{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:20:01Z","timestamp":1787732401998,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009530","name":"Jawaharlal Institute of Postgraduate Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ctro.2025.101066","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:30:24Z","timestamp":1762389024000},"page":"101066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Evaluation of submandibular gland function using quantitative 99mTc-pertechnetate scintigraphy in submandibular gland sparing radiotherapy for head-neck cancers, a prospective longitudinal study"],"prefix":"10.1016","volume":"56","author":[{"given":"Prasoon","family":"Garg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shyama Prem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusudhanan","family":"Ponnusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathappan","family":"Muthuveerappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Saravanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sreekumaran Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Anusuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ctro.2025.101066_b0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ctro.2025.101066_b0010","series-title":"Radiotherapy treatments for head and neck cancer update [Internet]","author":"Ratko","year":"2014"},{"issue":"12","key":"10.1016\/j.ctro.2025.101066_b0015","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.archoralbio.2015.09.014","article-title":"Radiotherapy-induced salivary dysfunction: Structural changes, pathogenetic mechanisms and therapies","volume":"60","author":"Acauan","year":"2015","journal-title":"Arch Oral Biol"},{"issue":"11","key":"10.1016\/j.ctro.2025.101066_b0020","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/cncr.22302","article-title":"Radiation-induced xerostomia in patients with head and neck cancer: a literature review","volume":"107","author":"Dirix","year":"2006","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.ctro.2025.101066_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2023.103867","article-title":"Current management of xerostomia in head and neck cancer patients","volume":"44","author":"Nathan","year":"2023","journal-title":"Am J Otolaryngol"},{"issue":"3","key":"10.1016\/j.ctro.2025.101066_b0030","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S1053-4296(03)00033-X","article-title":"How should we measure and report radiotherapy-induced xerostomia?","volume":"13","author":"Eisbruch","year":"2003","journal-title":"Semin Radiat Oncol"},{"issue":"2","key":"10.1016\/j.ctro.2025.101066_b0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"PARSPORT trial management group. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol."},{"issue":"31","key":"10.1016\/j.ctro.2025.101066_b0040","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1200\/JCO.2007.13.4874","article-title":"Reducing xerostomia by IMRT: what may, and may not, be achieved","volume":"25","author":"Eisbruch","year":"2007","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2025.101066_b0045","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2011.09.004","article-title":"Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands","volume":"83","author":"Little","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"2","key":"10.1016\/j.ctro.2025.101066_b0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jmrs.203","article-title":"Comparison of treatment techniques for reduction in the submandibular gland dose: a retrospective study","volume":"64","author":"Hoyne","year":"2017","journal-title":"J Med Radiat Sci"},{"issue":"4","key":"10.1016\/j.ctro.2025.101066_b0055","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/01.coc.0000158826.88179.75","article-title":"Late xerostomia after intensity-modulated radiation therapy versus conventional radiotherapy","volume":"28","author":"Pacholke","year":"2005","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2025.101066_b0060","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0360-3016(01)01512-7","article-title":"Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer","volume":"50","author":"Eisbruch","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ctro.2025.101066_b0065","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radonc.2006.02.017","article-title":"Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head and neck cancer","volume":"78","author":"Saarilahti","year":"2006","journal-title":"Radiother Oncol."},{"issue":"2","key":"10.1016\/j.ctro.2025.101066_b0070","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.radonc.2008.02.017","article-title":"Scintigraphy in prediction of the salivary gland function after gland-sparing intensity modulated radiation therapy for head and neck cancer","volume":"87","author":"Tenhunen","year":"2008","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2025.101066_b0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.radonc.2017.10.016","volume":"126","author":"Gr\u00e9goire","year":"2018","journal-title":"TROG Consensus Guidelines Radiother Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2025.101066_b0080","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.radonc.2009.09.008","article-title":"Delineation guidelines for organs at risk involved in radiation-induced salivary dysfunction and xerostomia","volume":"93","author":"van de Water","year":"2009","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2025.101066_b0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.radonc.2015.07.041","article-title":"CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines","volume":"117","author":"Brouwer","year":"2015","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2025.101066_b0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.radonc.2017.10.032","article-title":"International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma","volume":"126","author":"Lee","year":"2018","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.ctro.2025.101066_b0095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ijrobp.2007.12.033","article-title":"Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy","volume":"72","author":"Murdoch-Kinch","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101066_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2019.01.018","article-title":"Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update","volume":"134","author":"Biau","year":"2019","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2025.101066_b0105","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2013.10.010","article-title":"Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines","volume":"110","author":"Gr\u00e9goire","year":"2014","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2025.101066_b0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.radonc.2008.07.016","article-title":"The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy","volume":"89","author":"Rudat","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2025.101066_b0115","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4103\/0019-509X.176733","article-title":"Evaluation of salivary function by sialoscintigraphy in locally advanced nasopharyngeal cancer patients after intensity modulated radiotherapy","volume":"52","author":"Chuang","year":"2015","journal-title":"Indian J Cancer"},{"issue":"4","key":"10.1016\/j.ctro.2025.101066_b0120","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.remn.2010.02.012","article-title":"Gammagraf\u00eda salival cuantitativa en pacientes con c\u00e1ncer de cabeza y cuello tratados con radioterapia [Quantitative salivary gland scintigraphy in head and neck cancer patients following radiotherapy]","volume":"29","author":"Jim\u00e9nez-Heffernan","year":"2010","journal-title":"Rev Esp Med Nucl"},{"issue":"1","key":"10.1016\/j.ctro.2025.101066_b0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.radonc.2018.02.021","article-title":"Submandibular function recovery after IMRT in head and neck cancer: a prospective dose modelling study","volume":"129","author":"Murthy","year":"2018","journal-title":"Radiother Oncol"},{"issue":"9","key":"10.1016\/j.ctro.2025.101066_b0130","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.3389\/fonc.2019.01090","article-title":"A review on the assessment of radiation induced salivary gland damage after radiotherapy","volume":"17","author":"Wu","year":"2019","journal-title":"Front Oncol"},{"issue":"10","key":"10.1016\/j.ctro.2025.101066_b0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13014-015-0371-2","article-title":"Prospective longitudinal assessment of parotid gland function using dynamic quantitative pertechnate scintigraphy and estimation of dose-response relationship of parotid-sparing radiotherapy in head-neck cancers","volume":"15","author":"Gupta","year":"2015","journal-title":"Radiat Oncol"},{"issue":"Suppl 1","key":"10.1016\/j.ctro.2025.101066_b0140","first-page":"E1746","article-title":"Prospective investigation and literature review of tolerance dose on salivary glands using quantitative salivary gland scintigraphy in the intensity-modulated radiotherapy era","volume":"38","author":"Lee","year":"2016","journal-title":"Head Neck"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630825001582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630825001582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:37:04Z","timestamp":1787729824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630825001582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"alternative-id":["S2405630825001582"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2025.101066","relation":{},"ISSN":["2405-6308"],"issn-type":[{"value":"2405-6308","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of submandibular gland function using quantitative 99mTc-pertechnetate scintigraphy in submandibular gland sparing radiotherapy for head-neck cancers, a prospective longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2025.101066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101066"}}