{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:13:43Z","timestamp":1791036823190,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":2695,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Biology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.cub.2006.02.062","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T10:48:41Z","timestamp":1144234121000},"page":"710-716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":188,"title":["MeCP2-Dependent Transcriptional Repression Regulates Excitatory Neurotransmission"],"prefix":"10.1016","volume":"16","author":[{"given":"Erika D.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ege T.","family":"Kavalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Monteggia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cub.2006.02.062_bib1","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1086\/302690","article-title":"Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots","volume":"65","author":"Wan","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib2","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/hmg\/9.9.1369","article-title":"Rett syndrome: analysis of MECP2 and clinical characterization of 31 patients","volume":"9","author":"Huppke","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib3","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/hmg\/9.9.1377","article-title":"MECP2 mutations account for most cases of typical forms of Rett syndrome","volume":"9","author":"Bienvenu","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/(SICI)1096-8628(20000103)90:1<69::AID-AJMG12>3.0.CO;2-W","article-title":"Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq","volume":"90","author":"Amir","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib6","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2006.02.062_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome","volume":"21","author":"Asaka","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cub.2006.02.062_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0959-4388(96)80121-8","article-title":"Imaging exocytosis and endocytosis","volume":"6","author":"Betz","year":"1996","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.cub.2006.02.062_bib9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0166-2236(00)02030-0","article-title":"Limited numbers of recycling vesicles in small CNS nerve terminals: implications for neural signaling and vesicular cycling","volume":"24","author":"Harata","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cub.2006.02.062_bib10","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0896-6273(00)80146-4","article-title":"Definition of the readily releasable pool of vesicles at hippocampal synapses","volume":"16","author":"Rosenmund","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2006.02.062_bib11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.neuron.2004.12.056","article-title":"An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission","volume":"45","author":"Sara","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2006.02.062_bib12","doi-asserted-by":"crossref","first-page":"40545","DOI":"10.1074\/jbc.M402229200","article-title":"Regulation of histone acetylation during memory formation in the hippocampus","volume":"279","author":"Levenson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cub.2006.02.062_bib13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2005.02.003","article-title":"Minis: whence and wherefore?","volume":"45","author":"Zucker","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2006.02.062_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/4548","article-title":"Miniature synaptic events maintain dendritic spines via AMPA receptor activation","volume":"2","author":"McKinney","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cub.2006.02.062_bib15","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1126\/science.1096202","article-title":"Regulation of dendritic protein synthesis by miniature synaptic events","volume":"304","author":"Sutton","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cub.2006.02.062_bib16","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1086\/345360","article-title":"Rett syndrome and MeCP2: linking epigenetics and neuronal function","volume":"71","author":"Shahbazian","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib17","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/cercor\/10.10.981","article-title":"Dendritic anomalies in disorders associated with mental retardation","volume":"10","author":"Kaufmann","year":"2000","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.cub.2006.02.062_bib18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature01248","article-title":"Synaptic depression in the localization of sound","volume":"421","author":"Cook","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cub.2006.02.062_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0896-6273(02)00659-1","article-title":"Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo","volume":"34","author":"Chung","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.cub.2006.02.062_bib22","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature03010","article-title":"Synaptic computation","volume":"431","author":"Abbott","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cub.2006.02.062_bib23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2005.07.025","article-title":"Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett Syndrome in mice","volume":"59","author":"Gemelli","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cub.2006.02.062_bib24","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1093\/hmg\/ddh282","article-title":"Mild overexpression of MeCP2 causes a progressive neurological disorder in mice","volume":"13","author":"Collins","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib25","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.1107470","article-title":"Control of excitatory and inhibitory synapse formation by neuroligins","volume":"307","author":"Chih","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cub.2006.02.062_bib26","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/hmg\/ddh158","article-title":"Disorder-associated mutations lead to functional inactivation of neuroligins","volume":"13","author":"Chih","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cub.2006.02.062_bib27","doi-asserted-by":"crossref","first-page":"12893","DOI":"10.1073\/pnas.96.22.12893","article-title":"Activity-dependent regulation of synaptic clustering in a hippocampal culture system","volume":"96","author":"Kavalali","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cub.2006.02.062_bib28","doi-asserted-by":"crossref","first-page":"18206","DOI":"10.1073\/pnas.0407976101","article-title":"Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo","volume":"101","author":"Dittgen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Current Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982206012620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960982206012620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:05:46Z","timestamp":1760778346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982206012620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0960982206012620"],"URL":"https:\/\/doi.org\/10.1016\/j.cub.2006.02.062","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1033913.388050","asserted-by":"object"}]},"ISSN":["0960-9822"],"issn-type":[{"value":"0960-9822","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MeCP2-Dependent Transcriptional Repression Regulates Excitatory Neurotransmission","name":"articletitle","label":"Article Title"},{"value":"Current Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cub.2006.02.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}