{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:25:49Z","timestamp":1770078349578,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ctro.2025.101100","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T16:24:23Z","timestamp":1766420663000},"page":"101100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pharyngeal mucositis and esophagitis after re-irradiation spine stereotactic body radiotherapy with 24\u00a0Gy in two fractions"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-3795","authenticated-orcid":false,"given":"Kei","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9018-9112","authenticated-orcid":false,"given":"Kentaro","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-6299","authenticated-orcid":false,"given":"Yujiro","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko Nemoto","family":"Murofushi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctro.2025.101100_b0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.prro.2024.04.018","article-title":"External beam radiation therapy for palliation of symptomatic bone metastases: an ASTRO clinical practice guideline","volume":"14","author":"Alcorn","year":"2024","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.radonc.2022.05.024","article-title":"ESTRO ACROP guidelines for external beam radiotherapy of patients with uncomplicated bone metastases","volume":"173","author":"van der Velden","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1470-2045(13)70556-4","article-title":"Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial","volume":"15","author":"Chow","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0020","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3171\/2017.2.SPINE16976","article-title":"Reirradiation spine stereotactic body radiation therapy for spinal metastases: systematic review","volume":"27","author":"Myrehaug","year":"2017","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.ctro.2025.101100_b0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijrobp.2010.08.021","article-title":"Reirradiation human spinal cord tolerance for stereotactic body radiotherapy","volume":"82","author":"Sahgal","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0030","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s11604-024-01539-x","article-title":"Re-irradiation spine stereotactic body radiotherapy following high-dose conventional radiotherapy for metastatic epidural spinal cord compression: a retrospective study","volume":"42","author":"Koide","year":"2024","journal-title":"Jpn J Radiol"},{"key":"10.1016\/j.ctro.2025.101100_b0035","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/neuros\/nyz213","article-title":"Strategies to mitigate toxicities from stereotactic body radiation therapy for spine metastases","volume":"85","author":"Schaub","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ctro.2025.101100_b0040","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S1470-2045(21)00196-0","article-title":"Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2\/3 trial","volume":"22","author":"Sahgal","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0045","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.rpor.2019.12.018","article-title":"Appropriate endpoints for stereotactic body radiotherapy for bone metastasis: classification into five treatment groups","volume":"25","author":"Ito","year":"2020","journal-title":"Rep Pract Oncol Radiother"},{"issue":"1","key":"10.1016\/j.ctro.2025.101100_b0050","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijrobp.2010.08.021","article-title":"Reirradiation human spinal cord tolerance for stereotactic body radiotherapy","volume":"82","author":"Sahgal","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"10.1016\/j.ctro.2025.101100_b0055","doi-asserted-by":"crossref","first-page":"e597","DOI":"10.1016\/j.ijrobp.2012.03.009","article-title":"International spine radiosurgery consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery","volume":"83","author":"Cox","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijrobp.2016.09.014","article-title":"Consensus contouring guidelines for postoperative stereotactic body radiation therapy for metastatic solid tumor malignancies to the spine","volume":"97","author":"Redmond","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0065","unstructured":"National Cancer Institute. Common terminology criteria for adverse events (CTCAE) version 5.0. https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_5x7.pdf. [Accessed August 1, 2022]."},{"key":"10.1016\/j.ctro.2025.101100_b0070","doi-asserted-by":"crossref","first-page":"e595","DOI":"10.1016\/S1470-2045(15)00166-7","article-title":"Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group","volume":"16","author":"Thibault","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijrobp.2020.11.021","article-title":"Stereotactic body radiation therapy for spinal metastases: tumor control probability analyses and recommended reporting standards","volume":"110","author":"Soltys","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0080","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.ijrobp.2015.03.037","article-title":"Outcomes for spine stereotactic body radiation therapy and an analysis of predictors of local recurrence","volume":"92","author":"Bishop","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0085","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.ijrobp.2009.10.003","article-title":"Correlation of local failure with measures of dose insufficiency in the high-dose single-fraction treatment of bony metastases","volume":"77","author":"Lovelock","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0090","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2016.9.FOCUS16369","article-title":"The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery","volume":"42","author":"Yamada","year":"2017","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.ctro.2025.101100_b0095","doi-asserted-by":"crossref","first-page":"e661","DOI":"10.1016\/j.ijrobp.2012.01.080","article-title":"Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery","volume":"83","author":"Cox","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0100","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ijrobp.2014.01.022","article-title":"Stereotactic ablative radiation therapy for centrally located early stage or isolated parenchymal recurrences of non-small cell lung cancer: how to fly in a \u201cno fly zone\u201d","volume":"88","author":"Chang","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2014.07.001","article-title":"Dosimetric predictors of esophageal toxicity after stereotactic body radiotherapy for central lung tumors","volume":"112","author":"Wu","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.semradonc.2015.11.006","article-title":"Esophageal dose tolerance in patients treated with stereotactic body radiation therapy","volume":"26","author":"Nuyttens","year":"2016","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0115","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/COC.0000000000000195","article-title":"Dose-volume predictors of esophagitis after thoracic stereotactic body radiation therapy","volume":"40","author":"Harder","year":"2017","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0120","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1016\/j.ijrobp.2021.07.1139","article-title":"Stereotactic body radiation therapy (SBRT) in oropharynx and oral cavity cancer: toxicity and local control","volume":"111","author":"Eckstein","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0125","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3857\/roj.2013.31.4.234","article-title":"Esophageal tolerance to high-dose stereotactic radiosurgery","volume":"31","author":"Lee","year":"2013","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.ctro.2025.101100_b0130","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1118\/1.3438081","article-title":"Stereotactic body radiation therapy: the report of AAPM Task Group 101","volume":"37","author":"Benedict","year":"2010","journal-title":"Med Phys"},{"key":"10.1016\/j.ctro.2025.101100_b0135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.semradonc.2017.02.001","article-title":"Normal tissue constraints for abdominal and thoracic stereotactic body radiotherapy","volume":"27","author":"Pollom","year":"2017","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ctro.2025.101100_b0140","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.clon.2022.02.010","article-title":"UK 2022 consensus on normal tissue dose-volume constraints for oligometastatic, primary lung and hepatocellular carcinoma stereotactic ablative radiotherapy","volume":"34","author":"Diez","year":"2022","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ctro.2025.101100_b0145","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1442-2050.2009.01037.x","article-title":"Esophageal motion during radiotherapy: quantification and margin implications","volume":"23","author":"Cohen","year":"2010","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.ctro.2025.101100_b0150","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1056\/NEJMp0911494","article-title":"The missing voice of patients in drug-safety reporting","volume":"362","author":"Basch","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctro.2025.101100_b0155","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1477-7525-8-104","article-title":"Health care providers underestimate symptom intensities of cancer patients: a multicenter European study","volume":"8","author":"Laugsand","year":"2010","journal-title":"Health Qual Life Outcomes"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630825001922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630825001922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:22:03Z","timestamp":1770034923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630825001922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":31,"alternative-id":["S2405630825001922"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2025.101100","relation":{},"ISSN":["2405-6308"],"issn-type":[{"value":"2405-6308","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharyngeal mucositis and esophagitis after re-irradiation spine stereotactic body radiotherapy with 24\u00a0Gy in two fractions","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2025.101100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101100"}}