{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:39:56Z","timestamp":1793943596652,"version":"4.8.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004897","name":"European Organisation for Research and Treatment of Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cancertreatmentreviews.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment Reviews"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ctrv.2025.102926","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T02:42:14Z","timestamp":1743302534000},"page":"102926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["EORTC consensus recommendations on the optimal management of colorectal cancer liver metastases"],"prefix":"10.1016","volume":"136","author":[{"given":"Giacomo","family":"Bregni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Bale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A","family":"Bali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bargellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Blomqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cremolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Demetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Denecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Dohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Dopazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Elez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Evrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Feakins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Guckenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Gronlie","family":"Guren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hoorens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Huguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Intven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Koessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang G","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lordick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Lucidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas H","family":"Mahnken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Martinive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Mauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra M\u00e9ndez","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Nagtegaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim JG","family":"Oyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pellerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Ricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ricoeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Riddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Ronot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Scorsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Seligmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sempoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Sheahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"St\u00e4ttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Svrcek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Taieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucjan","family":"Wyrwicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J","family":"Zech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Moehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sclafani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctrv.2025.102926_b0005","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/cam4.2673","article-title":"Metastatic patterns and survival outcomes in patients with stage IV colon cancer: a population-based analysis","volume":"9","author":"Wang","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.ctrv.2025.102926_b0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejca.2022.01.012","article-title":"Predicting 10-year survival after resection of colorectal liver metastases; an international study including biomarkers and perioperative treatment","volume":"168","author":"Buisman","year":"2022","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/SLA.0000000000002524","article-title":"The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation","volume":"268","author":"Abu Hilal","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1200\/EDBK_320519","article-title":"Locoregional therapies for colorectal cancer liver metastases: options beyond resection","volume":"41","author":"Uhlig","year":"2021","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.ctrv.2025.102926_b0025","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S2468-1253(21)00219-3","article-title":"Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines","volume":"6","author":"Bonney","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.ctrv.2025.102926_b0030","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0140-6736(24)01595-2","article-title":"Liver transplantation plus chemotherapy versus chemotherapy alone in patients with permanently unresectable colorectal liver metastases (TransMet): results from a multicentre, open-label, prospective, randomised controlled trial","volume":"404","author":"Adam","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ctrv.2025.102926_b0035","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejca.2020.09.037","article-title":"Conversion strategies with chemotherapy plus targeted agents for colorectal cancer liver-only metastases: A systematic review","volume":"141","author":"Bolhuis","year":"2020","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0040","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/ijc.33881","article-title":"Survival after secondary liver resection in metastatic colorectal cancer: Comparing data of three prospective randomized European trials (LICC, CELIM, FIRE-3)","volume":"150","author":"Moehler","year":"2022","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","article-title":"Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Cervantes","year":"2023","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0050","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Colon Cancer Version 2.2024 \u2014 April 30, 2024. Available at https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colon.pdf (Accessed on 06.05.2024)."},{"key":"10.1016\/j.ctrv.2025.102926_b0055","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1046\/j.1365-2648.2000.t01-1-01567.x","article-title":"Research guidelines for the Delphi survey technique","volume":"32","author":"Hasson","year":"2000","journal-title":"J Adv Nurs"},{"key":"10.1016\/j.ctrv.2025.102926_b0060","unstructured":"OCEBM Levels of Evidence Working Group. The Oxford 2011 Levels of Evidence. Oxford Centre for Evidence-Based Medicine (available at http:\/\/www.cebm.net\/index.aspx?o=5653). Accessed on 09.02.2025."},{"key":"10.1016\/j.ctrv.2025.102926_b0065","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1470-2045(24)00660-0","article-title":"Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomized, controlled, phase 3 non-inferiority trial","volume":"26","author":"van der Lei","year":"2025","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1470-2045(23)00572-7","article-title":"MRI in addition to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): an international, multicentre, prospective, diagnostic accuracy trial","volume":"25","author":"G\u00f6rgec","year":"2024","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0075","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/bjc.2014.351","article-title":"Imaging in resectable colorectal liver metastasis patients with or without preoperative chemotherapy: results of the PROMETEO-01 study","volume":"111","author":"Rojas Llimpe","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.730854","article-title":"Comprehensive imaging characterization of colorectal liver metastases","volume":"11","author":"Maclean","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0085","article-title":"Repeated centralized multidisciplinary team assessment of resectability, clinical behavior, and outcomes in 1086 Finnish metastatic colorectal cancer patients (RAXO): a nationwide prospective intervention study","volume":"3","author":"Osterlund","year":"2021","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.ctrv.2025.102926_b0090","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1245\/s10434-023-13510-7","article-title":"Intersurgeon variability in local treatment planning for patients with initially unresectable colorectal cancer liver metastases: analysis of the liver expert panel of the Dutch Colorectal Cancer Group","volume":"30","author":"Bond","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0095","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/bjs\/znad233","article-title":"E-AHPBA-ESSO-ESSR Innsbruck consensus guidelines for preoperative liver function assessment before hepatectomy","volume":"110","author":"Primavesi","year":"2023","journal-title":"Br J Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0100","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3390\/cancers12071779","article-title":"Resectability and ablatability criteria for the treatment of liver only colorectal metastases: multidisciplinary consensus document from the COLLISION Trial Group","volume":"12","author":"Nieuwenhuizen","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ctrv.2025.102926_b0105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejca.2023.03.038","article-title":"A prospective multicentre trial on survival after Microwave Ablation VErsus Resection for Resectable Colorectal liver metastases (MAVERRIC)","volume":"187","author":"Tinguely","year":"2023","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0110","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.ijrobp.2020.11.045","article-title":"The Dutch-Belgian registry of stereotactic body radiation therapy for liver metastases: clinical outcomes of 515 patients and 668 metastases","volume":"109","author":"M\u00e9ndez Romero","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ctrv.2025.102926_b0115","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/s12885-024-12162-4","article-title":"Prognostic factors associated with early recurrence following liver resection for colorectal liver metastases: a systematic review and meta-analysis","volume":"24","author":"Tian","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0120","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.ejso.2022.06.021","article-title":"Prediction of survival in patients with colorectal liver metastases- development and validation of a prognostic score model","volume":"48","author":"Villard","year":"2022","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0125","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","article-title":"Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial","volume":"14","author":"Nordlinger","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0130","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/SLA.0b013e3182456aa2","article-title":"Predictive factors for the benefit of perioperative FOLFOX for resectable liver metastasis in colorectal cancer patients (EORTC Intergroup Trial 40983)","volume":"255","author":"Sorbye","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0135","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1470-2045(19)30798-3","article-title":"Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial","volume":"21","author":"Bridgewater","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0140","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1200\/JCO.21.01032","article-title":"Hepatectomy followed by mFOLFOX6 versus hepatectomy alone for liver-only metastatic colorectal cancer (JCOG0603): a phase II or III randomized controlled trial","volume":"39","author":"Kanemitsu","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0145","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1470-2045(22)00197-8","article-title":"Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study","volume":"23","author":"Diaz","year":"2022","journal-title":"Lancet Oncol"},{"issue":"Suppl_3","key":"10.1016\/j.ctrv.2025.102926_b0150","article-title":"Nivolumab (NIVO) plus ipilimumab (IPI) vs chemotherapy (chemo) as first-line (1L) treatment for microsatellite instability-high\/mismatch repair-deficient (MSI-H\/dMMR) metastatic colorectal cancer (mCRC): First results of the CheckMate 8HW study","volume":"42","author":"Andre","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.suronc.2019.02.005","article-title":"Disappearing liver metastases: A systematic review of the current evidence","volume":"29","author":"Tsilimigras","year":"2019","journal-title":"Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0160","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12957-020-02037-w","article-title":"Imaging in disappearing colorectal liver metastases and their accuracy: a systematic review","volume":"18","author":"Barimani","year":"2020","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0165","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/jnci\/djaa052","article-title":"Pathological tumor response following immune checkpoint blockade for deficient mismatch repair advanced colorectal cancer","volume":"113","author":"Ludford","year":"2021","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ctrv.2025.102926_b0170","doi-asserted-by":"crossref","DOI":"10.1093\/bjsopen\/zrac051","article-title":"The dilemma of the disappeared colorectal liver metastasis: systematic review of reviews and evidence gap map","volume":"6","author":"Nassar","year":"2022","journal-title":"BJS Open"},{"key":"10.1016\/j.ctrv.2025.102926_b0175","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.hpb.2020.10.005","article-title":"Management of disappearing colorectal liver metastases: an international survey","volume":"23","author":"Melstrom","year":"2021","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.ctrv.2025.102926_b0180","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1470-2045(23)00219-X","article-title":"First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group","volume":"24","author":"Bond","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0185","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1200\/JCO.22.00839","volume":"40","author":"Rossini","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004389","article-title":"Cetuximab plus FOLFOXIRI versus cetuximab plus FOLFOX as conversion regimen in RAS\/BRAF wild-type patients with initially unresectable colorectal liver metastases (TRICE trial): A randomized controlled trial","volume":"21","author":"Wang","year":"2024","journal-title":"PLoS Med"},{"key":"10.1016\/j.ctrv.2025.102926_b0195","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/annonc\/mdu580","article-title":"Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: the OLIVIA multinational randomised phase II trial","volume":"26","author":"Gruenberger","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0200","doi-asserted-by":"crossref","first-page":"8198","DOI":"10.1245\/s10434-021-10220-w","article-title":"Liver-first approach for synchronous colorectal metastases: analysis of 7360 patients from the LiverMetSurvey registry","volume":"28","author":"Giuliante","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.critrevonc.2019.05.004","article-title":"The treatment of rectal cancer with synchronous liver metastases: A matter of strategy","volume":"139","author":"Gelsomino","year":"2019","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ctrv.2025.102926_b0210","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.ejso.2022.11.010","article-title":"Two stage hepatectomy (TSH) versus ALPPS for initially unresectable colorectal liver metastases: a systematic review and meta-analysis","volume":"49","author":"D\u00edaz Vico","year":"2023","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2023.107081","article-title":"EORTC 1409 GITCG\/ESSO 01 - a prospective colorectal liver metastasis database for borderline or initially unresectable diseases (CLIMB): lessons learnt from real life. From paradigm to unmet need","volume":"49","author":"Collienne","year":"2023","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0220","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/SLA.0000000000002664","article-title":"Prognostic factors change over time after hepatectomy for colorectal liver metastases: a multi-institutional, international analysis of 1099 patients","volume":"269","author":"Margonis","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0225","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1097\/SLA.0000000000004077","article-title":"Risk factors of positive resection margin in laparoscopic and open liver surgery for colorectal liver metastases: a new perspective in the perioperative assessment: a European multicenter study","volume":"275","author":"Benedetti Cacciaguerra","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0230","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1001\/jamaoncol.2022.4394","article-title":"Treatment with stereotactic ablative radiotherapy for up to 5 oligometastases in patients with cancer: primary toxic effect results of the nonrandomized phase 2 SABR-5 clinical trial","volume":"8","author":"Olson","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0235","doi-asserted-by":"crossref","DOI":"10.1200\/EDBK_430152","article-title":"Treatment of oligometastatic GI cancers","volume":"44","author":"Marcinak","year":"2024","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.ctrv.2025.102926_b0240","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.hpb.2017.10.013","article-title":"Advanced imaging to predict response to chemotherapy in colorectal liver metastases \u2013 a systematic review","volume":"20","author":"Beckers","year":"2018","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.ctrv.2025.102926_b0245","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/his.13378","article-title":"Pathological factors and prognosis of resected liver metastases of colorectal carcinoma: implications and proposal for a pathological reporting protocol","volume":"72","author":"Fonseca","year":"2018","journal-title":"Histopathology"},{"key":"10.1016\/j.ctrv.2025.102926_b0250","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/annonc\/mdl386","article-title":"Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery","volume":"18","author":"Rubbia-Brandt","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0255","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5858\/arpa.2017-0505-RA","article-title":"Colorectal liver metastases: a pathologist's guide to creating an informative report and improving patient care","volume":"143","author":"Moreno Prats","year":"2019","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.ctrv.2025.102926_b0260","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41416-022-01859-7","article-title":"Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights","volume":"127","author":"Latacz","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0265","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/SLA.0000000000001427","article-title":"Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?","volume":"262","author":"Sadot","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0270","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1245\/s10434-015-5009-y","article-title":"Is tumor detachment from vascular structures equivalent to R0 resection in surgery for colorectal liver metastases?","volume":"23","author":"Vigan\u00f2","year":"2016","journal-title":"An observational cohort Ann Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0275","first-page":"1254","volume":"77","author":"Nordlinger","year":"1996","journal-title":"Surgical resection of colorectal carcinoma metastases to the liver A prognostic scoring system to improve case selection"},{"key":"10.1016\/j.ctrv.2025.102926_b0280","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","article-title":"Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases","volume":"230","author":"Fong","year":"1999","journal-title":"Ann Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0285","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.3748\/wjg.v12.i43.6961","article-title":"Proposal of a new and simple staging system of colorectal liver metastasis","volume":"12","author":"Nagashima","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ctrv.2025.102926_b0290","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1478-3231.2008.01845.x","article-title":"Prognostic factors and evaluation of a clinical score for predicting survival after resection of colorectal liver metastases","volume":"29","author":"Konopke","year":"2009","journal-title":"Liver Int"},{"key":"10.1016\/j.ctrv.2025.102926_b0295","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/ijc.33924","article-title":"Circulating tumor DNA for prognosis assessment and postoperative management after curative-intent resection of colorectal liver metastases","volume":"150","author":"Reinert","year":"2022","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0300","article-title":"Circulating tumor DNA as a marker of minimal residual disease after radical resection of colorectal liver metastases","volume":"6","author":"Marmorino","year":"2022","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0305","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejca.2021.12.026","article-title":"Tumour-agnostic circulating tumour DNA analysis for improved recurrence surveillance after resection of colorectal liver metastases: A prospective cohort study","volume":"163","author":"\u00d8gaard","year":"2022","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2023.107103","article-title":"Follow up after surgery for colorectal liver metastases: A systematic review","volume":"49","author":"Jones","year":"2023","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0315","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.annonc.2020.06.022","article-title":"Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Argil\u00e9s","year":"2020","journal-title":"Ann Oncol"},{"issue":"Suppl 4","key":"10.1016\/j.ctrv.2025.102926_b0320","doi-asserted-by":"crossref","first-page":"iv263","DOI":"10.1093\/annonc\/mdy161","article-title":"Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Glynne-Jones","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0325","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejca.2016.10.026","article-title":"Regional and inter-hospital differences in the utilisation of liver surgery for patients with synchronous colorectal liver metastases in the Netherlands","volume":"71","author":"J't Lam-Boer","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2025.102926_b0330","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.suronc.2020.09.024","article-title":"The value of a dedicated multidisciplinary expert panel to assess treatment strategy in patients suffering from colorectal cancer liver metastases","volume":"35","author":"Hellingman","year":"2020","journal-title":"Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0335","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/S1470-2045(22)00506-X","article-title":"Recurrence-free survival versus overall survival as a primary endpoint for studies of resected colorectal liver metastasis: a retrospective study and meta-analysis","volume":"23","author":"Ecker","year":"2022","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctrv.2025.102926_b0340","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.ctrv.2015.06.006","article-title":"Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus","volume":"41","author":"Adam","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ctrv.2025.102926_b0345","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.hpb.2023.05.360","article-title":"The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE","volume":"25","author":"Siriwardena","year":"2023","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.ctrv.2025.102926_b0350","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.hpb.2024.01.007","article-title":"Pan-European survey on current treatment strategies in patients with upfront resectable colorectal liver metastases","volume":"26","author":"Kuiper","year":"2024","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.ctrv.2025.102926_b0355","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.surg.2020.05.023","article-title":"Are academic hospitals better at treating metastatic colorectal cancer?","volume":"169","author":"Atallah","year":"2021","journal-title":"Surgery"},{"key":"10.1016\/j.ctrv.2025.102926_b0360","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1177\/00031348211023389","article-title":"Metastasectomy for stage IVA colon cancer: does the type of treating institution make a difference?","volume":"88","author":"Kang","year":"2022","journal-title":"Am Surg"},{"issue":"7","key":"10.1016\/j.ctrv.2025.102926_b0365","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/bjs.10501","article-title":"Impact of hepatobiliary service centralization on treatment and outcomes in patients with colorectal cancer and liver metastases","volume":"104","author":"Vallance","year":"2017","journal-title":"Br J Surg"},{"key":"10.1016\/j.ctrv.2025.102926_b0370","article-title":"Centralized multidisciplinary team assessment of metastasis resectability in patients with metastatic colorectal cancer: A fundamental necessity","volume":"3","author":"Andr\u00e9","year":"2021","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.ctrv.2025.102926_b0375","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djx015","article-title":"Local treatment of unresectable colorectal liver metastases: results of a randomized phase II trial","volume":"109","author":"Ruers","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ctrv.2025.102926_b0380","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.cgh.2023.04.005","article-title":"Liver Transplantation 2023: status report, current and future challenges","volume":"21","author":"Terrault","year":"2023","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Cancer Treatment Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305737225000489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305737225000489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T21:27:49Z","timestamp":1762291669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305737225000489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":76,"alternative-id":["S0305737225000489"],"URL":"https:\/\/doi.org\/10.1016\/j.ctrv.2025.102926","relation":{},"ISSN":["0305-7372"],"issn-type":[{"value":"0305-7372","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EORTC consensus recommendations on the optimal management of colorectal cancer liver metastases","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctrv.2025.102926","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102926"}}