{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:31:06Z","timestamp":1791984666287,"version":"4.4.0"},"reference-count":127,"publisher":"Elsevier BV","issue":"4","content-domain":{"domain":["patient-research.elsevier.com","cancertreatmentreviews.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment Reviews"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.ctrv.2013.10.001","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T06:45:42Z","timestamp":1381819542000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":397,"title":["The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets"],"prefix":"10.1016","volume":"40","author":[{"given":"Steven L.","family":"Wood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pernemalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Crosbie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Whetton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctrv.2013.10.001_b0005","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1200\/JCO.2010.28.8126","article-title":"The evolving role of histology in the management of advanced non-small-cell lung cancer","volume":"28","author":"Langer","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0010","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1164\/rccm.201206-1113OC","article-title":"Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease","volume":"186","author":"Thomsen","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ctrv.2013.10.001_b0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2011.09.024","article-title":"Tumor metastasis: molecular insights and evolving paradigms","volume":"147","author":"Valastyan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix metalloproteinases: regulators of the tumor microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"issue":"Suppl 1","key":"10.1016\/j.ctrv.2013.10.001_b0025","first-page":"73","article-title":"The modality of transendothelial passage of lymphocytes and tumor cells in the absorbing lymphatic vessel","volume":"51","author":"Azzali","year":"2007","journal-title":"Eur J Histochem"},{"key":"10.1016\/j.ctrv.2013.10.001_b0030","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0035","first-page":"149","article-title":"Roles of caveolin-1 on anoikis resistance in non small cell lung cancer","volume":"4","author":"Chunhacha","year":"2012","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0040","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/71429","article-title":"Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis","volume":"6","author":"Al-Mehdi","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.ctrv.2013.10.001_b0045","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc865","article-title":"Dissemination and growth of cancer cells in metastatic sites","volume":"2","author":"Chambers","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0050","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nature05760","article-title":"Mediators of vascular remodelling co-opted for sequential steps in lung metastasis","volume":"446","author":"Gupta","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ctrv.2013.10.001_b0055","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrc2621","article-title":"The metastatic niche: adapting the foreign soil","volume":"9","author":"Psaila","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccr.2008.11.012","article-title":"Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche","volume":"15","author":"Erler","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ccr.2009.05.017","article-title":"Latent bone metastasis in breast cancer tied to Src-dependent survival signals","volume":"16","author":"Zhang","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0070","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0075","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrc2622","article-title":"Metastasis: from dissemination to organ-specific colonization","volume":"9","author":"Nguyen","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0080","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ncb2548","article-title":"Classifying collective cancer cell invasion","volume":"14","author":"Friedl","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1476-4598-10-127","article-title":"L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer","volume":"10","author":"Tischler","year":"2011","journal-title":"Mol Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0090","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1172\/JCI42975","article-title":"The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1","volume":"121","author":"Pan","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ctrv.2013.10.001_b0095","doi-asserted-by":"crossref","first-page":"23514","DOI":"10.1074\/jbc.M801125200","article-title":"Snail regulates cell\u2013matrix adhesion by regulation of the expression of integrins and basement membrane proteins","volume":"283","author":"Haraguchi","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ctrv.2013.10.001_b0100","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/thx.2009.115691","article-title":"Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and snail expression in resectable non-small cell lung cancer","volume":"64","author":"Hung","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.ctrv.2013.10.001_b0105","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1097\/JTO.0b013e31826bfbc6","article-title":"The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy","volume":"7","author":"O\u2019Flaherty","year":"2012","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0110","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1517\/13543784.2012.693478","article-title":"Tumor-stromal interactions in lung cancer: novel candidate targets for therapeutic intervention","volume":"21","author":"El-Nikhely","year":"2012","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.ctrv.2013.10.001_b0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","author":"Ramaswamy","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.ctrv.2013.10.001_b0120","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc2618","article-title":"Microenvironmental regulation of metastasis","volume":"9","author":"Joyce","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.gde.2009.11.004","article-title":"Inflammation and oncogenesis: a vicious connection","volume":"20","author":"Grivennikov","year":"2010","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.ctrv.2013.10.001_b0130","doi-asserted-by":"crossref","first-page":"6630","DOI":"10.1158\/1078-0432.CCR-09-1001","article-title":"Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors","volume":"15","author":"Wang","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0135","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.cad.0000217434.48870.f9","article-title":"Pulmonary fibroblasts stimulate the proliferation of cell lines from human lung adenocarcinomas","volume":"17","author":"Cekanova","year":"2006","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.ctrv.2013.10.001_b0140","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1093\/hmg\/ddn252","article-title":"Expression of p21waf1\/Cip1 in stromal fibroblasts of primary breast tumors","volume":"17","author":"Trimis","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ctrv.2013.10.001_b0145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1155\/2010\/824217","article-title":"P21\/waf1 and smooth-muscle actin alpha expression in stromal fibroblasts of oral cancers","volume":"33","author":"Chatzistamou","year":"2010","journal-title":"Anal Cell Pathol (Amst)"},{"key":"10.1016\/j.ctrv.2013.10.001_b0150","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/onc.2008.445","article-title":"Cancer cells suppress p53 in adjacent fibroblasts","volume":"28","author":"Bar","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.ctrv.2013.10.001_b0155","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/hep.510260612","article-title":"Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor","volume":"26","author":"Neaud","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.ctrv.2013.10.001_b0160","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccr.2011.01.020","article-title":"Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth","volume":"19","author":"Quante","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0165","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/onc.2012.91","article-title":"Autocrine IL-1beta-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFalpha signalling to carcinoma-associated fibroblasts","volume":"32","author":"Chaudhry","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.ctrv.2013.10.001_b0170","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00432-012-1328-6","article-title":"Significance of cancer-associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer","volume":"139","author":"An","year":"2013","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0175","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jtcvs.2010.11.056","article-title":"Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12\/CXCR4 axis: role in non-small cell lung cancer tumor proliferation","volume":"141","author":"Wald","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ctrv.2013.10.001_b0180","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb2756","article-title":"Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts","volume":"15","author":"Calvo","year":"2013","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0185","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1620\/tjem.220.319","article-title":"Transforming growth factor-beta upregulates the expression of integrin and related proteins in MRC-5 human myofibroblasts","volume":"220","author":"Honda","year":"2010","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.ctrv.2013.10.001_b0190","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in cancer","volume":"134","author":"Massague","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0195","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/sj.bjc.6605950","article-title":"Bcl-2 and beta1-integrin predict survival in a tissue microarray of small cell lung cancer","volume":"103","author":"Lawson","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0200","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/cas.12099","article-title":"Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma","volume":"104","author":"Kinoshita","year":"2013","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ctrv.2013.10.001_b0205","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10555-010-9222-7","article-title":"Bone marrow-derived mesenchymal stem cells and the tumor microenvironment","volume":"29","author":"Bergfeld","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.ctrv.2013.10.001_b0210","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1634\/stemcells.2005-0271","article-title":"Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases","volume":"24","author":"Son","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.ctrv.2013.10.001_b0215","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/156652412800619950","article-title":"Immunosuppressive properties of mesenchymal stem cells: advances and applications","volume":"12","author":"De Miguel","year":"2012","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.ctrv.2013.10.001_b0220","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1080\/10428190701361869","article-title":"Multipotent mesenchymal stromal cells and immune tolerance","volume":"48","author":"Noel","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.ctrv.2013.10.001_b0225","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lungcan.2012.12.015","article-title":"Mesenchymal stem cells in non-small cell lung cancer\u2013different from others? Insights from comparative molecular and functional analyses","volume":"80","author":"Gottschling","year":"2013","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0230","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/JTO.0b013e3182542752","article-title":"Interleukin-17 and prostaglandin E2 are involved in formation of an M2 macrophage-dominant microenvironment in lung cancer","volume":"7","author":"Liu","year":"2012","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0235","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.lungcan.2011.04.009","article-title":"Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression","volume":"74","author":"Wang","year":"2011","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0240","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2407-10-112","article-title":"The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time","volume":"10","author":"Ma","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0245","doi-asserted-by":"crossref","first-page":"485468","DOI":"10.1155\/2010\/485468","article-title":"Cytokines and growth factors stimulate hyaluronan production: role of hyaluronan in epithelial to mesenchymal-like transition in non-small cell lung cancer","volume":"2010","author":"Chow","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0250","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1089\/cbr.2012.1241","article-title":"Lysyl oxidase may play a critical role in hypoxia-induced NSCLC cells invasion and migration","volume":"27","author":"Wei","year":"2012","journal-title":"Cancer Biother Radiopharm"},{"key":"10.1016\/j.ctrv.2013.10.001_b0255","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/cncr.25768","article-title":"Lysyl oxidase: a lung adenocarcinoma biomarker of invasion and survival","volume":"117","author":"Wilgus","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0260","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0265","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1158\/1055-9965.EPI-07-2840","article-title":"Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer","volume":"17","author":"Sauter","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ctrv.2013.10.001_b0270","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2407-12-121","article-title":"Genetic polymorphisms in MMP 2, 9 and 3 genes modify lung cancer risk and survival","volume":"12","author":"Gonzalez-Arriaga","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0275","doi-asserted-by":"crossref","first-page":"744","DOI":"10.2174\/187152012802650156","article-title":"Differential expressions of matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers","volume":"12","author":"Hida","year":"2012","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.ctrv.2013.10.001_b0280","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0140-6736(77)90663-8","article-title":"A common familial component in lung cancer and chronic obstructive pulmonary disease","volume":"2","author":"Cohen","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.ctrv.2013.10.001_b0285","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35065016","article-title":"Involvement of chemokine receptors in breast cancer metastasis","volume":"410","author":"Muller","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ctrv.2013.10.001_b0290","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/bcr3074","article-title":"Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis","volume":"13","author":"Hernandez","year":"2011","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0295","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1183\/09031936.00044911","article-title":"A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease","volume":"39","author":"Costello","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ctrv.2013.10.001_b0300","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/cncr.24281","article-title":"Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer","volume":"115","author":"Iwakiri","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0305","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1084\/jem.20052144","article-title":"A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development","volume":"203","author":"Burns","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.ctrv.2013.10.001_b0310","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1073\/pnas.101138098","article-title":"Notch signaling during vascular development","volume":"98","author":"Gridley","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ctrv.2013.10.001_b0315","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s12032-013-0595-7","article-title":"Notch3 overexpression associates with poor prognosis in human non-small-cell lung cancer","volume":"30","author":"Ye","year":"2013","journal-title":"Med Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0320","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/ijc.23825","article-title":"Review: biological relevance of disseminated tumor cells in cancer patients","volume":"123","author":"Riethdorf","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0325","first-page":"1027","article-title":"Immunocytological detection of bone marrow micrometastasis in operable non-small cell lung cancer","volume":"53","author":"Pantel","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0330","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.cellsig.2011.07.003","article-title":"Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells","volume":"23","author":"Grabinski","year":"2011","journal-title":"Cell Signal"},{"key":"10.1016\/j.ctrv.2013.10.001_b0335","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/JTO.0b013e31823c5c16","article-title":"Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches","volume":"7","author":"Krebs","year":"2012","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0340","doi-asserted-by":"crossref","first-page":"016005","DOI":"10.1088\/1478-3967\/9\/1\/016005","article-title":"Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology","volume":"9","author":"Wendel","year":"2012","journal-title":"Phys Biol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0345","doi-asserted-by":"crossref","first-page":"e12517","DOI":"10.1371\/journal.pone.0012517","article-title":"Molecular biomarker analyses using circulating tumor cells","volume":"5","author":"Punnoose","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ctrv.2013.10.001_b0350","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.lungcan.2012.04.005","article-title":"ERCC1 expression in circulating tumor cells (CTCs) using a novel detection platform correlates with progression-free survival (PFS) in patients with metastatic non-small-cell lung cancer (NSCLC) receiving platinum chemotherapy","volume":"77","author":"Das","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0355","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1158\/0008-5472.CAN-09-2123","article-title":"Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity","volume":"69","author":"Kopp","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0360","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.2741\/3909","article-title":"Interactions between endothelial selectins and cancer cells regulate metastasis","volume":"16","author":"St Hill","year":"2011","journal-title":"Front Biosci"},{"key":"10.1016\/j.ctrv.2013.10.001_b0365","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00418-011-0804-4","article-title":"Adhesion of small cell lung cancer cells to E- and P-selectin under physiological flow conditions: implications for metastasis formation","volume":"135","author":"Richter","year":"2011","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0370","doi-asserted-by":"crossref","first-page":"306879","DOI":"10.1155\/2012\/306879","article-title":"Anoikis resistance: an essential prerequisite for tumor metastasis","volume":"2012","author":"Kim","year":"2012","journal-title":"Int J Cell Biol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0375","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s12032-013-0536-5","article-title":"The prognostic value of platelet endothelial cell adhesion molecule-1 in non-small-cell lung cancer patients","volume":"30","author":"Kuang","year":"2013","journal-title":"Med Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0380","doi-asserted-by":"crossref","DOI":"10.1111\/cas.12154","article-title":"Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells","author":"Uekita","year":"2013","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ctrv.2013.10.001_b0385","first-page":"98","article-title":"The distribution of secondary growths in cancer of the breast. 1889","volume":"8","author":"Paget","year":"1989","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.ctrv.2013.10.001_b0390","doi-asserted-by":"crossref","first-page":"18721","DOI":"10.1073\/pnas.0609025103","article-title":"Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness","volume":"103","author":"Galaup","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ctrv.2013.10.001_b0395","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1158\/1541-7786.327.2.6","article-title":"Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells","volume":"2","author":"Lee","year":"2004","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0400","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/ijc.22879","article-title":"Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alphavbeta3 integrin","volume":"121","author":"Bauer","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0405","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/156800909787314002","article-title":"The urokinase plasminogen activator system: a target for anti-cancer therapy","volume":"9","author":"Ulisse","year":"2009","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.ctrv.2013.10.001_b0410","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1055\/s-0038-1657541","article-title":"Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy","volume":"78","author":"Schmitt","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ctrv.2013.10.001_b0415","first-page":"292","article-title":"Does ionizing radiation stimulate cancer invasion and metastasis?","volume":"95","author":"Madani","year":"2008","journal-title":"Bull Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0420","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10585-008-9209-8","article-title":"Three-dimensional context regulation of metastasis","volume":"26","author":"Erler","year":"2009","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.ctrv.2013.10.001_b0425","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1538-7836.2011.04571.x","article-title":"Megakaryocytes, malignancy and bone marrow vascular niches","volume":"10","author":"Psaila","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ctrv.2013.10.001_b0430","first-page":"63","article-title":"Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer","volume":"4","author":"Matthews","year":"1973","journal-title":"Cancer Chemother Rep 3"},{"key":"10.1016\/j.ctrv.2013.10.001_b0435","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0003-4975(96)00220-2","article-title":"Distribution of distant metastases from newly diagnosed non-small cell lung cancer","volume":"62","author":"Quint","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ctrv.2013.10.001_b0440","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1200\/JCO.1988.6.9.1474","article-title":"Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis","volume":"6","author":"Sorensen","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0445","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11060-004-8093-6","article-title":"Brain metastases: epidemiology and pathophysiology","volume":"75","author":"Gavrilovic","year":"2005","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0450","doi-asserted-by":"crossref","first-page":"156S","DOI":"10.1378\/chest.125.5_suppl.156S","article-title":"The SDF-1\/CXCL 12\/CXCR4 biological axis in non-small cell lung cancer metastases","volume":"125","author":"Belperio","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.ctrv.2013.10.001_b0455","first-page":"6304","article-title":"Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells","volume":"62","author":"Kijima","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0460","doi-asserted-by":"crossref","first-page":"E1291","DOI":"10.1073\/pnas.1220580110","article-title":"Targeting CXCL12\/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases","volume":"110","author":"Gil","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ctrv.2013.10.001_b0465","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7150\/thno.5376","article-title":"Small molecule inhibitors of CXCR4","volume":"3","author":"Debnath","year":"2013","journal-title":"Theranostics"},{"key":"10.1016\/j.ctrv.2013.10.001_b0470","first-page":"1801","article-title":"A cancer stem cell model for studying brain metastases from primary lung cancer","volume":"107","author":"Nolte","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ctrv.2013.10.001_b0475","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/cncr.22195","article-title":"Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer","volume":"107","author":"Castellvi","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0480","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1158\/1078-0432.CCR-06-1560","article-title":"4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis","volume":"13","author":"Rojo","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0485","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1021\/pr200065t","article-title":"Protein pathway activation mapping of brain metastasis from lung and breast cancers reveals organ type specific drug target activation","volume":"10","author":"Improta","year":"2011","journal-title":"J Proteome Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0490","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.lungcan.2007.03.013","article-title":"Skeletal metastases in non-small cell lung cancer: a retrospective study","volume":"57","author":"Tsuya","year":"2007","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0495","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.lungcan.2008.10.026","article-title":"Risk factors for skeletal-related events in patients with non-small cell lung cancer treated by chemotherapy","volume":"65","author":"Sekine","year":"2009","journal-title":"Lung Cancer"},{"issue":"3","key":"10.1016\/j.ctrv.2013.10.001_b0640","doi-asserted-by":"crossref","first-page":"e58361","DOI":"10.1371\/journal.pone.0058361","article-title":"Differential regulation of the RANKL\/RANK\/OPG system is associated with bone metastasis in human non-small cell lung cancer","volume":"8","author":"Peng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ctrv.2013.10.001_b0505","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/CCO.0b013e32835d720b","article-title":"Targeting receptor activator of nuclear factor-kappa B as a new therapy for bone metastasis in non-small cell lung cancer","volume":"25","author":"Peters","year":"2013","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0510","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1200\/JCO.2009.26.4325","article-title":"Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer","volume":"28","author":"Zhu","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0515","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1158\/1078-0432.CCR-11-2893","article-title":"L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer","volume":"18","author":"Hai","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0520","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1378\/chest.97.5.1052","article-title":"Extrathoracic staging of bronchogenic carcinoma","volume":"97","author":"Salvatierra","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.ctrv.2013.10.001_b0525","doi-asserted-by":"crossref","first-page":"33608","DOI":"10.1074\/jbc.M102754200","article-title":"Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit","volume":"276","author":"Brodt","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ctrv.2013.10.001_b0530","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1038\/onc.2011.89","article-title":"Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis","volume":"30","author":"Burnier","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.ctrv.2013.10.001_b0535","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1158\/0008-5472.CAN-09-0315","article-title":"Integrin alpha2 mediates selective metastasis to the liver","volume":"69","author":"Yoshimura","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.ctrv.2013.10.001_b0540","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10585-012-9540-y","article-title":"Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironment","volume":"30","author":"Sato","year":"2013","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.ctrv.2013.10.001_b0545","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/1097-0142(1950)3:1<74::AID-CNCR2820030111>3.0.CO;2-7","article-title":"Metastases in carcinoma; analysis of 1000 autopsied cases","volume":"3","author":"Abrams","year":"1950","journal-title":"Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0550","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jtcvs.2004.09.020","article-title":"Surgical treatment of solitary adrenal metastasis from non-small cell lung cancer","volume":"130","author":"Mercier","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ctrv.2013.10.001_b0555","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0096-5588(20)30197-5","article-title":"Direct lymphatic connections from the lower lobes of the lung to the abdomen","volume":"35","author":"Meyer","year":"1958","journal-title":"J Thorac Surg"},{"key":"10.1016\/j.ctrv.2013.10.001_b0560","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3816\/CLC.2010.n.024","article-title":"Expression of chemokine receptor CCR6 as a molecular determinant of adrenal metastatic relapse in patients with primary lung cancer","volume":"11","author":"Raynaud","year":"2010","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0565","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1165\/rcmb.2002-0272OC","article-title":"CCL20 is an inducible product of human airway epithelia with innate immune properties","volume":"29","author":"Starner","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0570","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/JTO.0b013e31815e8ba2","article-title":"Comparison between epidermal growth factor receptor (EGFR) gene expression in primary non-small cell lung cancer (NSCLC) and in fine-needle aspirates from distant metastatic sites","volume":"3","author":"Bozzetti","year":"2008","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0575","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.lungcan.2008.10.030","article-title":"Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases","volume":"65","author":"Raynaud","year":"2009","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0580","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm1469","article-title":"Tumor metastasis: mechanistic insights and clinical challenges","volume":"12","author":"Steeg","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.ctrv.2013.10.001_b0585","doi-asserted-by":"crossref","first-page":"740","DOI":"10.6004\/jnccn.2010.0056","article-title":"Non-small cell lung cancer","volume":"8","author":"Ettinger","year":"2010","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.ctrv.2013.10.001_b0590","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ccr.2009.01.027","article-title":"Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis","volume":"15","author":"Paez-Ribes","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ctrv.2013.10.001_b0595","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.ejca.2010.02.020","article-title":"Mechanisms of resistance to antiangiogenesis therapy","volume":"46","author":"Azam","year":"2010","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0600","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrc3055","article-title":"Cancer to bone: a fatal attraction","volume":"11","author":"Weilbaecher","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0605","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1586\/era.12.121","article-title":"EGF receptor tyrosine kinase inhibitors in the treatment of brain metastases from non-small-cell lung cancer","volume":"12","author":"Bartolotti","year":"2012","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.ctrv.2013.10.001_b0610","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1183\/09031936.00195609","article-title":"Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation","volume":"37","author":"Porta","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ctrv.2013.10.001_b0615","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1056\/NEJMoa061884","article-title":"Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer","volume":"355","author":"Sandler","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctrv.2013.10.001_b0620","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/bjc.2011.147","article-title":"Vascular phenotypes in primary non-small cell lung carcinomas and matched brain metastases","volume":"104","author":"Jubb","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0625","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1200\/JCO.2009.22.0616","article-title":"Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases","volume":"27","author":"Socinski","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2013.10.001_b0630","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrc1886","article-title":"Metastasis: a question of life or death","volume":"6","author":"Mehlen","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ctrv.2013.10.001_b0635","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1056\/NEJMoa011954","article-title":"Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer","volume":"346","author":"Schiller","year":"2002","journal-title":"N Engl J Med"}],"container-title":["Cancer Treatment Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305737213002053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305737213002053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T09:58:24Z","timestamp":1688551104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305737213002053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":127,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0305737213002053"],"URL":"https:\/\/doi.org\/10.1016\/j.ctrv.2013.10.001","relation":{},"ISSN":["0305-7372"],"issn-type":[{"value":"0305-7372","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctrv.2013.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}