{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:42:22Z","timestamp":1791812542302,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ctro.2024.100805","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T14:20:45Z","timestamp":1718288445000},"page":"100805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Remineralization of lytic spinal metastases after radiation therapy \u2013 A retrospective cohort study comparing conventional external beam radiation therapy with stereotactic ablative body radiation"],"prefix":"10.1016","volume":"48","author":[{"given":"Ruben","family":"Van den Brande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Van den Kieboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Billiet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Van de Kelft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctro.2024.100805_b0005","doi-asserted-by":"crossref","unstructured":"R. Van den Brande, E. MJ Cornips, M. Peeters, P. Ost, C. Billiet, and E. Van de Kelft, \u201cEpidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: A systematic review,\u201d Journal of Bone Oncology, vol. 35. Elsevier GmbH, Aug. 01, 2022. doi: 10.1016\/j.jbo.2022.100446.","DOI":"10.1016\/j.jbo.2022.100446"},{"issue":"10125","key":"10.1016\/j.ctro.2024.100805_b0010","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival: analysis of individual records for 37,513,025 patients diagnosed with one of 18 cncers during 2000\u20132014 from 322 populatio-based registries in 71 countries (CONCORD-3)","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ctro.2024.100805_b0015","unstructured":"World Health Organization, Who Report on Cancer: setting priorities, investing wesely and providing care for all. 2020."},{"issue":"2","key":"10.1016\/j.ctro.2024.100805_b0020","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/neuros\/nyaa380","article-title":"Survival trends after surgery for spinal metastatic tumors: 20-year cancer center experience","volume":"88","author":"Rothrock","year":"2021","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ctro.2024.100805_b0025","doi-asserted-by":"crossref","unstructured":"C. G. Fisher et al., \u201cA novel classification system for spinal instability in neoplastic disease: An evidence-based approach and expert consensus from the spine oncology study group,\u201d Spine (Phila Pa 1976), vol. 35, no. 22, pp. 1221\u20131229, 2010, doi: 10.1097\/BRS.0b013e3181e16ae2.","DOI":"10.1097\/BRS.0b013e3181e16ae2"},{"key":"10.1016\/j.ctro.2024.100805_b0030","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/os.12253","article-title":"Health-related quality of life in patients with metastatic spinal cord compression","volume":"8","author":"Morgen","year":"2016","journal-title":"Orthop Surg"},{"key":"10.1016\/j.ctro.2024.100805_b0035","doi-asserted-by":"crossref","unstructured":"A. J. Schoenfeld et al., \u201cCharacterizing Health-Related Quality of Life by Ambulatory Status in Patients with Spinal Metastases,\u201d Spine (Phila Pa 1976), vol. 47, no. 2, pp. 99\u2013104, Jan. 2022, doi: 10.1097\/BRS.0000000000004139.","DOI":"10.1097\/BRS.0000000000004139"},{"issue":"7","key":"10.1016\/j.ctro.2024.100805_b0040","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.spinee.2017.10.070","article-title":"Predictors of quality of life improvement after surgery for metastatic tumors of the spine: prospective cohort study","volume":"18","author":"Barzilai","year":"2018","journal-title":"Spine Journal"},{"issue":"2","key":"10.1016\/j.ctro.2024.100805_b0045","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.spinee.2017.07.008","article-title":"Patient-reported outcomes after surgical stabilization of spinal tumors: symptom-based validation of the spinal instability neoplastic score (SINS) and surgery","volume":"18","author":"Hussain","year":"2018","journal-title":"Spine Journal"},{"issue":"1","key":"10.1016\/j.ctro.2024.100805_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010148","article-title":"Understanding the progression of bone metastases to identify novel therapeutic targets","volume":"19","author":"Schmid-Alliana","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ctro.2024.100805_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.spinee.2022.12.018","article-title":"Remineralization of lytic spinal metastases after radiotherapy","author":"Pielkenrood","year":"2023","journal-title":"Spine Journal"},{"issue":"10","key":"10.1016\/j.ctro.2024.100805_b0060","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s000660050061","article-title":"Remineralisation und Schmerzlinderung von Knochenmetastasen nach unterschiedlich fraktionierter Strahlentherapie (10mal 3 Gy vs. 1mal 8 Gy) Eine prospektive Studie","volume":"175","author":"Koswig","year":"1999","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ctro.2024.100805_b0065","doi-asserted-by":"crossref","unstructured":"T. HANSSON, B. ROOS, and A. NACHEMSON, \u201cThe Bone Mineral Content and Ultimate Compressive Strength of Lumbar Vertebrae,\u201d Spine (Phila Pa 1976), vol. 5, no. 1, pp. 46\u201355, Jan. 1980, doi: 10.1097\/00007632-198001000-00009.","DOI":"10.1097\/00007632-198001000-00009"},{"issue":"1","key":"10.1016\/j.ctro.2024.100805_b0070","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3233\/THC-171086","article-title":"Fracture generation in human vertebrae under compression loading: The influence of pedicle preservation and bone mineral density on in vitro fracture behavior","volume":"26","author":"Kraxenberger","year":"2018","journal-title":"Technol Health Care"},{"issue":"4","key":"10.1016\/j.ctro.2024.100805_b0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0002-9343(01)01124-X","article-title":"Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs","volume":"112","author":"Cummings","year":"2002","journal-title":"Am J Med"},{"issue":"1","key":"10.1016\/j.ctro.2024.100805_b0080","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.3171\/2014.5.FOCUS1483","article-title":"Use of computed tomography for assessing bone mineral density","volume":"37","author":"Schreiber","year":"2014","journal-title":"Neurosurg Focus"},{"issue":"01","key":"10.1016\/j.ctro.2024.100805_b0085","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.4172\/2471-8416.100014","article-title":"Normative vertebral hounsfield unit values and correlation with bone mineral density","volume":"02","author":"Patel","year":"2016","journal-title":"J Clin Exp Orthopaedics"},{"issue":"7","key":"10.1016\/j.ctro.2024.100805_b0090","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S1470-2045(21)00196-0","article-title":"Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2\/3 trial","volume":"22","author":"Sahgal","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctro.2024.100805_b0095","doi-asserted-by":"crossref","unstructured":"R. Singh et al., \u201cSingle fraction radiosurgery, fractionated radiosurgery, and conventional radiotherapy for spinal oligometastasis (SAFFRON): A systematic review and meta-analysis,\u201d Radiotherapy and Oncology, vol. 146. Elsevier Ireland Ltd, pp. 76\u201389, May 01, 2020. doi: 10.1016\/j.radonc.2020.01.030.","DOI":"10.1016\/j.radonc.2020.01.030"},{"key":"10.1016\/j.ctro.2024.100805_b0100","first-page":"65","article-title":"Outcome and toxicity of hypofractionated image-guided SABR for spinal oligometastases","volume":"24","author":"Billiet","year":"2020","journal-title":"Clin Transl Radiat Oncol"},{"issue":"7","key":"10.1016\/j.ctro.2024.100805_b0105","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.clon.2024.04.004","article-title":"Comparative analysis of stereotactic radiation therapy and conventional radiation therapy in cancer pain control: a systematic review and meta-analysis","volume":"36","author":"Tariq","year":"2024","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ctro.2024.100805_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2023.8.SPINE23541","article-title":"Treatment of ambulatory patients with metastatic epidural spinal cord compression: a systematic review and meta-analysis","author":"Van den Brande","year":"2023","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.ctro.2024.100805_b0115","doi-asserted-by":"crossref","unstructured":"A. R. Vaccaro et al., \u201cAOSpine Thoracolumbar Spine Injury Classification System,\u201d Spine (Phila Pa 1976), vol. 38, no. 23, pp. 2028\u20132037, Nov. 2013, doi: 10.1097\/BRS.0b013e3182a8a381.","DOI":"10.1097\/BRS.0b013e3182a8a381"},{"issue":"6","key":"10.1016\/j.ctro.2024.100805_b0120","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1634\/theoncologist.2012-0293","article-title":"The NOMS framework: approach to the treatment of spinal metastatic tumors","volume":"18","author":"Laufer","year":"2013","journal-title":"Oncologist"},{"issue":"5","key":"10.1016\/j.ctro.2024.100805_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2021.2.FOCUS217","article-title":"Short-segment cement-augmented fixation in open separation surgery of metastatic epidural spinal cord compression: initial experience","volume":"50","author":"Newman","year":"2021","journal-title":"Neurosurg Focus"},{"issue":"2","key":"10.1016\/j.ctro.2024.100805_b0130","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1227\/NEU.0000000000001780","article-title":"Hybrid Therapy (Surgery and Radiosurgery) for the Treatment of Renal Cell Carcinoma Spinal Metastases","volume":"90","author":"Hussain","year":"2022","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ctro.2024.100805_b0135","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3171\/2016.5.FOCUS16145","article-title":"Factors associated with improved survival following surgery for renal cell carcinoma spinal metastases","volume":"41","author":"Petteys","year":"2016","journal-title":"Neurosurg Focus"},{"issue":"1","key":"10.1016\/j.ctro.2024.100805_b0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3171\/2013.9.SPINE13158","article-title":"Factors affecting survival in 267 consecutive patients undergoing surgery for spinal metastasis from renal cell carcinoma: Clinical article","volume":"20","author":"Tatsui","year":"2014","journal-title":"J Neurosurg Spine"},{"issue":"9","key":"10.1016\/j.ctro.2024.100805_b0145","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1097\/CORR.0000000000001749","article-title":"Which bone-modifying agent is associated with better outcomes in patients with skeletal metastases from lung cancer? a systematic review and network meta-analysis","volume":"479","author":"Bozzo","year":"2021","journal-title":"Clin Orthop Relat Res"},{"issue":"7413","key":"10.1016\/j.ctro.2024.100805_b0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bmj.327.7413.469","article-title":"Systematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer","volume":"327","author":"Ross","year":"2003","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.ctro.2024.100805_b0155","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s13018-021-02554-8","article-title":"Comparison of denosumab and zoledronic acid for the treatment of solid tumors and multiple myeloma with bone metastasis: a systematic review and meta-analysis based on randomized controlled trials","volume":"16","author":"Jiang","year":"2021","journal-title":"J Orthop Surg Res"},{"issue":"11","key":"10.1016\/j.ctro.2024.100805_b0160","article-title":"Bisphosphonates and other bone agents for breast cancer","volume":"Oct. 2017","author":"O\u2019Carrigan","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"14","key":"10.1016\/j.ctro.2024.100805_b0165","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1002\/cam4.2546","article-title":"Efficacy and safety of different fractions in stereotactic body radiotherapy for spinal metastases: A systematic review","volume":"8","author":"Gong","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.ctro.2024.100805_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109969","article-title":"Efficacy and safety of SBRT for spine metastases: A systematic review and meta-analysis for preparation of an ESTRO practice guideline","volume":"190","author":"Guninski","year":"2024","journal-title":"Radiother Oncol"},{"issue":"6","key":"10.1016\/j.ctro.2024.100805_b0175","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3171\/2020.5.SPINE191383","article-title":"Vertebral body fracture rates after stereotactic body radiation therapy compared with external-beam radiation therapy for metastatic spine tumors","volume":"33","author":"Vargas","year":"2020","journal-title":"J Neurosurg Spine"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240563082400082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240563082400082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T11:12:39Z","timestamp":1728126759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240563082400082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":35,"alternative-id":["S240563082400082X"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2024.100805","relation":{},"ISSN":["2405-6308"],"issn-type":[{"value":"2405-6308","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remineralization of lytic spinal metastases after radiation therapy \u2013 A retrospective cohort study comparing conventional external beam radiation therapy with stereotactic ablative body radiation","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2024.100805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100805"}}