{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:30:29Z","timestamp":1791351029093,"version":"4.3.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3029,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.cub.2005.02.029","type":"journal-article","created":{"date-parts":[[2005,4,12]],"date-time":"2005-04-12T12:23:10Z","timestamp":1113308590000},"page":"650-655","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":196,"title":["The Drosophila Homologue of the Hereditary Spastic Paraplegia Protein, Spastin, Severs and Disassembles Microtubules"],"prefix":"10.1016","volume":"15","author":[{"given":"Antonina","family":"Roll-Mecak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D.","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2005.02.029_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/15472","article-title":"Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia","volume":"23","author":"Hazan","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2005.02.029_bib2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1001\/archneur.61.6.830","article-title":"Hereditary spastic paraplegia: Spastin phenotype and function","volume":"61","author":"Fink","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.cub.2005.02.029_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jsb.2003.11.020","article-title":"Phylogenetic analysis of AAA proteins","volume":"146","author":"Frickey","year":"2004","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.cub.2005.02.029_bib4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00427-003-0340-x","article-title":"Identification of the Drosophila melanogaster homolog of the human spastin gene","volume":"213","author":"Kammermeier","year":"2003","journal-title":"Dev. Genes Evol."},{"key":"10.1016\/j.cub.2005.02.029_bib5","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.cub.2004.06.058","article-title":"The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function","volume":"14","author":"Trotta","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cub.2005.02.029_bib6","doi-asserted-by":"crossref","first-page":"e429","DOI":"10.1371\/journal.pbio.0020429","article-title":"Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function","volume":"2","author":"Sherwood","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cub.2005.02.029_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/hmg\/ddg004","article-title":"Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus","volume":"12","author":"Charvin","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2005.02.029_bib8","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1093\/hmg\/ddh223","article-title":"Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon","volume":"13","author":"Errico","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2005.02.029_bib9","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.bbrc.2004.03.195","article-title":"Identification of nuclear localisation sequences in spastin (SPG4) using a novel Tetra-GFP reporter system","volume":"318","author":"Beetz","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cub.2005.02.029_bib10","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/jnen\/62.11.1166","article-title":"The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene","volume":"62","author":"Wharton","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cub.2005.02.029_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/hmg\/ddi003","article-title":"The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B","volume":"14","author":"Reid","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2005.02.029_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/hmg\/11.2.153","article-title":"Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics","volume":"11","author":"Errico","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2005.02.029_bib13","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/ana.10757","article-title":"Hereditary spastic paraparesis: Disrupted intracellular transport associated with spastin mutation","volume":"54","author":"McDermott","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cub.2005.02.029_bib14","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1212\/01.WNL.0000118204.90814.5A","article-title":"Large-scale disruption of microtubule pathways in morphologically normal human spastin muscle","volume":"62","author":"Molon","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.cub.2005.02.029_bib15","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1126\/science.286.5440.782","article-title":"Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin","volume":"286","author":"Hartman","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.cub.2005.02.029_bib16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0092-8674(93)90377-3","article-title":"Identification of katanin, an ATPase that severs and disassembles stable microtubules","volume":"75","author":"McNally","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cub.2005.02.029_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/hmg\/9.4.637","article-title":"Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia","volume":"9","author":"Fonknechten","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2005.02.029_bib18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1046\/j.1365-2443.2001.00447.x","article-title":"AAA+ superfamily ATPases: Common structure\u2014diverse function","volume":"6","author":"Ogura","year":"2001","journal-title":"Genes Cells"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982205001703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982205001703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:03:06Z","timestamp":1760778186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982205001703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0960982205001703"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2005.02.029","relation":{},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Drosophila Homologue of the Hereditary Spastic Paraplegia Protein, Spastin, Severs and Disassembles Microtubules","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2005.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}