{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:47:50Z","timestamp":1764175670740},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ctro.2024.100822","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T17:10:26Z","timestamp":1722445826000},"page":"100822","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Proton therapy toxicity outcomes for localized prostate cancer: Long-term results at a comprehensive cancer center"],"prefix":"10.1016","volume":"48","author":[{"given":"Alan J.","family":"Sosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard D.","family":"Thames","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah W.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungtaek L.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quynh-Nhu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Mok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Kuban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Ron Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalin","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren L.","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen E.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean E.","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayan","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Pugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian F.","family":"Chapin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Corn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Kudchadker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noveen","family":"Ausat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctro.2024.100822_b0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijrobp.2007.06.054","article-title":"Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer","volume":"70","author":"Kuban","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0010","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.294.10.1233","article-title":"Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial","volume":"294","author":"Zietman","year":"2005","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.ctro.2024.100822_b0015","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.radonc.2013.09.026","article-title":"Long-term results of the Dutch randomized prostate cancer trial: Impact of dose-escalation on local, biochemical, clinical failure, and survival","volume":"110","author":"Heemsbergen","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2024.100822_b0020","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.ijrobp.2012.05.023","article-title":"Long-term survival and toxicity in patients treated with high-dose intensity modulated radiation therapy for localized prostate cancer","volume":"85","author":"Spratt","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.juro.2013.02.012","article-title":"Outcome and toxicity for patients treated with intensity modulated radiation therapy for localized prostate cancer","volume":"190","author":"Vora","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.ctro.2024.100822_b0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijrobp.2008.04.063","article-title":"Role of intensity-modulated radiotherapy in reducing toxicity in dose escalation for localized prostate cancer","volume":"73","author":"Al-Mamgani","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-8140(99)00036-5","article-title":"A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy","volume":"51","author":"Lomax","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2024.100822_b0040","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ijrobp.2007.03.018","article-title":"Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison","volume":"69","author":"Trofimov","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109854","article-title":"Proton therapy for the management of localized prostate cancer: Long-term clinical outcomes at a comprehensive cancer center","volume":"188","author":"Sosa","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2024.100822_b0050","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.clon.2016.04.041","article-title":"Acute and late genitourinary toxicity after 72 Gy of conventionally fractionated conformal radiotherapy for localised prostate cancer: impact of individual and clinical parameters","volume":"28","author":"Stankovic","year":"2016","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ctro.2024.100822_b0055","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0360-3016(97)00234-4","article-title":"Chronic rectal bleeding after high-dose conformal treatment of prostate cancer warrants modification of existing morbidity scales","volume":"38","author":"Hanlon","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0065","doi-asserted-by":"crossref","first-page":"e231439","DOI":"10.1001\/jamanetworkopen.2023.1439","article-title":"Time trends and variation in the use of active surveillance for management of low-risk prostate cancer in the US","volume":"6","author":"Cooperberg","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ctro.2024.100822_b0070","doi-asserted-by":"crossref","first-page":"R419","DOI":"10.1088\/0031-9155\/59\/22\/R419","article-title":"Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer","volume":"59","author":"Paganetti","year":"2014","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ctro.2024.100822_b0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/rpd\/ncq410","article-title":"Isoeffective dose: a concept for biological weighting of absorbed dose in proton and heavier-ion therapies","volume":"143","author":"Wambersie","year":"2011","journal-title":"Radiat Prot Dosim"},{"key":"10.1016\/j.ctro.2024.100822_b0080","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.ijrobp.2010.10.027","article-title":"Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning","volume":"80","author":"Grassberger","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0085","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0360-3016(93)90361-X","article-title":"Acute toxicity during external-beam radiotherapy for localized prostate cancer: comparison of different techniques","volume":"25","author":"Vijayakumar","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0090","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1748-717X-6-145","article-title":"Acute toxicity in prostate cancer patients treated with and without image-guided radiotherapy","volume":"6","author":"Gill","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ctro.2024.100822_b0095","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ijrobp.2015.04.030","article-title":"Hydrogel spacer prospective multicenter randomized controlled pivotal trial: dosimetric and clinical effects of perirectal spacer application in men undergoing prostate image guided intensity modulated radiation therapy","volume":"92","author":"Mariados","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0100","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ijrobp.2016.12.024","article-title":"Continued benefit to rectal separation for prostate radiation therapy: final results of a phase III trial","volume":"97","author":"Hamstra","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.urology.2017.11.016","article-title":"Absorbable hydrogel spacer use in prostate radiotherapy: a comprehensive review of phase 3 clinical trial published data","volume":"115","author":"Karsh","year":"2018","journal-title":"Urology"},{"key":"10.1016\/j.ctro.2024.100822_b0110","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ijrobp.2007.07.2335","article-title":"Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer","volume":"70","author":"Vargas","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2024.100822_b0115","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/cncr.29148","article-title":"A case-matched study of toxicity outcomes after proton therapy and intensity-modulated radiation therapy for prostate cancer","volume":"121","author":"Fang","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.ctro.2024.100822_b0120","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/cncr.27956","article-title":"Patient-reported outcomes after 3-dimensional conformal, intensity-modulated, or proton beam radiotherapy for localized prostate cancer","volume":"119","author":"Gray","year":"2013","journal-title":"Cancer"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630824000995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630824000995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T11:12:56Z","timestamp":1728126776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630824000995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":24,"alternative-id":["S2405630824000995"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2024.100822","relation":{},"ISSN":["2405-6308"],"issn-type":[{"type":"print","value":"2405-6308"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proton therapy toxicity outcomes for localized prostate cancer: Long-term results at a comprehensive cancer center","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2024.100822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100822"}}