{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:20:38Z","timestamp":1792729238465,"version":"4.5.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3364,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.cub.2004.04.036","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T07:29:28Z","timestamp":1083655768000},"page":"782-786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["The Drosophila Carbonyl Reductase Sniffer Prevents Oxidative Stress-Induced Neurodegeneration"],"prefix":"10.1016","volume":"14","author":[{"given":"Jose A","family":"Botella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K","family":"Ulschmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Gruenewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Moehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Kretzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Schneuwly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2004.04.036_BIB1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/0929867013372922","article-title":"Chemistry and biochemistry of oxidative stress in neurodegenerative disease","volume":"8","author":"Sayre","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.cub.2004.04.036_BIB2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","article-title":"Molecular pathways of neurodegeneration in Parkinson's disease","volume":"302","author":"Dawson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cub.2004.04.036_BIB3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2174\/0929867013373048","article-title":"Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease","volume":"8","author":"Butterfield","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.cub.2004.04.036_BIB4","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0047-6374(01)00249-4","article-title":"Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins","volume":"122","author":"Butterfield","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cub.2004.04.036_BIB5","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0960-9822(07)00514-3","article-title":"A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system","volume":"22","author":"Melzig","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2004.04.036_BIB6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF01148464","article-title":"Glial membrane specializations and the compartmentalization of the lamina ganglionaris of the housefly compound eye","volume":"2","author":"Saint Marie","year":"1983","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.cub.2004.04.036_BIB7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.291.5504.643","article-title":"Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster","volume":"291","author":"Kanzok","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cub.2004.04.036_BIB8","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","article-title":"The genome sequence of Drosophila melanogaster","volume":"287","author":"Adams","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cub.2004.04.036_BIB9","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1021\/bi00018a001","article-title":"Short-chain dehydrogenases\/reductases (SDR)","volume":"34","author":"Jornvall","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.cub.2004.04.036_BIB10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0009-2797(00)00196-4","article-title":"Carbonyl reductase","volume":"129","author":"Forrest","year":"2000","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cub.2004.04.036_BIB11","first-page":"193","article-title":"Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheime\u0155s disease","volume":"61","author":"Blacz","year":"2001","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.cub.2004.04.036_BIB12","first-page":"6849","article-title":"Cloning and bacterial expression of monomeric short-chain dehydrogenase\/reductase (carbonyl reductase) from CHO-K1 cells","volume":"267","author":"Terada","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cub.2004.04.036_BIB13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cub.2004.04.036_BIB14","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1096\/fasebj.13.13.1733","article-title":"Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia","volume":"13","author":"Mockett","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.cub.2004.04.036_BIB15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.micro.57.030502.090938","article-title":"Pathways of oxidative damage","volume":"57","author":"Imlay","year":"2003","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.cub.2004.04.036_BIB16","doi-asserted-by":"crossref","first-page":"15671","DOI":"10.1074\/jbc.270.26.15671","article-title":"Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster","volume":"270","author":"Sohal","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2004.04.036_BIB17","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/S0960-9822(01)00393-1","article-title":"Cooperative action of antioxidant defense systems in Drosophila","volume":"11","author":"Missirlis","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2004.04.036_BIB18","doi-asserted-by":"crossref","first-page":"8574","DOI":"10.1073\/pnas.92.19.8574","article-title":"Subunit-destabilizing mutations in Drosophila copper\/zinc superoxide dismutase","volume":"19","author":"Phillips","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096098220400301X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096098220400301X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:57:12Z","timestamp":1760777832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096098220400301X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S096098220400301X"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2004.04.036","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Drosophila Carbonyl Reductase Sniffer Prevents Oxidative Stress-Induced Neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2004.04.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Cell Press. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}