1 codon 399Gln polymorphism is associated with radiotherapy-induced acute dermatitis and mucositis in nasopharyngeal carcinoma patients","volume":"8","author":"Li","year":"2013","journal-title":"Radiat Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0370","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.radonc.2011.05.062","article-title":"Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer","volume":"99","author":"Pratesi","year":"2011","journal-title":"Radiother Oncol"},{"issue":"37","key":"10.1016\/j.ctro.2023.100669_b0375","doi-asserted-by":"crossref","first-page":"62286","DOI":"10.18632\/oncotarget.19725","article-title":"Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0380","doi-asserted-by":"crossref","first-page":"8789","DOI":"10.1038\/s41598-018-27070-4","article-title":"Genome-wide association study identifies genes associated with neuropathy in patients with head and neck cancer","volume":"8","author":"Reyes-Gibby","year":"2018","journal-title":"Sci Rep"},{"issue":"17","key":"10.1016\/j.ctro.2023.100669_b0385","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.2217\/pgs-2018-0070","article-title":"Genetic polymorphism contributes to (131)I radiotherapy-induced toxicities in patients with differentiated thyroid cancer","volume":"19","author":"Liu","year":"2018","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.ctro.2023.100669_b0390","first-page":"1","article-title":"Potential Functional Variants in DNA Repair Genes Are Associated with Efficacy and Toxicity of Radiotherapy in Patients with Non-Small-Cell Lung Cancer","volume":"2020","author":"Yang","year":"2020","journal-title":"J Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2023.100669_b0395","doi-asserted-by":"crossref","DOI":"10.1186\/s40246-019-0212-8","article-title":"Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study","volume":"13","author":"Lee","year":"2019","journal-title":"Hum Genomics"},{"issue":"3","key":"10.1016\/j.ctro.2023.100669_b0400","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.4143\/crt.2018.527","article-title":"Associations of Genetic Variations in Mismatch Repair Genes MSH3 and PMS1 with Acute Adverse Events and Survival in Patients with Rectal Cancer Receiving Postoperative Chemoradiotherapy","volume":"51","author":"Yang","year":"2019","journal-title":"Cancer Res Treat"},{"issue":"11","key":"10.1016\/j.ctro.2023.100669_b0405","first-page":"457","article-title":"Radioprotection with cytokines: a clarification of terminology","volume":"3","author":"Neta","year":"1991","journal-title":"Cancer Cells"},{"issue":"6","key":"10.1016\/j.ctro.2023.100669_b0410","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/154405910708600604","article-title":"Orofacial pain in cancer: part I\u2013mechanisms","volume":"86","author":"Benoliel","year":"2007","journal-title":"J Dent Res"},{"issue":"6","key":"10.1016\/j.ctro.2023.100669_b0415","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/154405910708600605","article-title":"Orofacial pain in cancer: part II\u2013clinical perspectives and management","volume":"86","author":"Epstein","year":"2007","journal-title":"J Dent Res"},{"issue":"11","key":"10.1016\/j.ctro.2023.100669_b0420","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1158\/1055-9965.EPI-08-0125","article-title":"The influence of tumor necrosis factor-alpha -308 G\/A and IL-6 -174 G\/C on pain and analgesia response in lung cancer patients receiving supportive care","volume":"17","author":"Reyes-Gibby","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"Suppl 1","key":"10.1016\/j.ctro.2023.100669_b0425","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1016\/S0889-1591(02)00079-X","article-title":"Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment","volume":"17","author":"Maier","year":"2003","journal-title":"Brain Behav Immun"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630823000940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630823000940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:11:01Z","timestamp":1762503061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630823000940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":85,"alternative-id":["S2405630823000940"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2023.100669","relation":{},"ISSN":["2405-6308"],"issn-type":[{"type":"print","value":"2405-6308"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic Review of Genetic Polymorphisms Associated with Acute Pain Induced by Radiotherapy for Head and Neck Cancers","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2023.100669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100669"}}