{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:16:56Z","timestamp":1783397816085,"version":"3.54.6"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007352","name":"Swiss State Secretariat for Education Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ctro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Translational Radiation Oncology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ctro.2026.101160","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:08:02Z","timestamp":1775495282000},"page":"101160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Assessing the impact of proton versus photon therapy on health-related quality of life in lung cancer"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-7497","authenticated-orcid":false,"given":"Bradley M.","family":"Sugden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-4284","authenticated-orcid":false,"given":"Willem J.A.","family":"Witlox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cortiula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizza E.L.","family":"Hendriks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"van Loon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djoya","family":"Hattu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-6768","authenticated-orcid":false,"given":"Manuela A.","family":"Joore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram L.T.","family":"Ramaekers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk K.M.","family":"De Ruysscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctro.2026.101160_b0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/resp.13870","article-title":"Radiotherapy treatment for lung cancer: current status and future directions","volume":"25 Suppl 2","author":"Vinod","year":"2020","journal-title":"Respirology (Carlton, Vic)"},{"key":"10.1016\/j.ctro.2026.101160_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.110019","article-title":"Proton and photon radiotherapy in stage III NSCLC: effects on hematological toxicity and adjuvant immune therapy","volume":"190","author":"Cortiula","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2026.101160_b0015","unstructured":"York Health Economics Consortium. (2025, October). Health-related quality of life (HRQoL). https:\/\/www.yhec.co.uk\/glossary-term\/health-related-quality-of-life-hrqol\/."},{"issue":"1","key":"10.1016\/j.ctro.2026.101160_b0020","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13014-020-01654-9","article-title":"Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review","volume":"15","author":"K\u00e4smann","year":"2020","journal-title":"Radiat Oncol (London, England)"},{"issue":"34","key":"10.1016\/j.ctro.2026.101160_b0025","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1200\/JCO.2013.51.5353","article-title":"Dose-limiting toxicity after hypofractionated dose-escalated radiotherapy in non-small-cell lung cancer","volume":"31","author":"Cannon","year":"2013","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.ctro.2026.101160_b0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-019-0064-5","article-title":"Radiotherapy toxicity","volume":"5","author":"De Ruysscher","year":"2019","journal-title":"Nat Rev. Dis Primers"},{"issue":"3","key":"10.1016\/j.ctro.2026.101160_b0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2013.05.007","article-title":"Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach","volume":"107","author":"Langendijk","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2026.101160_b0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.radonc.2019.09.005","article-title":"Multifactorial risk factors for mortality after chemotherapy and radiotherapy for non-small cell lung cancer","volume":"152","author":"Defraene","year":"2020","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.ctro.2026.101160_b0045","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.radonc.2018.07.021","article-title":"External validation of an NTCP model for acute esophageal toxicity in locally advanced NSCLC patients treated with intensity-modulated (chemo-)radiotherapy","volume":"129","author":"Dankers","year":"2018","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.1016\/j.ctro.2026.101160_b0050","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3109\/0284186X.2013.820341","article-title":"Towards individualized dose constraints: Adjusting the QUANTEC radiation pneumonitis model for clinical risk factors","volume":"53","author":"Appelt","year":"2014","journal-title":"Acta Oncol (Stockholm, Sweden)"},{"issue":"4","key":"10.1016\/j.ctro.2026.101160_b0055","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0360-3016(02)02847-X","article-title":"Quality of life after curative radiotherapy in stage I non-small-cell lung cancer","volume":"53","author":"Langendijk","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"10.1016\/j.ctro.2026.101160_b0060","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/thx.2010.136390","article-title":"Health-related quality of life in patients surviving non-small cell lung cancer","volume":"65","author":"Grutters","year":"2010","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.ctro.2026.101160_b0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijrobp.2009.04.080","article-title":"Quality of life after stereotactic radiotherapy for stage I non-small-cell lung cancer","volume":"77","author":"van der Voort van Zyp","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctro.2026.101160_b0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13014-015-0405-9","article-title":"Quality of life during 5 years after stereotactic radiotherapy in stage I non-small cell lung cancer","volume":"10","author":"Ubels","year":"2015","journal-title":"Radiat Oncol (London, England)"},{"key":"10.1016\/j.ctro.2026.101160_b0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.radonc.2019.10.016","article-title":"Health-related quality of life after prophylactic cranial irradiation for stage III non-small cell lung cancer patients: results from the NVALT-11\/DLCRG-02 phase III study","volume":"144","author":"Witlox","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2026.101160_b0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.lungcan.2022.03.010","article-title":"Overview of health-related quality of life and toxicity of non-small cell lung cancer patients receiving curative-intent radiotherapy in a real-life setting (the REQUITE study)","volume":"166","author":"Van der Weijst","year":"2022","journal-title":"Lung Cancer (Amsterdam, Netherlands)"},{"issue":"3","key":"10.1016\/j.ctro.2026.101160_b0085","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.radonc.2009.02.010","article-title":"High-dose radiotherapy or concurrent chemo-radiation in lung cancer patients only induces a temporary, reversible decline in QoL","volume":"91","author":"Pijls-Johannesma","year":"2009","journal-title":"Radiother Oncol"},{"issue":"22","key":"10.1016\/j.ctro.2026.101160_b0090","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1200\/JCO.2007.14.6647","article-title":"Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy","volume":"26","author":"Langendijk","year":"2008","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1016\/j.ctro.2026.101160_b0095","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.oraloncology.2011.05.012","article-title":"The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy","volume":"47","author":"Ramaekers","year":"2011","journal-title":"Oral Oncol"},{"issue":"3","key":"10.1016\/j.ctro.2026.101160_b0100","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.radonc.2016.08.021","article-title":"Ten years results of the Canadian breast intensity modulated radiation therapy (IMRT) randomized controlled trial","volume":"121","author":"Pignol","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2026.101160_b0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.radonc.2022.09.020","article-title":"The correlation between pre-treatment symptoms, acute and late toxicity and patient-reported health-related quality of life in non-small cell lung cancer patients: results of the REQUITE study","volume":"176","author":"van der Weijst","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2026.101160_b0110","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.radonc.2021.01.014","article-title":"Towards the clinical implementation of intensity-modulated proton therapy for thoracic indications with moderate motion: Robust optimised plan evaluation by means of patient and machine specific information","volume":"157","author":"Ribeiro","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2026.101160_b0115","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.radonc.2022.11.001","article-title":"Robustness assessment of clinical adaptive proton and photon radiotherapy for oesophageal cancer in the model-based approach","volume":"177","author":"Visser","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ctro.2026.101160_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmp.2024.104890","article-title":"Proton therapy of lung cancer patients - Treatment strategies and clinical experience from a medical physicist's perspective","volume":"130","author":"Taasti","year":"2025","journal-title":"Phys Medica: PM"},{"issue":"4","key":"10.1016\/j.ctro.2026.101160_b0125","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jval.2016.01.003","article-title":"Dutch tariff for the five-level version of EQ-5D","volume":"19","author":"Versteegh","year":"2016","journal-title":"Value Health"},{"issue":"1","key":"10.1016\/j.ctro.2026.101160_b0130","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/0284186X.2019.1670356","article-title":"The relative effectiveness of eribulin for advanced breast cancer treatment: a study of the southeast Netherlands advanced breast cancer registry","volume":"59","author":"Pouwels","year":"2020","journal-title":"Acta Oncol (Stockholm, Sweden)"},{"key":"10.1016\/j.ctro.2026.101160_b0135","unstructured":"Ridgeway, G., McCaffrey, D., Morral, A., Cefalu, M., Burgette, L., Pane, J., & Griffin, B. A. (2024). Toolkit for Weighting and Analysis of Nonequivalent Groups: A Guide to the twang Package. Retrieved from https:\/\/cran.r-project.org\/web\/packages\/twang\/vignettes\/twang.pdf."},{"key":"10.1016\/j.ctro.2026.101160_b0140","series-title":"Flexible imputation of missing data","first-page":"161","article-title":"Stepwise model selection","author":"van Buuren","year":"2018"},{"issue":"1","key":"10.1016\/j.ctro.2026.101160_b0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12955-024-02294-3","article-title":"Estimating the minimally important difference for the EQ-5D-5L and EORTC QLQ-C30 in cancer","volume":"22","author":"Bourke","year":"2024","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.ctro.2026.101160_b0150","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejca.2023.04.027","volume":"188","author":"Musoro","year":"2023","journal-title":"Eur J Cancer (Oxford, England: 1990)"},{"issue":"8","key":"10.1016\/j.ctro.2026.101160_b0155","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s11136-018-1809-4","article-title":"Measuring health-related quality of life in patients with advanced cancer: a systematic review of self-administered measurement instruments","volume":"27","author":"van Roij","year":"2018","journal-title":"Qual Life Res"},{"issue":"14","key":"10.1016\/j.ctro.2026.101160_b0160","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1200\/JCO.18.01074","article-title":"Comparison of population-based observational studies with randomized trials in oncology","volume":"37","author":"Soni","year":"2019","journal-title":"J Clin Oncol"}],"container-title":["Clinical and Translational Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630826000558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405630826000558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:45:33Z","timestamp":1783395933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405630826000558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"alternative-id":["S2405630826000558"],"URL":"https:\/\/doi.org\/10.1016\/j.ctro.2026.101160","relation":{},"ISSN":["2405-6308"],"issn-type":[{"value":"2405-6308","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the impact of proton versus photon therapy on health-related quality of life in lung cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical and Translational Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctro.2026.101160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101160"}}