{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:31:36Z","timestamp":1767846696902,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007376","name":"Associazione Italiana di Oncologia Medica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cancertreatmentreviews.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Treatment Reviews"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ctrv.2025.102976","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T17:46:36Z","timestamp":1750009596000},"page":"102976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["PREDICTIVE BRCA GENETIC TESTING IN ITALIAN PATIENTS WITH BREAST CANCER: A POSITION PAPER OF ITALIAN SCIENTIFIC SOCIETIES [Italian Association of Medical Oncology(AIOM); Italian Association of Radiotherapy and Clinical Oncology (AIRO); Italian National Association of Breast Surgeons (ANISC); Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP); Italian Society of Surgical Oncology (SICO); Italian Society of Human Genetic (SIGU); Italian Society of General Practice (SIMG); Italian Society of Medical and Interventional Radiology (SIRM)]"],"prefix":"10.1016","volume":"139","author":[{"given":"L.","family":"Cortesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Miglietta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Arecco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Biganzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Del Mastro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MV.","family":"Dieci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Foglietta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fortunato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.Lucci","family":"Cordisco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mantellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Marchio\u2019","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Meduri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Micallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Musolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Salvetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Turchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zambelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Angiolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cinieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PF.","family":"Conte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Curigliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dessena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MC.","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Meattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Montemezzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Puglisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sapino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Taffurelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cinquini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ctrv.2025.102976_b0005","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1913948","article-title":"Breast cancer risk genes - association analysis in more than 113,000 women","volume":"384","author":"Dorling","year":"2021","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ctrv.2025.102976_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/genes14051025","article-title":"Hereditary cancer syndromes: a comprehensive review with a visual tool","volume":"14","author":"Garutti","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.ctrv.2025.102976_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2024.104431","article-title":"Multigenic panels in breast cancer: clinical utility and management of patients with pathogenic variants other than BRCA1\/2","volume":"201","author":"Fabi","year":"2024","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ctrv.2025.102976_b0020","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.annonc.2024.04.005","article-title":"Recommendations for the use of next-generation sequencing (NGS) for patients with advanced cancer in 2024: a report from the ESMO Precision Medicine Working Group","volume":"35","author":"Mosele","year":"2024","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0025","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10549-023-06946-8","article-title":"The association between age at breast cancer diagnosis and prevalence of pathogenic variants","volume":"199","author":"Daly","year":"2023","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ctrv.2025.102976_b0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejca.2020.12.023","article-title":"Clinical practice guidelines for BRCA1 and BRCA2 genetic testing","volume":"146","author":"Pujol","year":"2021","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2025.102976_b0035","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1056\/NEJMoa2005936","article-title":"A population-based study of genes previously implicated in breast cancer","volume":"384","author":"Hu","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0040","unstructured":"Fondazione AIOM-AIRTUM-PASSI. I Numeri del Cancro in Italia 2020. Available online: www.fondazioneaiom.it (Accessed February 9, 2025)."},{"key":"10.1016\/j.ctrv.2025.102976_b0045","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1200\/JCO.21.01532","article-title":"Adjuvant PARP inhibitors in patients with high-risk early-stage HER2-negative breast cancer and germline BRCA mutations: ASCO hereditary breast cancer guideline rapid recommendation update","volume":"39","author":"Tung","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0050","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1056\/NEJMoa2105215","article-title":"Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer","volume":"384","author":"Tutt","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0055","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1706450","article-title":"Olaparib for metastatic breast cancer in patients with a germline BRCA mutation","volume":"377","author":"Robson","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0060","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1056\/NEJMoa1802905","article-title":"Talazoparib in patients with advanced breast cancer and a germline BRCA mutation","volume":"379","author":"Litton","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0065","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1056\/NEJMoa1910549","article-title":"Pembrolizumab for early triple-negative breast cancer","volume":"382","author":"Schmid","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10549-014-2890-1","article-title":"Surgical management of breast cancer in BRCA-mutation carriers: a systematic review and meta-analysis","volume":"144","author":"Valachis","year":"2014","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ctrv.2025.102976_b0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.breast.2021.02.001","article-title":"Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - a systematic review and meta-analysis","volume":"56","author":"Davey","year":"2021","journal-title":"Breast"},{"issue":"2","key":"10.1016\/j.ctrv.2025.102976_b0080","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10549-010-0894-z","article-title":"Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy","volume":"121","author":"Pierce","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ctrv.2025.102976_b0085","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/annonc\/mdy515","article-title":"Prophylactic irradiation to the contralateral breast for BRCA mutation carriers with early-stage breast cancer","volume":"30","author":"Evron","year":"2019","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0090","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.ctrv.2025.102976_b0095","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrclinonc.2010.175","article-title":"The role of BRCA mutation testing in determining breast cancer therapy","volume":"7","author":"Trainer","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/annonc\/mdt422","article-title":"A rapid genetic counselling and testing in newly diagnosed breast cancer is associated with high rate of risk-reducing mastectomy in BRCA1\/2-positive Italian women","volume":"25","author":"Cortesi","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0105","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1200\/JCO.2007.12.6078","article-title":"Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation: the Hereditary Breast Cancer Clinical Study Group","volume":"26","author":"Metcalfe","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0110","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1245\/s10434-010-1136-7","article-title":"Contralateral prophylactic mastectomy is associated with a survival advantage in high-risk women with a personal history of breast cancer","volume":"17","author":"Boughey","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/jnci\/djq018","article-title":"Population-based study of contralateral prophylactic mastectomy and survival outcomes of breast cancer patients","volume":"102","author":"Bedrosian","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ctrv.2025.102976_b0120","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ygyno.2004.09.039","article-title":"The risk of ovarian cancer after breast cancer in BRCA1 and BRCA2 carriers","volume":"96","author":"Metcalfe","year":"2005","journal-title":"Gynecol Oncol"},{"issue":"4","key":"10.1016\/j.ctrv.2025.102976_b0125","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/jamaoncol.2023.6937","article-title":"Bilateral oophorectomy and all-cause mortality in women with BRCA1 and BRCA2 sequence variations","volume":"10","author":"Kotsopoulos","year":"2024","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0130","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012","volume":"49","author":"Ferlay","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ctrv.2025.102976_b0135","first-page":"87","article-title":"Global cancer statistics","volume":"2015","author":"Torre","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ctrv.2025.102976_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2024.108603","article-title":"Can contralateral prophylactic mastectomy and oophorectomy increase survival in BRCA-related breast cancer? Results from the Italian MUTina study","volume":"50","author":"Cortesi","year":"2024","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13053-017-0071-z","article-title":"Preoperative genetic testing impacts surgical decision making in BRCA mutation carriers with breast cancer: a retrospective cohort analysis","volume":"15","author":"Yadav","year":"2017","journal-title":"Hered Cancer Clin Pract"},{"key":"10.1016\/j.ctrv.2025.102976_b0150","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.breast.2022.12.001","article-title":"Does mainstream BRCA testing affect surgical decision-making in newly-diagnosed breast cancer patients?","volume":"67","author":"Ain","year":"2023","journal-title":"Breast"},{"key":"10.1016\/j.ctrv.2025.102976_b0155","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.annonc.2022.09.159","article-title":"Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1\/2 and high-risk, early breast cancer","volume":"33","author":"Geyer","year":"2022","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0160","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMoa2409932","article-title":"Overall survival with pembrolizumab in Early-stage triple-negative breast cancer","volume":"391","author":"Schmid","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0165","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.annonc.2024.02.002","article-title":"Event-free survival by residual cancer burden with pembrolizumab in early-stage TNBC: exploratory analysis from KEYNOTE-522","volume":"35","author":"Pusztai","year":"2024","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0170","article-title":"Tumor suppressor heterozygosity and homologous recombination deficiency mediate resistance to front-line therapy in breast cancer","author":"Safonov","year":"2024","journal-title":"bioRxiv [Preprint]"},{"issue":"2","key":"10.1016\/j.ctrv.2025.102976_b0175","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/S1470-2045(23)00534-X","article-title":"International multidisciplinary consensus on the integration of radiotherapy with new systemic treatments for breast cancer: European Society for Radiotherapy and Oncology (ESTRO)-endorsed recommendations","volume":"25","author":"Meattini","year":"2024","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0180","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1245\/s10434-019-07549-8","article-title":"Consensus guidelines on genetic testing for hereditary breast cancer from the American Society of Breast Surgeons","volume":"26","author":"Manahan","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0185","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.56078","article-title":"Cost-effectiveness of population-based multigene testing for breast and ovarian cancer prevention","volume":"7","author":"Guo","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ctrv.2025.102976_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/mps7040063","article-title":"Evaluation of an Italian population-based programme for risk assessment and genetic counselling and testing for BRCA1\/2-related hereditary breast and ovarian cancer after 10 years of operation: an observational study protocol","volume":"7","author":"Ferretti","year":"2024","journal-title":"Methods Protoc"},{"key":"10.1016\/j.ctrv.2025.102976_b0195","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1002\/cam4.2824","article-title":"A regional population-based hereditary breast cancer screening tool in Italy: first 5-year results","volume":"9","author":"Cortesi","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0200","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.breast.2023.03.017","article-title":"Patients' experiences with pre-test genetic counseling provided by breast cancer healthcare professionals: results from a large prospective multicenter study","volume":"69","author":"Bokkers","year":"2023","journal-title":"Breast"},{"key":"10.1016\/j.ctrv.2025.102976_b0205","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12687-024-00720-z","article-title":"Exploring family communication preferences in hereditary breast and ovarian cancer and lynch syndrome: a national Canadian survey","volume":"15","author":"Burke","year":"2024","journal-title":"J Commun Genet"},{"key":"10.1016\/j.ctrv.2025.102976_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100235","article-title":"Impact of deleterious variants in other genes beyond BRCA1\/2 detected in breast\/ovarian and pancreatic cancer patients by NGS-based multi-gene panel testing: looking over the hedge","author":"Bono","year":"2021","journal-title":"ESMO Open"},{"key":"10.1016\/j.ctrv.2025.102976_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1060504","article-title":"Clinical usefulness of NGS multi-gene panel testing in hereditary cancer analysis","volume":"14","author":"Anaclerio","year":"2023","journal-title":"Front Genet"},{"key":"10.1016\/j.ctrv.2025.102976_b0220","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1200\/JCO.20.02151","article-title":"Marcom PK et al TBCRC 048: phase II study of Olaparib for metastatic breast cancer and mutations in homologous recombination-related genes","volume":"38","author":"Tung","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0225","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jgc4.1075","article-title":"Patients' perspectives of variants of uncertain significance and strategies for uncertainty management","volume":"28","author":"Makhnoon","year":"2019","journal-title":"J Genet Couns"},{"key":"10.1016\/j.ctrv.2025.102976_b0230","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/pon.1467","article-title":"Distress among women receiving uninformative BRCA1\/2 results: 12-month outcomes","volume":"18","author":"O'Neill","year":"2009","journal-title":"Psychooncology"},{"key":"10.1016\/j.ctrv.2025.102976_b0235","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.pec.2020.10.020","article-title":"How patients deal with an ambiguous medical test: decision-making after genetic testing","volume":"104","author":"Scherr","year":"2021","journal-title":"Patient Educ Couns"},{"issue":"2","key":"10.1016\/j.ctrv.2025.102976_b0240","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/cge.13966","article-title":"Clinical management among individuals with variant of uncertain significance in hereditary cancer: a systematic review and meta-analysis","volume":"100","author":"Makhnoon","year":"2021","journal-title":"Clin Genet"},{"issue":"4","key":"10.1016\/j.ctrv.2025.102976_b0245","doi-asserted-by":"crossref","first-page":"e472","DOI":"10.1200\/OP.21.00322","article-title":"Association between genetic testing for hereditary breast cancer and contralateral prophylactic mastectomy among multiethnic women diagnosed with early-stage breast cancer","volume":"18","author":"Ro","year":"2022","journal-title":"JCO Oncol Pract"},{"issue":"20","key":"10.1016\/j.ctrv.2025.102976_b0250","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1002\/cncr.34429","article-title":"Use of breast surveillance between women with pathogenic variants and variants of uncertain significance in breast cancer susceptibility genes","volume":"128","author":"Makhnoon","year":"2022","journal-title":"Cancer"},{"key":"10.1016\/j.ctrv.2025.102976_b0255","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12687-021-00556-x","article-title":"Fragmented responsibility: views of Israeli HCPs regarding patient recontact following variant reclassification","volume":"13","author":"Fridman","year":"2022","journal-title":"J Commun Genet"},{"key":"10.1016\/j.ctrv.2025.102976_b0260","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.44526","article-title":"Clinical variant reclassification in hereditary disease genetic testing","volume":"7","author":"Kobayashi","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ctrv.2025.102976_b0265","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1200\/JCO.23.02225","article-title":"Germline testing in patients with breast cancer: ASCO-society of surgical oncology guideline","volume":"42","author":"Bedrosian","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ctrv.2025.102976_b0270","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1001\/jama.2020.0229","article-title":"Prevalence of pathogenic variants in cancer susceptibility genes among women with postmenopausal breast cancer","volume":"323","author":"Kurian","year":"2020","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.ctrv.2025.102976_b0275","article-title":"Deep learning identifies morphological patterns of homologous recombination deficiency in luminal breast cancers from whole slide images","volume":"3","author":"Lazard","year":"2022","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.ctrv.2025.102976_b0280","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1200\/JCO.23.02641","article-title":"Deep learning artificial intelligence predicts homologous recombination deficiency and platinum response from histologic slides","volume":"42","author":"Bergstrom","year":"2024","journal-title":"J Clin Oncol"}],"container-title":["Cancer Treatment Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305737225000982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305737225000982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:49:32Z","timestamp":1755499772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305737225000982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":56,"alternative-id":["S0305737225000982"],"URL":"https:\/\/doi.org\/10.1016\/j.ctrv.2025.102976","relation":{},"ISSN":["0305-7372"],"issn-type":[{"value":"0305-7372","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PREDICTIVE BRCA GENETIC TESTING IN ITALIAN PATIENTS WITH BREAST CANCER: A POSITION PAPER OF ITALIAN SCIENTIFIC SOCIETIES [Italian Association of Medical Oncology(AIOM); Italian Association of Radiotherapy and Clinical Oncology (AIRO); Italian National Association of Breast Surgeons (ANISC); Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP); Italian Society of Surgical Oncology (SICO); Italian Society of Human Genetic (SIGU); Italian Society of General Practice (SIMG); Italian Society of Medical and Interventional Radiology (SIRM)]","name":"articletitle","label":"Article Title"},{"value":"Cancer Treatment Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ctrv.2025.102976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102976"}}