{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:47:28Z","timestamp":1778964448301,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["10978"],"award-info":[{"award-number":["10978"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ctro.2024.100857","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T01:21:53Z","timestamp":1726190513000},"page":"100857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Prognostic value of pretreatment radiological MRI variables and dynamic contrast-enhanced MRI on radiotherapy treatment outcome in laryngeal and hypopharyngeal tumors"],"prefix":"10.1016","volume":"49","author":[{"given":"Hilde J.G.","family":"Smits","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia J.","family":"Vink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mischa","family":"de Ridder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle E.P.","family":"Philippens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan W.","family":"Dankbaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctro.2024.100857_b0005","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/hed.26698","article-title":"Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy; a systematic review and meta-analysis","volume":"43","author":"Smits","year":"2021","journal-title":"Head Neck"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mric.2021.08.002","article-title":"MR imaging of laryngeal and hypopharyngeal cancer","volume":"30","author":"Becker","year":"2022","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"10.1016\/j.ctro.2024.100857_b0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/HP.S93413","article-title":"The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy","author":"Muz","year":"2015","journal-title":"Hypoxia"},{"issue":"2","key":"10.1016\/j.ctro.2024.100857_b0020","first-page":"147","article-title":"Dynamic contrast-enhanced magnetic resonance imaging: fundamentals and application to the evaluation of the peripheral perfusion","volume":"4","author":"Gordon","year":"2014","journal-title":"Cardiovasc Diagn Ther"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0025","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.ejrad.2013.10.022","article-title":"Primary staging of laryngeal and hypopharyngeal cancer: CT, MR imaging and dual-energy CT","volume":"83","author":"Kuno","year":"2014","journal-title":"Eur J Radiol"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0030","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.radonc.2016.05.009","article-title":"Dynamic contrast-enhanced MRI for treatment response assessment in patients with oesophageal cancer receiving neoadjuvant","volume":"120","author":"Heethuis","year":"2016","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0035","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"elastix: a toolbox for intensity-based medical image registration","volume":"29","author":"Klein","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"JAN","key":"10.1016\/j.ctro.2024.100857_b0040","first-page":"1","article-title":"Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer\u2019s disease","volume":"7","author":"Shamonin","year":"2014","journal-title":"Front Neuroinform"},{"issue":"5","key":"10.1016\/j.ctro.2024.100857_b0045","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/RLI.0000000000000132","article-title":"T1 relaxivities of gadolinium-based magnetic resonance","volume":"50","author":"Shen","year":"2015","journal-title":"Invest Radiol"},{"key":"10.1016\/j.ctro.2024.100857_b0050","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Published online 2022. http:\/\/www.r-project.org."},{"key":"10.1016\/j.ctro.2024.100857_b0055","unstructured":"Kassambara A, Kosinski M, Biecek P. survminer: Drawing Survival Curves using \u201cggplot2\u201d. R package version 0.4.9. https:\/\/CRAN.R-project.org package=survminer. Published online 2021."},{"issue":"23","key":"10.1016\/j.ctro.2024.100857_b0060","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1158\/1078-0432.CCR-22-1522","article-title":"Randomized phase II study of physiologic MRI-directed adaptive radiation boost in poor prognosis head and neck cancer","volume":"28","author":"Mierzwa","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"12","key":"10.1016\/j.ctro.2024.100857_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0144770","article-title":"DCE-MRI for pre-treatment prediction and post-treatment assessment of treatment response in sites of squamous cell carcinoma in the head and neck","volume":"10","author":"King","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ctro.2024.100857_b0070","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jmri.23704","article-title":"Pharmacokinetic analysis based on dynamic contrast-enhanced MRI for evaluating tumor response to preoperative therapy for oral cancer","volume":"36","author":"Chikui","year":"2012","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"10.1016\/j.ctro.2024.100857_b0075","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/nbm.731","article-title":"Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: comparison of quantitative and semi-quantitative analysis","volume":"15","author":"Galbraith","year":"2002","journal-title":"NMR Biomed"},{"issue":"4","key":"10.1016\/j.ctro.2024.100857_b0080","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/jmri.20529","article-title":"Comparative study into the robustness of compartmental modeling and model-free analysis in DCE-MRI studies","volume":"23","author":"Roberts","year":"2006","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.ctro.2024.100857_b0085","doi-asserted-by":"crossref","unstructured":"K\u00e5stad H\u00f8iskar M, Delange M, Kathrine R. Quantitative dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer: a systematic comparison of different modelling approaches. 2024;29(February). doi:10.1016\/j.phro.2024.100548.","DOI":"10.1016\/j.phro.2024.100548"},{"key":"10.1016\/j.ctro.2024.100857_b0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ima.22013","article-title":"In vivo correlation between semi-quantitative hemodynamic parameters and ktrans derived from DCE-MRI of brain tumors","volume":"22","author":"Chih-Feng","year":"2012","journal-title":"Int J Imaging Syst Technol"},{"issue":"14","key":"10.1016\/j.ctro.2024.100857_b0095","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1088\/0031-9155\/51\/14\/021","article-title":"Evaluation of response to treatment using DCE-MRI: the relationship between initial area under the gadolinium curve (IAUGC) and quantitative pharmacokinetic analysis","volume":"51","author":"Walker-Samuel","year":"2006","journal-title":"Phys Med Biol"},{"issue":"June","key":"10.1016\/j.ctro.2024.100857_b0100","article-title":"Prognostic functional MR imaging parameters in head and neck squamous cell carcinoma: a systematic review","volume":"144","author":"Bos","year":"2021","journal-title":"Eur J Radiol"},{"issue":"37","key":"10.1016\/j.ctro.2024.100857_b0105","doi-asserted-by":"crossref","first-page":"62606","DOI":"10.18632\/oncotarget.15904","article-title":"Multiparametric imaging using (18)F-FDG PET\/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy","volume":"8","author":"Chan","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2478\/raon-2019-0010","article-title":"Prognostic role of diffusion weighted and dynamic contrast-enhanced MRI in loco-regionally advanced head and neck cancer treated with concomitant chemoradiotherapy","volume":"53","author":"Garbajs","year":"2019","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.ctro.2024.100857_b0115","first-page":"616","article-title":"Multiparametric functional MRI and 18F-FDG-PET for survival prediction in patients with head and neck squamous cell carcinoma treated with (chemo)radiation","volume":"31","author":"Martens","year":"2021","journal-title":"Head Neck"},{"issue":"10","key":"10.1016\/j.ctro.2024.100857_b0120","first-page":"1391","article-title":"Impact of primary tumor volume on local control after definitive radiotherapy for head and neck cancer","volume":"36","author":"Mendenhall","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.ctro.2024.100857_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109771","article-title":"The influence of tumor volume on the risk of distant metastases in head and neck squamous cell carcinomas","volume":"186","author":"Kjems","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2024.100857_b0130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/jmp.jmp_101_22","article-title":"Prognosticating gross tumor volume in head-and-neck cancer \u2013 redefining gross tumor volume beyond contouring","volume":"48","author":"Ahmed","year":"2023","journal-title":"J Med Phys"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-015-0440-6","article-title":"Treatment of T3 laryngeal cancer in the Netherlands: a national survey","volume":"10","author":"Doornaert","year":"2015","journal-title":"Radiat Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0167-8140(98)00114-5","article-title":"Predicting the local outcome of glottic squamous cell carcinoma after definitive radiation therapy: value of computed tomography-determined tumour parameters","volume":"50","author":"Hermans","year":"1999","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.ctro.2024.100857_b0145","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0360-3016(99)00039-5","article-title":"Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy","volume":"44","author":"Hermans","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ctro.2024.100857_b0150","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1148\/radiol.2322031001","article-title":"Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging","volume":"232","author":"Ljumanovic","year":"2004","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.ctro.2024.100857_b0155","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1148\/radiol.2441060593","article-title":"MR imaging predictors of local control of glottic squamous cell carcinoma treated with radiation alone","volume":"244","author":"Ljumanovic","year":"2007","journal-title":"Radiology"},{"issue":"14","key":"10.1016\/j.ctro.2024.100857_b0160","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1200\/JCO.2009.24.7544","article-title":"Prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy","volume":"28","author":"Beitler","year":"2010","journal-title":"J Clin Oncol"},{"issue":"997","key":"10.1016\/j.ctro.2024.100857_b0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1259\/bjr\/66700901","article-title":"Overstaging of cartilage invasion by multidetector CT scan for laryngeal cancer and its potential effect on the use of organ preservation with chemoradiation","volume":"84","author":"Li","year":"2011","journal-title":"Br J Radiol"},{"issue":"6","key":"10.1016\/j.ctro.2024.100857_b0170","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3109\/00016489.2012.761352","article-title":"Diagnostic accuracy of computed tomography findings for patients undergoing salvage total laryngectomy","volume":"133","author":"Han","year":"2013","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.ctro.2024.100857_b0175","doi-asserted-by":"crossref","DOI":"10.1007\/s00405-023-07904-2","article-title":"Oncological outcome of vocal cord-only radiotherapy for cT1-T2 glottic laryngeal squamous cell carcinoma","author":"de Ridder","year":"2023","journal-title":"Eur Arch Oto-Rhino-Laryngology"},{"key":"10.1016\/j.ctro.2024.100857_b0180","series-title":"AJCC Cancer Staging Manual","author":"Amin","year":"2017"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630824001344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630824001344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T13:49:53Z","timestamp":1730555393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630824001344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":36,"alternative-id":["S2405630824001344"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2024.100857","relation":{},"ISSN":["2405-6308"],"issn-type":[{"value":"2405-6308","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of pretreatment radiological MRI variables and dynamic contrast-enhanced MRI on radiotherapy treatment outcome in laryngeal and hypopharyngeal tumors","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2024.100857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100857"}}